Fabiane Mulinari Brenner

• MD, MSc, PhD
• Professor at Federal University of Paraná

J Am Acad Dermatol 2003;48:103-10

Trichotillomania (TM) is a chronic disorder in which patients traumatically remove their own hair in a bizarre pattern. TM histopathological findings are not well defined. Twenty-eight scalp biopsies of TM were reviewed. Multiple vertical sections and special stains were used to evaluate the specimens. Twenty-six patients (24 female, 2 male) were i...

Hair loss is a common problem in men and women. Correct diagnosis of hair disorders is complex and requires evaluation of clinical presentation, history, physical examination, and laboratory tests. Hair loss may be categorized as hair shaft abnormalities, permanent alopecia, or nonpermanent alopecia. Nonpermanent alopecia, the most common type, inc...

Although telogen effluvium, or shedding-the most common type of diffuse hair loss in both women and men-is usually self-limiting, the condition may become chronic if the trigger is not identified and corrected. The authors discuss the physiologic and emotional triggers, clinical presentation, diagnosis, and management strategies, including the impo...

FUNDAMENTOS: A biópsia por punch é de grande auxílio no diagnóstico das doenças do couro cabeludo quando avaliada por patologista experiente. O conhecimento das estruturas encontradas no couro cabeludo normal facilita o diagnóstico histopatológico nessa área tão complexa da dermatopatologia. OBJETIVO: Determinar dados quantitativos normais do couro...

Platelet‐rich plasma (PRP) is a platelet concentrate obtained from whole blood centrifugation. The use of PRP in hair transplants (HT) has suggested better postoperative recovery with less erythema and crust formation, faster and better growth of transplanted follicular units (FU). A retrospective study was performed evaluating all male patients wi...

Permanent alopecia after haematopoietic stem cell trans- plantation (HSCT) is often associated with high doses of the chemotherapeutic agents used in the conditioning

Psychologic and social effects of scalp hair are more important than its biologic significance. Etiology of alopecia areata (AA) suggests a predominantly autoimmune reaction. Correlation between AA and psychologic disorders is reciprocal. Psychiatric disorders can trigger the onset of AA and its negative consequences may develop or exacerbate psych...

Background Folliculotropic mycosis fungoides (FMF) is a cutaneous T‐cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon. Objectives To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression. Methods Immunohistochemistry f...

A sarcoidose é doença granulomatosa não infecciosa de etiologia desconhecida, em que fatores ambientais, infecciosos, imunológicos e genéticos parecem estar relacionados. Manifestações clínicas podem ocorrer em qualquer órgão, mas há predomínio em pulmão e linfonodos intratorácicos. O envolvimento cutâneo da doença ocorre em cerca de 25% dos casos,...

Frontal fibrosing alopecia is a variant of lichen planopilaris with marginal progressive hair loss on the scalp, eyebrows and axillae. We report a case of frontal fibrosing alopecia and lichen planus pigmentosus in a postmenopausal woman, that started with alopecia on the eyebrows and then on the frontoparietal region, with periocular and cervical...

Due to mounting evidences of interaction between Hansen's bacilli with endothelial cells and the paucity of studies addressing the presence of nailfold capillaroscopic alterations in patients with Hansen's disease, a study was carried out in order to verify the presence of capillaroscopic alterations in patients with leprosy in its various forms an...

The referred article presents an all-encompassing view regarding the hair of Afro-American women.1 We consider relevant to emphasize an association observed with greater frequency in black patients: frontal fibrosing alopecia (FFA) and lichen planus pigmentosus (LPP). Lichen planus pigmentosus is a variant of lichen planus with symptoms such as gre...

As Ligas Acadêmicas de Dermatologia são atividades extracurriculares criadas por estudantes de Medicina em diversas escolas médicas do Brasil. Aceitas como extensão universitária, as Ligas trazem tanto benefícios como riscos à formação médica. Como benefícios é possível citar a inserção do estudante na rotina da especialidade e em contato com a com...

Background: Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversible alopecia, remains associated in recent cases. The pathogenesis...

Primary cutaneous nodular amyloidosis is a rare form of amyloidosis. The authors report the case of a 44-year old woman with nodules and plaques on the legs with three years of development and increase in the number and size of lesions. Clinical, histological and laboratory investigation dismissed the possibility of systemic amyloidosis, and the di...

