Eyal Schiff

• Medical Doctor at Sheba Medical Center

Research question: What pregnancy rates are achieved after transfer of cryopreserved double slow-frozen embryos in IVF cycles? Patients in whom surplus thawed cleaved embryos (day 2 or 3) were grown to the blastocyst stage, re-frozen and then re-thawed for transfer (double freezing) were included. Design: Data were collected on all patients who...

Objective To evaluate ovarian reserve in women after preservative cesarean delivery using uterine artery embolization due to morbidly adherent placenta. Study design A historical cohort study including all women admitted to a single tertiary care center, with morbidly adherent placenta that had preservative cesarean delivery with bilateral uterine...

TREND statement checklist. (PDF)

Uterine artery embolization procedure. (MP4)

Objective The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation. Methods This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (SD) were included. Obstetrics and neonatal out...

Objective Bed rest or activity restriction is a common obstetrical practice, despite a paucity of data to support its efficacy. The aim of this study was to determine whether physical activity, as assessed by a smart band activity tracker, is associated with preterm birth in pregnant women at high risk for preterm delivery. Methods This was a pilo...

Background: Persistently high rates of cesarean deliveries are cause for concern for physicians, patients, and health systems. Prelabor assessment might be refined by identifying factors that help predict an individual patient's risk of cesarean delivery. Such factors may contribute to patient safety and satisfaction as well as health system plann...

Objective To determine whether antenatal corticosteroids administration prior to an elective cesarean section (ECS) at 34–37 weeks gestation is associated with improved neonatal outcome. Materials and methods A case control study of women with singleton pregnancies who underwent ECS between 34 and 37 weeks of gestation including two groups: (1) st...

Objective: To describe a successful autologous ovarian tissue re-transplantation in a sterile leukemia survivor after evaluation for minimal residual disease and provide a review of the current literature. Design: Presentation of a carefully designed workup taken to evaluate tissue for minimal residual disease, its limitations, and applicability...

Background Methods available for assessing the learning curve, such as a predefined number of procedures or direct mentoring are lacking. Our aim was to describe the use of a statistical method to identify the minimal training length of an experienced sonographer, newly trained in deep infiltrating endometriosis (DIE) mapping by evaluating the lear...

Objectives To determine the prevalence of ultrasound features suggestive of adenomyosis in women undergoing surgery for endometriosis compared with a control group of healthy women without endometriosis. Methods Retrospective case-control study comparing women with intractable pain or infertility, who underwent transvaginal ultrasound and subseque...

Objective: Intracytoplasmic sperm injection (ICSI) is commonly used during pre-implantation genetic diagnosis (PGD) in vitro fertilization (IVF), aiming to eliminate the risk of contamination from extraneous sperm DNA. Recently, ICSI "overuse" in non-male infertility has been doubted, since it does not offer an advantage over IVF. Prompted by the...

Objective: Cesarean-induced niche can cause symptoms such as abnormal postmenstrual bleeding, pain and associated infertility. Hysteroscopic niche resection is usually a successful treatment, but can result in a failure to improve symptoms or symptoms can recur. In the present study we aim to evaluate the feasibility, effectiveness, and safety of...

Aims: To determine the clinical yield of abdominal ultrasound in the evaluation of elevated liver enzymes (ELEs) in the second and the third trimester of pregnancy. Methods: A retrospective cohort study including all pregnant women admitted to a single tertiary care center was conducted between April 2011 and January 2015 with ELE. Inclusion cri...

Study objective: To determine an effective method of intrauterine device (IUD) retrieval from pregnant women who had previous unsuccessful ultrasound-guided IUD extraction failure. Design: Retrospective cohort study (Canadian task force classification II-1) SETTING: Gynecology department of an outpatient clinic. Patients: Pregnant patients in...

We compared the rates of instrumental delivery in a cohort of nulliparous women at term (n = 19,416), to primiparous women who attempted labour after prior caesarean (TOLAC) (n = 1747). The rate of instrumental deliveries was higher in the TOLAC group compared to nulliparous gravidas (17.3 vs. 15% respectively, p = 0.001). The difference was more p...

Purpose: To determine success rate of induction of labor using Foley transcervical balloon (FTB) versus PGE2 vaginal insert, following failure of cervical ripening with PGE2 vaginal insert. Material and methods: A retrospective cohort study of all pregnant women admitted for induction of labor with either Foley transcervical balloon or PGE2 vagi...

Objective: To determine the preferred mode of delivery (vacuum, forceps or cesarean delivery) for second stage dystocia. Methods: Retrospective cohort study of women delivered by forceps, vacuum or cesarean delivery due to abnormalities of the second stage of labor. Primary outcome included neonatal and maternal composite adverse effects. Resul...

