Fabien Pierron

Fabien Pierron
French National Centre for Scientific Research | CNRS

About

67
Publications
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1,188
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Publications

Publications (67)
Article
New Caledonia is particularly affected by nickel open pit mining activities because of the presence of ultramafic soils rich in metals. The particles dispersed by atmospheric transport and soil erosion during the excavation of nickel end up by deposition or leaching in rivers where they may be bioaccumulated by organisms living downstream the mines...
Conference Paper
Full-text available
Les rayonnements ionisants induisent des effets délétères chez les organismes, notamment au fil des générations. En effet, une étude précédente a montré une altération du sexe ratio (1 femelle pour 4 mâles) chez la descendance de poisson zèbre après irradiation des parents. Un tel effet pourrait s'avérer drastique pour le devenir des populations. A...
Presentation
Full-text available
Les rayonnements ionisants induisent des effets délétères chez les organismes, notamment au fil des générations. En effet, une étude précédente a montré une altération du sexe ratio (1 femelle pour 4 mâles) chez la descendance de poisson zèbre après irradiation des parents. Un tel effet pourrait s'avérer drastique pour le devenir des populations. A...
Article
Mutigenerational studies are now of great interest in ecotoxicology and previous studies have shown the importance of conducting multigenerational studies when assessing radiation toxicity in fish. In our study, the first objective was to study the early life stages (embryo-larval stages) and critical functions such as reproduction (which are gener...
Article
Sex determination is a complex process that can be influenced by environment in various taxa. Disturbed environments can affect population sex ratios and thus threaten their viability. Emerging evidences support a role of epigenetic mechanisms, notably DNA methylation, in environmental sex determination (ESD). In this work, using zebrafish as model...
Article
Nanometric revolution is underway, promising technical innovations in a wide range of applications, leading to a potential boost in environmental discharges. Nanoparticle propensity to be transferred throughout trophic chains and to generate toxicity was mainly assessed in primary consumers while a lack of knowledge for higher trophic levels persis...
Article
Full-text available
Gold nanoparticles (AuNPs) are being developed and produced for a wide variety of industrial and biomedical applications, which raises the concern about their release and potential effects in the environment. In this study, we aim to assess the effects of PEGylated AuNPs and ionic gold on the freshwater bivalve Corbicula fluminea. As NP bioavailabi...
Article
Multiple eel species of the genus Anguillidae are under anthropogenic pressure. This review presents strong evidence that chemical pollution is a driving force behind the cata- strophic decline in recruitment and abundance of both the European (Anguilla anguilla) and the American eel (Anguilla rostrata). In response to this crisis, stock and habita...
Article
Full-text available
MicroRNAs (miRNAs) are a class of small non-coding RNA that control multiple biological processes through negative post-transcriptional regulation of gene expression. Recently a role of miRNAs in the response of aquatic organisms to environmental toxicants emerged. Toxicant-induced changes in miRNA expression might then represent novel biomarkers t...
Article
Recently, we reported an emerging pathology named Brown Muscle Disease (BMD) affecting Asari clams inhabiting the most productive area for this species in France, the Arcachon Bay. The main macroscopic feature of the pathology relies on the atrophy of the posterior adductor muscle, affecting the ability of clams to burry. The research of the etiolo...
Article
Full-text available
The increase in human population and urbanization are resulting in an increase in the volume of wastewater and urban runoff effluents entering natural ecosystems. These effluents may contain multiple pollutants to which the biological response of aquatic organisms is still poorly understood mainly due to mixture toxicity and interactions with other...
Article
Understanding how organisms cope with global change is a major question in many fields of biology. Mainly, understanding the molecular mechanisms supporting rapid phenotypic changes of organisms in response to stress and linking stress-induced molecular events to adaptive or adverse outcomes at the individual or population levels remain a major cha...
Article
Full-text available
L’anguille européenne Anguilla anguilla est une espèce catadrome avec un cycle de vie complexe incluant des migrations entre la mer de Sargasses, l’Europe et l’Afrique du Nord. Du fait de sa baisse drastique de population depuis 30 ans, l’anguille est considérée aujourd’hui comme « en danger critique d’extinction ». Une des causes de ce déclin est...
