Eyup Ilker Saygili

Sanko University · School of Medicine

Statement of the problem: In recent years, the development of innovative and increasingly optimized barrier membranes has focused on marine algae , which as a biopolymer can form a membrane composite together with polylactic acid, thus a combination could show numerous advantages such as antioxidant, antitumor, antibacterial, antiviral as well as a...

Objectives: The objectives of this study were a) to investigate the effect of targeting the PANoptosome with 3,4-methylenedioxy-β-nitrostyrene (MNS) on PANoptosis in the Renal ischemia-reperfussion (RIR) model b) to investigate the kidney protective effect of MNS toward RIR injury. Methods: Thirty-two rats were divided into four groups randomly. Th...

In present study, biochemical compositions (ash, lipid and protein) of five different macroalgae ((Green Algae (Chaetomorpha linum and Caulerpa prolifera), Red Algae (Pterocladiella capillacea), Brown Algae (Sargassum vulgare and Cystoseira amentacea)) and Angiosperms/Seagrass (Halophila stipulace) collected from Iskenderun Bay (Arsuz and Kale regi...

Numerous studies have been conducted to elucidate the relation of tumor proximity to cancer prognosis and treatment efficacy in colorectal cancer. However, the molecular pathways and prognoses of left- and right-sided colorectal cancers are different, and this difference has not been fully investigated at the genomic level. In this study, a set of...

Alginate is a biomaterial that can be easily integrated into many application areas such as biomedical, pharmaceutical, engineering, due to its favorable properties such as biocompatibility and ease of gelation. Alginate polymers are used in tissue engineering (preserving structural similarity in tissues to extracellular matrices) applications in m...

Abstract Algae biomass could be one of the most important economic values in near future. For this reason, we determined the biochemical compositions and molecular weight profiles (MWPs) of eight macroalgae; Green Algae (Codium fragile, Ulva intestinalis, Chaetomorpha linum, and Codium bursa), Red Algae ( Ellisolandia elongata, Jania rubens, and Am...

The world’s population is ageing at an accelerated pace. Ageing is a natural, physiological but highly complex and multifactorial process that all species in the Tree of Life experience over time. Physical and mental disabilities, and age-related diseases, would increase along with the increasing life expectancy. Ginger (Zingiber officinale) is a p...

Abstract Öz Purpose: The outbreak of SARS-CoV-2 infection has been named as Coronavirus Disease 2019 (Covid-19) by the World Health Organization (WHO). Covid-19 spread rapidly to many countries and was officially declared a pandemic by WHO on March 11, 2020, killing more than 4000 people. The disease is highly contagious and has many symptoms. Amon...

Sargassum vulgare was sampled by free dives in Iskenderun Bay, Hatay, Turkey, in September 2018. Sargassum vulgare is a material with high economic value because it has compounds that can be used in medical applications such as alginic acid and at the same time it contains carbohydrates and vitamins. Alginates were extracted with a sequential extra...

Naturally occurring fatty acids can be classified into three categories based on the number of double bonds in side-chain. These are saturated fatty acids, (no double bonds), monounsaturated fatty acids (MUFAs, a single double bond), and polyunsaturated fatty acids (PUFAs, ≥2 double bonds). Long-chain-PUFAs contain 13–19 carbon atoms whereas very-l...

Cancer is a multicomplex disease brought about uncontrolled proliferation of cells with contribution of hereditary and environmental factors. Although there are more than 100 known types of cancer and standard approaches have been developed for certain types of cancer, cancer is also an individual disease. With the advances in technology, new thera...

Facioscapulohumeral muscular dystrophy (FSHD) is in the top three list of all dystrophies with an approximate 1:8000 incidence. It is not a life-threatening disease; however, progression of the disease extends over being wheel-chair bound. Despite some drug trials have been continuing, including DUX4 inhibition, TGF-ß inhibition and resokine which...

In current study, proximate compositions (ash, lipid and protein) and fatty acid profiles of 5 different brown macroalgae (Stypopodium schimperi, Halopteris scoparia, Cystoseira compressa, Padina pavonica, Sargassum vulgare) collected from Isken-derun Bay (Arsuz and Kale regions) in July 2019 were determined. The highest and lowest ash values were...

Bone marrow mesenchymal stem cells have been investigated for many years, especially for tissue regeneration, and have inherent limitations. One of the rapidly developing fields in the scientific world in recent years is extracellular vesicles. Especially, bone marrow mesenchymal stem cell originated extracellular vesicles are known to have positiv...

Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, s...

Objective: The outbreak of COVID-19 caused by SARS-CoV-2 has promptly spread worldwide. This study aimed to predict mature miRNA sequences in the SARS-CoV-2 genome, their effects on protein-protein interactions in the affected cells, gene-drug relationships to detect possible drug candidates. Methods: Viral hairpin structure prediction and classif...

Objective The present study aims to evaluate the antioxidant effect of beta glucan on oxidative DNA damage by comet assay. Methods A total of 19 adult females and males diagnosed with stage 3-4 colorectal cancer and a control group of 20 age-matched healthy subjects were enrolled in the study. Blood samples of the participants were analyzed using...

The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chem...

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first FDA approved first-line BCR-ABL targeting drug for the treatment of newly diagnosed CML cases. Nowadays there are recently developed and more efficie...