Background: The current options for the treatment of acne vulgaris present many mechanisms of action. For several times, dermatologists try topical agents combinations, looking for better results. Objectives: To evaluate the efficacy, tolerability and safety of a topical, fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel for...

BACKGROUND: Lichen planopilaris is a frequent presentation of primary cicatricial alopecia. Scalp distribution characterizes the main clinical presentations: classic lichen planopilaris, frontal fibrosing alopecia and Graham-Little Piccardi-Lassueur Syndrome (GLPLS). OBJECTIVE: Description of the clinical, dermoscopic and histopathological finding...

BACKGROUND: Leprosy is an infectious disease that may lead to irreversible nerve damage, compromising patient's quality of life and leading to loss of working years. OBJECTIVES: To evaluate the epidemiological profile of patients followed at a University Hospital. MATERIALS AND METHODS: This is a retrospective observational study, based on a revi...

Letter to the authors of " Update on therapy for superfi cial mycoses: review article part I". Three considerations are made.

Dermatosis neglecta is the name of a skin condition characterized by papules and polygonal plaques, which are sometimes warty, brownish and hyperpigmented, adherent and symmetric, though removable with ethyl or isopropyl alcohol. It occurs due to inadequate skin cleansing causing accumulation of sebum, sweat, keratin and impurities. Its occurrence,...

BACKGROUND Masseter hypertrophy has been treated with botulinum toxin injections because of esthetic complaints especially in Asians. OBJECTIVES The goal of the present study was to evaluate the efficacy of abobotulin toxin use in masseter hipertrophy treatment in Brazilians. METHODS Ten Brazilian female patients with masseter hypertrophy were su...

Confluent and reticulated papillomatosis of Gougerot and Carteaud is a disease of uncertain etiology, the main differential diagnosis being pityriasis versicolor. The authors describe two cases of the disease – one in a man and one in a woman – both with good therapeutic response without recurrence after use of minocycline

BACKGROUNDAlopecia areata is a chronic disorder of the hair follicles and nails, of unknown etiology, with clear autoimmune components and genetic factors. Several therapeutic options have been suggested; however, no treatment is able to modify the disease course. Methotrexate is an immunosuppressant used in various dermatoses and recently introduc...

Background. Cryopeeling is a technique that uses cryotherapy not only on actinic keratoses lesions, but also all over the photodamaged skin. Objectives. To investigate the histological changes induced by two cryopeeling methods (liquid nitrogen (LN) and portable system (PS)). Methods. Sixteen patients (n = 16) with multiple actinic keratoses on the...

De acordo com o último censo da Sociedade Brasileira de Dermatologia, as alopecias não cicatriciais estão entre as cinco queixas mais frequentes nos consultórios dermatológicos. (CENSO DERMATOLÓGICO). A alopecia androgenética (AAG) é a causa mais comum de alopecia em ambos os sexos, se apresentando como rarefação capilar; enquanto o eflúvio telógen...

Confluent and reticulated papillomatosis of Gougerot and Carteaud is a disease of uncertain etiology, the main differential diagnosis being pityriasis versicolor. The authors describe two cases of the disease - one in a man and one in a woman - both with good therapeutic response without recurrence after use of minocycline.

Forehead and glabella rhytides are treated mostly with neurotoxins, although some practitioners prefer the concurrent use of fillers. It has been suggested that combination treatments can result in a better overall improvement. To compare the safety and effectiveness of treatment of forehead and glabellar lines with botulinum toxin A alone versus b...

Erosive pustular dermatosis of the scalp is a rare inflammatory disorder of the scalp, affecting elderly patients after local trauma and leading to scarring or cicatricial alopecia. Case Report: An elderly female patient complained of painful pustules on the parietal region bilaterally with progressive enlargement and ulceration. A biopsy suggested...

Ichthyoses are a common group of keratinization disorders. A non-inflammatory generalized persistent skin desquamation is observed. It is characterized by increased cell turnover, thickening of the stratum corneum and functional changes of sebaceous and sweat glands. All of these favor fungal proliferation. Dermatophytes may infect skin, hair and n...

