Fabiana Arduini

Università degli Studi di Roma "Tor Vergata", Rome, Italy · Dipartimento di Scienze e Tecnologie Chimiche

A wearable potentiometric device is reported based on an innovative butterfly-like paper-based microfluidic system, allowing for continuous monitoring of pH and Na⁺ levels in sweat during physical activity. Specifically, the use of the butterfly-like configuration avoids evaporation phenomena and memory effects, enabling precise and timely biomarke...

In the orthopaedic surgery field, the use of medical implants to treat a patient's bone fracture is nowadays a common practice, nevertheless, it is associated with possible cases of infection....

The last decade has been incredibly fruitful in proving the multifunctionality of paper for delivering innovative electrochemical (bio)sensors. The paper material exhibits unprecedented versatility to deal with complex liquid matrices and facilitate analytical detection in aerosol and solid phases. Such remarkable capabilities are feasible by explo...

Points-of-care (PoCs) augment healthcare systems by performing care whenever needed and are becoming increasingly crucial for the well-being of the worldwide population. Personalized medicine, chronic illness management, and cost reduction can be achieved thanks to the widespread adoption of PoCs. Significant incentives for PoCs deployment are nowa...

Among the multiple healthcare applications and systems exploiting sensing RFID boards, monitoring sweat’s pH can be extremely useful for sportsmen and sportswomen. Furthermore, given the multiple known benefits that sports yield, measuring pH during physical activity can be integrated with points-of-care (PoCs) for patients who need working out. Th...

This communication describes the development of polyvinyl chloride electrochemical system in which a paper layer loaded with reagents is inserted into the device, demonstrating a new concept of a paper card-like pad for a reagent-free and easy measurement of the target analyte in solution. This device detects glucose in artificial tears in the rang...

Points-of-care (PoCs) augment healthcare systems by performing care whenever needed and are becoming increasingly crucial for the well-being of the worldwide population. Personalized medicine, chronic illness management, and cost reduction can be achieved thanks to the widespread adoption of PoCs. Significant incentives for PoCs deployment are nowa...

Herein, we report the first paper-based microfluidics devices encompassing the filter paper to manage the flow and to load the reagents for a reagent-free competitive magnetic-bead-based immunosensor for cortisol analysis in sweat. The paper-based microfluidics pattern was made using wax printing and laser-cutter techniques, for the delivery of cap...

Infections are a relevant problem in the orthopaedic field because the risk of infection is universal for all implanted orthopaedic devices. Herein, we reported the design, develop, and test of a miniaturized, cost-effective, and Bluetooth-assisted device for fast and easy monitoring of infections during orthopaedic surgery. The new portable miniat...

In recent years, body-worn RFID and NFC (near field communication) devices have become one of the principal technologies concurring to the rise of healthcare internet of thing (H-IoT) systems. Similarly, points of care (PoCs) moved increasingly closer to patients to reduce the costs while supporting precision medicine and improving chronic illness...

In human history, numerous infectious diseases have emerged and reemerged threatening countries worldwide, due to agents of different sources, from bacteria to viruses, fungi, protozoa, helminths, and prions. Among them, bacterial infection is gaining huge attention due to their antibiotic-resistance, which leads to higher medical costs, prolonged...

The development of enhanced and cost-effective materials for the adsorption and determination of pesticides in water is urgently required. Dicofol is an acaricide belonging to persistent organic pollutants that can lead to several diseases including cancer, passiveness, ataxia, vomiting, and affects sex hormones. In this study, we synthesized a mag...

The increasing demand for food and the need for a sustainability vision in the agri-food sector have boosted novel approaches for food management, enhancing the valorization of wastes and by-products belonging to the food industry. Herein, we present a novel paper-based origami device to assess the amount of both glucosinolate and glucose in a food...

In the last few decades, nanomaterials have made great advances in the biosensor field, thanks to their ability to enhance several key issues of biosensing analytical tools, namely, sensitivity, selectivity, robustness, and reproducibility. The recent trend of sustainability has boosted the progress of novel and eco-designed electrochemical paper-b...

Coeliac disease is a very common autoimmune disease estimated to affect 1 in 100 people worldwide. It occurs in genetically predisposed people where the ingestion of gluten leads to damage in the small intestine, and it is accurately diagnosticated through duodenal biopsy, an invasive diagnostic method. The liquid biopsy, generally used for monitor...

According to World Health Organization reports, large numbers of people around the globe have been infected or died for COVID-19 due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Researchers are still trying to find a rapid and accurate diagnostic method for revealing infected people by low viral load with the overriding goal...

