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Publications (97)
Hydrotherapy has been utilized in horse rehabilitation programs for over four decades. However, a comprehensive description of the swimming cycle of horses is still lacking. One of the challenges in studying this motion is 3D underwater motion capture, which holds potential not only for understanding equine locomotion but also for enhancing human s...
The assessment of lameness in horses can be aided by objective gait analysis tools. Despite their key role of evaluating a horse at trot on a circle, asymmetry thresholds have not been determined for differentiating between sound and lame gait during this exercise. These thresholds are essential to distinguish physiological asymmetry linked to the...
Osteoarthritis (OA) is a widespread osteoarticular pathology characterized by progressive hyaline cartilage degradation, exposing horses to impaired well-being, premature career termination, alongside substantial financial losses for horse owners. Among the new therapeutic strategies for OA, using mesenchymal stromal cell (MSC)-derived exosomes (MS...
Context: Osteoarthritis (OA) is an invalidating articular disease characterized by cartilage degradation and inflammatory events. In horses, OA is associated with up to 60% of lameness and leads to reduced animal welfare along with extensive economic losses; currently, there are no curative therapies to treat OA. The mesenchymal stromal cell (MSC)...
The burden of osteoarthritis (OA), one of the major causes of functional disabilities in humans and animals, continues to increase worldwide while no disease-modifying OA drugs (DMOADs) that either slow down or reverse disease progression have been made available. Here, we provide a brief overview of recent advances in: designing new OA drug delive...
Histology of the equine hind suspensory ligament (SL) has mainly focussed on the ligament itself. In human medicine, the enthesis or tendon-to-bone insertion is generally considered a linked entity or 'enthesis-organ' and several types have been determined. Dedicated research in equine medicine is lacking. This poster describes the preliminary resu...
Equine standing cone beam computed tomography (sCBCT) is a recent modality, with most research focusing on the distal extremity and head. This pilot study was intended to determine feasibility for sCBCT of the proximal metatarsal suspensory enthesis.
Osteoarthritis (OA) is a degenerative and heterogeneous disease that affects all types of joint structures. Current clinical treatments are only symptomatic and do not manage the degenerative process in animals or humans. One of the new orthobiological treatment strategies being developed to treat OA is the use of drug delivery systems (DDS) to rel...
Equine osteoarthritis (OA) leads to cartilage degradation with impaired animal well-being, premature cessation of sport activity, and financial losses. Mesenchymal stem cell (MSC)-based therapies are promising for cartilage repair, but face limitations inherent to the cell itself. Soluble mediators and extracellular vesicles (EVs) secreted by MSCs...
Objective:
To describe scintigraphic and transrectal ultrasonographic anatomic variants of the lumbosacral (LS) articulation in horses and to determine the agreement between results obtained with each imaging modality.
Animals:
243 horses (81 Selle Français Warmbloods, 81 French Standardbred Trotters, and 81 Thoroughbreds).
Procedures:
A retro...
This prospective study aimed to blindly compare the ultrasonographic and standing magnetic resonance imaging (sMRI) findings in deep digital flexor tendon (DDFT), navicular bone, and navicular bursa in horses with foot pain, positive digital analgesia, and without definitive radiographic diagnosis. Ultrasonography detected more DDFT abnormalities (...
Osteoarthritis (OA) is a significant cause of pain in both humans and horses with a high socio-economic impact. The horse is recognized as a pertinent model for human OA. In both species, regenerative therapy with allogeneic mesenchymal stem cells (MSCs) appears to be a promising treatment but, to date, no in vivo studies have attempted to compare...
Osteoarthritis is a common cause of pain and economic loss in both humans and horses. The horse is recognized as a suitable model for human osteoarthritis, because the thickness, structure, and mechanical properties of equine articular cartilage are highly comparable to those of humans. Although a number of equine experimental osteoarthritis models...
Osteoarthritis (OA) remains incurable in humans or horses and mesenchymal stromal/stem cells (MSCs) represent an attractive solution for producing a neocartilage substitute. However, the best MSC source still needs to be identified. This study compared the chondrogenic potential of equine MSCs derived from bone marrow (BM) and umbilical cord blood...
