Fabrice Berna

Fabrice Berna
CHRU de Strasbourg, Université de Strasbourg, Inserm U1114 · Department Psychiatry

Prof. of Psychiatry (MD, PhD)

About

152
Publications
28,514
Reads
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Introduction
My main research topic is about autobiographical memory and the self in schizophrenia. More specifically, with Jean-Marie Danion and his coworkers we are interested in exploring the autobiographical memory deficits underlying the disorders of the self which are observed in patients with schizophrenia. We are also developing cognitive remediation methods in order to improve patients' autobiographical memory.
Additional affiliations
September 2018 - September 2018
New York University Shanghai
Position
  • Research Assistant
Description
  • In the lab of Prof. Sze Chai Kwok
September 2017 - present
University of Strasbourg
Position
  • Professor (Full)
June 2015 - November 2015
University Medical Center Hamburg - Eppendorf
Position
  • Post doctoral position
Education
November 2006 - August 2010
University of Strasbourg, University Hospital of Strasbourg, INSERM U666, France
Field of study
September 1996 - October 2006
University of Nancy, France
Field of study
  • Medicine

Publications

Publications (152)
Article
Résumé La psychiatrie actuelle reconnaît les « dyskinésies spontanées » comme des manifestations possibles de la schizophrénie. Nous pensons qu’il ne s’agit que d’un nouveau nom donné à des mouvements anormaux intrinsèques aux psychoses endogènes décrits depuis plus d’un siècle sous le nom de « parakinésies ». Celles-ci ont été décrites, filmées et...
Article
The World Health Organization (WHO) recommends adults complete 150-300 min per week of moderate physical activity or 75-150 min of vigorous physical activity or an equivalent combination of both, to optimize health. To explore the factors associated with adequate MVPA in stabilized outpatients with schizophrenia. 425 stabilized outpatients were rec...
Article
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Background Previous research has reported that patients with schizophrenia would regard false memories with higher confidence, and this meta-memory deficit was suggested as a neurocognitive marker of schizophrenia. However, how schizophrenia patients determine their memory decision confidence has received scant consideration. This study, therefore,...
Article
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Current classification systems use the terms “catatonia” and “psychomotor phenomena” as mere a-theoretical descriptors, forgetting about their theoretical embedment. This was the source of misunderstandings among clinicians and researchers of the European collaboration on movement and sensorimotor/psychomotor functioning in schizophrenia and other...
Article
Objectif Le « seasonal pattern assessment questionnaire » (SPAQ) est le questionnaire le plus utilisé pour évaluer les effets saisonnier de l’humeur et du comportement, et est souvent utilisé comme outil de dépistage de dépression saisonnière syndromale et sous-syndromale. L’objectif de cette étude est de valider la version française du questionnai...
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Background Metabolic syndrome (MetS) is a highly prevalent and harmful medical disorder often comorbid with psychosis where it can contribute to cardiovascular complications. As immune dysfunction is a key shared component of both MetS and schizophrenia (SZ), this study investigated the relationship between immune alterations and MetS in patients w...
Article
Objectives High rates of non-right-handedness (NRH) including mixed-handedness have been reported in neurodevelopmental disorders. In schizophrenia (SZ), atypical handedness has been inconsistently related to impaired features. We aimed to determine whether SZ subjects with NRH and mixed-handedness had poorer clinical and cognitive outcomes compare...
Article
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Recovery is a multidimensional construct that can be defined either from a clinical perspective or from a consumer-focused one, as a self-broadening process aimed at living a meaningful life beyond mental illness. We aimed to longitudinally examine the overlap and mutual distinctions between clinical and personal recovery. Of 1239 people with schiz...
Article
On December 11, 2018, five people were killed and 11 injured during a terrorist attack on Strasbourg's Christmas market. As the attacker was on the run during the night, part of the population was locked down for several hours. Our study aimed at assessing factors associated with the development of PTSD and health services use among the victims. Fo...
Article
The aim of our study was to compare the performance of three different instruments measuring clinical and cognitive dimensions of insight. Data on 182 outpatients with schizophrenia and one-year follow-up assessments was drawn from the FACE-SZ cohort. Awareness of clinical state (« clinical insight ») was measured using both a clinician-rated measu...