Objective: Investigate a novel office hysteroscopic tubal catheterization therapeutic method for proximal tubal occlusion. Study design: Prospective cohort study in a tertiary referral center. We evaluated the procedure on a group of 27 patients that were referred to our unit for proximal tubal occlusion demonstrated by hysterosalpingography, 9...

Objective: To report the single-center results of orthotopic retransplantations of cryopreserved ovarian tissue in cancer survivors and evaluate the validity of commonly accepted procedure limitations. Design: Prospective cohort study. Setting: Tertiary university-affiliated assisted reproduction technology (ART) and oncology centers. Patient...

Study objective: To investigate whether hysteroscopic proximal tubal occlusion with Essure® micro-inserts can improve pregnancy rates in patients with hydrosalpinges who had failed in vitro fertilization (IVF) treatment. Design: Prospective-cohort study. Setting: University affiliated tertiary centers. Patients: Twenty-four consecutive women...

Objectives: In light of the potential physical and emotional costs to both woman and child, this study was conducted to assess pregnancy complications and birth outcomes in primiparae at very advanced maternal age (VAMA, aged ≥45) compared to younger primiparae. Methods: Retrospective cohort study comparing 222 VAMA primiparae and a reference gr...

Objective: To determine, using four-dimensional (4D) transperineal ultrasound, whether the appearance, position or dimensions of sacrocolpopexy mesh implants or the degree of tissue support change in the long term. Methods: Women who had undergone minimally invasive abdominal sacrocolpopexy for pelvic organ prolapse were invited for follow-up as...

Objective: The current study aimed to evaluate the profile of women who are most likely to undergo caesarean delivery on maternal request (CDMR) and clarify their reasons for this decision. Methods: For this multicentre case-control study, data were collected from 429 women who underwent CDMR and 429 matched controls who delivered vaginally from...

This study compared the odds of adverse obstetrical outcomes of pregnancies in women who conceived from IVF (n = 464) versus spontaneous conception (n = 1171) after stratification into three body mass index (BMI) groups: normal weight (18.5-24.9 kg/m(2)), overweight (25.0-29.9 kg/m(2)) and obese (>30 kg/m(2)). With increasing BMI, incidences of com...

Omentin, a newly identified adipokine, enhances insulin mediated glucose uptake in human adipocytes, thus, inducing systemic insulin-sensitizing effect. The aims of this study were to determine whether circulating maternal omentin levels are associated with insulin resistance indices and to assess which compartment, maternal, fetal, or placental, i...

To compare the outcome of radiofrequency ablation (RFA) and bipolar coagulation (BPC) methods for selective feticide in complicated MC twin gestations and to determine risk factors for adverse pregnancy outcome METHODS: A retrospective cohort study of all patients with complicated MC twin pregnancies who underwent selective reduction in a single te...

The purpose of this study was to evaluate a novel sonographic scoring system for risk assessment of complications in patients suspected of having morbidly adherent placenta. This retrospective study evaluated the association between maternal complications and a grayscale sonographic scoring system for adherent placenta before surgery. Criteria for...

To determine whether planned vaginal delivery is associated with increased risk of perinatal mortality and morbidity in twin pregnancies complicated by a very low birth weight (VLBW) of the second twin. We conducted a retrospective cohort study of twin pregnancies in which the second twin's birth weight was 1500 grams or less. 193 twin gestations m...

Low molecular weight heparin (LMWH) has been shown to be effective in decreasing the recurrence of placenta-mediated complications of pregnant women. The aim of this study was to determine the effect of LMWH on circulating levels of soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PLGF) in pregnant w...

Objective: Magnesium sulfate (MgSO4) administered to women at risk for preterm delivery decreases the risk of cerebral palsy in their children. However, the neuroprotective effect of MgSO4 has not been shown in twin gestations. Thus, the aim of this study was to determine the maternal serum levels of magnesium in twin vs. singleton pregnancies fol...

To characterize, using 3D transperineal ultrasound, the appearance, position, and dimensions of mesh implants following minimally invasive abdominal sacrocolpopexy. In women who underwent sacrocolpopexy, mesh was evaluated at rest and on maximal valsalva, on all 3D orthogonal planes and rendered views. Mesh dimensions were obtained by 3D processing...

Induction of labor (IOL) when the fetus appears small for gestational age (SGA) toward term may improve perinatal outcomes and prevent fetal death. If these fetuses are small as a variant of the normal spectrum, early induction may not improve outcomes and may cause obstetric complications. This study was undertaken to determine the impact of early...

To determine the admission to delivery interval and the rate of immediate delivery in twin versus singleton gestation complicated by spontaneous preterm labor (SPTL). A retrospective cohort study of pregnant women presenting with advanced cervical dilatation of 3–5 cm and frequent uterine contractions at 24–34 weeks of gestation was performed. The...