Osteoarthritis is a significant and costly cause of pain for both humans and horses. The horse has been identified as a suitable model for human osteoarthritis. Regenerative therapy with allogeneic mesenchymal stem cells (MSCs) is a promising treatment, but the safety of this procedure continues to be debated. The aim of this study is to evaluate t...
This descriptive study aimed to compare the magnetic resonance appearance of the distal interphalangeal joint articular cartilage between standing weight-bearing and non-weight-bearing conditions. Ten forefeet of live horses were scanned in a standing low-field magnetic resonance system (0.27 T). After euthanasia for reasons unrelated to the study,...
Frontal measurements data.
(CSV)
Sagittal measurements data.
(CSV)
Results of blinded reading.
(CSV)
Proximal suspensory desmopathy is one of the most common injuries in sporthorses. In cases with suspected bone pathology, radiography is a routine on-site imaging modality, but its sensitivity and specificity for diagnosing proximal suspensory enthesiopathy are considered low. The present study aimed to determine the best LM x-ray beam incident ang...
Cartilage engineering is a new strategy for the treatment of cartilage damage due to osteoarthritis or trauma in humans. Racehorses are exposed to the same type of cartilage damage and the anatomical, cellular, and biochemical properties of their cartilage are comparable to those of human cartilage, making the horse an excellent model for the devel...
Articular cartilage is a tissue characterized by its poor intrinsic capacity for self-repair. This tissue is frequently altered upon trauma or in osteoarthritis (OA), a degenerative disease that is currently incurable. Similar musculoskeletal disorders also affect horses and OA incurs considerable economic loss for the equine sector. In the view to...
Supplementary materials of "Characterization of different sources of human MSCs expanded in serum-free conditions with quantification of chondrogenic induction in 3D" (Stem Cells International, Volume 2019, Article ID 2186728, 19 pages
https://doi.org/10.1155/2019/2186728
Imaging of the proximal tarsus can be achieved in both standing and anaesthetized horses. The height of the horse and the amount of hind end musculature determines which magnet configuration will produce the best images of this region. Soft tissue and osseous abnormalities of the proximal tarsus can be assessed using magnetic resonance imaging (MRI...
Introduction Matrix therapy was introduced as a new branch in regenerative medicine led by the concept that reorganisation of the extracellular matrix (ECM) and restoration of the cellular micro-environment can trigger a regeneration process. Robust demonstration were provided in many publications [1] describing the efficacy of ReGeneraTing Agents...
Cisternal puncture in dogs and cats is commonly carried out. This article describes the percutaneous ultrasound anatomy of the cisternal region in the dog and the cat and an indirect technique for ultrasound-guided cisternal puncture. Ultrasound images obtained ex vivo and in vivo were compared with anatomic sections and used to identify the landma...
Background
Articular cartilage defects are a veritable therapeutic problem because therapeutic options are very scarce. Due the poor self-regeneration capacity of cartilage, minor cartilage defects often lead to osteoarthritis. Several surgical strategies have been developed to repair damaged cartilage. Autologous chondrocyte implantation (ACI) giv...
Objective:
To determine history; clinical, radiographic, ultrasonographic, and scintigraphic features; management; and outcome associated with third trochanter fractures in horses.
Design:
Retrospective case series.
Animals:
8 horses.
Procedures:
Records from 2000 to 2012 were reviewed, and signalment, case history, severity and duration of...
i>Diagnostic imaging of equine thoracolumbar disorders
Equine thoracolumbar conditions represent a major cause of poor performance and locomotor disorders in sports and race horses. Advances in diagnostic imaging during the last 15 years allow today to diagnose most equine back lesions in the standing sedated horse. Radiography is the first choice...
We present a method for the automatic analysis of whole slide histological images of equine tendinopathy. This computer-aided analysis is a pre-screening tool that helps veterinarians doctors to evaluate the efficacy of new treatments. A set of textural, arrangement, and alignment features are extracted to reproduce visual histological criteria, ea...
To characterize the clinical features, diagnostic procedures, treatment, and outcome for horses with an exostosis on the palmar or plantar cortex of the third metacarpal bone (MC3) or third metatarsal bone (MT3).
Retrospective case series.
16 horses.
Records from 2001 through 2010 were evaluated to identify horses with radiographic and ultrasonogra...
