Ez-Zouhra El Maaiden

UM6P - Mohammed VI Polytechnic University

This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overa...

An inexpensive, accurate, and simple green spectrophotometric assay was developed and validated for the determination of the antibiotic drug, Amoxicillin (AMX), in pure drug and tablet using ninhydrin (NIH). The method relied on the condensation reaction between the drug and Ninhydrin reagent (NIH) in the present NaHCO3, and then the colored produc...

Background Naringenin (NA) is a natural flavonoid used in the formulation of a wide range of pharmaceutical, fragrance, and cosmetic products. In this research, NA was extracted from Searsia tripartita using an environmentally friendly, high efficiency extraction method: an ultrasound-assisted extraction with deep eutectic solvents (UAE-DES).Method...

Isoquercetin (ISQ) is reported to be a powerful antioxidant with extremely high bioavailability and structural stability compared to aglycone quercetin. Despite this, it is not well studied due to the limited methods for its extraction. With the growing interest in the research and analysis of ISQ-rich herbs, there is a need to optimize an efficien...

Plants are the main source of bioactive compounds that can be used for the formulation of cosmetic products. Plant extracts have numerous proven health benefits, among which are antiageing and skin-care properties. However, with the increased demand for plant-derived cosmetic products, there is a crucial prerequisite for establishing alternative ap...

The importance of pharmaceuticals comes from their direct connection to human life. Therefore, many analysis techniques such as chromatography, spectroscopic methods, and others have been developed for one goal, which is to ensure that the drug reaches humans with high quality. Spectrophotometric and titrimetric methods have been in general use for...

Cacti are one of the most significant and diversified groups of angiosperms, distributed and cultivated globally, mostly in semi-arid, arid, and the Mediterranean climate regions. Conventionally, they are propagated by seeds or through vegetative propagation via rooted offshoots or grafting. However, these multiplication procedures remain insuffici...

This study aimed to compare the influence of extraction methods on the pharmaceutical and cosmetic properties of medicinal and aromatic plants (MAPs). For this purpose, the dried plant materials were extracted using advanced (microwave (MAE), ultrasonic (UAE), and homogenizer (HAE) assisted extractions) and conventional techniques (maceration, perc...

El Maaiden, E.; Bouzroud, S.; Nasser, B.; Moustaid, K.; El Mouttaqi, A.; Ibourki, M.; Boukcim, H.; Hirich, A.; Kouisni, L.; El Kharrassi, Y. A Comparative Study between Conventional and Advanced Extraction Techniques: Pharmaceutical and Cosmetic Properties of Plant Extracts. Molecules 2022, 27, 2074. https://doi.org/10.3390/molecules27072074

Ziziphus spina-christi has been traditionally used as a folk medicine for a variety of therapeutic benefits. However, there is no well-documented information regarding the protective role of this plant against toxicity induced by the overdose of trace metals, including iron. This work aimed to investigate the major components, as well as the antiox...

Salt stress is one of the major environmental factors limiting cereal productivity in worldwide agriculture. Evaluating and selecting salt tolerant genotypes are an effective approach to overcome yield losses. This study aimed to characterize and compare phenotypic variability among doubled haploid (DH) barley lines and their parent under different...

The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ se...

Two non-aqueous titrimetric and one visible spectrophotometric methods were developed and validated for the determination of valganciclovir hydrochloride (VLGH) in pure drug and tablets. The titrimetric methods were carried out by titrating the VLGH solution in glacial acetic acid with acetous perchloric acid (HClO4) in the presence of mercuric ace...

In Morocco, despite the adaptation of the prickly pear cactus (Opuntia spp) to edaphoclimatic conditions, differing from those that prevail in the countries from which it originates, this introduced species is regressing due to biotic and abiotic stresses that impact its survival. Hence, finding innovative technologies to preserve this species are...

The present study aims to design for the first time the physicochemical properties, fatty acids, tocopherols and phytosterols of cactus juice and seed oil from O. aequatorialis (O.A) and O. leucotricha (O.L) than compared with two other species widely studied [O. ficus indica (O.F.I) and O. megacantha (O.M)]. Fatty acids and phytosterols were quant...

Awarded since August 2020 (1 review) presented to EZZOUHRA ELMAAIDEN in recognition of the review contributed to the journal: Industrial Crops & Products

Ethnopharmacological relevance The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this r...

Ethnopharmacological relevance The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this re...

Vegetables from the genus Ziziphus (Rhamnaceae) have been identified as one of the main dietary antioxidants, especially phenolic compounds. However, their chemical composition varies according to the specie or the part of the plant. Mineral composition (potassium, magnesium, calcium, sodium, iron, and zinc), polyphenolic content (Flavan-3-ol, Proa...

Vegetables from the genus Ziziphus (Rhamnaceae) have been identified as one of the main dietary antioxidants, especially phenolic compounds. However, their chemical composition varies according to the specie or the part of the plant. Mineral composition (potassium, magnesium, calcium, sodium, iron, and zinc), polyphenolic content (Flavan-3-ol, Proa...

Tetrahymena pyriformis (protozoa) is intensely investigated as a model organism, offering numerous advantages in comprehensive and multidisciplinary studies using morphologic or molecular methods. Since DNA extraction is a vital step of any molecular experiment, here a new mixed surfactant (Sodium dodecyl sulfate (SDS) 20%/Triton X-100) was adopted...

Ziziphus spina-christi and Z. lotus are very important medicinal plants of the family Rhamnaceae. The need for accurate identification and authentication of powdered crude drug samples in the face of growing world demand for herbal products cannot be over-emphasized. The aim of this study was to determine the content of essential nutrients and phyt...

Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the –COOH grou...