Poster
Full-text available
MicroRNAs (miRNAs) are a class of small non-coding RNA. These 20-24 nucleotides-long sequences associate with the 3’-untranslated region (3’-UTR) of target messenger RNAs (mRNAs), and post-transcriptionally regulate the expression of numerous genes by mediating translational repression or mRNA degradation. In mammals, more than 50% of mRNAs are pre...
Article
Full-text available
An international sampling program investigating the causes of the decline of American eels (Anguilla rostrata) and European eels (Anguilla anguilla) in the St. Lawrence (Canada) and Gironde (France) rivers systems provided the opportunity to compare early growth of eels of each species among habitats using back-calculated size-at-age from 1 to 5 ye...
Article
Full-text available
The freshwater pearl mussel Margaritifera margaritifera is one of the most threatened freshwater bivalves worldwide. In this study, we aimed (i) to study the processes by which water quality might affect freshwater mussels in situ and (ii) to provide insights into the ecotoxicological significance of water pollution to natural populations in order...
Article
In this study, we tested the hypothesis that metal exposure affected the normal thermal response of cell membrane FA composition and of elongase and desaturase gene transcription levels. To this end, muscle and brain membrane FA composition and FA desaturase (fads2, degs2 and scd2) and elongase (elovl2, elovl5 and elovl6) gene transcription levels...
Article
Dwarf eelgrasses (Zostera noltei) populations have decreased since 2005 in Arcachon Bay (southwest France). Various stressors have been pointed out, however the role of xenobiotics like pesticides or copper (Cu) and of parameters like water temperature warming have not yet been explored. To determine their impact, Z. noltei individuals were collect...
Article
Since the early 1980s, populations of American (Anguilla rostrata) and European eels (Anguilla anguilla) have suffered a sharp decline. The causes of their decline are likely multifactorial and include chemical pollution. A field study was conducted in eight sites varying in organic and metal contamination along the St. Lawrence (Eastern Canada) an...
Poster
Full-text available
La moule perlière Margaritifera margaritifera est l’un des bivalves d’eau douce les plus menacés au monde. L’espèce est actuellement en voie de disparition. En France, 100 000 individus sont recensés, dont 15 000 sur la rivière Dronne. L’altération générale de la qualité de l’eau et la destruction des habitats peuvent expliquer sa disparition. En...
Article
Full-text available
Fishways are built on obstacles to restore the connectivity between aquatic habitats. Our study investigated how species-specific fishways interact with interindividual trait differences among fish. We compared several groups of glass eels (Anguilla anguilla) climbing two types of fishways with those remaining below the water impoundments. We analy...
Article
Aquatic ecosystems are subjected to a variety of man-induced stressors but also vary spatially and temporally due to variation in natural factors. In such complex environments, it remains difficult to detect, dissociate and evaluate the effects of contaminants in wild organisms. In this context, the aim of this study was to test whether the hepatic...
Article
American (Anguilla rostrata) and European (Anguilla anguilla) eel populations are declining since the 1980s, and contamination is thought to play a role. To determine the influence of organic (organochlorinated pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs)) and inorganic (Zn, As, Cd, Cu, Pb, Cr, Ni, Ag,...
Article
Full-text available
Detecting and separating specific effects of contaminants in a multi-stress field context remain a major challenge in ecotoxicology. In this context, the aim of this study was to assess the usefulness of a non-invasive transcriptomic method, by means of a complementary DNA (cDNA) microarray comprising 1000 candidate genes, on caudal fin clips. Fin...
Article
Full-text available
European eel (Anguilla anguilla) is a catadromous fish species that received substantial attention as its population has markedly declined in the last three decades. The possible causes of this decline include habitat fragmentation factors such as dams and weirs. In some cases, these obstacles are equipped with fish friendly passage devices that ma...
Article
Full-text available
Measuring the effects of selection on the genome imposed by human-altered environment is currently a major goal in ecological genomics. Given the polygenic basis of most phenotypic traits, quantitative genetic theory predicts that selection is expected to cause subtle allelic changes among covarying loci rather than pronounced changes at few loci o...
