Fabien D'Hondt

Fabien D'Hondt
Université de Lille · Faculty of Medicine

PhD/HDR in Neuroscience

About

101
Publications
15,833
Reads
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1,051
Citations
Additional affiliations
September 2016 - present
Université de Lille
Position
  • Professor (Associate)
September 2014 - September 2016
Université Catholique de Louvain - UCLouvain
Position
  • PostDoc Position
September 2012 - September 2014
CHU Sainte-Justine
Position
  • PostDoc Position
Education
January 2019 - January 2019
Université de Lille
Field of study
  • Neuroscience
September 2008 - September 2011
Université de Lille
Field of study
  • Neuroscience

Publications

Publications (101)
Article
Full-text available
Background: Substance use disorders (SUDs) are associated with impairments of cognitive functions, and cognitive training programs are thus rapidly developing in SUD treatment. However, neuropsychological impairments observed early after withdrawal (i.e., early impairments), that is, approximately in the first six months, may be widespread. Consequ...
Article
Eye tracking has emerged as a reliable neuroscience tool indexing the eye movements’ correlates of impairments resulting from alcohol-use disorders, ranging from perceptive abilities to high-level cognitive functions. This systematic review, following PRISMA guidelines, encompasses all human studies using eye tracking in participants presenting acu...
Article
Full-text available
Previous reports suggest that adverse events during childhood could be related to an array of psychiatric problems. Here, we question the relationship between childhood traumatic experiences and the sensory complexity of hallucinations in a cohort of 75 children and adolescents. We evidence a positive link between the number of sensory modalities i...
Article
Full-text available
Importance The coronavirus disease 2019 (COVID-19) pandemic and quarantine measures have raised concerns regarding their psychological effects on populations. Among the general population, university students appear to be particularly susceptible to experiencing mental health problems. Objectives To measure the prevalence of self-reported mental h...
Article
Full-text available
This study aimed to investigate the time course of attentional bias for negative information in healthy individuals and to assess the associated influence of trait anxiety. Thirty-eight healthy volunteers performed an emotional dot-probe task with pairs of negative and neutral scenes, presented for either 1 or 2 s and followed by a target placed at...
Conference Paper
Despite the increasing computerization of hospital information systems, segments of patient care are still in paper format. Data extracted automatically from the hospital databases for one specific project are thus supplemented by data collected manually. Data collection tools are usually developed entirely, which requires computer knowledge and is...
Article
Full-text available
Rationale Visuo-perceptive deficits in severe alcohol use disorder (SAUD) remain little understood, notably regarding the respective involvement of the two main human visual streams, i.e., magnocellular (MC) and parvocellular (PC) pathways, in these deficits. Besides, in healthy populations, low-level visual perception can adapt depending on the na...
Article
Full-text available
Introduction The COVID-19 related quarantine had negative psychological effects among University students. Evidence from previous epidemics suggests that negative psychological effects of quarantine measures can last or even worsen after the quarantine lift. The objective of this study was to assess the evolution of students' mental health and to i...
Article
Full-text available
Background Criminal responsibility is a key concept in the criminal sanctioning of people diagnosed with mental health disorders who have committed crimes. In France, based on the recommendations of one or more expert psychiatrists, a judge can declare a person not criminally responsible on account of mental disorder (NCRMD) if, at the time of the...
Article
Full-text available
Background Despite the poor mental health status of people who are incarcerated, few studies have examined the number of psychiatric hospitalisations in this population. Since 2010, France has progressively opened nine full-time inpatient psychiatric wards exclusively for people who are incarcerated, called “specially adapted hospital units” (unité...
Article
Visuospatial impairments have long been reported in Severe Alcohol Use Disorder but remain poorly understood, notably regarding the involvement of magnocellular (MC) and parvocellular (PC) pathways. This empirical gap hampers understanding the implications of these visual changes, especially since the MC and PC pathways are thought to sustain centr...
Article
Full-text available
Background Cognitive models indicated that social anxiety disorder (SAD) would be caused and maintained by a biased attentional processing of threatening information. This study investigates whether socially anxious children may present impaired attentional engagement and disengagement from negative emotional faces, as well as their underlying even...
Article
(238 words) Research has consistently shown high levels of post-traumatic stress disorder (PTSD) in correctional settings. We aimed to compare the prevalence rates of trauma exposure, subthreshold PTSD, and full PTSD in incarcerated people with those observed in the general population. We used the Mini-International Neuropsychiatric Interview to sc...
