Eziuche Amadike Ugbogu

Eziuche Amadike Ugbogu
Abia State University · Department of Biochemistry

B.Sc, M.Sc, Ph.D Biochemistry

About

106
Publications
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Introduction
My area of interest include: (i) Evaluating the biochemical significance and toxicity profile of medicinal plants, (ii) Utilizing biochemical and genetic approaches to gain insight onto how the mutations of the phosphoribosyl pyrophosphate synthetase (PRS) genes lead to cancer and neurological disorders, (iii) To investigate the effectiveness of the use of enzymes and plant extracts/bioactive compounds in reducing greenhouse gas emissions from livestock production.
Education
September 2011 - September 2014
Heriot-Watt University
Field of study
  • Biochemistry

Publications

Publications (106)
Article
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Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7.6.1) is a rate-limiting enzyme that irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5-phosphate and adenosine triphosphate (ATP). This key metabolite is required for the synthesis of purine and pyrimidine nucleotides, the two aromatic amino acids histidine a...
Article
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Psidium guajava L., commonly known as guava is an important tropical food plant with diverse medicinal values. In traditional medicine, it is used in the treatment of various diseases such as diarrhoea, diabetes, rheumatism, ulcers, malaria, cough, and bacterial infections. The aim of this review is to provide up-to-date information on the ethnomed...
Article
Purpose Garcinia kola is a medicinal plant commonly known as bitter kola. It is utilized in ethnomedicine for the treatment of diarrhoea, bronchitis, bacterial infection, cough, hepatitis, gonorrhea, laryngitis, food poison, liver and gastric diseases. Objective This study reviewed the phytochemistry, pharmacological activities, and ethnomedicinal...
Article
Objectives Ocimum gratissimum L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of O. gratissimum leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats. Methods The experimental rats were divided into five groups (A–E) (n=6/sex/group). Each...
Article
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In traditional medicine, Ocimum gratissimum (scent leaf) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum. The bioactive compounds extract...
Article
Purpose: Psidium guajava L. (Family, Myrtaceae) is reportedly used in ethnomedicine for the treatment of diarrhoea, inflammation, and gastroenteritis. Objective: This study evaluated the gastrointestinal function of Psidium guajava leaf extract (PGLE) in rats and rabbits. Materials and methods: Crude ethanolic PGLE was subjected to phytochemic...
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Background Vernonia amygdalina is traditionally used to treat a variety of diseases including diarrhoea, fungal and bacterial infections, inflammation, cancer, diabetes, and its squeezed juice can be applied on wounds. Objective This study reviewed the phytochemistry, ethnopharmacological, and pharmacological potentials of Vernonia amygdalina. Me...
Article
Purpose Coconut water is used in folklore medicine for oral rehydration, treatment of childhood diarrhoea, gastroenteritis and cholera, and is also known to possess antioxidant properties. Objective In this study, we examined the ameliorative potentials of coconut water on carbon tetrachloride (CCl4) induced toxicity in rats. Materials and method...
Article
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Background Red palm oil (RPO) is antioxidant rich oil extracted from palm tree (Elaeis guineensis) fruit. It is used as an antiatherogenic, antihypertensive, anticancer, antidiabetic and to prevent vitamin A deficiency. In traditional medicine practices, RPO is given to an individual who is suspected to have ingested a poisonous substance. Industri...
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Most edible insects have high nutritional values and are considered as a cheap source of animal protein. This study evaluated the nutritional values of three edible insects in Nigeria: Zonocerus variegatus, Macrotermes bellicosus and Cirina forda as well as their functional properties. The insects had high values of crude fat, protein and vitamins...
Article
Objectives: Ocimum gratissimum L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of O. gratissimum leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats. Methods: The experimental rats were divided into five groups (A-E) (n=6/sex/group). E...
Article
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly transmittable pathogenic viral infection that causes a disease known as COVID-19. It is a pandemic and public health challenge ravaging the world today. Unfortunately, with the daily increase of infected individuals, there is no known drug approved for the treatment of COVID-1...