Introduction: Acne scars are common, and their treatment is challenging. Several techniques have been used to remove, reposition, and flatten acne scars to improve the appearance of the skin's surface. More recently, fractional CO2 laser has been used to correct such scars due its good results and shorter recovery time. Objective: To evaluate and c...

Diffuse alopecia is mainly caused by telogen effluvium, diffuse androgenetic alopecia (female-pattern hair loss) and diffuse alopecia areata. Differential diagnosis between the three disorders may be difficult in several occasions. In this second part of our study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail, inclu...

The association of porphyria cutanea tarda (PCT) and systemic lupus erythematosus (SLE) is rare. Systemic lupus erythematosus, of complex pathophysiology and pleomorphic clinical manifestations, is similar to PCT regarding photosensitivity. One finding that can differentiate both diseases is the presence of cutaneous blisters, which are rare in SLE...

Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata-Part I * Desafio clínico e histológico no diagnóstico diferencial de alopecia difusa: alopecia androgenética, eflúvio telógeno e alopecia areata-Parte I Abstract: Diffuse androgenetic alopecia (f...

assessment instruments of nail psoriasis have been published in literature as means to standardize the previous subjective assessments of authors. Using Nail Psoriasis Severity Index for evaluation in patients with plaque psoriasis during treatment with acitretin. Thirty volunteers with plaque psoriasis were selected for the study. Twenty patients...

1. A queixa de queda de cabelo está entre as mais frequentes nos consultórios dermatológicos, especialmente entre jovens e mulheres. 2. Reconhecer as características do couro cabeludo e do ciclo do cabelo normal é fundamental para definir alterações referidas pelo paciente. 3. Anamnese cuidadosa e exame clínico, acompanhados de dermatoscopia, carac...

Introduction: Melasma is an acquired hyperpigmentation that affects primarily the face and occurs more frequently in women with darker skin. There are several therapies for treating melasma, however its longterm management remains a challenge. Objectives: To evaluate fractional Erbium:YAG laser's clinical effectiveness in treating refractory melasm...

In this work, a structured methodology is proposed and tested through infrared imaging temperature measurements of a healthy control group to establish expected normality ranges and of basal cell carcinoma patients (a type of skin cancer) previously diagnosed through biopsies of the affected regions. A method of conjugated gradients is proposed to...

The aim of the present work was to study the clinical aspects and relevance of molecular diagnosis in late mucocutaneous leishmaniasis patients in Parana, Brazil. Twenty one suspected cases of mucocutaneous leishmaniasis (MCL) in patients from the endemic areas of leishmaniasis were assessed. Different methods used in diagnosing the disease and the...

Cryopelling uses diffuse cryotherapy not only on lesions of actinic keratosis but all over the photodamaged skin. The aim of this study was to compare two cryopeeling methods (liquid nitrogen- LN and portable system - PS) and demonstrate their efficiency in the treatment of actinic keratoses, patient tolerance, researcher and patient preference and...

There is no appropriate and reliable method of evaluating and monitoring severity in rosacea. To determine the importance of nailfold capillaroscopy as a diagnostic and prognostic method for patients with rosacea. A cross-sectional study where eight patients with rosacea and 8 control subjects were submitted to nailfold capillaroscopy from May to J...

Basal cell carcinoma usually occurs in sun exposed areas of older male individuals. To emphasize the importance of histological step sections in the pursuit of the correct diagnosis when microscopic findings do not correspond to clinical hypothesis. 21-year-old female with a superficial basal cell carcinoma in pubic region diagnosed after histologi...

Introdução: Skin tumors are common and may present irregular growth, requiring resections with diverse geometric shapes. Many descriptions have been reported. Objective: To describe a triangle-shaped excision technique followed by primary closure in the treatment of skin cancer. Methods: Patients (n = 11) with tumors of between 1.8 and 5.7 cm locat...

Introduction: Calcium hydroxyapatite is a radiopaque material that was traditionally used to provide radiologic contrast. It has recently been approved for use in cutaneous filling. Objectives: To define the radiologic characteristics of Calcium hydroxyapatite and its potential to compromise radiologic evaluations. Methods: Twelve patients received...