Herein, we report a proof-of-concept algal cytosensor for the electrochemical quantification of bacteria in wastewater, exploiting the green photosynthetic alga Chlamydomonas reinhardtii immobilized on carbon black (CB) nanomodified screen-printed electrodes. The CB nanoparticles are used as nanomodifiers, as they are able to sense the oxygen produ...

miRNA detection using microfluidics-based devices is one of the most important innovations in biology and modern medicine. miRNAs are small regulatory molecules, whose varied concentrations can indicate diseases or pathologic conditions, boosting their use as reliable modern biomarkers for advanced medical diagnostics. Due to their small size and l...

Flexible and epidermal sensing devices are becoming vital to enable precision medicine and telemonitoring systems. The NFC (Near Field Communication) protocol is also becoming increasingly important for this application since it is embedded in most smartphones that can be used as pervasive and low-cost readers. Furthermore, the responder can be pas...

Herein, we report the environmental impact quantification of a newly developed fully printed electrochemical device to assist a colorimetric detection of phosphate in saliva. The evaluation of the analytical procedure was performed according to the principles of Green Analytical Chemistry and White Analytical Chemistry. The standard method for phos...

Pesticides are largely used at worldwide level to improve food production, fulfilling the needs of the global population which is increasing year by year. Although pesticides are beneficial for crop production, their extensive use has serious consequences for the pollution of the produced food as well as for soil and groundwaters. Indeed, it is rep...

The adhesion of amino acids and small organic molecules on TiO 2 nanoparticles is fundamental for bio-nano functionalization of peptides and proteins. The adsorption free energy is the main physical quantity that regulates the adsorption process. Its evaluation is particularly challenging both experimentally, due to the weak interfacial signal in a...

Coronavirus disease 2019 (COVID-19) has been recognized as a global pandemic outbreak, opening the most severe socio-economic crisis since World War II. Different scientific activities have been emerged in this global scenario, including the development of innovative analytical tools to measure nucleic acid, antibodies, and antigens in the nasophar...

The use of paper as a multifunctional material in electrochemical sensing has been intensively explored over the last decade. The combination among different kinds of paper as well as their coupling with different electrochemical cell configurations have been demonstrated, disclosing innovative sensing performances and features that are still to be...

Corrosion occurring in reinforced concrete has turned into a primary concern of the current century, concrete being the most ubiquitous and predominant material used in the construction industry. Among the many interrelated processes that trigger corrosion of metallic reinforcements, the penetration of chloride ions into the concrete matrix is the...

In the last 10 years, paper-based electrochemical biosensors have gathered attention from the scientific community for their unique advantages and sustainability vision. The use of papers in the design the electrochemical biosensors confers to these analytical tools several interesting features such as the management of the solution flow without ex...

Point of care devices have attracted a huge interest by the scientific community because of the valuable potentiality for rapid diagnosis and precision medicine through cost-effective and easy-to-use devices for on-site measurement by unskilled personnel. Herein, we reported a smartphone-assisted electrochemical device consisted of a screen-printed...

The recent global events of COVID-19 in 2020 have alerted the world to the risk of viruses and their impacts on human health, including their impacts in the social and economic sectors. Rapid tests are urgently required to enable antigen detection and thus to facilitate rapid and simple evaluations of contagious individuals, with the overriding goa...

A family of inherently chiral electroactive selectors based on the 2,2’‐biindole atropisomeric scaffold, of easy synthesis and modulable functional properties, is studied in cascade in two enantioselection contexts. They are at first investigated as probes in enantioselective HPLC, studying molecular structure and temperature effects, and achieving...

The synergic combination of printed electronics and printed electrochemical sensors has recently emerged as a new route for developing smart chemical wearable devices applied to sweat monitoring. Sodium ion is one of electrolytes monitored in sweat to evaluate sweating level for electrolyte replacement recommendations. Herein, we report the develop...

Reinforced concrete has been employed worldwide as a leading building material for public and private structures as well as in modern sculptural art. Although the unrivalled mechanical strength and modelling versatility of this material, several interrelated processes are responsible for its progressive degradation (e.g., carbonation, penetration o...

The indiscriminate use of herbicides in agriculture contributes to soil and water pollution, with important endangering consequences on the ecosystems. Among the available analytical systems, algal biosensors have demonstrated to be valid tools thanks to their high sensitivity, cost-effectiveness, and eco-design. Herein, we report the development o...

Herein, we report a novel paper-based electrochemical sensor for on-site detection of sulphur mustards. This sensor was conceived combining office paper-based electrochemical sensor with choline oxidase enzyme to deliver a sustainable sensing tool. The mustard agent detection relies on the evaluation of inhibition degree of choline oxidase, which i...

Botulinum neurotoxins (BoNTs) produced by soil bacterium Clostridium botulinum are cause of botulism and listed as biohazard agents, thus rapid screening assays are needed for taking the correct countermeasures in a timely fashion. The gold standard method relies on the mouse lethality assay with a lengthy analysis time, i.e., 2-5 days, hindering t...