Homozygous carriers of factor V Leiden (FVL) have an up to 80-fold increased risk of venous thrombosis, but the risk of obstetric complications in FVL homozygosity is unclear. To compare obstetric and thromboembolic complications among factor V Leiden (FVL) homozygous and heterozygous carriers treated with prophylactic dose anticoagulation during p...

To determine the neonatal outcome at late prematurity of uncomplicated monochorionic (MC) twin pregnancies. A retrospective cohort study of 166 patients with uncomplicated MC diamniotic twins delivered between 34 and37 weeks of gestation at a single tertiary center. The study population was classified into four groups according to the gestational a...

To determine maternal plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), placental growth factor (PLGF) and soluble endoglin (sEng) in monochorionic diamniotic (MC/DA) twin pregnancies complicated by twin to twin transfusion syndrome (TTTS) or selective intra-uterine growth restriction (sIUGR). A longitudinal cohort...

To investigate the intraoperative features and long-term postoperative results of patients with ureteral endometriosis who underwent ureteral reimplantation. In this retrospective study, we reviewed records of all patients with ureteral endometriosis treated by ureteral reimplantation. Pre-, intra- and post-operative information was collected. Of p...

Introduction: In order to investigate the dynamics of genomic alterations that occur at different developmental stages in vitro, we examined the chromosome content of human preimplantation embryos by molecular-cytogenetic techniques at the single-cell level, up to 13 days post fertilization. Methods: The embryos were genetically analyzed several...

Objective: To evaluate obstetric outcome after stillbirth according to placental and prothrombotic risk factors. Methods: Obstetric outcomes of women with prior stillbirth and subsequent pregnancies were reviewed. Data on the immediate subsequent pregnancy included fetal loss, stillbirth, obstetric/medical complications, gestational age and birt...

We present two patients who delivered vaginally following a prior cesarean section in whom uterine rupture was detected a few minutes after delivery. Both deliveries occurred within 12 h. The sonographic findings were different in each case and consistent with the clinical and operative findings. Ultrasound may assist in the diagnosis of uterine ru...

To evaluate the clinical and surgical features of thoracic endometriosis syndrome (TES) represented by catamenial pneumothorax and pelvic endometriosis and to describe their association with infertility. Retrospective clinical study (Canadian Task Force classification: II-2). Academic tertiary referral endometriosis center. Seven patients who had u...

Objective: The association between of mode of delivery and perinatal morbidity in monochorionic (MC) twins is not clear. Thus there is no agreement regarding the optimal mode of delivery of MC twins. The aim of this study is to determine the impact of the mode of delivery on neonatal outcome of uncomplicated MC twins in a tertiary center with a str...

The purpose of this study was to determine whether corticosteroid administration after 34 weeks of gestation is associated with improved neonatal outcome in the presence of fetal lung immaturity. We conducted a retrospective cohort study of women who underwent amniocentesis to determine fetal lung maturity from 34-37 weeks of gestation. Patients wi...

Pluripotency and proliferative capacity of human embryonic stem cells (hESCs) make them a promising source for basic and applied research as well as in therapeutic medicine. The introduction of human induced pluripotent cells (hiPSCs) holds great promise for patient-tailored regenerative medicine therapies. However, for hESCs and hiPSCs to be appli...

Preeclampsia, a severe unpredictable complication of pregnancy, occurs in 6% of pregnancies, usually in the second or third trimester. The specific etiology of preeclampsia remains unclear, although the pathophysiological hallmark of this condition appears to be an inadequate blood supply to the placenta. As a result of the impaired placental blood...

Selected genes induced by (A) hypoxia and (B) p53. (PDF)

Analysis of the study population: Significant results (p<0.05) are highlighted by a grey background. Average (Avg), standard deviation (SD), interquartile range (IQR), hypoxia (H), normal (N). (JPG)

Characteristics of the study cohort: H, Hypoxia; N, Normal; NA, Not available; G, Number of pregnancies; P, Previous pregnancies; HTN, Hypertension; *, Smoker; **, Twins; ***, Dollberg 2005. (PDF)

Delta Ct and Delta-Delta Ct calculations for the study cohort. (PDF)

To evaluate the perinatal outcome of MC twins with selective IUGR (sIUGR). A prospective study, which included three groups of MC twins: Group A, uncomplicated MC twin pregnancies (n = 91); group B, sIUGR with normal umbilical artery Doppler (n = 19); and group C, sIUGR with abnormal (absence or reversed EDV) umbilical artery Doppler (n = 18). The...

The aim of this study was to determine the association between cord blood adiponectin and leptin and early infant growth at one year in small for gestational age (SGA) and appropriate for gestational age (AGA) infants. In this prospective study adiponectin and leptin concentrations were determined in cord blood of (i) AGA newborns (n = 44) and (ii)...