Chapter
In aquatic toxicology, it is now well-established that the chemical characterization of pollutants exposure is not sufficient and that multidisciplinary approaches coupling chemistry and biology have to be developed to allow linking of the presence of contaminants and their putative toxic impacts. Along with the improvement of molecular biology met...
Article
Since the early 1980s, the population of European eels (Anguilla anguilla) has dramatically declined. Nowadays, the European eel is listed on the red list of threatened species (IUCN Red List) and is considered as critically endangered of extinction. Pollution is one of the putative causes for the collapse of this species. Among their possible effe...
Article
Full-text available
European eel is a panmictic species, whose decline has been recorded since the last 20 years. Among human-induced environmental factors of decline, the impact of water dams during species migration is questioned. The main issue of this study was to pinpoint phenotypic traits that predisposed glass eels to successful passage by water barriers. The a...
Poster
Full-text available
Physical obstacles to upstream migration such as dams are a major impairment of natural colonisation and dispersion of eels. Dams and obstacles increase the energy demand of fish, even when they are equipped with fish friendly devices. Besides, local accumulation of eels below dams increase the mortality associated with predation. Obstacles may als...
Article
Full-text available
We determined the intracellular compartmentalization of the trace metals Ag, As, Cd, Ni, Pb and Tl in the livers of yellow eels collected from the Saint Lawrence River system in Canada (Anguilla rostrata) and in the area of the Gironde estuary in France (Anguilla anguilla). Differential centrifugation, NaOH digestion and thermal shock were used to...
Article
Full-text available
Identifying specific effects of contaminants in a multi-stress field context remain a challenge in ecotoxicology. In this context, "omics" technologies, by allowing the simultaneous measurement of numerous biological endpoints, could help unravel the in situ toxicity of contaminants. In this study, wild Atlantic eels were sampled in 8 sites present...
Article
There is increasing evidence that pollutants may cause diseases via epigenetic modifications. Epigenetic mechanisms such as DNA methylation participate in the regulation of gene transcription. Surprisingly, epigenetics research is still limited in ecotoxicology. In this study, we investigated whether chronic exposure to contaminants experienced by...
Conference Paper
Full-text available
Several reasons may account for the decline of American (Anguilla rostrata) and European (Anguilla anguilla) eel populations. This study aims at developing a better understanding of eel reproductive biology, and to investigate the effects of contaminants on their reproductive capacity. Eels bioaccumulate contaminants during their long continental g...
Conference Paper
This study is part of an international program ‘IMMORTEEL’ investigating the possible contribution of habitat contamination in the decline of Atlantic eels. Biomarker responses and muscle concentrations of persistent organic contaminants (POPs) were examined in European eels (Anguilla anguilla) and American eels (Anguilla rostrata) in the Gironde a...
Article
There is increasing evidence that epigenetics can play a key role in the etiology of diseases engendered by chronic pollutant exposure. Although epigenetics has received significant attention in the field of biomedicine during the last years, epigenetics research is surprisingly very limited in ecotoxicology. The aim of the present study was to inv...
Article
Full-text available
In summer 2001, the St. Lawrence River (Québec, Canada) experienced perhaps the largest massive fish kill of its history, with more than 25 000 carp (Cyprinus carpio) found dead. This experiment therefore investigated the effects of heat stress on the gene transcription level of heat shock protein 70, cytochrome c oxidase and mitochondrial superoxi...
Article
The molecular mechanisms underlying nickel (Ni) and cadmium (Cd) toxicity and their specific effects on fish are poorly understood. Documenting gene transcription profiles offers a powerful approach toward identifying the molecular mechanisms affected by these metals and to discover biomarkers of their toxicity. However, confounding environmental f...
Article
In a recent study on indigenous yellow perch chronically exposed to metals, we reported a negative correlation between liver metal concentration and liver transcription levels of genes encoding for enzymes involved in the metabolism of retinoids. We therefore speculated that metals, and especially the non-essential metal Cd, could alter the metabol...
Article
Despite its role as an essential micronutrient, copper (Cu) can be present in aquatic ecosystems at concentrations able to cause adverse health effects on aquatic organisms. Although Cu is acquired by fish by either water or diet, studies that have investigated Cu impacts in fish have mainly focused on the toxicity of waterborne Cu. Moreover, as th...