Equine superficial digital flexor tendons (SDFT) are often injured, and they represent an excellent model for human sport tendinopathies. While lesions can be precisely diagnosed by clinical evaluation and ultrasonography, a prognosis is often difficult to establish; the knowledge of the injured tendon's mechanical properties would help in anticipa...
Ultrasonography is an easy and rewarding technique for the assessment of collateral ligaments of the distal interphalangeal joint (CL-DIPJ) desmopathies and enthesopathies. Comparison between ligaments of both feet and oblique incidence improve sensitivity and specificity of the ultrasonographic diagnosis. The main limitation of the procedure is im...
The collateral ligaments (CL) of the distal interphalangeal joint (DIPJ) are important structures for DIPJ stability. Collateral ligament injuries must be considered in the differential diagnosis of foot pain. An accurate examination of the CL-DIPJ can be performed with an adequate ultrasonographic technique and equipment. This paper describes the...
Magnetic resonance (MR) imaging has become an important diagnostic tool in the investigation of foot pain in horses. The aim of this study was to qualitatively compare ex-vivo MR images of the same equine feet obtained at three magnetic field strengths: 0.27, 1.5, and 3 tesla (T). Ten cadaver feet were used. All feet were imaged with two high-field...
Lateral scintigraphic images of the necks of 12 show jumping horses, 12 thoroughbreds and 12 French trotters were evaluated. Custom-written automatic analysis software was used to segment the regions of the articular processes and vertebral symphyses from C3 to C7 and to calculate their mean radiopharmaceutical uptakes. The uptakes by the two sides...
PROXIMAL palmar metacarpal pain is recognised as a major cause of forelimb lameness in athletic horses ([Dyson 2003][1]). The differential diagnosis is routinely based on clinical findings, perineural analgesia, and ultrasonographic, radiographic and nuclear scintigraphic examinations ([Dyson 2003][
To evaluate the efficacy of tiludronate for the treatment of horses with signs of pain associated with lesions of the thoracolumbar vertebral column.
29 horses with clinical manifestations of pain associated with lesions of the thoracolumbar vertebral column and abnormal radiographic findings indicative of osteoarthritis of the articular processes-...
Objective-To evaluate the efficacy of tiludronate for the treatment of horses with signs of pain associated with lesions of the thoracolumbar vertebral column. Animals-29 horses with clinical manifestations of pain associated with lesions of the thoracolumbar vertebral column and abnormal radiographic findings indicative of osteoarthritis of the ar...
L’Imagerie par Résonance Magnétique (IRM) est aujourd’hui en médecine humaine la technique d’imagerie de référence pour l’appareil locomoteur. L’objectif de cet article est de présenter les apports de l’IRM dans le diagnostic des affections locomotrices du cheval à partir des patients examinés au CIRALE à l’aide d’une machine bas champ (0,2 T) avec...
Magnetic Resonance Imaging (MRI) is the current gold standard in human medicine for locomotor apparatus imaging. This paper presents the interest of MRI in the diagnosis of equine locomotor disorders, based on patients examined at the CIRALE centre with a C-shape low-field system (0.2 T). The protocols used and indications of this technique are des...
Bone scintigraphy is a valuable technique in the diagnosis of lameness in horses, nevertheless it implies radiation exposure of staff members. Spectrometry during a bone scintigraphic examination (soft tissue and bone phase) was performed to determine efficiency of leaded protections, and the energy spectrum which should be detected for the staff w...
The anatomic variations and the degenerative changes in the collateral cartilages and middle and distal phalanges in 6 Ardenner colts were characterized by radiography, scintigraphy, and magnetic resonance imaging (MRI). The radiographic changes were assessed between the ages of 16.5 and 25 months. An anatomic variation of the middle and distal pha...
L’examen scintigraphique osseux est une technique intéressante pour les examens locomoteurs chez le cheval, cependant il impose une exposition aux rayonnements ionisants du personnel pendant sa réalisation. Une spectrométrie durant les deux phases de l’examen scintigraphique osseux (examen des tissus mous et osseux) chez le cheval a permis de déter...
Bone scintigraphy is a valuable technique in the diagnosis of lameness in horses. Dosimetry and measurements of waste contamination have been done to determine radiation hazards during bone scintigraphy exams in horses. For a single examination of an adult horse (500 kg bw) requiring 5.027 GBq of technetium, dose rates have been detected according...