Article
Full-text available
This study investigates how asymmetry, expressed emotion, and sex of the expresser impact the perception of emotional facial expressions (EFEs) in terms of perceived genuineness. Thirty-five undergraduate women completed a task using chimeric stimuli with artificial human faces. They were required to judge whether the expressed emotion was genuinel...
Article
Full-text available
Background The COVID-19 pandemic has raised concerns regarding its psychological effect on university students, especially healthcare students. We aimed at assessing the risk of mental health problems according to the type of university studies, by adjusting for potential confounders. Methods We used data from the COSAMe study, a national cross-sec...
Article
Full-text available
The present literature review aimed at offering a comprehensive and critical view of the behavioral data collected during the past seventy years concerning visuoperception in severe alcohol use disorders (SAUD). To pave the way for a renewal of research and clinical approaches in this very little understood field, this paper: (1) provides a critica...
Article
Many studies have reported negative outcomes of the COVID-19 pandemic on people's mental health. Notably, high prevalence rates of posttraumatic stress disorder (PTSD) symptoms have been described in healthcare workers (26.9% [20.3%-33.,6%]), individuals with COVID-19 (23.8% [16.6%-31.0%]) and in the general population (19.3% [15.3%-23.2%]) (1).
Article
Full-text available
The COVID-19 pandemic and quarantine measures have sparked debate regarding their traumatic nature. This cross-sectional study reports the prevalence rate of probable post-traumatic stress syndrome (PTSD) and associated factors among French university students. A total of 22,883 students completed the online questionnaire. The prevalence rate of pr...
Article
Background: Dominant theoretical models consider that attentional biases (AB) towards alcohol-related stimuli play a key role in the development and maintenance of alcohol use disorder (AUD). Their assessment has however showed high inconsistencies and has been mostly based on unreliable behavioral measures. This study evaluated the presence and ex...
Article
Full-text available
Acute alcohol intoxication and alcohol use disorders are characterized by a wide range of psychological and cerebral impairments, which have been widely explored using neuropsychological and neuroscientific techniques. Eye tracking has recently emerged as an innovative tool to renew this exploration, as eye movements offer complementary information...
Article
Background: Severe Alcohol Use Disorder (SAUD) is associated with widespread cognitive impairments, including low-level visual processing deficits persisting even after prolonged abstinence. However, the extent and characteristics of these visual deficits remain largely undetermined, impeding the identification of their underlying mechanisms and i...
Article
Background: Severe alcohol use disorder (SAUD) is associated with social cognition deficits. Patients with SAUD are impaired for the recognition of emotional facial expressions, particularly at early stages of abstinence. These deficits damage interpersonal relations and increase relapse risk. However, uncertainties still abound on their variation...
Article
Visuoperceptive deficits are frequently reported in severe alcohol use disorder (SAUD) and are considered as pervasive and persistent in time. While this topic of investigation has previously driven researchers’ interest, far fewer studies have focused on visuoperception since the ‘90s, leaving open central questions regarding the origin and implic...
Article
Rationale: Severe alcohol use disorder (SAUD) is a psychiatric condition linked to cerebral and cognitive consequences. SAUD is notably characterized by an over-activation of the reflexive/reward system when confronted with alcohol-related cues. Such over-reactivity generates a preferential allocation of attentional resources towards these cues, la...
Chapter
While severe alcohol use disorder (SAUD) is classically characterized as a compulsion to seek and consume alcohol and a reduced ability to control these behaviors, a growing number of studies shows social cognition difficulties among recently detoxified patients. The present chapter proposes an overview of this literature by presenting the main fin...
Article
Objective: To assess the prevalence of and risk factors for posttraumatic stress disorder (PTSD) in patients with COVID-19. Methods: We conducted a cohort study between March and May 2020 at the Lille University Hospital (France), including all patients with laboratory-confirmed COVID-19. Psychological distress symptoms were measured 3 weeks aft...
Article
Full-text available
Résumé Le trouble de stress post-traumatique (TSPT) est l’un des troubles psychiatriques les plus fréquents en milieu pénitentiaire, puisque sa prévalence « vie entière » atteint 17,8 % chez les hommes et 40,1 % chez les femmes en détention. Pourtant, le TSPT reste sous-diagnostiqué et peu étudié dans cette population. Cette revue de la littérature...
Article
Background Depersonalization is a complex phenomenological experience initially described as a psychological disturbance of self-awareness. Among the different dimensions underlying depersonalization, emotional numbing appears to be a key symptom but remains a poorly understood phenomenon. Method We conducted a systematic review, following PRISMA...
Article
The widespread cognitive and cerebral consequences of prenatal alcohol exposure have been established during the last decades, through the exploration of fetal alcohol spectrum disorders (FASD) using neuropsychological and neuroscience tools. This research field has recently benefited from the emergence of innovative measures, among which eye track...
