Ezgi Cinan

Ezgi Cinan

Master of Science

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Publications

Publication (1)
Article
Full-text available
Considering the significant advances in nanostructured systems in various biomedical applications and the escalating need for levan-based nanoparticles as delivery systems, this study aimed to fabricate levan nanoparticles by the electrohydrodynamic atomization (EHDA) technique. The hydrolyzed derivative of levan polysaccharide from Halomonas smyrn...

Questions

Questions (3)
Question
I prepared my polymer-drug solution by dissolving all materials in an organic solvent
How can I improve the encapsulation efficiency of my fructose-based exopolysaccharide which is used to encapsulate a hydrophobic drug?
Could you suggest some articles to give ideas and also to be a reference for representing possible ways?
Question
I produced drug-loaded polymeric nanoparticles by using electrospraying/electrohydrodynamic atomisation. My spray solution contains DMSO as solvent, polymer, and drug. After spraying, I collect my particles on a glass petri dish. A bit sticky and powder-kind sample was obtained after I scratched it from the surface of the petri.
I don't have a chance to change my solvent at the moment. Therefore, I want to remove DMSO after obtained sprayed particles.
1)How can I remove DMSO from my sample in dry-form?
2)If you say lyophilization, should I put the sample with water (freezer overnight before lyophilization process)? Can I put it without water?
Because I don't want to allow dissolution of my polymeric particles because the polymer is soluble in water and I don't want the drug to be released during this time, in any case.
Question
I know that PLA is soluble in DCM, not soluble in water and hard to dissolve in DMF. What kind of solvents will be suitable for electrospray system for the amphiphilic polysaccharide and amphiphilic polysaccharide & PLA ?

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