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Aju Mbaise polyherbal extract (APE) is used in southeast Nigeria by many women to enhance labour, remove retained placenta after delivery, and for managing pains from postnatal and menstrual cramps. This study investigated the toxicity and the pharmacological activities of APE in Wistar rats. A single dose of 5000 mg/kg APE was orally administered...
Article
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Termitomyces robustus (Agaricomycetes) and Lentinus squarrosulus (Mont.) Singer mushrooms are considered as important source of nutrient. They are used as remedy for treatment of various ailments in Southeastern part of Nigeria, yet there is inadequate documentation on the nutritional composition of these mushrooms. This study therefore aimed at ev...
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The aim of this present study was to evaluate the effect of rabbit diets supplemented with garlic (Allium sativum L.) extract on in vitro cecal gas production (GP), carbon dioxide (CO2) productions and some cecal fermentation parameters. Garlic extracts were prepared at 0.125 g/mL and administered at four different doses: 0 (control without garlic...
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Background and objective: Physiological and biochemical changes in plants are indicators used for monitoring cellular activity of plant prior and post exposure to harsh environment. This study investigated the impact of quarrying and stone crushing activities on heavy metals, plant nutritional composition, phytochemicals and oxidative stress indic...
Article
Objectives Traditionally, Justicia carnae is used in treatment of anaemia. In this study, the haematoprotective effects of ethanol and aqueous leaf extracts of J. carnae were evaluated in sodium nitrate-treated male rats. Methods Acute toxicity values, phytochemical, vitamin B12, vitamin C and iron contents of the extracts were analytically determ...
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In the past decade, there has been a tremendous increase in the number of cases of age-related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. These diseases are the leading causes of visual impairment and blindness all over the world and are associated with many pathological risk factors su...
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Abstract: Background and Objective: Ageratum conyzoides L. (Asteraceae) is nutrient compliant weed used as forage for grazing animals. It is used in the treatment of various ailments such as wounds, diabetes, pneumonia, asthma and stomach upset. This present study investigated the influence of quarrying on the nutritional composition, heavy metals...
Article
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Cantharellus species (Purple mushroom) natively known as Ero ububa in Southeastern Nigeria is used for nutritional and medicinal purposes. This study evaluated the nutritional composition of ero ububa and its toxicity profile in rats. Proximate, phytochemicals, minerals, vitamins, fatty acids and amino acids were analyzed using standard biochemical...
Article
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This study investigated the physicochemical characteristics of cashew nut shell oil (CNSO) as well as its acute and subacute toxicity in rats. In acute toxicity test, the CNSO was orally administrated up to 3 g/kg in a single dose and thereafter toxicity signs and mortality rates were observed in the rats within 24 h. In subacute toxicity study, th...
Article
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Objective: This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of P. macrophylla. Materials and methods: The chemical constituents of fermented P. macrophylla were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally...
Article
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Solanum aethiopicum is used in ethnomedicine for the treatment of overweight, constipation and anaemia. This study evaluated the ameliorative effect of aqueous leaf extract of S. aethiopicum on phenylhydrazine-induced anaemia in rats. Acute toxicity was determined in male and female rats (n = 5/group/sex) by oral administration of single dose of up...
Article
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Background: Ocimum gratissimum and Solanum aethiopicum are widely utilized medicinal plants employed in ethnomedicine for the treatment of myriads of health abnormalities including anaemia, constipation, inflammation and ulcers. The present study compared the nutritional compositions of these two medicinal plants. Methods: The leaf of these plants...
Article
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The study assessed the physiochemical properties and anticipated performance index (API) of some plants in Lokpaukwu quarry site to determine the impact of quarrying activities on the plants as well as the most suitable plants for green belt development in the area. Three plants species; Dialium guineense, Psidium guajava and Pterocarpus soyauxii w...
Article
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Lentinus squarrosulus (Mont.) is an edible wild mushroom with tough fruiting body that belongs to the family Polyporaceae. It is used in ethnomedicine for the treatment of ulcer, anaemia, cough and fever. Recent studies have demonstrated its anticancer, anti-diabetic and antioxidant properties. However, little or no information is available regardi...
