Fabio Godinho

• MD. PhD
• Hospital Santa Marcelina

Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to evaluate the effectiveness of spinal cord stimulation in Parkinson's disease. Methods Participants had Parkinson's d...

Background Deep Brain Stimulation (DBS) is an established treatment option for refractory dystonia, but the improvement among the patients is variable. Objective To describe the outcomes of DBS of the subthalamic region (STN) in dystonic patients and to determine whether the volume of tissue activated (VTA) inside the STN or the structural connecti...

Objective: Parkinson’s disease (PD) patients may be categorized into tremor-dominant (TD) and postural-instability and gait disorder (PIGD) motor phenotypes, but the dynamical aspects of subthalamic nucleus local field potentials (STN-LFP) and the neural correlates of this phenotypical classification remain unclear. Methods: 35 STN-LFP (20 PIGD and...

Parkinson’s Disease (PD) is a neurodegenerative progressive disorder characterized by asymmetric lateral motor impairment, usually associated with key clinical motor symptoms, such as tremor, rigidity and bradykinesia. Although it is known that specific local field potentials (LFP) band power recorded from the subthalamic nucleus (STN) correlate wi...

Parkinson’s Disease (PD) is a neurodegenerative illness associated with dopaminergic loss in the basal ganglia circuit which can lead to heterogeneous motor symptoms such as tremor, rigidity and bradykinesia. The electrophysiological phenomena underlying these symptoms is not completely understood, which imposes a major challenge for designing cust...

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Currently, PD represents a complex “circuitopathy” involving the cortex, thalamus, basal ganglia, and associated locomotor networks. Freezing of gait (FOG) is a typical symptom affecting around 50% of advanced PD patients with a massive impact on their mobility, safet...

Background and Study Aims Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a highly effective therapy for primary generalized and focal dystonias, but therapeutic success is compromised by a nonresponder rate of up to 20%. Variability in electrode placement and in tissue stimulated inside the GPi may explain in part different o...

Objective: Deep brain stimulation (DBS) was proposed in 1999 to treat refractory obsessive-compulsive disorder (OCD). Despite the accumulated experience over more than two decades, 30–40% of patients fail to respond to this procedure. One potential reason to explain why some patients do not improve in the postoperative period is that DBS might not...

Abstract BACKGROUND Gait and balance disturbance are challenging symptoms in advanced Parkinson's disease (PD). Anatomic and clinical data suggest that the fields of Forel may be a potential surgical target to treat these symptoms. OBJECTIVE To test whether bilateral stimulation centered at the fields of Forel improves levodopa unresponsive freezi...

Abstract Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficient treatment of primary dystonia. Few studies have reported the effect of STN-DBS on secondary or acquired dystonia. Methods: We reported 2 patients with acquired dystonia treated by subthalamic DBS and followed up for 24 months, besides providing a s...

Parkinson's disease (PD) is clinically heterogeneous across patients and may be classified in three motor phenotypes: tremor dominant (TD), postural instability and gait disorder (PIGD), and undetermined. Despite the significant clinical characterization of motor phenotypes, little is known about how electrophysiological data, particularly subthala...

Parkinson's Disease (PD) leads to heterogeneous clinical symptoms. The underlying electrophysiological phenomena in the basal ganglia circuit remains poorly understood, imposing a major challenge for designing customized and more efficient Deep Brain Stimulation (DBS) protocols to match patients' specificities and needs. To fill this gap, this work...

Adaptive deep brain stimulation (DBS) is expected to improve Parkinson's disease (PD) symptoms. This advance in neurostimulation strategy requires to interact with pathological electrical signaling from basal ganglia circuitry and to use this continuous feedback for controlling therapeutic DBS. Further knowledge about how such signals change in ter...

Introduction: Obsessive-compulsive disorder (OCD) is a common, chronic and long-lasting mental disorder. The current first-line therapy for OCD is high doses of selective serotonin reuptake inhibitor (SSRI) and cognitive-behavioral psychotherapy. For patients with refractory symptoms, studies demonstrated that they may respond well to Deep Brain St...

Parkinson’s disease (PD) has a high impact on motor and cognitive impairment. Recent studies have suggested that abnormal beta band activity (13–35 Hz) in local field potentials (LFP) within the Subthalamic Nucleus (STN) are associated with PD’s symptoms. Moreover, these oscillations are characterized by non-stationary behavior throughout the LFP d...

Background: Stereotactic lesion in the Forel's field H (campotomy) was proposed in 1963 to treat Parkinson disease (PD) symptoms. Despite its rationale, very few data on this approach have emerged. Additionally, no study has assessed its effects on nonmotor symptoms, neuropsychological functions and quality of life. Objective: To provide a prosp...

Background: Fear of falling (FOF) creates a psychological barrier to performing activities for many older adults. The negative impact of fear of falling increases risk of curtailment of activities, social refrainment, future falls, and injury. Objective: to evaluate FOF among urban mid-age healthy adults, associated risks factors, and the impact up...