To investigate whether in patients with antiphospholipid syndrome (APS), high positive antibody titers are associated with adverse pregnancy outcome. A retrospective cohort study of prospectively collected data. Sheba Medical Center, Israel, a tertiary referral center. POPULATION SAMPLE: Pregnant women with APS. Anticardiolipin, a-β2-glycoprotein I...

To examine the efficiency of laparoscopic ureterolysis for ureteral endometriosis and to describe appropriate treatment. Prospective trial (Canadian Task Force classification II-2). University hospital. Forty-five patients who underwent surgery to treat ureteral endometriosis between 2005 and 2009. Laparoscopic ureteral ureterolysis. Long-term foll...

Early postpartum period is characterised by a dramatic decrease in insulin resistance and significant metabolic alterations. The aims of this study were to determine the changes in circulating maternal concentrations of total adiponectin, adiponectin multimers, leptin and resistin before and after the delivery and to explore their relationship with...

The objective of the study was to evaluate the vertical transmission rate and fetal risk following primary maternal cytomegalovirus infection before and around conception. Data of patients referred to fetal medicine clinic in 1 tertiary center in Israel were evaluated. Each included subject had primary maternal cytomegalovirus infection determined...

This study describes maternal and birth outcomes of primiparae aged ≥ 45. High rates of pregnancy complications and poor birth outcomes were found, stressing that the personal risks and ramifications to the health system should be taken into account in establishing obstetric health policy regarding primiparity at advanced maternal age.

To define the characteristics of placental stillbirth and the possible contribution of thrombophilic risk factors. A prospective cohort study was performed. Women diagnosed with antenatal stillbirth (>20 weeks) of singleton pregnancies between 2006 and 2008 were referred postpartum for evaluation. Maternal risk factors, fetal, placental and cord ab...

Since 1995, Israel allows social sex selection (SxS) under certain circumstances. However, data regarding the attitudes of potential users are limited. The study population composed of a stratified sample of Israeli married men and women at the reproductive age (women aged 17-45, men aged 17-65), who had 1-2, 3, or 4+ children of the same sex. We c...

The objective of this study was to determine if transvaginal ultrasound (TVUS) examination of cervical length correlates to digital pelvic examination and if it can predict time to and mode of delivery in term pregnancies. We conducted a prospective cohort study of 726 consecutive non-laboring, term pregnant women presenting to University-based ant...

We present the outcome of a relatively large cohort of women with suspected placenta accreta who underwent prophylactic pelvic artery catheterization prior to cesarean section. All pregnant women with suspected placenta accreta who delivered in one tertiary center were included in this retrospective study. All patients underwent an elective cesarea...

To determine the long-term outcome of intrauterine pregnancies after treatment of heterotopic pregnancies. Retrospective cohort study (Canadian Task Force classification II-3). Tertiary center university hospital. All women who underwent surgery because of heterotopic pregnancy over 12 years. Laparoscopic surgery. Infant development and future preg...

To compare the maternal and perinatal outcome of triplet pregnancies delivered by cesarean section with those delivered vaginally and to assess whether a vaginal delivery of triplets is still acceptable among women who are interested in further births. A retrospective analysis of 73 triplet pregnancies delivered at ≥28 week between 1997 and 2005 in...

The purpose of the study was to construct a clinical profile of a patient more likely to have ovarian torsion (OT). The study design was a retrospective chart review (Canadian Task Force Classification II-3). The study was done in a tertiary referral center setting. Patients were 78 women who underwent laparoscopy for suspected ovarian torsion. Int...

We aimed to investigate whether multifetal pregnancies are at risk of more pregnancy complications in women of advanced age after ovum donation. Pregnancy outcome in women after ovum donation aged 40 and above was extracted. Labor and delivery data as well as antenatal records of women carrying twins were compared with those of singletons, as well...

The goal of this study was to assess the correlation between true fetal macrosomia and abnormal oral glucose tolerance test (OGTT) in pregnant women at term gestation who had a negative glucose challenge screen (GCT) at 24-28 weeks. In this cohort observational study, we enrolled all term pregnant patients who presented to our antenatal unit with e...

Discordant twin gestation, in which one fetus is growth restricted, is a unique model that can elucidate the mechanism(s) by which the intrauterine environment affects fetal growth. The objective of the study was to determine the cord blood adiponectin and leptin concentrations and evaluate their association with birth weight in dichorionic twins,...

To reevaluate the rate of correct diagnosis of ovarian torsion (OT) in our department. Retrospective computerized chart review. Tertiary referral center. Seventy-eight women who underwent laparoscopy for suspected OT. Laparoscopy. Rate of true diagnosis of torsion, correlation with Doppler studies. The preoperative diagnosis of OT was confirmed in...