Article
Full-text available
Given the inherent variability of aquatic systems, predicting the in situ effects of contaminants on such ecosystems still represents a major challenge for ecotoxicology. In this context, transcriptomic tools can help identify and investigate the mechanisms of toxicity beyond the traditional morphometric, physiological and population-level endpoint...
Article
Full-text available
European eels are dangerously threatened with extinction. Recent advances tend to show that pollution could, in addition to other already identified factors, contribute to this drama. In a previous report, cadmium (Cd) pre-exposure was found to strongly stimulate the pituitary-liver-gonad axis of maturing female silver eels, leading, lastly, to ooc...
Article
Full-text available
To investigate the mechanisms involved in metal stress in wild fish, yellow perch (Perca flavescens) were collected in eight lakes of the Rouyn-Noranda and Sudbury regions (Canada). Due to mining and smelting activities, these two regions indeed present a broad contamination gradient in metal concentrations (Cd, Cu, Zn and Ni; water, sediment and p...
Article
Full-text available
The European eel (Anguilla anguilla L.) is severely threatened with extinction. Surprisingly, even though their unusual life cycle makes them particularly vulnerable to pollution, the possible contribution of contamination remains especially poorly known. Here we have investigated the possible effect of cadmium (Cd), a widespread nonessential metal...
Article
Due to its status of threatened species and being heavily contaminated by metals, the European eel (Anguilla anguilla) was selected to investigate cadmium contamination levels of fish settled along a historically cadmium-contaminated hydrosystem, the Garonne-Gironde continuum (France), according to its various location sites and fish length. Result...
Article
The aim of the present study was to investigate the role of two key environmental factors of estuarine ecosystems, salinity and hypoxia, on the Cd bioaccumulation by direct exposure in the white shrimp Palaemon longirostris. Two types of experiments were performed in the laboratory. First, we studied Cd accumulation by shrimp after metal exposure a...
Article
European eel (Anguilla anguilla) populations are in decline. Glass eel recruitment has fallen 10-fold since the early 1980s. Estuaries play a fundamental role in the life history of eels because glass eels must pass through them to reach freshwater ecosystems. Unfortunately, because of their geographical position at the upstream basin slopes, estua...
Article
Because European silver eels (Anguilla anguilla) fast during their reproductive migration to the Sargasso Sea, the successful completion of their unusual life cycle depends on quantity of lipids stored beforehand. These lipids are mainly accumulated during the growth phase stage of the animals, called yellow eel, as triglycerides in muscle. They ar...

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Projects

Projects (6)
Archived project
MicroRNA Sequencing in Stressed Eels
Project
The importance of the interactions between gut microbial communities (microbiome or microbiota) and host health is increasingly recognized, particularly in mamalians. However, the potential effects of environmental parameters on the structure and function of this microbiome are poorly known in aquatic organisms. The MicMAq project will propose a multidisciplinary approach combining ecology, ecotoxicology and molecular biology to study the response of the microbiome associated within the gut of the critically endangered European eel Anguillaanguillato environmental stressors. The first objective of the project is to study wild eels from four contrasted sites in the Gironde Estuary in term of physicochemistry and micropollution. Analytical chemistry technics will be used to characterize the contamination level in fish tissues while the most recent high throughput DNA sequencing technology will be used to determine the composition and the metabolic functions of the microbiome and its alterations. Second, MicMaq will evaluate the impact of eels restocking program on their microbiome structure as well as the potential role of the functional gene repertoire provided by the bacterial partners in the adaptation of eels to new environments. This project will ultimately allow the identification of key drivers of microbiome composition amongst a large range of variables including water physicochemistry, presence of trace metals and organic pollutants, life history and diet quality. The data that will be obtained during the MicMAq project will certainly shed light onto an overlooked aspect of pollution and disease aetiology, contributing to a better comprehension of fish biology in response to restocking and to water pollution.
Archived project
Study of the water temperature spatio-temporal dynamic of the St. Lawrence River and the role of elevated water temperatures on a massive fish kill event.