Introduction: Thalamic ventralis intermedius deep brain stimulation (VIM-DBS) is generally effective in treating refractory tremor in Parkinson's disease (PD) and in essential tremor (ET), but some patients do not respond well due to side effects or from loss of the effect of stimulation over time. The caudal zona incerta (ZI) has emerged as a pro...

The dissociation between the processing of verbs and nouns has been debated in light of the Embodied Cognition Theory (EC). The objective of this paper is to verify how action and verb processing deficits of PD patients are modulated by different tasks with different cognitive demands. Action and object lexical-semantic processing was evaluated in...

Objectives: Parkinson disease (PD) psychosis is a condition associated with several negative outcomes. Despite its impact, there is a lack of validated diagnostic tools for this condition. In this study, we aim to verify the validity of the proposed NINDS criteria for PD psychosis and explore its possible applications in clinical practice. Design...

The effect of psychotic symptoms in Parkinson's disease (PD) is variable among patients, and different methods to assess psychosis may yield conflicting results. A sample of 102 patients with a diagnosis of idiopathic PD underwent neurological, psychiatric, and neuropsychological assessment. Participants were divided into three groups: those who me...

Objective: To describe the motor, non-motor and neuropsychological outcomes in one PD patient before and 6-months after FFDBS. Background: We recently reported clinical improvements in 9 Parkinson’s disease (PD) patients who underwent H1 Forel’s Field campotomy1. These results, along with anatomical evidences, support us to test the feasibility of...

Objective: This study aimed to perform a clinical analysis of different subgroups of patients with Parkinson’s disease (PD) and psychotic symptoms. Background: A significant percentage of PD patients show changes of perception and thought characteristic of psychotic syndromes, however only in some cases these phenomena will present any clinical imp...

Objective: To compare the performance of PD patients without dementia and healthy controls in semantic memory tests for nouns and verbs; and the association between performance on these tests to the age, education, gender and overall cognitive performance. Background: The Embodied Cognition theory (EC) proposes that the semantic processing of actio...

Risk factors for psychosis in patients with Parkinson’s disease M.S.G. Rocha, R.G. Borges, C.D.M. Costa, M.O. Oliveira, S.M.D. Brucki, F.F. Godinho, P.C. Gordon (Sao Paulo, Brazil) Objective: The aim of this study is to evaluate risk factors, particularly sleep alterations and dementia, associated with psychosis diagnosis in PD. Background: Parkins...

Observing other people's pain increases our own reports to painful stimuli, a phenomenon that can be defined as 'compassional hyperalgesia' (CH). This functional magnetic resonance imaging study examined the neural correlates of CH, and whether CH could emerge when exposure to the driving stimulus was subliminal. Subjects received electric somatose...

This study compares the amplitude, latency, morphology, scalp topography and intracranial generators of laser-evoked potentials (LEPs) to CO(2) and Nd:YAP laser stimuli. LEPs were assessed in 11 healthy subjects (6 men, mean age 39+/-10 years) using a 32-channel acquisition system. Laser stimuli were delivered on the dorsum of both hands (intensity...

It is acknowledged that the emotional state created by visual inputs can modulate the way we feel pain; however, little is known about how acute pain influences the emotional assessment of what we see. In this study healthy subjects scored affective images while receiving painful or innocuous electrical shocks. Painful stimuli did not make unpleasa...

Observing other people's pain increases our own reports to painful stimuli, a phenomenon that can be defined as 'compassional hyperalge-sia' (CH). This functional magnetic resonance imaging study examined the neural correlates of CH, and whether CH could emerge when exposure to the driving stimulus was subliminal. Subjects received electric somatos...

Emotions modulate pain perception, although the mechanisms underlying this phenomenon remain unclear. In this study, we show that intensity reports significantly increased when painful stimuli were concomitant to images showing human pain, whereas pictures with identical emotional values but without somatic content failed to modulate pain. Early so...

1 - To assess the anatomical localization of the active contacts of deep brain stimulation targeted to the subthalamic nucleus (STN) in Parkinson's disease patients. 2 - To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologically-defined borders of the STN and the stereota...

Glossopharyngeal neuralgia is an uncommon craniofacial pain syndrome that is occasionally associated with cardiac syncope. However, we relate Chiari I syndrome as a cause of this clinical picture for the first time in the literature. The authors analyze the relevant literature and discuss the pathogenesis and treatment of associated syndromes. We d...

Os autores apresentam 7 casos de pacientes portadores de hemangiopericitomas meningeos (HPM), operados no Hospital das Clínicas da Universidade de São Paulo (HCFMUSP) de 1990 a 1997 Aspectos relativos ao quadro clinico, anatomia patológica e terapêutica são discutidos, com ênfase na necessidade de embolização pré-operatória e na complementação tera...