Fabio Vignoletti

Fabio Vignoletti
Complutense University of Madrid | UCM · Facultad de Odontología

DDS, PhD

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99
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Publications

Publications (99)
Article
Full-text available
The dynamics of tissue wound healing associated with dental implants placed in fresh extraction sockets or in healed alveolar ridges are not fully understood. Therefore, the aim of this preclinical in vivo investigation was to evaluate soft tissue healing and osseointegration after immediate implant placement, compared with delayed implant placemen...
Article
Objective To evaluate the influence of patient and implant‐related factors on the changes of marginal bone levels (MBL) at implants with a follow‐up ≥5 years. Materials and Methods At baseline (within 6 months from prosthetic insertion) and long‐term (≥5 years after implant placement) visits, interproximal (mesial and distal) MBL were radiographic...
Article
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This study aimed to determine the performance and characteristics of a synthetic barrier membrane of polylactic acid and acetyl butyl citrate (PLAB) for the lateral bone augmentation of peri-implant dehiscence defects (mean height × depth = 3 mm × 1 mm). In eight dogs, three treatment groups were randomly allocated at each chronic peri-implant dehi...
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Aim: To evaluate the hard and soft tissues healing around teeth prepared with the biologically oriented preparation technique (BOPT) versus the chamfer technique versus non-prepared teeth. Materials and methods: Thirty-two teeth in eight beagle dogs were randomly prepared with the BOPT (test = 16) or chamfer (control = 16) techniques and covered...
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Objectives The aims of the present longitudinal retrospective observational case series study were to investigate the survival and success rates of primary non-surgical endodontic therapy. Materials and methods Patients with at least one endodontically treated tooth (ETT), with 5 years of follow-up and in compliance with the recall programme of at...
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Aim: The present pilot RCT aimed to investigate the influence of a connective tissue graft (CTG) in combination with the immediate implant placement (IIP) on hard and soft tissue healing, without a bone replacement graft in the gap between the implant and the socket walls. Materials and methods: Thirty patients requiring extraction of one anteri...
Article
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(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, trans...
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Objectives Evaluate the dimensions and morphology of peri-implant tissues around a modified dental implant designed with tissue level connection and a convergent transmucosal neck, when compared with a conventional bone level implant connected to a cylindrical machined titanium abutment. Material and methods Eight experimental animals were used fo...
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Objectives The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the development of experimental peri-implantitis. Material and methods Eight beagle dogs received 5 tests and 5 control implants each following a split-mouth design...
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Objective To evaluate the hard tissue volumetric and soft tissue contour linear changes in implants with two different implant surface characteristics after a ligature-induced peri-implantitis.Material and methodsIn eight beagle dogs, implants with the same size and diameter but distinct surface characteristics were placed in the healed mandibular...
Article
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Objectives Purpose of this experimental in-vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the de novo bone formation and osseointegration. Material and Methods The study was designed as an animal pre-clinical trial with intra-animal control and two healing p...
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COVER ILLUSTRATION: The cover image is based on the Original Article Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects An experimental in vivo study by Ui‐Won Jung et al., https://doi.org/10.1111/clr.13726.
Article
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Objective To assess the contour and volumetric changes of hard and soft tissues after guided bone regeneration (GBR) using two types of barrier membranes together with a xenogeneic bone substitute in dehiscence-type defects around dental implants.Material and methodsIn 8 Beagle dogs, after tooth extraction, two-wall chronified bone defects were dev...
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THE USE OF AUTOLOGOUS BONE blocks is often associated with great morbidity. This article describes a technique with a lower risk of complications for the harvesting of bone block grafts and their later use for the horizontal bone regeneration of the alveolar process. We present two cases and their long-term evolution. We can conclude that this tech...
Article
Aim To investigate the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross‐linked collagen membrane for guided bone regeneration. Methods Three experimental groups were randomly allocated at chronic peri‐implant dehiscence defect in 8 beagle dogs: (i) biphasic calcium phosphate covered by a cross‐linked col...