Complications of cervical myelography arising from the puncture of the subarachnoid space to collect the cerebrospinal fluid and to inject the contrast medium have been described in humans and animals. In this study, 2 ultrasound-guided procedures were developed for puncture of the atlanto-occipital subarachnoid space, collection of cerebrospinal f...
The purpose of this paper was to correlate the magnetic resonance imaging (MRI) characteristics of a mature brain abscess in a horse with histopathologic alterations of brain tissue. Eight months after the onset of clinical signs, MRI of the brain of a 10-month-old filly was performed. A large space-occupying lesion in the right cerebral hemisphere...
General anaesthesia and lateral recumbency on a special table are compulsory for magnetic resonance imaging of the horse. Specific equipments (table, anaesthetic equipment and monitoring) are introduced in the magnet room. These equipments can modify the image quality and thus alter the diagnostic quality. The purpose of this study was to evaluate...
In humans, magnetic resonance (MR) imaging is the method of choice for the diagnosis of stress fractures. In this paper, bilateral stress fracture of the lateral condyle of the third metacarpal bone in a French trotter is described. Results of the radiographic, MR imaging, and histologic examinations are presented, with a focus on the MR signal abn...
L’application de l’IRM (imagerie par résonance magnétique) chez le cheval nécessite son couchage sous anesthésie générale. Des équipements spécifiques (table de couchage, matériel d’anesthésie, monitoring) sont ainsi introduits dans la salle de l’aimant. Ces équipements sont susceptibles de dégrader la qualité propre de l’image et de nuire ainsi à...
A thorough knowledge of the horse's back and limb movements at different speeds is important in the design of training programmes and the prevention of speed‐related injuries. The objective of this study was to investigate changes in muscle activity and kinematics of the trot with increased speed. To evaluate these effects, 4 Saddlehorses were reco...
The aim of this paper is to present a method allowing the identification of the lame limb in trotting horses. Using a 3-D kinematic analysis system, 13 sound and 25 lame horses fitted with 4 skin markers placed on the dorsal midline of their trunk were recorded while trotting on a track in the conditions of the routine lameness examination. The ver...
The objective of this study was to assess the effects of asymmetric placement of the foot on the three-dimensional motions of the interphalangeal joints. Four isolated forelimbs were used. Trihedrons, made of three axes fitted with reflective markers, were screwed into each phalanx. They allowed to establish a local frame associated with each bone...
This study was undertaken to describe the symmetry of movements of fore- and hindlimbs in horses suffering from various spontaneous lamenesses. Two groups of horses were studied: 13 clinically sound horses and 24 lame horses. Using a 3-dimensional (3-D) kinematic analysis system, movements of both sides of each horse were recorded simultaneously wh...
Speed related changes in trunk mechanics have not yet been investigated, although high-speed training is currently used in the horse. To evaluate the effects of speed on back kinematics and trunk muscles activity, 4 saddle horses were recorded while trotting on a horizontal treadmill at speeds ranging from 3.5 to 6 m/s. The 3-dimensional (3-D) traj...
The proximal interphalangeal joint (PIPJ) has always been considered as a low‐motion joint with an almost constant angle during loading of the limb. Until very recently, its motion was not taken into account in kinematic studies in vivo . Recent in vivo studies yielded surprisingly high ranges of motion in this joint. The aim of this study was to m...
The purpose of this study was to quantify small amplitude rotational movements in the metacarpophalangeal joint (MPJ) of the horse and to measure the influence of asymmetric placement of the foot on these articular angles. Trihedrons, supporting kinematic markers defining a local frame, were screwed into the third metacarpal bone and the proximal p...
The aim of this paper is to present a method which enables the recordings of cameras that are not equipped with a synchronisation system to be synchronised a posteriori. Using the Direct Linear Transformation technique, this method estimates the phase difference between two cameras by minimising the reconstruction errors of a moving point. Once the...
The diagnosis of lesions can be made with ultrasonography in many painful joints with no abnormal radiographic findings. These lesions include ligament, capsule, synovial, and meniscal injuries as well as periarticular injuries. When abnormal radiographic findings are present, complementary ultrasonographic evaluation provides more information conc...