Fabien Vinckier

Fabien Vinckier
Sorbonne Université | UPMC

MD-PhD

About

61
Publications
10,886
Reads
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2,791
Citations
Additional affiliations
November 2014 - May 2015
Université de Montréal
Position
  • Fellow
November 2012 - November 2014
L'Institut du Cerveau et de la Moelle Épinière
Position
  • PostDoc Position

Publications

Publications (61)
Article
Background Motivational deficit is a core clinical manifestation of depression and a strong predictor of treatment failure. However, the underlying mechanisms, which cannot be accessed through questionnaire-based conventional scoring, remain largely unknown. According to decision theory, apathy could result either from biased subjective estimates (...
Article
Full-text available
Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of subjects (n = 30), while they were performin...
Preprint
Objectives: Bipolar disorder (BD) is defined by alternation of depressive and (hypo)manic states. An essential dimension related to mood fluctuations is reward sensitivity. The expression of mood disorders can be modulated by environmental factors and life events, as well as by their subsequent learning related to reward or punishment sensitivity....
Article
Background and Hypothesis Motivation deficit is a hallmark of schizophrenia that has a strong impact on their daily life. An alteration of reward processing has been repeatedly highlighted in schizophrenia, but to what extent it involves a deficient amplification of reward representation through conscious processing remains unclear. Indeed, patient...
Article
Introduction: Recent changes in psychiatric care and teaching, which limit patient contact for medical students, can be partially overcome by simulation-based education in psychiatry. The authors explored the learning processes of medical students during meetings with simulated patients to inform efforts to improve this teaching. Methods: After...
Article
Full-text available
Catatonia is a severe neuropsychiatric syndrome, usually treated by benzodiazepines and electroconvulsive therapy. However, therapeutic alternatives are limited, which is particularly critical in situations of treatment resistance or when electroconvulsive therapy is not available. Transcranial direct-current stimulation (tDCS) is a promising non-i...
Article
Context The Department of neurosurgery of the Sainte-Anne Hospital hosted Jean Talairach who created and developed stereotactic neurosurgery in France. Despite numerous neurosurgical and neuroscientific achievements, little is known about the life of Jean Talairach. Methods Systematic screening of Sainte-Anne Hospital Museum, Henry Ey Library, and...
Article
Full-text available
Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unkn...
Article
The Sainte-Anne Hospital, founded in 1867, is a leading psychiatric hospital in France. A neurosurgery Department was founded there in 1941 where Jean Talairach developed modern stereotactic neurosurgery. Despite making major contributions to the field, very little is generally known about him. Here, we present some glimpses of a remarkable career...
Article
Full-text available
Interoception, the perception of internal bodily states, is thought to be inextricably linked to affective qualities such as anxiety. Although interoception spans sensory to metacognitive processing, it is not clear whether anxiety is differentially related to these processing levels. Here we investigated this question in the domain of breathing, u...
Article
Full-text available
Autism is a neurodevelopmental condition defined on clinical criteria related to diminished social reciprocity and stereotyped behavior. An influential view explains autism as a social motivation disorder characterized by less attention paid to the social environment and less pleasure experienced with social rewards. However, experimental attempts...
Preprint
Full-text available
Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of participants (n = 30), while they were perfo...
Article
The frequency of schizophrenia, and of the related verbal hallucinations, is comparable in deaf and in hearing persons. Nevertheless, the diagnosis, treatment, and fundamental understanding of verbal hallucinations in deaf schizophrenia patients are overall inadequate, as revealed for instance by the paradoxical characterization of verbal hallucina...
Preprint
Full-text available
Interoception, the perception of bodily states, is thought to be inextricably linked to affective qualities such as anxiety. While interoception spans sensory to metacognitive processing, it is not clear whether anxiety is differentially related to these processing levels. Here we investigated this question in the domain of breathing, using computa...
Article
Full-text available
Introduction Urgent action is needed to fight the ongoing COVID-19 pandemic by reducing the number of infected people along with the infection contagiousness and severity. Chlorpromazine (CPZ), the prototype of typical antipsychotics from the phenothiazine group, is known to inhibit clathrin-mediated endocytosis and acts as an antiviral, in particu...
Article
Résumé Depuis les années 1950, l’arsenal thérapeutique permettant de lutter contre la dépression s’est considérablement enrichi. De la découverte des inhibiteurs de la monoamine oxydase (IMAO) à celle de la kétamine, ces percées pharmacologiques ont marqué l’histoire de la psychiatrie et guidé la recherche sur la physiopathologie de la dépression,...
Article
Since the 1950s, the therapeutic arsenal against depression has grown considerably. From the discovery of mono-amine oxidase inhibitors (MAOIs) to the antidepressant effect of ketamine, several pharmacological breakthroughs made the history of psychiatry. These discoveries oriented the research about the pathophysiology of depression, which is one...