Article
Autobiographical memory disorders are well described in schizophrenia. Current research on patients’ memory impairments aims to: 1) better understand the cognitive processes responsible for those difficulties, and 2) develop new methods to palliate autobiographical memory disorders in schizophrenia. The present review describes how the use of weara...
Article
Full-text available
The aim of our study was to compare the performance of three different instruments measuring clinical and cognitive dimensions of insight. Data on 182 outpatients with schizophrenia and one-year follow-up assessments was drawn from the FACE-SZ cohort. Awareness of clinical state (« clinical insight ») was measured using both a clinician-rated meas...
Article
The Seasonal Pattern Assessment Questionnaire (SPAQ), by Rosenthal et al. (1984), is by far the most used questionnaire to evaluate seasonal effects on mood and behavior. It includes a general seasonality score (GSS), composed of 6 items, from which cutoffs have been established to screen for seasonal affective disorder (SAD). However, it has never...
Article
Full-text available
Treatment resistant schizophrenia (TRS) affects around 30% of patients with schizophrenia resulting in poor functioning, relapses and reduced quality of life. Convergent findings show that inflammation could contribute to resistance. We thus search for immune signatures of patients with TRS/UTRS in a sample of community-dwelling outpatients with sc...
Article
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Introduction: The literature has provided contradictory results regarding the status of episodic memory in autism spectrum disorder (ASD). This might be explained by methodological differences across studies. In the present one, the well-recommended Autobiographical Interview was used in which important aspects of episodic memory were assessed, nam...
Article
Bipolar disorder (BD) is a disabling disorder with functional impact on everyday life. Recent studies suggest that autobiographical memory impairment may contribute to the maintenance of psychopathology, leading to enduring altered self-construct. Moreover, past personal experiences also support the ability to project oneself into the future to pre...
Article
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We conducted a longitudinal online study to examine attenuated psychotic symptoms (APS) over time in a sample of locked-down individuals. We used (i) questionnaires and (ii) the automatic analysis of the emotional content of narratives. Participants ( N = 162) were recruited to complete an online survey 4 times between March and June 2020 (T1, T2,...
Article
Patients with schizophrenia show severe autobiographical memory impairment, thought to reflect retrieval deficits caused by executive dysfunction. However, prior research has focused exclusively on strategic (voluntary) retrieval, and ignored involuntary retrieval resulting from automatic and associative processes, involving minimal cognitive contr...
Article
Schizophrenia is associated with memory disorders that affect patients in their daily life. Patients complain about difficulty to remember knowledge that has been recently learnt together with its context (episodic memory, EM) but also more complex events that have been personally experienced (autobiographical memory, AM). While deficits at both en...
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The structural characteristics of self-concept refer to the way in which the elements of self-knowledge are organized and can be experienced by individuals in the form of self-concept clarity. It is intimately linked to autobiographical memory. Therefore, we sought to compare self-concept clarity and autobiographical memory between adults with ASD...
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Background: There is growing concern about measuring patient experience with mental health care. There are currently numerous patient-reported experience measures (PREMs) available for mental health care, but there is little guidance for selecting the most suitable instruments. The objective of this systematic review was to provide an overview of...
Article
Introduction Delivering bad news is a stressful moment for both patient and clinician. As poor bad-news consultation quality may lead to misunderstandings, lack of treatment adherence, acute or even post-traumatic stress in patients, training interventions to improve communication skills and stress-management are necessary. Mindfulness is a recogni...
Article
Full-text available
Background The acknowledgment of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a pandemic status. Indeed, high prevalence rates of depression, sleep disorders, and post-traumatic stress disorder (PTSD) have been reported in Chinese healthcare workers during the epidemic...
Article
Full-text available
Background: The determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive v...
Article
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Involuntary autobiographical memories are mental representations of personally experienced past events that come to mind spontaneously, with no preceding attempt to recall them. They have been showed to be more frequent and more emotional in the psychosis continuum. Although schizophrenia is strongly associated with thought disorders, including cog...
