Fabian Termorshuizen

Fabian Termorshuizen
University Medical Center Utrecht | UMC Utrecht

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65
Publications
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Publications

Publications (65)
Article
Background The high risk of psychosis among migrants is often attributed to social stressors in the host country. We examined whether the relative risk of psychosis among migrants is low on arrival and increases thereafter. Methods In this cohort study, first-generation immigrants to the Netherlands, aged 10 years and older ( N = 1 281 678), were...
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Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating t...
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Background: In various countries, general practitioners (GPs) play an important role after treatment for non-affective psychotic disorder (NAPD) in mental health care. It is unclear how these patients fare. Aim: To compare the clinical course of patients largely recovered from NAPD and referred to the GP with the course of patients who remain in...
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Objective To compare the mortality in people using clozapine to that of people using other antipsychotics. Methods Danish incidence cohort of 22 110 patients with a first diagnosis of non‐affective psychotic disorder (1995‐2013) and a prevalence cohort of 50 881 patients ever diagnosed with such a disorder (1969‐2013). Hazard ratios (HR) were calc...
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Background: In Europe, the incidence of psychotic disorder is high in certain migrant and minority ethnic groups (hence: 'minorities'). However, it is unknown how the incidence pattern for these groups varies within this continent. Our objective was to compare, across sites in France, Italy, Spain, the UK and the Netherlands, the incidence rates f...
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Background To provide an overview of epidemiological studies of dementia among migrant groups in Europe and to estimate their pooled odds ratio (OR) v. the reference population. Methods Search for articles reporting on incidence or prevalence of dementia among ethnic minorities and migrants in Europe, published before 21 December 2018. We performe...
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Reports of decreased mortality among patients with schizophrenia who use clozapine may be biased if clozapine is prescribed to relatively healthy patients and if intensive monitoring during its use prevents (under-treatment of) somatic disorder. We aimed to assess whether there is a difference in: (1) somatic comorbidity between patients who start...
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Background The incidence of psychotic disorder is increased among various migrant and ethnic minority populations in Europe. Consistent evidence shows that risk estimates are moderated by ethnic background, but there may also be moderation by host country (1,2). We therefore aimed to study the risk of psychotic disorder in first- and second-generat...
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Background The aims of this meta-analysis are (i) to estimate the pooled relative risk (RR) of developing non-affective psychotic disorder (NAPD) and affective psychotic disorder (APD) among migrants and their children; (ii) to adjust these results for socioeconomic status (SES); (iii) to examine the sources of heterogeneity that underlie the risk...
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Background Individuals with autism spectrum disorder (ASD) appear to be at increased risk of non-affective psychotic disorder (NAPD) and bipolar disorder (BD). However, most previous studies examined the co-occurrence of ASD and NAPD or BD, ignoring possible diagnostic bias and selection bias. We used longitudinal data from Dutch psychiatric case r...
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Purpose: A higher own-group ethnic density in the area of residence is often associated with a lower risk for psychotic disorder. For common mental disorders the evidence is less convincing. This study explores whether these findings are mirrored in data on dispensing of antipsychotics and antidepressants. Methods: Health insurance data on dispe...
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Purpose: Previously, a high prevalence of certain psychiatric disorders was shown among non-Western immigrants. This study explores whether this results in more prescriptions for psychotropic medication. Methods: Data on dispensing of medication among adults living in the four largest Dutch cities in 2013 were linked to demographic data from Sta...
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Background A causal relationship between antidepressants (ADs) and high risk of suicide behavior at young age has been suggested. We analyzed the rates of suicide attempts during treatment with AD in comparison with the rates before treatment initiation for different ages.Methods Claims of insurance company Achmea were linked to the population regi...
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Objective: A causal relationship between antidepressants (ADs) and high risk of suicide behavior at young age has been suggested. We analyzed the rates of suicide attempts during treatment with AD in comparison with the rates before treatment initiation for different ages. Design: Observational retrospective cohort study. Method: Claims of ins...
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Recent studies suggested a favorable association between the ethnic density of the neighborhood and the risk of psychotic disorders among ethnic minorities. In this study, it was investigated whether this so-called 'ethnic density hypothesis' is also relevant to suicide risk, which is not sensitive to bias associated with ethnic differences in acce...
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Recent studies have shown increased incidence of non-affective psychotic disorders (NAPD) among ethnic minorities compared to the native population, but not, or less so, in areas with a high own-group proportion. The aim is to investigate this ethnic density effect in Utrecht and whether this effect is due to higher rates of NAPD among Dutch person...
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There is a large mortality gap between patients with a nonaffective psychotic disorder and those in the general population, is associated with both natural and nonnatural death causes. This study aims to assess whether mortality risks vary for different causes of death according to the duration since diagnosis and age in a large sample of patients...
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Different studies have shown similar or even lower mortality among homeless persons with compared to homeless persons without a severe mental disorder. To clarify the association between presence of a psychiatric diagnosis and mortality among the socially marginalized. The Public Mental health care (PMHc) is a legal task of the municipal authority...