Article
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Aim: to compare soft tissue dimensional changes and relative differences in soft and hard tissue volumes 4 months after single tooth extraction and 3 different treatment modalities: spontaneous healing (SH) and alveolar ridge preservation by means of a deproteneized bovine bone mineral and a collagen matrix, with (IMPL/DBBM/CM) or without (DBBM/CM...
Article
Aim: To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. Material and methods: This quasi-randomized controlled pilot phase II clinical trial included patients requiring a t...
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Objective To evaluate the changes in alveolar contour after guided bone regeneration (GBR) with two different combinations of biomaterials in dehiscence defects around implants. Material and methods Chronic alveolar ridge defects were created bilaterally in the mandible of eight Beagle dogs. Once implants were placed, three treatment groups were r...
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Objectives The aim of this cross-sectional study is to (i) determine the prevalence, extent, severity, and distribution of gingival recessions and patient perception in a young population and (ii) to identify potential risk indicators. Material and methods Two hundred fifty-one students with a mean age of 22.9 ± 4.7, attending the School of Dentis...
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Background: The transition from a tooth requiring extraction to its replacement (with a dental implant) requires a series of clinical decisions related to timing, approach, materials, cost-effectiveness and the assessment of potential harm and patient preference. This workshop focused on the formulation of evidence-based consensus statements and c...
Article
Aim to radiographically evaluate the effect of immediate implant placement plus alveolar ridge preservation (ARP) with a deproteneized bovine bone mineral and a collagen matrix (IMPL/DBBM/CM) as compared to ARP (DBBM/CM) or spontaneous healing (SH) on vertical and horizontal bone dimensional changes after 4 months of healing. Materials and methods...
Article
Aim Reports regarding prevalence of peri‐implant diseases show widely varying prevalence rates, which can be explained partially by variable diagnostic criteria adopted. Furthermore, several different factors have been associated with peri‐implant diseases. Hence, the aim of this cross‐sectional study is to i) determine the prevalence, extent and s...
Article
Full-text available
Periodontitis is a chronic inflammatory condition leading to destruction of the tooth supporting tissues, which if left untreated may cause tooth loss. The treatment of periodontitis mainly aims to arrest the inflammatory process by infection control measures, although in some specific lesions a limited periodontal regeneration can also be attained...
Article
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Objectives to study the early and late bone healing around implants placed according to a flapless immediate (test) or flapped delayed (control) implant surgical protocol. Material and Methods in eight beagle dogs, immediate and delayed implants were placed. Test and Control implants were randomly assigned and horizontal and vertical bone remodell...
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Purpose The aim of this systematic review was to critically analyze the available evidence on the effect of different modalities of alveolar ridge preservation (ARP) as compared to tooth extraction alone in function of relevant clinical, radiographic and patient‐centered outcomes. Material and Methods A comprehensive search aimed at identifying pe...
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The objective of this review is to analyze the available literatura considering the surgical procedures aiming to accelerate the orthodontic tooth movement to evaluate the safety and efficacy. Several surgical techniques based on corticotomy and dental distraction have been developed to improve the movement of teeth and reduce the duration of ortho...
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Objectives To study the hard and soft tissue volume after placing immediate (IMI) or delayed implants (DLI) with a triangular coronal macro‐design (Test/T) or a conventional cylindrical design (Control/C). Material and Methods T/C implants were inserted in healed ridges or in fresh extraction sockets of eight beagle dogs. Biopsies were processed f...
Article
This report describes the long-term outcomes of nonsurgical periodontal therapy and supportive periodontal treatment (SPT) of a 21-year-old patient affected by generalized aggressive periodontitis at multiple teeth with a compromised prognosis. After 25 years of SPT, no teeth had been extracted and no periodontal pockets associated with bleeding on...