Article
Background: Attentional bias towards alcohol-related stimuli is a core characteristic of severe alcohol use disorders (AUD), directly linked to clinical variables (alcohol consumption, relapse). Nevertheless, the extent of this bias in subclinical populations remains poorly documented. This is particularly true for binge drinking, an alcohol consum...
Article
Background: Severe alcohol use disorder (SAUD) is associated with impaired discrimination of emotional expressions. This deficit appears increased in crossmodal settings, when simultaneous inputs from different sensory modalities are presented. However, so far, studies exploring emotional crossmodal processing in SAUD relied on static faces and unm...
Article
Full-text available
Rationale. Binge drinking (i.e., excessive episodic alcohol consumption) among young adults has been associated with deleterious consequences, notably at the cognitive and brain levels. These behavioural impairments and brain alterations have a direct impact on psychological and interpersonal functioning, but they might also be involved in the tran...
Article
Reward processing impairments have been linked with positive and negative symptoms of schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven BOLD-fMRI studies comparing reward anticipation signals between schizophrenia patients and healthy controls. We observed a reduced difference in activation in schizophrenia pat...
Presentation
Full-text available
Dans ce document, nous reprenons l’ensemble des outils, étapes et ressources de base indispensables à la réalisation d’un premier travail de recherche (dans le cadre de la thèse de médecine ou du mémoire de DES par exemple). Des explications simples et claires et de nombreux liens sont fournis. Ce document est destiné à évoluer et nous serons ravis...
Presentation
L’ensemble des troubles psychiatriques, et singulièrement les conduites addictives, sont susceptibles d’être associés à des atteintes des fonctions cognitives, préexistantes ou conséquentes aux usages. Ces atteintes, variant, selon le type de trouble addictif, dans leur nature, dans leur fréquence, et dans leur caractère plus ou moins réversible, a...
Presentation
De nombreuses études rapportent l’existence de déficits cognitifs, et notamment des fonctions exécutives, dans le trouble sévère lié à l’usage d’alcool (TSUA). Ces troubles, qui concerneraient au moins 50 % des patients, ont un effet néfaste sur la prise en charge et contribuent à la rechute. Il convient donc de les dépister de manière systématique...
Poster
Full-text available
Introduction La dépression psychotique (DP) est un trouble mental sévère souvent sous-diagnostiqué alors qu’il existe des facteurs de risque, caractéristiques, traitements et prises en charge spécifiques [1], [2], [3], [4]. L’objectif de cette étude est de rechercher des caractéristiques sociodémographiques et cliniques associées aux DP en comparan...
Article
Visuoperceptive impairments are among the most frequently reported deficits in alcohol-use disorders, but only very few studies have investigated their origin and interactions with other categories of dysfunctions. Besides, these deficits have generally been interpreted in a linear bottom-up perspective, which appears very restrictive with respect...
Chapter
Theoretical and experimental approaches to alcohol use disorders (AUD) have mostly focused on the exploration of cognitive factors. More recently, several studies have explored socio-emotional variables in this population, documenting massive impairments and suggesting that they could have a key role in the emergence and persistence of alcohol-rela...
Article
Full-text available
Emotional crossmodal integration (i.e., multisensorial decoding of emotions) is a crucial process that ensures adaptive social behaviors and responses to the environment. Recent evidence suggests that in binge drinking—an excessive alcohol consumption pattern associated with psychological and cerebral deficits—crossmodal integration is preserved at...
Presentation
Il est désormais reconnu que les processus émotionnels influencent la perception visuelle par le biais de facteurs exogènes (propres aux stimuli visuels) et endogènes (propres à l’individu) [1]. Parmi les facteurs endogènes, l’anxiété-trait, qui correspond à la propension à vivre fréquemment des états anxieux au quotidien, serait associée à un biai...
Article
Background: Patients with severe alcohol use disorder (SAUD) frequently show cognitive deficits that can be efficiently identified using screening tools such as the Montreal Cognitive Assessment (MoCA) test. These cognitive deficits, which reduce the efficacy of therapeutic interventions and may contribute to dropout and relapse, could be, however...
Presentation
Emotional processing is known to be modulated by several psychopathological dimensions. In particular, anxious behavior is associated with an attentional bias toward emotional information often characterized by contradictory manifestations at neural and behavioral levels. In healthy participants, the emotional visual stimuli have been shown to capt...
Article
Full-text available
This study evaluated inhibition and performance monitoring abilities through the explicit processing of alcohol cues. Twenty-two binge drinkers and 22 control participants performed a speeded Go/No-Go task using pictures of alcohol and soft cans as Go and No-Go targets. This task measures inhibitory control and performance monitoring (i.e. task adj...