Androgenetic alopecia is the most common type of alopecia in both women and men. Although there are clear clinical differences between its male and female patterns, there are physiopathogenic peculiarities in each gender. Changes in the hair cycle, with the shortening of the anagen phase, is responsible for the miniaturization process, transforming...

Introdução: Nas últimas quatro décadas a dermatologia transformou-se, de especialidade puramente clínica, em especialidade clinicocirúrgica. O dermatologista passou a realizar, além da diagnose e do tratamento clínico,o tratamento cirúrgico das afecções e neoplasias cutâneas,a correção de cicatrizes e procedimentos cutâneos necessários para melhora...

Localized scleroderma or morphea is a chronic disease of the connective tissue. Its etiology may be autoimmune and the condition results from a disturbance in collagen synthesis and deposition, clinically represented by sclerotic skin lesions. Some plaques may be yellowish, which can be misleading at diagnosis. This article reports the case of an a...

Introduction: During the last four decades, dermatology has evolved from a purely clinic into a clinical-surgical specialty. In addition to diagnosing conditions and conducting clinical therapies, dermatologists began performing surgical treatments of cutaneous affections and neoplasias, corrections of scars, and cosmetic cutaneous procedures. Obje...

Porocarcinoma écrino é um tumor de pele raro derivado do acrossiríngeo. Quatro casos de porocarcinoma écrino são estudados. Os pacientes tinham idade entre 49 e 64 anos, sendo dois homens e duas mulheres. O tempo de crescimento dos tumores variou de um a 20 anos. As lesões mediam de 1,2 x 2 a 4 x 5 cm e se localizavam nas extremidades ou na face. D...

Eccrine porocarcinoma is an extremely rare skin tumor derived from the acrosyringium. Four cases of eccrine porocarcinoma are described, two males and two females, aged from 49 to 64 years. Tumors grew in an interval of one to 20 years. Lesions ranged from 1.2 x 2 cm to 4 x 5 cm and were on limbs or face. Two patients had basal cell carcinoma in a...

A alopecia androgenética ou calvície em homens é caracterizada clinicamente pela rarefação simétrica de cabelos em couro cabeludo frontal e coroa. O desenvolvimento da alopecia androgenética é geneticamente determinado e dependente de andrógenos. Estima-se uma prevalência de alopecia androgenética em cerca de 50% dos homens brancos aos cinquenta an...

Introduction: Striae are frequent complaints in dermatology, however most studies are based on the use of laser, and the effects of other treatment modalities are observed by few doctors. Objective: To compare three therapeutic modalities: Subcision alone, trichloroacetic acid (TCA) 20% alone, and subcision combined with application of TCA 20% in t...

The objective of the present study was to establish a polymerase chain reaction (PCR) technique for the diagnosis of cutaneous and mucocutaneous leishmaniosis from autochthonous cases in the state of Paraná in southern Brazil as well as imported cases. We sought to determine its utility and accuracy compared with smears and present culture methods....

Sarcoidosis is a multi-system granulomatous disease that generally affects the respiratory tract and hilar lymph nodes. The skin is also commonly involved, although cutaneous sarcoidosis on the scalp is rare. Two cases of scalp sarcoidosis are reported: the first presented with patchy alopecia, cutaneous sarcoidosis and also systemic disease in a b...

In a study on scalp psoriasis of 19 patients (11 males and 8 females, 15-64 years of age, psoriasis area severity index partial score of the head ranging from 0.5 to 2.8), we came to notice that, apart from the classical criteria for the diagnosis of psoriasis which were present in all cases, in a majority of patients, sebaceous glands were extreme...

Acitretin has been shown to be effective for psoriasis treatment. Its mechanism of action is not completely understood, and there are few studies focusing on histological and immunohistochemical differences before and after treatment of psoriasis with acitretin. This is a prospective study of 17 patients with plaque psoriasis treated with acitretin...

O caso demonstra apresentação atípica de verrugas vulgares no dorso das mãos de paciente do sexo masculino de 53 anos e com história prévia de tratamento para linfoma de Hodgkin. As pápulas espiculadas, confluentes, de superfície rugosa, com centro ceratótico e ligeiramente descamativas são comparáveis a cristais de rocha.This case demonstrates an...