Article
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Objective: The objective of this study was to evaluate soft tissue contour changes after three different regenerative therapies in chronic ridge defects. Material and methods: Buccal bone defects were created in the mandible of nine beagle dogs. Augmentation procedures were performed 3 months later using a bone replacement graft (BRG), resorbabl...
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Aim: The objective of this in-vivo experimental study to evaluate the regenerative potential of a cell therapy combining allogenic periodontal ligament derived cells with in a xenogeneic bone substitute in a similar experimental model. Methods: In 9 beagle dogs, critical-size 6 mm supra-alveolar periodontal defects were created around the PIII a...
Article
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Background The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. Methods In 15 patients with severe horizontal alveola...
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El objetivo del trabajo es presentar, de forma descriptiva, los datos de supervivencia de implantes colocados con la técnica de elevación transcrestal. Se presentan datos de 109 implantes colocados de forma consecutiva con hueso residual menor a 6mm y con un seguimiento de hasta 13 años. Se analizan las variables y consideraciones quirúrgicas que p...
Article
Aim: To study the healing of peri-implant tissues around implants with a triangular coronal third (test) or cylindrical (control). Material and methods: In eight beagle dogs, immediate and delayed implants were placed. Test and control implants were randomly assigned and the hard and soft tissue healing was evaluated with histology and Micro CT...
Article
Aim: The aim of this pre-clinical in?vivo study was to analyse different stages of wound healing after guided bone regeneration in non-contained mandibular buccal bone defects. Materials and methods: Eighteen female beagle dogs, between 1.5 and 2?years old, were used. Buccal bone defects were created in the mandible following extraction of the m...
Article
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Actualmente, el abordaje más apropiado para el tratamiento con implantes dentales es planificar la rehabilitación protésica más adecuada para el paciente y, posteriormente, colocar los implantes en la posición tridimensional óptima para su posterior restauración. Por este motivo, es frecuente la necesidad de realizar procedimientos de aumento óseo...
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Aim: To assess patient-reported outcome measures (PROMs), aesthetics and stability of root coverage procedures from a previous 6-month RCT after 1 year. Material & methods: 45 patients (90 recessions) had received a coronally advanced flap (CAF = control) only or a xenogeneic collagen matrix in addition (CAF + CMX = test). Visual analogue scales...
Article
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El objetivo de este artículo es realizar una descripción so-bre las similitudes y diferencias del tejido periimplantario y periodontal y cómo influyen en la etiología, desarrollo y tra-tamiento de recesiones en dientes y dehiscencias del tejido blando en implantes. A lo largo del artículo se realiza una re-visión de la influencia de la encía querat...
Article
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The aim of this paper is to describe a new technique for the regeneration of severe peridontal defects with the combined aplicación of enamel matriz proteins derivatives and a particulated xenograft covered with a bioabsorbable collagen membrane. The technique is presented with a clinical case where the regeneration of multiple sever periodontal de...
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The aim of this paper is to describe a new technique for the vertical and horizontal reconstruction of the alveolar crest using autogenous bone blocks stabilized through a minimal invasive tunnel access previous to the dental implants placement. Thus, the technique and a clinical case in which a reconstruction of the hard and soft tissues is perfor...
Article
Presentamos el caso de una paciente de 50 años que acude por primera vez a nuestra consulta. No refiere dolor y demanda mejorar su estética. A pesar del moti-vo de la consulta, tiene unas expectativas realistas, se muestra muy colaboradora y asume en todo momento la dificultad que entraña el caso y el tiempo probable de tratamiento. Además, la paci...
Article
To review the histological and clinical outcomes of the use of bone substitues in different oral bone regenerative procedures: socket preservation, immediate implant placement, lateral and vertical bone augmentation. Histological animal studies and clinical trials regarding the performances of bone substitutes, either allogenic, xenogeneic or allop...
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In this preliminary study, the 3-year radiological outcomes of Osseospeed implant-supported fixed complete or partial prostheses made with two different laboratory protocols were compared. A convenience sample of 34 patients, who were either partially or completely edentulous in either jaw, were randomly assigned to two groups, of 17 patients each,...