Article
OBJECTIVE: Excessive alcohol drinking, particularly among college students, is a major health concern worldwide. The implicit associations between alcohol-related concepts and affective attributes has been repeatedly postulated as a reliable predictor of these drinking behaviors. The Implicit Association Test (IAT) is considered as one of the most...
Article
Objectives: Concussions affect the processing of emotional stimuli. This study aimed to investigate how sex interacts with concussion effects on early event-related brain potentials (ERP) measures (P1, N1) of emotional facial expressions (EFE) processing in asymptomatic, multi-concussion athletes during an EFE identification task. Methods: Forty...
Article
Full-text available
Objective Familiarity is a subjective sensation that contributes to person recognition. This process is described as an emotion-based memory-trace of previous meetings and could be disrupted in schizophrenia. Consequently, familiarity disorders could be involved in the impaired social interactions observed in patients with schizophrenia. Previous s...
Article
Introduction: Decoding emotional information from faces and voices is crucial for efficient interpersonal communication. Emotional decoding deficits have been found in alcohol-dependence (ALC), particularly in crossmodal situations (with simultaneous stimulations from different modalities), but are still underexplored in Korsakoff syndrome (KS). T...
Article
Objective: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of r...
Article
Background Alcohol-dependence is related to large-scale cognitive impairments, particularly for executive functions (EF). These deficits persist even after long-term abstinence and have a major impact on patients’ everyday life and relapse risk. Earlier studies, based on multi-determined tasks, mostly focused on inhibition and did not offer a theor...
Article
Evidence suggests that social skills are affected by childhood mild traumatic brain injury (mTBI), but the neural and affective substrates of these difficulties are still underexplored. In particular, nothing is known about consequences on the perception of emotional facial expressions, despite its critical role in social interactions and the impor...
Article
As earlier research on Korsakoff syndrome (KS), a frequent neurological complication of alcohol-dependence (AD), mainly focused on cognition, affective impairments have been little investigated despite their crucial impact in AD. This article proposes new research avenues on this topic by combining two theoretical frameworks: (a) dual-process model...
Article
Full-text available
Background: Emotional and interpersonal deficits play a crucial role in alcohol related disorders as they predict alcohol consumption and relapse. Recent models of emotion regulation in psychopathology postulate that these deficits are centrally related to increased abstract/analytic repetitive thinking, combined with reduced concrete/experiential...
Poster
Full-text available
Generalized Anxiety Disorder (GAD) is associated with an attentional bias toward emotional information leading to behavioral manifestations which need to be clarified. In healthy participants, the emotional visual stimuli have been shown to capture the attentional resources not only in central vision (CV) but also in peripheral vision (PV). Objec...
Article
We investigated explicit and implicit emotional processing in peripheral vision using saccadic choice tasks. Emotional-neutral pairs of scenes were presented peripherally either at 10, 30 or 60degrees away from fixation. The participants had to make a saccadic eye movement to the target scene: emotional vs neutral in the explicit task, and oval vs...
Article
Background: Emotional and interpersonal impairments have been widely described in alcohol dependence, and their role in relapse has been clearly established. However, several components of social cognition have not been well explored in this context. Particularly, Theory of Mind (ToM) abilities, which are critical social skills enabling one to und...
Poster
Full-text available
Le décodage des expressions faciales émotionnelles (EFE) permet de se représenter rapidement l’état affectif d’autrui. En outre, les basses fréquences spatiales (BFS) véhiculées par la voie magnocellulaire sont susceptibles de capter l’attention précocement. Cette étude examine séparément l’effet des basses (0,35-1,5 cycles par degré), moyennes (1,...
Article
Full-text available
Recent research has demonstrated the critical role of the feeling of familiarity in recognition memory. Various neuroimaging paradigms have been developed to identify the brain regions that sustain the processing of familiarity; however, there is still considerable controversy about the functional significance of each brain region implicated in fam...
Article
Full-text available
Objective: The aim of this study was to develop a presurgical magnetoencephalography (MEG) protocol to localize and lateralize expressive and receptive language function as well as verbal memory in patients with epilepsy. Two simple language tasks and a different analytical procedure were developed. Methods: Ten healthy participants and 13 epile...
Article
Full-text available
This perspective aims at underlining the usefulness of event-related potentials (ERP) to better understand the brain correlates of Korsakoff’s syndrome (KS), a neuropsychiatric disease characterized by severe memory impairment and most frequently resulting as a neurological complication of alcohol-dependence (AD). While ERP have been broadly used i...