Article
Background: Music therapy is based on the use of musical elements by a trained and qualified therapist. Clinical researches have suggested that children with Autism Spectrum Disorders (ASD) may benefit from MT. In this regard, this study examines if MT is more effective than simply listening to music for children with ASD. Method: A 8-month RCT...
Article
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Acyl coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI) is a multifunctional protein with an intracellular action (as ACBP), as well as with an extracellular role (as DBI). The plasma levels of soluble ACBP/DBI are elevated in human obesity and reduced in anorexia nervosa. Accumulating evidence indicates that genetic...
Preprint
Full-text available
Background: The acknowledgement of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a pandemic status. Indeed, high prevalence rates of depression, sleep disorders and post-traumatic stress disorder (PTSD) have been reported in Chinese healthcare workers during the epidemic...
Article
Full-text available
Autobiographical memory (AM) impairment in schizophrenia affects the richness of detail in personal memories and is one of the major predictors of patients’ social functioning. Despite the empirical evidence attributing these difficulties to a defective encoding process, cognitive remediation interventions targeting AM in schizophrenia often focus...
Article
Full-text available
Résumé Les effets psychologiques de l’isolement ont déjà été décrits dans la littérature (expéditions polaires, sous-marins, prison). Néanmoins l’échelle du confinement mis en œuvre à l’occasion de la pandémie à COVID-19 est inédite. Il nous faut non seulement relire les études publiées, mais aussi anticiper les problèmes psychologiques qui pourrai...
Article
Full-text available
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-L...
Article
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Objective: To compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551). Method: In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were...
Article
The prevalence of auditory hallucinations in schizophrenia, and theories suggesting a link between autobiographical memory and hallucination, raise the possibility of a dominant role of auditory imagery in autobiographical remembering in patients with schizophrenia, whereas visual imagery is dominant in autobiographical memory of healthy adults. Th...
Article
Full-text available
Objective: To compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551). Method: In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were as...
Article
Full-text available
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-L...
Article
Introduction La catatonie périodique (KP) est un des phénotypes de psychose endogène le plus fréquent, souvent responsable d’un handicap sévère. Elle se caractérise par une désorganisation des processus psychomoteurs dont la séméiologie est peu maîtrisée par les psychiatres et difficile à quantifier en raison d’un parasitage de la clinique par les...
Article
Full-text available
Background: Schizophrenia is associated with severe cognitive deficits, particularly episodic memory deficits, that interfere with patients' socio-professional functioning. Retrieval practice (also known as testing effect) is a well-established episodic memory strategy that involves taking an initial memory test on a previously learned material. T...
Article
Although long-acting injection (LAI) is presented as first line treatment option for patients with psychosis, negative attitudes toward this galenic negatively impact the selection of this treatment option. However, these negative attitudes may not be confined to patients but also observed in the general population. A web-based study on 1807 partic...
Article
Résumé Au tournant du siècle, la valeur DSM s’est effondrée outre-Atlantique, entraînant dans sa chute la notion médicale classique de phénotype même pour la recherche fondamentale sur les psychoses. Sur leurs ruines ont émergé de nouveaux concepts : les dimensions prônées par l’association des psychiatres américains dans la partie recherche du DSM...
Article
Résumé Ces dernières années, les publications d’écrits autobiographiques de personnes avec autisme se multiplient et connaissent un important succès. Elles donnent la parole à des personnes que leur handicap empêche habituellement d’exprimer leur vécu et leur expérience. Nous avons étudié les récits autobiographiques publiés de cinq personnes avec...
Article
Full-text available
Cognitive disorders are considered as a core symptom of schizophrenia. Importantly, episodic autobiographical memory deficits are strongly related to patients’ social dysfunction. Although the cognitive mechanisms underlying autobiographical memory deficit are highly important to open the door for specific cognitive remediation, they are yet to be...
Article
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People with schizophrenia experience difficulties in remembering their past and envisioning their future. However, while alterations of event representation are well documented, little is known about how personal events are located and ordered in time. Using a think-aloud procedure, we investigated which strategies are used to determine the times o...
