Ewura Yahaya

University of Cape Coast | UCC · Department of Pharmacology

Background: Antimicrobial resistance has rendered several anti-infective agents ineffective, necessitating the need to intensify efforts to identify and develop novel drugs against microbial infection. Structural modification of existing antibiotics continues to be one of the areas of intense research focus in recent times. Objective: This study as...

Breast cancer is the most prevalent cancer among African women, with high mortality rates in Ghana. Nuclear factor kappa B (NF-kB) has been associated with tumor progression in breast cancer. However, its clinical validation is controversial and understudied with no known published data on NF-kB (p65) among breast cancer patients in Ghana and other...

Background Malaria/HIV co-infection (MHC) is a public health challenge which may present with worse health outcomes due to interactions. Coadministration of artemether lumefantrine (ALU) and antiretroviral therapy may have potential drug-drug interactions that can affect the course of treatment for both diseases. Generic ALU medications are used in...

Background: Guiera senegalensis (Ghibaish) is a medicinal plant extensively used in central and west Africa for the management of various diseases. Aim: This study aimed to determine the antioxidant activity of the ethanol leaf extract of the plant. Method: The ethanol leaf extract was sequentially sub-fractionated using liquid–liquid extraction,...

Onsite technique for determining drug integrity in Sub Saharan Africa is needed for ensuring drug integrity and enhancing public health. This current study presents the application of handheld NIR spectroscopic...

Phyllanthus urinaria has been characterized for its several biological and medicinal effects such as antiviral, antibacterial, anti- inflammatory, anticancer, and immunoregulation. In recent years, Phyllanthus urinaria has demonstrated potential to modulate the activation of critical pathways such as NF-κB, P13K/AKT, and ERK/JNK/P38/MAPKs associate...

Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed w...

Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed wi...

Background: Ethnomedicinal preparations have for many years served as medication for treatment of diverse diseases. These possess various pharmacologically-active phytochemicals which may be harnessed for the treatment of diseases such as wounds. This study investigated the ability of ethnomedicinal extracts prepared from Aspilia africana CD Adams,...

What would it take in terms of the structural reforms in science, technology, and culture to cultivate sustainable therapeutic and preventive medicine innovations against zoonotic infections such as coronavirus disease 2019 (COVID-19) in the 21st century? In May 2019, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Servi...

Objectives Ziziphus abyssinica (ZA) is employed in managing several ailments in Traditional African Medicine. Scientific evaluations are necessary to ascertain the medicinal potential of ZA as a source of new drug molecules. This study investigated the possible therapeutic benefit of ZA leaf (ZAL) and root bark (ZARB) extracts in an experimental mo...

Context: Erythrina senegalensis (ES) DC. is used traditionally in the management of various free radical-related diseases, including wound healing. Aims: To evaluate sequentially prepared leaf extracts of ES for the ability to protect against oxidative stress in fibroblasts and macrophages. Methods: Sequential extracts were prepared using hexane,...

The use of traditional herbal remedies as alternative medicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological levels of free radicals are essential to the healing process, they are known to partly contribute to wound chronicity when i...

The inhibition of reactive oxygen species (ROS) and the migration of fibroblasts are key processes involved in wound healing. In this study, the ability of aqueous ethnomedicinal plant extracts prepared from Aspilia africana CD Adams, Boerhavia diffusa L. and Erythrina senegalensis DC. to mediate fibroblast migration and ROS release was determined....

Objectives: Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential extracts of B. diffusa to influence oxidation and wound closure in myoblast cells in vitro. Methods: Sequential extracts w...

Background: Croton membranaceus is a plant cherished by traditional healers in Ghana for its anti-prostate cancer properties. Its cytotoxic effect as well as safety has been proved. However, to the best of our knowledge, no study has been conducted to assess its genotoxic and cytotoxic potential using the rodent bone marrow and colony formation ass...

Phyllanthus niruri is a medicinal plant (commonly known as stone breaker) found in the tropics and other parts of the world. It is known for its capacity to block the formation of calcium oxalate crystals and kidney stone formation in urolithiasis. This plant has been used to treat hyperglycemia, hypertension, pain, and mild cases of malaria. We ex...