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  • Eylem Kulkoyluoglu Cotul
Eylem Kulkoyluoglu Cotul

Eylem Kulkoyluoglu Cotul
Purdue University | Purdue · Department of Medicinal Chemistry and Molecular Pharmacology (MCMP)

PhD.

About

29
Publications
2,477
Reads
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197
Citations
Additional affiliations
January 2019 - April 2021
Purdue University
Position
  • PostDoc Position
September 2017 - May 2019
University of Illinois, Urbana-Champaign
Position
  • Graduate Teaching Assistant
August 2015 - August 2019
University of Illinois, Urbana-Champaign
Position
  • Research Assistant
Education
August 2015 - August 2019
University of Illinois, Urbana-Champaign
Field of study
  • Food Science and Human Nutrition
August 2013 - July 2015
Koc University
Field of study
  • Molecular Biology and Genetics
August 2010 - February 2014
Istanbul Technical University
Field of study
  • Chemical Engineering

Publications

Publications (29)
Article
Introduction: Metastatic triple-negative breast cancer (TNBC) is one of the deadliest cancers amongst women in the US, with a 5-year survival rate of 12%. Due to a lack of targeted therapies, investigation into the metabolic drivers of TNBC progression at both the primary and secondary site is vital to direct future treatment strategies. Pyruvate c...
Article
Full-text available
Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2+ subtype of breast cancer. Using an isogeneic progression series of HER2+ breast cancer metastasis we demonstrate that metastatic cells have an increased capacity to acquire resistance to the covalent, pan-ErbB inhibitor, neratinib. RNA sequencing analyse...
Preprint
Metabolic reprogramming and immune evasion are established hallmarks of the tumor microenvironment (TME). Growing evidence supports tumor metabolic dysregulation as an important mediator of tumor immune evasion. High TME levels of lactate potently suppress antitumor immunity. Pyruvate carboxylase (PC), the enzyme responsible for the anaplerotic con...
Article
Estrogen receptor-positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer-related deaths. Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant as standard of care. Yet, among such patients, metastasis in liver is associated with reduced overall survival compared...
Preprint
Full-text available
Estrogen receptor-positive (ER ⁺ ) metastatic tumors contribute to nearly 70% of breast cancer-related deaths. Most patients with ER ⁺ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant (Fulv) as standard-of-care. Yet, among such patients, metastasis in liver is associated with reduced overall surviva...
Article
Full-text available
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty...
Article
Full-text available
The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate...
Conference Paper
Introduction: Approximately 70% of human breast cancers express estrogen receptor alpha (ERα), providing a potential for targeted endocrine therapy for patients. Unfortunately, 30-40% of ER+ patients still experience recurrence and metastasis with a 5-year relative overall survival rate of just 24%. The tumor microenvironment (TME) plays a key role...
Article
Full-text available
Circadian disruption influences metabolic health. Metabolism modulates circadian function. However, the mechanisms coupling circadian rhythms and metabolism remain poorly understood. Here we report that Cystathionine β‐synthase (CBS), a central enzyme in one‐carbon metabolism, functionally interacts with the core circadian protein Cryptochrome1 (CR...
Preprint
Full-text available
Circadian disruption influences metabolic health. Metabolism modulates circadian function. However, the mechanisms coupling circadian rhythms and metabolism remain poorly understood. Here we report that Cystathionine β-synthase (CBS), a central enzyme in one-carbon metabolism, functionally interacts with the core circadian protein Cryptochrome1 (CR...
Conference Paper
Majority of breast cancer specific deaths in women with ERα (+) tumor occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to prevent or delay recurrence of ERα (+) tumors. The objective of this study was to elucidate the role of mitochondrial pathways that are activated in the p...
Article
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver diseases in the United States. Simple and benign steatosis can gradually develop into the more serious conditions of nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies have demonstrated that men and postmenopausal women have higher incidences of NA...
Article
Full-text available
A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combi...
Article
Obesity is a risk factor for postmenopausal estrogen receptor alpha positive (ER(+)) breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify such mechanisms, we performed whole metabolite and protein profiling in plasma sampl...
Article
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based on their ER expression. Crosstalk between estrogen signaling elements and several key metabolic regulators alters metabolism in breast cancer cells, and enables tumors to...
Conference Paper
Majority of breast cancer specific deaths occur in women with recurrent, ERα (+), metastatic tumors that are endocrine therapy resistant. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combi...
Article
Majority of breast cancer specific deaths in women with ERα (+) tumor occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combined...
Article
The majority of breast cancer-specific deaths occur in women with recurrent, ERα (+), metastatic tumors that are initially responsive to endocrine therapy yet become endocrine-resistant. There is a critical need for novel therapeutic approaches to re-sensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to eluci...
Article
There is a critical need for novel therapeutic approaches to re-sensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to elucidate mechanisms of improved effectiveness of combined targeting of ERα and XPO1, a nuclear transport protein in overcoming endocrine resistance. Using Cignal Finder pathway analysis, Seah...
Article
Full-text available
Obesity is a preventable risk factor for post-menopausal ERα-(+) breast cancer. We hypothesized that serum from obese post-menopausal women contain factors that would increase tumorigenicity of breast cancer cells and increase risk of ERα-(+) breast cancer. Using whole metabolite profiling and OLINK biomarker panel of about 400 proteins associated...
Article
Diet and nutrition are undeniably two factors that have a major impact on the prevention, progression, and treatment of various cancers. In this review, we will discuss how bioactives from diet and nutritional status affect each of the hallmarks of cancer. We will present recent research and discuss using diet and nutrition as a means to prevent an...
Poster
Integrative -omics approach identifies novel roles for extranuclear ER alpha signaling in rewiring cancer cell metabolism during obesity-associated breast cancer
Article
Full-text available
Most breast cancer deaths occur in women with recurrent, ERα (+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be resensitized to endocrine therapies. The objective of this study was to validate a group of nuclear transport genes as poten...
Article
Currently, around 75% of patients with breast tumors test positive for estrogen receptor alpha (ERa) and are treated with endocrine therapies, such as tamoxifen. One-third of the breast tumors eventually become refractory, reducing the survival rate for affected patients. A combination of alternative endocrine therapies and kinase inhibitors is cur...
Article
Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors. The impact of direct nuclear ac...
Poster
The circadian clock is a biological timing system that oscillates with a period of 24 hours and is coordinated with the day-night cycle. Therefore, understanding the molecular clockwork help us to develop treatments against various disease and disorders such as diabetes, cardiovascular diseases, obesity, jetlag, insomnia, and psychological disorder...

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Projects

Projects (3)
Project
We investigate the role of pyruvate carboxylase in breast cancer metastasis progression.
Project
Tamoxifen is an oestrogen antagonist and it is widely used in premenopausal and postmenopausal women who has major side effects with aromatase inhibitors. However, 1/3rd of these patients who were treated with tamoxifen have recurrence after the therapy. For this reason, we are trying to find novel strategies to prevent or overcome tamoxifen resistance and XPO-1 is a good target to overcome Tamoxifen resistance.