Article
La psychiatrie computationnelle est une approche théorique utilisant des modèles mathématiques pour éclairer les liens entre symptômes et anomalies neurobiologiques observées dans les troubles mentaux. Cette introduction passe en revue trois champs d'application principaux : les modèles issus de l'apprentissage par renforcement, les modèles issus d...
Preprint
Full-text available
In uncertain environments, accurate decision-making requires integrating ambiguous or conflicting signals - a cognitive inference process thought to require n-methyl-d-aspartate (NMDA) synaptic receptors. Here we characterized the causal impact of human NMDA receptor hypofunction on cognitive inference using placebo-controlled infusions of ketamine...
Preprint
Full-text available
Urgent action is needed to fight the ongoing COVID-19 pandemic by reducing the number of infected people along with the infection contagiousness and severity. Chlorpromazine (CPZ), the prototype of typical antipsychotics from the phenothiazine group, is known to inhibit clathrin-mediated endocytosis and acts as an antiviral, in particular against S...
Article
Full-text available
Objectives: The ongoing COVID-19 pandemic has caused approximately 2,350,000 infections worldwide and killed more than 160,000 individuals. In Sainte Anne Hospital (GHU PARIS Psychiatrie & Neuroscience, Paris, France) we have observed a lower incidence of symptomatic forms of COVID-19 among patients than among our clinical staff. This observation l...
Article
Full-text available
Résumé OBJECTIFS: La pandémie mondiale actuelle de COVID-19 a touché environ 2 350 000 personnes et fait plus de 160 000 morts. Nous avons observé dans le GHU PARIS Psychiatrie & Neurosciences (site Sainte-Anne, Paris, France) une incidence moins importante de formes symptomatiques de COVID-19 chez les patients (environ 4 %) que dans notre personne...
Article
Full-text available
Major depressive disorder is a complex multifactorial condition with a so far poorly characterized underlying pathophysiology. Consequently, the available treatments are far from satisfactory as it is estimated that up to 30% of patients are resistant to conventional treatment. Recent comprehensive evidence has been accumulated which suggests that...
Article
Full-text available
In high stakes situations, people sometimes choke under pressure, performing below their abilities. Here, we suggest a novel mechanism to account for this paradoxical effect of motivation: the automatic adjustment of action vigour to potential reward. Although adaptive on average, this mechanism may impede fine motor control. Such detrimental effec...
Article
Full-text available
Classical decision theory postulates that choices proceed from subjective values assigned to the probable outcomes of alternative actions. Some authors have argued that opposite causality should also be envisaged, with choices influencing subsequent values expressed in desirability ratings. The idea is that agents may increase their ratings of item...
Data
Effects of action-related factors on all subsequent behaviors (rating, choice, success, force) in extended models (H3), separately for each experiment. (DOCX)
Data
Summary of the bootstrap analysis for restricted models. (DOCX)
Data
Summary of the bootstrap analysis for extended models. (DOCX)
Data
Weights of hidden values on action-related factors. (DOCX)
Article
Background and case presentation: Electroconvulsive therapy (ECT) is a common therapeutic procedure in psychiatry associated with a low rate of complications. We report a rare case of subdural hematoma (SDH) associated with ECT. Clinical presentation: a 64 year old woman, with a medical history of persistent depression which required ECT six years...
Article
Clinical assessment of motivation disorders, such as apathy or compulsivity, is currently based on psychometric scales that do not provide any mechanistic insight susceptible to better target therapeutic intervention. Here, we expose a new approach that consists in phenotyping motivation states by fitting computational models to the behavioral resp...
Article
Recent evidence suggests that high-level executive control can occur unconsciously. In this study, we tested whether unconscious executive control extends to memory retrieval and forgetting. In a first experiment, participants learned word-word associations and were trained to either actively recall or forget theses associations in response to cons...
Article
Full-text available
The influence of mood on choices is a well-established but poorly understood phenomenon. Here, we suggest a three-fold neuro-computational account: (1) the integration of positive and negative events over time induce mood fluctuations, (2) which are underpinned by variations in the baseline activities of critical brain valuation regions, (3) which...
Article
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric diseases. Even when they are not the core symptom, they reduce quality of life, compromise functional outcome and increase the burden for caregivers. They are currently assessed with clinical scales that do not give any mechanistic insight susceptible to guide t...
Article
Full-text available
Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into prac...
Article
Background: Anhedonia is a core symptom of major depression and a key prognostic factor that is often poorly explored in clinical trials of major depressive disorder (MDD). Beyond symptomatic remission, psychosocial functioning also reveals difficulty in achieving remission in patients with MDD. The main objective of this study was to explore the...
Article
Full-text available