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Objective: To estimate the risk of developing autism-spectrum disorder (ASD) in children born to immigrants as compared with children of Dutch-born parents. Method: Retrospective, population-based cohort study of all live births (n = 106 953) between 1998 and 2007 in a circumscribed geographical region in the Netherlands. Cohort members were lin...
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Purpose: Both increased as well as decreased cancer mortality among psychiatric patients has been reported, but competing death causes were not included in the analyses. This study aims to investigate whether observed cancer mortality in patients with psychiatric disorders might be biased by competing death causes. Method: In this retrospective...
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There is an increased incidence of non-affective psychotic disorders (NAPD) among first- and second-generation migrants in Europe. The purpose of this population-based study was to compare the risk of suicide in Dutch natives and immigrants with or without NAPD. Cases of NAPD (n=12 580) from three Dutch psychiatric registers were linked to the caus...
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To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder. Combining data from a psychiatric case registry and Statistics Netherlands provided information on 4,673 affected probands and 18,692 matched population controls. Probands with schizophrenia had relative risks (RRs) for having a sibling with schizo...
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Several studies have demonstrated increased mortality associated with depression and with anxiety. Mortality due to comorbidity of two mental disorders may be even more increased. Therefore, we investigated the mortality among patients with depression, with anxiety and with both diagnoses. By linking the longitudinal Psychiatric Case Register Middl...
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We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. In total, 14231 patients and 56924 matched controls were collected and analyzed for an association with paternal age by logistic regression. ASD is significan...
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To investigate the 'real world' effectiveness of robust statin therapy, focusing on the effect of dose and early treatment discontinuation on the risk of hospitalization for acute myocardial infarction (AMI). In the PHARMO database, including among others drug-dispensing and hospital discharge records for more than two million subjects in the Nethe...
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Residual glomerular filtration rate (GFR) is a much more important determinant of survival in peritoneal dialysis patients, than peritoneal solute clearances. However, anuric peritoneal dialysis patients are solely dependent on peritoneal solute clearances. The aim of the study was to analyze the effects of peritoneal small solute clearances and ul...
Article
Ultraviolet radiation (UVR) is associated with an increased risk of squamous cell carcinoma (SCC), which is in part due to immunomodulation. In addition, human papilloma virus (HPV), especially the epidermodysplasia verruciformis (EV)-associated types, may be involved. In view of the capacity of UVR to impair host resistance to infections, we inves...
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A high delivered Kt/V(urea) (dKt/V(urea)) is advocated in the U.S. National Kidney Foundation Dialysis Outcomes Quality Initiative guidelines on hemodialysis (HD) adequacy, irrespective of the presence of residual renal function. The contribution of treatment adequacy and residual renal function to patient survival was investigated. The Netherlands...
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Ultraviolet radiation (UVR) is an important risk factor for skin cancer in transplant recipients. In view of the potential suppressive effect of UVR on host resistance it was examined whether exposure to UVR was also associated with the occurrence of various skin infections. In a cohort of renal transplant recipients (n = 137), lifetime exposure wa...
Article
Various studies indicate that fair comparisons of mortality rates between hemodialysis (HD) patients and peritoneal dialysis (PD) patients are difficult because of differences in patient characteristics, because of nonconstant relative risks of death (RR), and because the survival times of patients who switch treatment modalities can be censored in...
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The guidelines from the US National Kidney Foundation Dialysis Outcomes Quality Initiative on peritoneal dialysis (PD) assume equivalence between the peritoneal and the renal solute clearance. The authors examined in a prospective cohort study of incident dialysis patients the relative contribution of residual renal function and peritoneal clearanc...
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The guidelines published by the NKF-Dialysis Outcomes Quality Initiative (DOQI) in 1997 advocate an earlier start of dialysis in ESRD patients and a higher dialysis dose than usual. We studied the possible influence of the increasing emphasis on adequate dialysis on the management of ESRD patients in The Netherlands in 1993-2000. The NECOSAD study...
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A high delivered Kt/Vurea is advocated in the DOQI guidelines on hemodialyis (HD) adequacy. However, the contribution of residual renal function to overall urea clearance is neglected. We investigated the relative contribution of residual renal Kt/Vurea and delivered Kt/Vurea to patient survival. Furthermore, we investigated whether other character...
Article
We studied a group of HIV-infected homosexuals who participated in the Amsterdam Cohort Study on HIV and AIDS to investigate whether greater exposure to sunlight is associated with a less favorable course of some important immunological parameters. This was done because ultraviolet radiation (UVR) is potentially harmful to the cellular immunity and...
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In view of the capacity of ultraviolet radiation (UVR) to induce suppression of various immunological parameters and to enhance the viral replication of HIV, we investigated whether seasonal influences on immunological parameters that are relevant for HIV infection could be identified. As the sunny season is associated with high levels of ambient U...