Article
Livestock production is one of the major contributors of greenhouse gases such as methane (CH4) and carbon dioxide (CO2). These gases contribute greatly to global warming, environmental degradation and pollution. Livestock production is responsible for 18% CH4 and 9% CO2 productions of all greenhouse gases emissions. Methane has a greater global wa...
Article
Termitomyces robustus is a wild edible and highly nutritious mushroom that belongs to the class of fungi known as basidiomycetes. It is used in ethnomedicine for the treatment of malnutrition related diseases, rheumatism, diarrhea, gonorrhea, anemia and hypertension. Despite the tremendous use of this delicious edible mushroom as a source of nutrie...
Article
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Background. Corn silk (Stigma maydis) is used in ethnomedicine for the management of diabetes, kidney stones, depression, fatigue, urinary infections and as a slimming tea. However, there is limited literature on its effect on body weight, lipid, hematological, hepatocellular, nephrological and histopathological indices which the present study eval...
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Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for...
Article
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Objective This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for...
Article
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BACKGROUND: Corn silk (Stigma madyis) is used in ethnomedicine for the management of diabetes, kidney stones, depression, fatigue, urinary infections and as a slimming tea. However, there is limited literature on its effect on body weight, lipid, hematological, hepatocellular, nephrological and histopathological indices which the present study eval...
Article
The current context was investigated to evaluate the antibacterial potency of aqueous extract of coriander (Coriandrum sativum L.) leaves against bacterial pathogens isolated from the digestive system associated organs of rabbit. Another part of this study was also aimed to estimate the influence of varied doses of aqueous extract of C. sativum (AE...
Article
In livestock production, ruminal fermentation leads to significant loss of digestible feed energy and increase methane (CH4) and carbon dioxide (CO2) productions. These gases are the major sources of greenhouse gases that cause environmental degradation and climate change. The present study aimed at investigating the sustainable control of CH4 and...
Article
Over 250 species of resident flora in the class of bacteria are known to be associated with humans. These conventional flora compositions is often determined by factors which may not be limited to stress, nutrition, genetics, and age, sex, stress, nutrition of humans. Man is constantly in contact with bacteria through media such as air, water, soil...
Article
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This present study assessed oxidative stress and air pollution tolerance of selected broad leaved trees in the vicinity of a quarry site at Ugwuele, Uturu by assessing some physiological and biochemical properties of their leaves. Three trees Alchornea cordifolia, Nauclea latifolia and Newbouldia laevis growing in the quarry site were randomly sele...
Article
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Abstract The effect of fermentation on nutritional composition of Pentaclethra macrophylla (Benth) seeds was evaluated. P. macrophylla seeds were procured and divided into four portions. The seeds were hydrothermally treated to extract the cotyledons which were allowed to ferment for 24 h, 48 h and 72 h, while 0 h served as the control. The samples...
Article
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Aim: The micronutrients and antinutrients of leaf extracts of Pterocarpus soyauxii and Pterocarpus santaiinoides were investigated. Methods: The leaf extracts were air-dried for 7 days and pulverized using a mechanical homogenizer, and then passed through a 0.5 mm size mesh sieve. They were subjected to atomic absorption spectrophotometry, standar...
Article
This present study was conducted to evaluate the antimicrobial effects of tannic acid (TA) against isolated ruminal bacteria from adult sheep. Rumen samples were collected from two (2) adults sheep, and a total of nine (9) ruminal bacterial were isolated from the sample. The sensitivity of the ruminal bacteria isolates to 0.63, 1.25, 2.50, 5.00 and...
Article
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ABSTRACT Medicinal plants and plant-derived medicines are widely used in treatment of various diseases all over the world. Medicinal plants are of socio-economic importance to the rural population, both as a source of raw materials for health care remedies and also serve as a source of income. They are equally growing popular in modern societies as...
Article
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The present study evaluated the proximate, antinutritional and mineral contents of five selected vegetables consumed by Afaha Eket indigenes, Akwa Ibom State, Nigeria. Standard analytical procedures were employed in this assay. The analysed leafy vegetables include; Telferia occidentalis, Ocimum grattissimum, Lasianthera africana, Heinsia crinita a...