The outbreak of COVID-19 is caused by high contagiousness and rapid spread of SARS-CoV-2 virus between people when an infected person is in close contact with another one. In this overall scenario, the disinfection processes have been largely improved. For instance, some countries have approved no-touch technologies by vaporizing disinfectants such...

In this work, a wax-patterned chromatographic paper has been utilized as a holistic platform to 1) synthesize Prussian Blue Nanoparticles (sensing species), 2) load the reagents for the assay, 3) concentrate the sample through multistep and 4) visualize the determination of silver ions. Surface waters are continuously affected by changes in the com...

The indiscriminate use of herbicides in agriculture contributes to soil and water pollution, with important endangering consequences on the ecosystems. Among the available analytical systems, algal biosensors have demonstrated to be valid tools thanks to their high sensitivity, cost-effectiveness, and eco-design. Herein, we report the development o...

The growth of (bio)sensors in analytical chemistry is mainly attributable to the development of affordable, effective, portable, and user-friendly analytical tools. In the field of sensors, paper-based devices are gaining a relevant position for their outstanding features including foldability, ease of use, and instrument-free microfluidics. Herein...

Deep Eutectic Solvents (DESs) offer advantages similar to ionic liquid (IL) ones, with easier and more sustainable synthesis; moreover, bio-based DESs often include chiral components, surprisingly underexploited. A proof of concept is now offered of the impressive potential of enantiopure chiral DESs as chiral media for enantioselective electroanal...

Herein, a novel configuration for the detection of a chemical warfare agent, namely sulfur mustard (bis(2-chloroethyl)sulphide) was designed to develop a biosensor that can play a relevant role in the monitoring of such a chemical threat in risk and war areas. In detail, a tailor-made heterogeneous oligonucleotide-antibody biosensor was realised, b...

The diffusion of novel SARS-CoV-2 coronavirus over the world generated COVID-19 pandemic event as reported by World Health Organization on March 2020. The huge issue is the high infectivity and the absence of vaccine and customised drugs allowing for hard management of this outbreak, thus a rapid and on site analysis is a need to contain the spread...

A colorimetric paper-based sensor is proposed for the rapid monitoring of six major organophosphate and carbamate pesticides. The assay was constructed by dropping gold and silver nanoparticles on the hydrophilic zones of a paper substrate. The nanoparticles were modified by L-arginine, quercetin, and polyglutamic acid. The mechanism of sensing is...

The introduction of paper-based platforms for developing novel energy storage devices such as supercapacitors (SCs) highlights new promising opportunities in the field of flexible electronics. Herein, the use of paper-based substrate has shown reduced manufacturing cost and simplified coating process by screen-printing technology, as well as an imp...

From the first investigations on peptide nucleic acids (PNA), peculiar features have been described as intrinsic of the singular chemical nature of these biomolecules. Relevant applications in the development of biosensors occurred in the last decades, exploiting them as bioreceptors. Their outstanding chemical and thermal stability as well as high...

Seafood products are widely accepted for their high nutritional properties. However, their safety should be comprehensively monitored, because chemical contaminants/xenobiotics may accumulate in seafood at levels that can pose a potential human health hazard. Indeed, seafood is one of the most vulnerable and perishable products, so its quality asse...

Towards the development of miniaturised and low‐cost sensors for heavy metals detection in water, herein we describe an electrochemical sensor for the co‐detection of lead and cadmium. The sensor was developed using screen‐printed electrode modified with a composite of poly(propylene imine) dendrimer and carbon black. The electrode was modified by...

In the last decade, wearable sensors have gained a key role on biomedical research field for reliable health state monitoring. A wide plethora of physics marker sensors is already commercially available, including activity tracker, heart rate devices, and fitness smartwatch. On the contrary, wearable and epidermal sensors for chemical biomarker mon...

This work presents an effective strategy for the well-oriented immobilization of antibodies in which boronic acid is directly attached to the surface and with no need of the long and flexible spacer. A magnetic graphene nanoribbon-boronic acid-based immunosensor was developed and tested for the impedimetric detection of lymphoma cancer cells, a blo...

Sustainable development goals reported in 2030 Agenda established the global challenges in different fields including agrifood, health, and climate change. Smart electrochemical eco-designed sensors can support the achievement of some goals thanks the capability to detect analyte on site using cost-effective instrumentation by unskilled personnel....

The development of portable and user-friendly sensing platforms is a hot topic in the field of analytical chemistry. Among others, electroanalytical approaches exhibit a high amenability for reaching this purpose, i.e. the commercial strips for diabetes care are an obvious success. However, providing fully-integrated and reagent-free methods is alw...