Alzheimer’s disease (AD) is globally the most prevalent age-related neurodegenerative disease. There are drugs available for symptomatic treatment of the disease to delay the progression of symptoms of neurocognitive and physical decline. Studies have demonstrated many phytochemicals as candidates for the treatment of AD with anti-cholinesterase, a...

The calcium-alginate/multi-walled carbon nanotube hybrid beads (Ca-ALG/MWCNT-COOH) as a novel kind of matrix were fabricated and characterized in detailed. l-Asparaginase (l-ASNase), which is important chemotherapeutic enzyme-drug in leukemia, was immobilized on the Ca-ALG/MWCNT-COOH hybrid beads. To the best of our knowledge, this is the first stu...

Resorbable and volume-stable collagen matrices have been preferred as grafting materials for diverse clinical applications in recent years. On the other hand, there is always an existing risk of transmission of infection with the cells or the tissues of the graft in using such collagen matrices. Moreover, considering the economic aspects, there is...

Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive loss of neurons, which leads to behavioral systems and mental decline. HD is linked to repeat expansions of cytosine, adenine, and guanine in the Huntingtin (HTT) gene that give rise to mutation, leading to the formation of the HTT protein product. Oxidative stre...

Collagen is a protein molecule that is present in all living things. Among the collagen sources, the collagen obtained from seafood is the best alternative to terrestrial collagen due to its advantageous properties such as high product yield, biocompatibility, high processability and no risk of any disease. Not only fish and fish products but also...

Purpose: In our study, it was aimed to investigate the preventive effect of milrinone on renal damage in experimental controlled non-heart-beating donors (NHBDs) model. Materials and methods: Sixteen rats randomly divided into 2 groups, 8 rats in each were used. Group 1 was control, group 2 was milrinone group. Group 1 rats received 1.25 ml 0.09...

Oxidative stress and generalized inflammatory state are features of bipolar disorders (BD). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with bipolar disorders and attention deficit/hyperactivity disorder (ADHD) and to determine the relationship between oxidative...

The aim of the present study is to evaluate the relationship of total antioxidant capacity, total oxidant status, oxidative stres and total free sulfydryl groups in patients with diabetic and nondiabetic senil cataract. The study was carried out on venous blood samples from 70 subjects admitted to the ophtalmology clinic of a research hospital. Of...

The aim of the present study was to evaluate oxidative stress by investing oxidatively damaged DNA AS Formamidopyrimidine DNA glycosylase (Fpg) -sensitive sites, glutathione peroxidase (GPx), superoxide dismutase (SOD) activities reduced glutathione (GSH) level and nitrite level as satble end product of in women receiving hormone replacement therap...

The aim of this study was to investigate how myeloperoxidase (MPO) G-463A gene polymorphism and enzyme levels varied among patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) and to find the relationship between the MPO gene, enzyme levels, and clinical parameters. We studied the sera from 40 healthy volunteers, patients with...

Vitiligo is an acquired depigmentary disorder characterized by white areas of the skin due to loss of epidermal melanocytes. Oxidative stress and free radicals are suggested as important phenomena in the pathogenesis of vitiligo. Myeloperoxidase is a lysosomal enzyme of polymorphonuclear leukocytes and acts as a catalyst in the production of hypoch...

Epidemiological studies revealed increased gastric cancer risk in helicobacter pylori-infected cases and Helicobacter pylori-mediated oxidative DNA damage is suggested as responsible factor. In order to examine the effect of clarithromycin+amoxicillin treatment on oxidative DNA damage in helicobacter pylori-infected cases, DNA damage in the basis o...

Elevated plasma homocysteine is considered to be an independent risk factor forcardiovascular diseases. In the present study, relations between plasma homocysteineand demographics, lifestyle factors and blood vitamin concentrations wereinvestigated in a population-based sample. Homocysteine and vitamin concentrationswere measured in the 126 healthy...

Tumor formation is a multistep process that can be divided in to the stages of tumor initiation, promotion, and progression. DNA repair protein; MGMT is a key suicide enzyme that repairs the mispairing base methylguanine, which is induced in DNA as a minor lesion. The glutathione S transferases (GSTs) are a family of enzymes that are important to p...

Recent studies have addressed the possibility of an association between polycystic ovaries and ovarian cancer. DNA damage is the first step of the carcinogenesis, and susceptibility to cancer, in general, is characterized by high DNA damage. Free radical-mediated DNA damage and impaired antioxidant defence have been implicated as contributory facto...

In recent years much attention has been focused on the role of glutathione (GSH) and GSH-related enzymes such as glutathione peroxidase (GSH Px), glutathione reductase (GSH Red), and glutathione S-transferase (GST) in the inhibition of free radical-induced carcinogenesis. In this study, erythrocyte GSH levels and activities of GSH Px, GSH Red, and...

Vitamin E and vitamin C are involved in the defense of the body against free radical and reactive oxygen molecule induced damage. The best characterized biological damage caused by radicals is known as lipid peroxidation. Free radical formation is known to play a major role in the development of cancer. In this study, we measured plasma levels of t...

Reactive oxygen species-induced damage to DNA plays a major role in carcinogenesis. In order to estimate the level of oxidative damage in bladder cancer, 8-hydroxy-2'-deoxyguanosine (8-OHdG) was determined in DNA isolated from peripheral blood leukocytes of healthy adults and patients with superficial transitional cell carcinoma. Patients with tran...