Article
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Pentaclethra macrophylla popularly known as African oil bean is a member of the Leguminosae family. A decoction of fermented extract of the plant has been known to be effective in the management of malnutrition, gastrointestinal disorders and dental caries. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented P. macro...
Article
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This study was conducted to investigate effects of quarry dust on physiological and biochemical properties of selected edible fruit trees in the vicinity of a rock quarry site at Ugwuele, Uturu. Five fruit trees growing in the quarry site were randomly selected for the study. Control samples were collected six kilometers away from the study area. S...
Article
Two of the five unlinked genes theoretically capable of encoding 5-phosphoribosyl-1(α)-pyrophosphate (PRPP) synthetase (Prs) in Saccharomyces cerevisiae, PRS1 and PRS5, contain in-frame insertions which separate the cation- and PRPP-binding sites, diagnostic of Prs polypeptides. The impairment of cell wall integrity (CWI) mitogen-activated protein...
Article
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Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of t...
Article
Abstract The study evaluated some biochemical and physiological properties of selected plants growing in the Ishiagu lead-Zinc mining area, Nigeria, in order to assess oxidative stress. Using sampling without replacement, twelve plants were randomly selected from the thirty five identified. Control samples were collected from a non-mining area abou...
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Seasonal impact on soil trace metals and phytoaccumulation potentials of Cucurbita pepo , Cucumis sativus and Taliferia occidentalis grown in Ishiagu quarry mining effluent discharge soils were investigated. Soil samples were collected 200 m (sample C), 100 m (sample B) away from discharge point (sample A) in wet and dry seasons. Trace metals were...
Article
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Aim: This study evaluated the phytochemicals, proximate and the toxicity effect of aqueous stem extract of Senna alata using wistar rats. Materials and methods:In acute toxicity test, aqueous dried stem extract of Senna alata were administered orally up to 10 g/kg body weight to male wistar rats. In sub-acute study, the wistar rats were daily admin...
Article
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The study assessed four biochemical properties of roadside trees along the old Umuahia-Aba expressway in order to determine their air pollution tolerance. Four edible fruit trees common in the study area dominant, Magnifera indica, Psidium guajava, Citrus sinensis and Persea Americana, were randomly selected for the study. Triplicate samples of roa...
Article
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Pawpaw, banana and watermelon are tropical fruits with short shelf-lives under the prevailing temperatures and humid conditions in tropical countries like Nigeria. Production of wine from these fruits could help reduce the level of post-harvest loss and increase variety of wines. Pawpaw, banana and watermelon were used to produce mixed fruit wines...
Article
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This study assessed the air pollution tolerance indices of plants growing in the Ishiagu lead-zinc mining area of South Eastern Nigeria. Twelve plant species namely; Adiantum caudatum, Alchornea cordifolia, Andropo-gon tectorum, Centrosema pubescens, Chromolaena odorata, Clotalaria retusa, Imperata cylindrica, Ipomoea asarifolia, Millettia aboensis...
Article
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This study assessed phytoremediation potential of plant species in Ishiagu lead-zinc mining area of Eb-onyi State, Nigeria to determine the possibility of using them to extract, stabilize or accumulate heavy metals as an approach to environmental management of lead-Zinc mines. Twelve plant species were randomly selected for the study. Heavy metals...
Article
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This study assessed phytoremediation potential of plant species in Ishiagu lead-zinc mining area of Ebonyi State, Nigeria to determine the possibility of using them to extract, stabilize or accumulate heavy metals as an approach to environmental management of lead-Zinc mines. Twelve plant species were randomly selected for the study. Heavy metals a...
Article
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The present study was conducted to assess the seasonal variations in soil physicochemical properties and enzymatic activities of quarry mining waste contaminated soil in Ishiagu, Ebonyi State, Nigeria. The results of physicochemical properties measured showed that pH in wet and dry seasons varied from acidic (3.98-5.93) in the mining sites to sligh...