Pancreatic ductal adenocarcinoma is the predominant neoplastic disease of the pancreas and it represents the fourth most frequent cause of death in cancer-related disease, with only 8% of survivors after 5-year to the diagnosis. The main issues of this type of cancer rely on fast progress (i.e. 14 months from T1 to a T4 stage), nonspecific symptoms...

In the overall scenario of precision medicine, we propose a novel paper-based lab-on-a-chip to deliver a cost-effective and easy to use sensing tool for customized administration of drugs in Alzheimer’s disease. Among several drugs, we designed the device for evaluating the efficacy of compounds (e.g. physostigmine, rivastigmine, donepezil) which a...

Herein, we present the first paper‐based device for facing one of the worldwide concerns of the Modern age: the corrosion‐induced deterioration of reinforced concrete. Indeed, the monitoring of corrosion extent in reinforced concrete constructions has been acknowledged as a priority for public safety. In this work, the porosity properties of a pape...

The highest risk of novel coronavirus SARS-CoV-2 to be spread through human-to-human transmission has boosted the use of personal protective equipment at worldwide level. In Europe, the medical face masks must be tested to certify the essential requirements in agreement with European Standard UNI EN 14683: 2019, and face masks for industrial use in...

The search for sustainability has now become a duty for all those entities, nations or people who intend to combat poverty in the world, safeguard the environment and bridge the gap of disparities that unfortunately still exist between underdeveloped countries and medium-high developed nations. The agrifood sector plays an important role in this vi...

Enzymes immobilisation represents a critical issue in the design of biosensors to achieve standardization as well as suitable analytical performances in terms of sensitivity, selectivity, and stability. In this work electrospray deposition (ESD) has been exploited as a novel technique for the immobilisation of laccase enzyme on carbon black modifie...

Nowadays, environmental pollution is one of the major worldwide problems. There are various types of pollutants (i.e., organic, inorganic, and biological materials), which can contaminant water resources, land, and air. Therefore, there is a high demand to develop and design new devices for the detection and determination of various contaminants in...

The current international pharmaceutical scenario encompasses several steps in drug production, with complex and extremely long procedures. In the last few decades, scientific research has been trying to offer valid and reliable solutions to replace or support conventional techniques, in order to facilitate drug development procedures. These innova...

In the last years, there was a growing demand for handheld, affordable and reliable analytical tools able in providing sensitive and effective monitoring of clinical biomarkers for the follow-up of many diseases. To this aim, the ensemble of biological elements and nanomaterials played a crucial role in the development of hybrid nanostructured bios...

A novel amperometric algae-based biosensor was developed for the detection of photosynthetic herbicides in river water. The green photosynthetic algae Chlamydomonas reinhardtii was immobilized on carbon black modified screen-printed electrodes, exploiting carbon black as smart nanomaterial to monitor changes in algae oxygen evolution during the pho...

In the last decade, electrochemical paper-based (bio)sensors have garnered much attention in the sensing field thanks to their cost-effectiveness, easiness to use, and miniaturisation. Besides these characteristics in common with the other electrochemical (bio)sensors, the features of paper such as foldability and porosity have opened new unprecede...

Bisphenol A is one the most relevant endocrine disruptors for its toxicity and ubiquity in the environment, being largely employed as raw material for manufacturing processes of a wide number of compounds. Furthermore, bisphenol A is released in the drinking water when plastic-based bottles are incorrectly transported under sunlight, delivering a c...

The application of nanotechnologies to the agrifood sector provides one of the innovative tools able to support change in a system that, through its intensification and industrialization, currently fails both humans and the environment. The development of green nanotechnology, which exploits biological routes for the synthesis of nanomaterials, and...

Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. The principle of the detection relays on the decrease of enzymatic activity due to the capabi...

Biosensor development exploiting various transduction principles is characterized by a strong competition to reach high detectability, portability and robustness. Nevertheless, a literature-based comparison is not possible, as different conditions are employed in each paper. Herein, we aim at evaluating which measurement, photons or electrons, yiel...

Advances in cutting-edge technologies including nanotechnology, microfluidics, electronic engineering, and materials science have boosted a new era in the design of robust and sensitive biosensors. In recent years, carbon black has been re-discovered in the design of electrochemical (bio)sensors thanks to its interesting electroanalytical propertie...

The development of paper-based electroanalytical strips as powerful diagnostic tools has gained a lot of attention within the sensor community. In particular, the detection of nucleic acids in complex matrices represents a trending topic, especially when focused towards the development of emerging technologies, such as liquid biopsy. The DNA-based...

The recent trend of using sustainable disinfectants in water treatment sector boosted the employment of chlorine dioxide (ClO 2 ) as green disinfectant. Indeed, this disinfectant is characterised by several attractive features such as the working capability in a wide range of pH and the absence of harmful by‐products. These characteristics confer t...