Article
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Periodic catatonia (PC) is a psychomotor phenotype with a progressive-remitting course. While it can fit any disorder diagnosis of the schizoaffective spectrum, its core features consist of a mix of hypo- and hyperkinesias resulting in distortions of expressive movements such as grimacing and parakinesias. The replication of cerebral blood flow (CB...
Article
Full-text available
Schizophrenia is characterised by difficulty understanding the thoughts and intentions of other people. Misunderstandings could lead people to attribute hostility to others’ actions. Theories suggest that we use our autobiographical memories to inform our understanding of other people but no study has examined the relation between memory and hostil...
Article
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Background: Up to half of the patients with schizophrenia attempt suicide during their lifetime. Better insight is associated with better functioning but also with increased suicidality. The direction of the relationship between insight and suicidality is not clear, hence we aimed to provide new elements using structural equation modeling. Method...
Article
Objective: Existing staging models have not been fully validated. Thus, after classifying patients with schizophrenia according to the staging model proposed by McGorry et al. (2010), we explored the validity of this staging model and its stability after one-year of follow-up. Method: Using unsupervised machine-learning algorithm, we classified...
Article
Introduction Chronic and treatment resistant catatonias are orphans’ pathologies. No treatment has ever been developed or is currently in the pipeline for these conditions. As a toolbox, rTMS might correct abnormal brain activity in relation with psychomotor disorders provided the knowledge on where and how to modulate it using functional brain ima...
Article
Full-text available
Background Integrative and complementary health approaches (ICHA) are often pursued by patients facing chronic illnesses. Most of the studies that investigated the factors associated with ICHA consumption have considered that the propensity to use ICHA is a stable or fixed characteristic of an individual. However, people may prefer using ICHA in so...
Article
Introduction: This study aimed was to investigate the relationship between different types of childhood trauma and the level of insight (i.e., awareness of having a psychiatric disorder) in subjects suffering from schizophrenia, as well as the putative role of clinical mediators. Methods: 294 community-dwelling subjects with stable schizophrenia...
Article
The relationship between hallucinations and stressful life events in psychosis is recognised, and has recently been supported by findings showing that the frequency of involuntary autobiographical memory and future projection predicts hallucination-proneness in the general population. To better understand the nature of this relationship, an online...
Article
Background: Extrapyramidal side effects (EPS) have been identified as a complication of antipsychotic treatment. Previous meta-analyses have investigated EPS prevalence and risk factors in randomized clinical trials with highly selected patients, but studies in real-world schizophrenia are missing. Objective: To examine the prevalence and clinic...
Article
There is a debate over the extent to which personal identity or the self is preserved in patients with Alzheimer’s disease (AD). Autobiographical memory deficits at early stages of AD could contribute to altering patients’ self. However, the nature of the relationship between autobiographical memory deficits and the self in AD has not been much inv...
Article
Neurocognitive deficits in patients with mental disorders are partially due to secondary influences. “Stereotype threat” denotes the phenomenon that performance is compromised when a participant is confronted with a devaluing stereotype. The present study examined the impact of stereotype threat on neuropsychological performance in schizophrenia. S...
Article
La catatonie périodique, telle que définie par l’école de Wernicke-Kleist-Leonhard [1], ne correspond pas à une forme récurrente de catatonie définie par la CIM ou le DSM. Elle ne correspond pas plus à la catatonie périodique de Gjessing avec laquelle l’homonymie prête systématiquement à confusion dans la littérature. En effet, il ne s’agit pas d’u...
Article
Les recherches menées dans le domaine de la cognition en psychiatrie ont permis de mieux comprendre non seulement certains aspects de la physiopathologie des grands syndromes psychiatriques mais également de préciser les sources du handicap fonctionnel des patients. Le bilan cognitif ou neuropsychologique s’est ainsi imposé progressivement dans les...
Article
La notion d’une transmission inter et transgénérationnelle d’une vulnérabilité voire de troubles psychiatriques connaît un intérêt grandissant depuis les travaux présentés dans les deux conférences précédentes (celle du Professeur Mansuy portant sur des modèles animaux de transmission transgénérationnelle et celle du Professeur Rutten en épigénétiq...