Article
In recent years, immediate implant placement has become a common clinical therapeutic protocol representing an alternative to the classical delayed surgical protocol of implant placement. This protocol, however, has not been fully validated, either in terms of fully understanding the influence of implant placement on the socket-healing process or o...
Article
AimTo evaluate the aesthetic outcomes of zirconia versus titanium abutments for single tooth implant-supported crowns in the anterior maxilla.Material & methodsA parallel, double blind clinical trial was conducted at the Complutense University (Madrid), where 38 patients were recruited. After random allocation (via computer generated permuted block...
Article
Aim: To evaluate histologically the healing of a xenogeneic collagen matrix (CM) used to augment the width of keratinized tissue around teeth. Materials and methods: The gingiva on the buccal aspect of mandibular and maxillary premolars was surgically excised on 12 minipigs. After 1 month of plaque accumulation, the resulting defects were random...
Article
AimTo evaluate the impact that immediate implant placement may have on bone remodelling in comparison with adjacent sockets left to heal spontaneously.Materials and methodsIn a beagle dog model (N = 16 dogs), mandibular premolars were extracted, and implants were placed in each distal socket (test) with the corresponding mesial site left to heal un...
Article
To review the biological processes of wound healing following periodontal and periimplant plastic surgery when different technologies are used in a) the coverage of root and implant dehiscences, b) the augmentation of keratinized tissue (KT) and c) the augmentation of soft tissue volume. An electronic search from The National Library of Medicine (M...
Article
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L os procesos alveolares de los maxilares son estructu-ras óseas dependientes de la existencia de los dien-tes. Este área ósea será sometido a cambios es-tructurales significativos cuando se pierden los dientes. La dinámica y la magnitud de estos cambios han sido investi-gados en modelos animales (1), así como en seres huma-nos (2). Estas investiga...
Conference Paper
Objective: to evaluate the impact on the crest vertical and horizontal bone remodelling after immediate implants were placed in extraction sockets, in comparison with the adjacent socket left heal spontaneously. Method: 16 adult beagle dogs and 5 healing periods were analyzed. Mandibular premolars were extracted and immediate implants were placed...
Article
Aim: To describe the early healing events in the alveolar socket during the first 8 weeks of spontaneous healing after tooth extraction. Materials and methods: 16 adult beagle dogs were selected and five healing periods were analysed (4 h, 1 week, 2 weeks, 4 weeks, 8 weeks). Mandibular premolars were extracted and each socket corresponding to th...
Article
Aim: To evaluate the clinical outcomes of the use of a xenogeneic collagen matrix (CM) in combination with the coronally advanced flap (CAF) in the treatment of localized recession defects. Material & methods: In a multicentre single-blinded, randomized, controlled, split-mouth trial, 90 recessions (Miller I, II) in 45 patients received either C...
Conference Paper
Objective: to study the early modeling and remodeling of the buccal and lingual alveolar crests during the first 8 weeks of spontaneous healing after tooth extraction. Method: this prospective, randomised, examiner blinded pre-clinical study studied 16 beagle dogs with 5 healing periods from 4 hours to 8 weeks. Teeth 3P3 and 4P4 were extracted an...
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Manejo de tejidos duros y blandos para la obtención de un adecuado perfi l de emergencia en implantes del sector anterior Resumen Uno de los mayores retos de la implantología es la obten-ción de un resultado estético adecuado tanto a nivel de las restauraciones (estética blanca), como de los tejidos blandos que rodean a las restauraciones (estética...
Article
The aim was to assess the quality of reporting of experimental research in implant dentistry by a critical evaluation of study design, outcome assessments and model validation. An online search was performed using the MEDLINE. Experimental studies performed in both animals and humans were included. A’stratified random sample of the included studies...