This case demonstrates an unusual presentation of verruca vulgaris on the dorsum of the hands in a 53 year-old man with previous history of treated Hodgkin lymphoma. The spiculate, confluent and rough-surfaced papules, with slight desquamation and keratotic core are comparable to rock crystals.

Frontal fibrosing alopecia is a progressive cicatricial alopecia. The first cases were described in Australia in postmenopausal women, in 1994. Since then, numerous cases were reported, suggesting that frontal fibrosing alopecia is more prevalent than initially thought. Its progressive course in postmenopausal women, clinically resembles androgenet...

Piloleiomioma é tumor benigno de músculo liso que tem origem no músculo eretor do pêlo. Pode ocorrer isoladamente ou em grande número. Apresenta-se doloroso, sensível ao frio, toque, pressão e emoção. Relata-se caso de um homem com nódulos intradérmicos compostos por fibras de músculo liso. A imuno-histoquímica mostra-se positiva para desmina e act...

FUNDAMENTOS: A biópsia por punch é de grande auxílio no diagnóstico das doenças do couro cabeludo quando avaliada por patologista experiente. O conhecimento das estruturas encontradas no couro cabeludo normal facilita o diagnóstico histopatológico nessa área tão complexa da dermatopatologia. OBJETIVO: Determinar dados quantitativos normais do couro...

FUNDAMENTOS: A caracterização histológica do folículo piloso normal em humanos é escassa na literatura, considerando que o reconhecimento da arquitetura folicular normal e suas variações nas diversas áreas do couro cabeludo é fundamental para o estudo das doenças do couro cabeludo. OBJETIVOS: Analisar fragmentos do couro cabeludo normal em indivídu...

Realizaçăo: UFPR TV Produçăo e ediçăo : Ney Hamilton Entrevistado: Fabiane Mulinari Brenner

Descreve-se uma família com síndrome dos cabelos anágenos frouxos (SCAF) associada à distrofia macular. Foram descritos os achados dermatológicos, oftalmológicos e de microscopia óptica e eletrônica de varredura de 11 indivíduos. Dois apresentaram SCAF, sem qualquer alteração ocular. Dos quatro indivíduos com alteração ocular, duas irmãs apresentar...

Descreve-se uma família com síndrome dos cabelos anágenos frouxos (SCAF) associada à distrofia macular. Foram descritos os achados dermatológicos, oftalmológicos e de microscopia óptica e eletrônica de varredura de 11 indivíduos. Dois apresentaram SCAF, sem qualquer alteração ocular. Dos quatro indivíduos com alteração ocular, duas irmãs apresentar...

A lipoidoproteinose (doença de Urbach-Wiethe) é doença autossômica recessiva rara, caracterizada pela deposição progressiva de substância hialina na pele, membranas mucosas e órgãos internos. Clinicamente, os pacientes apresentam lesões papulonodulares na face, com áreas de infiltração difusa da pele principalmente nos joelhos, cotovelos e mãos; a...

A lipoidoproteinose (doença de Urbach-Wiethe) é doença autossômica recessiva rara, caracterizada pela deposição progressiva de substância hialina na pele, membranas mucosas e órgãos internos. Clinicamente, os pacientes apresentam lesões papulonodulares na face, com áreas de infiltração difusa da pele principalmente nos joelhos, cotovelos e mãos; a...

Alopecia is usually treatable and self-limited, but it may be permanent. Careful diagnosis of the type of hair loss will aid in selecting effective treatment. Reassurance is an important component of any treatment regimen.

A acne é uma dermatose de alta prevalência, especialmente em adolescentes e adultos jovens. Acomete homens e mulheres, mas geralmente os homens são afetados pelas formas mais graves da acne. Muitas vezes os pacientes são inicialmente avaliados pelo clínico ou pediatra. Diversas opções terapêuticas estão disponíveis, desde os esfoliantes, antibiótic...

A 52-year old healthy female complains about hair thining during the last 5 years. She denies hair shedding and noticed a predominant thinning in the frontal area. She menopaused 6 years ago and did not start hormonal replacement therapy due to a history of a benign breast tumor. Her family history is remarkable for diabetes (two older sisters) and...