Fábio Henrique Fernandes

Fábio Henrique Fernandes
São Paulo State University | Unesp · Department of Pathology

PhD

About

23
Publications
3,731
Reads
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188
Citations
Citations since 2016
14 Research Items
179 Citations
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Introduction
Fábio Henrique Fernandes is Co-founder of SciVisual (www.scivisual.com) and currently develop research at the Department of Pathology, São Paulo State University. Fábio Henrique does research in Environmental Mutagenesis, Medicinal Chemistry, and Molecular Biology.
Additional affiliations
February 2021 - present
SciVisual
Position
  • Scientific Illustrator
Description
  • Co-founder and Scientific Illustrator at SciVisual - Design for Science
February 2020 - July 2020
Universidade Nove de Julho
Position
  • Professor (Full)
Description
  • Teacher of Physiopathology (Medical School)
January 2019 - December 2019
Faculdade da Alta Paulista
Position
  • Teacher of Higher Education
Description
  • Teacher - Human Genetics, Molecular Biology, Chemistry, Oncology, Biotechnology
Education
October 2012 - December 2016
São Paulo State University
Field of study
  • Biological Sciences (Genetics)
January 2010 - June 2012
Universidade Federal de Mato Grosso do Sul
Field of study
  • Chemistry of Natural Products and Mutagenesis
January 2006 - January 2009
Universidade para o Desenvolvimento do Estado e da Região do Pantanal
Field of study
  • Reproductive Toxicology

Publications

Publications (23)
Article
Among the great number of studies on the chemical and biological features of propolis from Brazil, none have been found on the evaluation of the biological properties of propolis from the Cerrado biome of Center-West Brazil. Propolis biological activities have principally been attributed to its phenolic compounds, notable for significant antioxidan...
Article
Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (...
Article
Color Index (C.I.) Disperse Red 1 (DR1) is a widely used textile azo dye found in rivers. As it may not be completely removed by conventional treatments, humans can be exposed through drinking water. Studies have supported in vitro toxicity and mutagenicity of commercial DR1. This study aimed to investigate the mutagenic and toxicogenomic effects o...
Article
Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, prim...
Article
Some agrochemicals are genotoxic to several organisms. Nevertheless, few protocols are currently available for measuring the toxicogenetic effects of these compounds in target and non-target field-collected species of insects important to agriculture. Herein, we used the species Ceraeochrysa claveri (Neuroptera: Chrysopidae), a non-target predator...
Article
Cannabidiol (CBD) is a natural cannabinoid present in the Cannabis sativa plant, widely prescribed as an anticonvulsant drug, especially for pediatric use. However, its effects on male reproduction are still little investigated. Therefore, the present study assessed the effects of CBD on the spermatogenesis and sperm quality. For this, twenty-one-d...
Article
Dinitrophenylazo dyes can form 2‐phenylbenzotriazoles (PBTAs) in the textile dyeing process upon the addition of chemical reducing agents. Some dinitrophenylazo dyes, as well as their respective reduced (non‐chlorinated) and chlorinated PBTAs, are now found in rivers owing to wastewater from textile plants. This study aimed to investigate the genot...
Article
The use of doxorubicin (DOX) as an antineoplastic drug is compromised by its cardiotoxicity risk. Although several mechanisms have been proposed for DOX-induced cardiac dysfunction, there is still increased interest in assessing its effects. Likewise, it is important to find protocols that can prevent or minimize the side effects of DOX without hin...
Article
Full-text available
In the present study, we aimed to evaluate the effects of different concentrations of selenium (Se) ovine nutritional supplementation on spermatozoa DNA integrity. Thirty male ovines (age: 10 months) were used. They were fed with hay and ram food in an intensive system, which was divided into stalls (5 m long and 3 m wide) with feeding troughs, and...
Article
Full-text available
Few information on the biological properties of the chemical constituents of propolis produced by Apis mellifera from the Cerrado of Midwest Brazil has hitherto been reported. In the present work, the mutagenic properties of five compounds isolated from a sample of brown propolis from the aforesaid biome, namely, caffeic (1), p-coumaric (2), dihydr...
Article
Full-text available
Background: Oxidative stress is one potential mechanism that explain the direct effects of smoking on cardiac remodeling process. However, no study has compared different myocardial products of macromolecule oxidation after tobacco smoke exposure. Thus, the aim of this study was to investigate the lipid hydroperoxide (LH) levels, protein carbonyl...
Article
Accidents involving snakebites constitute a serious public health problem in many regions around the world. However, there are no study about a possible action of snake venom on the reproductive system. Herein we show that Crotalus durissus sp. (Linnaeus) rattlesnake venom (25 μg/kg of body weight) affected chromatin condensation, and increased the...
Article
Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile ma...
Article
Prenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1 mg/...
Chapter
Full-text available
Corantes são moléculas orgânicas, naturais ou sintéticas, largamente empregados em diversas indústrias, como a têxtil, alimentícia, farmacêutica, de couros, de cosméticos, de combustíveis, entre outras. A baixa fixação dos corantes em fibras têxteis, couros e cabelos tem sido responsável pela contaminação de efluentes, águas superficiais e águas de...
Article
Full-text available
Biological, and particularly antimicrobial, activities have been demonstrated for the essential oil of propolis samples worlwide, yet their mutagenic effects remain unknown. To correlate antimicrobial effects with mutagenic risks, the present study evaluated the antifungal and antibacterial activities of the essential oil obtained from brown propol...
Conference Paper
Solanum lycocarpum A. St.-Hil. (Solanaceae), popularly known as “fruit-of-wolf”, is a hairy shrub or small much-branched tree of the Brazilian Cerrado. Plants belonging to the genus Solanum are known for their high concentration of alkaloids. Solasonine and solamargine are two of the major glycoalkaloids found in at least 100 Solanum species. Studi...
Article
Disperse Red 1 (DR1), which is widely used in the textile industry, is an azo dye that contributes to the toxicity and pollution of wastewater. To assess the toxic effects of DR1 on reproduction, sexually mature male mice (Mus musculus, strain CF-1) were orally (gavage) treated with single doses of the compound at 20, 100 and 500mg/kg body weight....
Article
Full-text available
We evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess...
Article
Full-text available
Arsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mi...

Questions

Question (1)
Question
Hi everone, I’m looking to extract high quality RNA (including miRNA) from mouse semen. In this context, the Direct-zol™ RNA MiniPrep Kit shows an exciting promise. However, could anyone share any personal experience about it? Thanks!

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Projects

Projects (2)
Project
1. Sharing & recommending publications. 2. Connecting with colleagues. 3. Seeking new collaborations. Внедрение на нашей планете предложенного и разработанного автором источника чистой энергии-нано-энергетики Шестого экономического уклада -единственного в мире безвредного, возобновляемого, эффективного, воспроизводимого, устойчивого и дешевого источника энергии даёт возможность выжить человечеству в замкнутом пространстве тропосферы на планете Земля в условии чрезвычайного отравления атмосферы отходами производства промышленности-отходящими газами и запредельными количествами промышленных и бытовых отходов на поверхности планеты, сохранив при этом иммунитет населения, так как топливом для предложенной Кулаковым нано энергетики новой технологической парадигмы являются все отходы жизнедеятельности самого же человечества.