Mimetic desire (MD), the spontaneous propensity to pursue goals that others pursue, is a case of social influence that is believed to shape preferences. Autism spectrum disorder (ASD) is defined by both atypical interests and altered social interaction. We investigated whether MD is lower in adults with ASD compared to typically developed adults an...
Article
Background Anhedonia is a core dimension of major depressive disorder (MDD). Paradoxically, the association between anhedonia and social impairment is poorly known. Objective To determine the longitudinal relationships between depressive symptoms, anhedonia, and social functioning in depressed patients treated with agomelatine. Material and metho...
Article
Les troubles de la motivation constituent une dimension essentielle de nombreuses pathologies psychiatriques. Ils sont associés à un handicap considérable, interfèrent avec l’observance des traitements et restent peu accessible à ceux-ci. Pourtant, les déficits motivationnels restent évalués en clinique au travers de questionnaires qui ne permetten...
Article
Full-text available
A state of pathological uncertainty about environmental regularities might represent a key step in the pathway to psychotic illness. Early psychosis can be investigated in healthy volunteers under ketamine, an NMDA receptor antagonist. Here, we explored the effects of ketamine on contingency learning using a placebo-controlled, double-blind, crosso...
Article
Reading deficit and schizophrenia: Evidence of functional disconnectivity within the visual system. Schizophrenia is characterized not only by a delusional syndrome or dissociative syndrome but also includes many cognitive deficits. In particular, a visual perception deficit has been clearly demonstrated in schizophrenia. This impairment may result...
Article
Patients with schizophrenia suffer from perceptual visual deficits. It remains unclear whether those deficits result from an isolated impairment of a localized brain process or from a more diffuse long-range dysconnectivity within the visual system. We aimed to explore, with a reading paradigm, the functioning of both ventral and dorsal visual path...
Article
Reading deficit and schizophrenia: Evidence of functional disconnectivity within the visual system Schizophrenia is characterized not only by a delusional syndrome or dissociative syndrome but also includes many cognitive deficits. In particular, a visual perception deficit has been clearly demonstrated in schizophrenia. This impairment may result...
Article
Full-text available
Letter-position tolerance varies across languages. This observation suggests that the neural code for letter strings may also be subtly different. Although language-specific models remain useful, we should endeavor to develop a universal model of reading acquisition which incorporates crucial neurobiological constraints. Such a model, through a pro...
Article
Full-text available
Identifying letters and their relative positions is the basis of reading in literate adults. The Local Combinations Detector model hypothesizes that this ability results from the general organization of the visual system, whereby object encoding proceeds through a hierarchy of neural detectors that, in the case of reading, would be tuned to letters...
Article
Full-text available
Expert readers exhibit a remarkable ability to recognize handwriting, in spite of enormous variability in character shape-a competence whose cerebral underpinnings are unknown. Subliminal priming, combined with neuroimaging, can reveal which brain areas automatically compute an invariant representation of visual stimuli. Here, we used behavioral an...
Chapter
This chapter confronts a simple anatomical and functional scheme for the architecture of the reading system, with multimodal data from patients with various deficits affecting the visual stages of word processing. It first outlines the proposed architecture for reading, then sketches an overview of peripheral dyslexias, and eventually considers how...
Article
Fast, parallel word recognition, in expert readers, relies on sectors of the left ventral occipito-temporal pathway collectively known as the visual word form area. This expertise is thought to arise from perceptual learning mechanisms that extract informative features from the input strings. The perceptual expertise hypothesis leads to two predict...
Article
Visual word recognition has been proposed to rely on a hierarchy of increasingly complex neuronal detectors, from individual letters to bigrams and morphemes. We used fMRI to test whether such a hierarchy is present in the left occipitotemporal cortex, at the site of the visual word-form area, and with an anterior-to-posterior progression. We expos...
Article
Full-text available
The visual system of literate adults develops a remarkable perceptual expertise for printed words. To delineate the aspects of this competence intrinsic to the occipitotemporal "what" pathway, we studied a patient with bilateral lesions of the occipitoparietal "where" pathway. Depending on critical geometric features of the display (rotation angle,...
Article
Full-text available
Whether masked words can be processed at a semantic level remains a controversial issue in cognitive psychology. Although recent behavioral studies have demonstrated masked semantic priming for number words, attempts to generalize this finding to other categories of words have failed. Here, as an alternative to subliminal priming, we introduce a se...
Article
Full-text available
How is reading, a cultural invention, coded by neural populations in the human brain? The neural code for written words must be abstract, because we can recognize words regardless of their location, font and size. Yet it must also be exquisitely sensitive to letter identity and letter order. Most existing coding schemes are insufficiently invariant...

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