Article
This systematic review aims to evaluate the scientific evidence on the efficacy in the surgical protocols designed for preserving the alveolar ridge after tooth extraction and to evaluate how these techniques affect the placement of dental implants and the final implant supported restoration. A thorough search in MEDLINE-PubMed, Embase and the Coch...
Article
Objective This systematic review aims to evaluate the scientific evidence on the efficacy in the surgical protocols designed for preserving the alveolar ridge after tooth extraction and to evaluate how these techniques affect the placement of dental implants and the final ...
Article
Full-text available
La rehabilitación dental de los pacientes parcial o total-mente edéntulos con implantes orales se ha convertido en una práctica común en las últimas décadas, con resultados predecibles a largo plazo (1). Sin embargo, no sólo se debe tener en cuenta la supervi-vencia de los implantes a largo plazo sino también la salud de los tejidos periimplantario...
Article
The purpose of this investigation is to describe histologically the undisturbed healing of fresh extraction sockets when compared to immediate implant placement. In eight beagle dogs, after extraction of the 3P3 and 4P4, implants were inserted into the distal sockets of the premolars, while the mesial sockets were left to heal spontaneously. Each a...
Article
The periodontal regeneration of bone defects is often unsatisfactory and could be largely improved by cell therapy. Therefore, the purpose of this study was to evaluate the regenerative potential of implanting canine cementum-derived cells (CDCs) and canine periodontal ligament-derived cells (PDLDCs) in experimentally created periodontal intrabony...
Article
To describe the histological and clinical outcomes of the use of a xenogeneic collagen matrix (CM) in combination with the coronally advanced flap (CAF) in the treatment of localized Miller class-I gingival recessions. Gingival recession defects were surgically created on 12 minipigs. The defects were randomly treated with either the CAF procedure...
Article
To evaluate whether different implants placed immediately upon tooth extraction may affect the dimension and composition of the peri-implant soft tissues. Eight beagle dogs received implants randomly installed into the distal socket of 3P3 and 4P4. Four commercially available implant systems were evaluated: 3i Osseotite Certain straight; Astra Micr...
Conference Paper
Objectives: to evaluate the soft tissue healing when implants of different surfaces and designs are placed into fresh extraction sockets Methods: eight beagle dogs were included in the study. Four implant systems were evaluated: 3i, AstraTech, Thommen and Straumann. Implants were randomly installed into the distal sockets of third and fourth mandib...
Conference Paper
Objectives: to study the healing of fresh extraction sockets and compare the dimensional alterations of the alveolar ridge that occurred 6 weeks after immediate implant placement or following undisturbed healing. Methods: eight beagle dogs were included in the study. Implants were installed into the distal socket of third and fourth mandibular prem...
Article
Full-text available
Les relations entre les tissus mous et la surface implantaire représentent un défi considérable pour les fabricants d'im-plants si l'on considère les différents types de connexions, de cols implantaires et de plateformes qui existent. La pré-sence assez constante d'une hauteur d'attache conjonctive sur les implants dentaires, qui est semblable sous...
Article
Full-text available
Periodontitis is a chronic inflammatory condition that leads to the destruction of the tooth-supporting tissues. Its treatment includes the arrest of the inflammatory process and, in some circumstances, the restoration of the lost anatomy and function, including the formation of new cementum, periodontal ligament (PDL), and bone. With this goal, we...
Article
To describe histologically the early phases of soft tissue healing to implants placed into fresh extraction sockets. In 16 beagle dogs, 64 3.25-mm-wide cylindrical screw implants were inserted into the distal sockets of the third and fourth lower premolars using a one-stage trans-mucosal healing protocol. Biopsies were then taken at 1, 2, 4 and 8 w...
Article
To study the wound healing of acellular dermal matrix (ADM) allografts when used together with coronally advanced flaps (CAF) in the treatment of localized gingival recessions in the mini-pig experimental model. Dehiscence defects 4 x 5 mm were surgically created in one buccal root surface in each quadrant of PI, II, or III in three mini-pigs. They...