Fabian Pius Mghanga

Tanzanian Training Centre for International Health

Background One of the main limitations of radiation therapy is the resistance of tumor cells. This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) and tumor radiosensitivity in patients with non-sma...

The aim of this study was to screen for and determine the prevalence, severity and determinants of anaemia in pregnant women attending antenatal clinics in south of Tanzania. In this facility-based cross-sectional descriptive study, pregnant women attending antenatal clinics were selected through a convenient non-probability sampling in one distric...

Introduction: Gestational diabetes mellitus (GDM) is a potential risk factor for both maternal and foetal complications during pregnancy. This study aimed to determine the prevalence and factors associated with GDM among pregnant women in Southern Tanzania. Methods: A cross-sectional study was conducted among 612 randomly selected pregnant women...

Introduction: The prevalence of non-communicable diseases, and hypertension in particular, has been increasing. Objective: To determine the prevalence and associated factors for hypertension among adults in Ruvuma, Southern Tanzania. Methods: A cross-sectional study was conducted from September to October 2017; 802 patients were recruited, and data...

Objective: To improve current knowledge of coronary flow reserve and non-obstructive coronary artery disease in terms of definition, features and clinical implications of measurement of coronary flow reserve (CFR), is an integrated measure of focal, diffuse, and small vessel coronary artery disease, can also be explained as a calculated ratio of h...

Objective: The purpose of this study is to evaluate the association between PET/CT CFR and biomarkers combined in confirming the diagnosis of coronary microvascular dysfunction. Results: A total of 28 patients (21 males and 7 females) were included in this descriptive observational study (both qualitative and quantitative). The mean patient age...

Introduction: To assess patients’ awareness on the risk factors, complications and prevention of complications of hypertension. Methods: This cross-sectional study was carried out on a non-random sample of hypertensive patients attending Songea Regional Referral Hospital, Tanzania using an interview based questionnaire. Data entry and analysis were...

Introduction: The role of Virtual Touch Imaging Quantification (VTIQ), a non-invasive Shear Wave Elastography (SWE) mechanism for analysing Thyroid Nodule (TN) elasticity, in differentiating benign from malignant thyroid nodules has been little studied. Aim: To evaluate the role of VTIQ in distinguishing between benign and malignant thyroid nodules...

Introduction: Superficial skin fungal infections are among the neglected communicable diseases in many developing countries. Schoolchildren are among the most affected groups in Southern Tanzania. The main objective of this study was to determine the magnitude and associated risk factors of superficial skin fungal infections among primary schoolchi...

Introduction: Kikuchi-Fujimoto disease (KFD), also known as Kikuchi’s disease or histiocytic necrotizing lymphadenitis, is a self-limiting case of non-cancerous lymphadenopathy. Although previous reports have demonstrated its physical findings and traditional imaging characteristics, few studies mentioned the application of 18fluorodeoxyglucose pos...

Introduction: Kikuchi-Fujimoto disease (KFD), also known as Kikuchi’s disease or histiocytic necrotizing lymphadenitis, is a self-limiting case of non-cancerous lymphadenopathy. Although previous reports have demonstrated its physical findings and traditional imaging characteristics, few studies mentioned the application of 18fluorodeoxyglucose pos...

Introduction Anemia is a significant public health problem among children and women globally. It is one of the most common causes of deaths among children admitted to hospitals in sub-Saharan Africa. Case fatality rates of 6 percent to 18 percent have been reported even in facilities that have blood transfusions services. The purpose of this study...

Background Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary greatly across studies. The aim of this study was to pool the existing literature and assess the overall performance of EUS-FNA in the...

Introduction: To evaluate the diagnostic performance of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in monitoring the response of breast cancers to neoadjuvant chemotherapy. Methods: Articles published in medical and oncologic journals between January 2000 and June 2012 were identified by systematic MEDLINE, Cochrane Da...

Background Arrhythmogenic right ventricular dysplasia is an autosomal dominant disorder affecting parts of myocardium known as desmosomes, areas on the surface of heart muscle cells which link the cells together. The hallmark feature is fibro-fatty replacement of the right ventricle myocardium characterized by hypokinetic areas with associated arrh...

Objective We determined the overall effects of microRNA-21 and Interleukin-6 on development of heart failure by aggregating literature and subjecting studies meeting the inclusion and exclusion criteria to statistical meta-analysis. Background MicroRNA's are short regulatory RNA's that act as negative regulators of gene expression by inhibiting mRN...

The aim of this study was to identify molecular markers associated with differentiated thyroid carcinoma (DTC) patients and to determine whether there was a correlation between clinicopathological features or molecular markers and the outcome of radioiodine therapy. We retrospectively reviewed the records of 68 patients with papillary thyroid carci...

The aim of this study is to explore the feasibility of a triple-fused reporter gene, termed TGF [herpes simplex virus type 1 thymidine kinase (HSV1-tk), enhanced green fluorescent protein (eGFP) and firefly luciferase (Fluc)], to monitor stem cells using multimodality molecular imaging. A recombinant adenovirus vector carrying the triple-fused repo...