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We designed a 6-week retrospective questionnaire on sunlight exposure. Estimation of the short-term exposure to sunlight is important for observational human studies concerning the effects of ultraviolet radiation (UVR) on the human immune system and related resistance to infections. This questionnaire was given to the parents of 1672 1-year-old ch...
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Recent studies on the immunosuppressive effects of ultraviolet radiation (UVR) and the related resistance to infections in rodents and humans are presented. The waveband dependency of trans-to-cis isomerisation of urocanic acid in the stratum corneum and the role of DNA damage in UVR-induced erythema and immunosuppression were investigated to furth...
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The prevalence of antibodies to hepatitis A virus was assessed in a Dutch nationwide sample (n = 7367). A questionnaire was used to study the association with various sociodemographic characteristics. Overall, 33·8% (95% CI 31·6–36%) of the population had hepatitis A antibodies. The seroprevalence was less than 10% in people under 35; it increas...
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The long average incubation time from HIV infection to AIDS makes it difficult to estimate recent HIV transmission from AIDS incidence data. Age-period-cohort (APC) analysis can separate out the effects of age, calendar time and birth cohort to provide a clearer picture of transmission trends. AIDS incidence data from 1981 to 1994 among intravenous...
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The capture-recapture method was used to estimate the sensitivity of case finding in two national STD surveillance systems: (1) STD registration at municipal health services (STD-MHS); (2) statutory notification by clinicians (NNS). To identify those cases common to both surveillance systems, cases from 1995 were compared using individual identifie...
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Far more cases of hepatitis A were identified in the Netherlands in the first five months of 1998 than in the same period of 1997. In order to investigate the reasons for this upsurge we compared the notified cases of hepatitis A in the first five months
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To describe the incidence of hepatitis A in the Netherlands, 1957-1997 to find an explanation for the increase in 1998. Descriptive. National Institute of Public Health and Environment (RIVM), Bilthoven, the Netherlands. Following an increase of the number of hepatitis A notifications in 1998 the national notification data over the period 1957-1997...
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To examine the prevalence and correlates of infection with herpes simplex virus type 2 (HSV-2) among sexually transmitted disease (STD) clinic attenders, we studied the prevalence of antibodies to HSV-2 and their association with risk behaviour. Data were collected in a cross-sectional study among STD clinic attenders in Amsterdam. Seropositivity f...
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To study trends in AIDS incidence in Europe by age and year of birth. Age-period-cohort analyses were adopted to distinguish the different time factors of calendar year, age and year of birth. Non-aggregate AIDS incidence data from 12 European countries (1978-1994) were adjusted for reporting delay and expressed per unit of population (per 100000 p...
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Objectives: To study trends in AIDS incidence in Europe by age and year of birth. Design: Age-period-cohort analyses were adopted to distinguish the different time factors of calendar year, age and year of birth. Methods: Non-aggregate AIDS incidence data from 12 European countries (1978–1994) were adjusted for reporting delay and expressed per uni...
Article
An abrupt decrease of the number of reported new AIDS cases took place in the first half of 1997 in the Netherlands. This decrease was most prominent in homosexual/bisexual men and intravenous drug users, and less conspicuous in heterosexual men and women. The number of heterosexual patients with a non-Dutch nationality even increased compared with...
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To evaluate the outcomes of a partner referral program at the sexually transmitted disease (STD) clinic in Amsterdam that encourages gonorrhea and chlamydia patients to refer their own partners to medical examination. 355 patients with a confirmed infection cooperated in partner referral and gave specific details on their sexual contacts. Univariat...
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To document the recent developments in the course of the AIDS epidemic in the Netherlands, 1982-1995. Descriptive. National Institute of Public Health and Environment, Bilthoven, Municipal Health Service, Amsterdam, and Inspectorate of Public Health, Rijswijk, the Netherlands. Based on the new AIDS patients reported to the Inspectorate of Public He...
Article
An abrupt decrease of the number of reported new AIDS cases took place in the first half of 1997 in the Netherlands. This decrease was most prominent in homosexual/bisexual men and intravenous drug users, and less conspicuous in heterosexual men and women. The number of heterosexual patients with a non-Dutch nationality even increased compared with...
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Full-text available
Whether sunlight (especially ultraviolet B radiation: UVB) exposure is harmful to the cellular immunity of HIV infected individuals and whether it is associated with an accelerated progression toward AIDS is still under debate. Among HIV+ homosexual participants of the Amsterdam Cohort Study, the degree of exposure to UVB was assessed over a period...
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Full-text available
We investigated whether exposure to solar UVR would influence the occurrence of skin infections in a cohort of renal transplant recipients. In various experimental studies, exposure to UVR was demonstrated to possibly cause immunosuppression and impaired resistance to infections. We expected that such effects could be demonstrated more easily in th...
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Full-text available
The effect of season on the antibody response after Hepatitis B (HB), Measles and Rubella vaccination in humans was investigated. In view of the immunosuppressive effects of ultraviolet radiation (UVR), especially the B-waveband (UVB), it was hypothesised that a lower antibody response after vaccination procedures that were started in summer might...

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