Ewald Wöll

Ewald Wöll
Krankenhaus St. VInzenz Zams | KRANKENHAUSZAMS · Internal Medicine

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153
Publications
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Publications

Publications (153)
Article
Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its association with long-term pulmonary and symptomatic recovery. The prospective, multicentre, observational cohort stud...
Preprint
Background Olfactory dysfunction (OD) often accompanies acute coronavirus disease 2019 (COVID-19) and its sequelae. Herein, we investigated OD during COVID-19 recovery in the context of other symptoms, quality of life, physical and mental health. Methods Symptom recovery patterns were analyzed in a bi-national, ambulatory COVID-19 survey (n = 906,...
Article
Various registries of patients with cancer and coronavirus disease 2019 (COVID-19) emerged over the last few months and patients with cancer are reported to be at increased risk for severe outcome of COVID-19. Yet, many studies lack a direct control group and include patients with different baseline parameters. Here we report data for patients with...
Article
Background The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) is not well known. Purpose To characterize patterns and rates of improvement of chest CT abnormalities one year after COVID-19 pneumonia. Materials and Methods This was a secondary analysis of a prospective, multicenter observational cohort study conducted fro...
Article
Full-text available
Background Safety and efficacy of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction (GEJ) cancer could be demonstrated in predominantly Asian cohorts, whereas data in Western patients outside of clinical trials are vastly missing. Methods In this multi-institutional retrospective analysis conducted at nine oncologic cen...
Article
Full-text available
Introduction Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Methods A retrospective efficacy and safety analysis wa...
Article
Background SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme 2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed to test our hypothesis that discontinuation of chronic treatment with ACE-inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) mitigates the course o\f recent-onset CO...
Article
Full-text available
T cells play a fundamental role in the early control and clearance of many viral infections of the respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically reduced CD4+ and CD8+ T cells correlates with Coronavirus disease 2019 (COVID-19)-associated disease severity and mortality. In this study, we characterized cellular...
Conference Paper
Rapid induction of remission is a favorable prognostic factor in several cancers (AML, breast cancer). In multiple myeloma, only few data are available on response kinetics and outcome. Here, we evaluated the association between time to best response in patients with transplant non-eligible, newly diagnosed multiple myeloma (TNE NDMM) enrolled in a...
Article
Background: The Corona Virus Disease 2019 (COVID-19) pandemic increases the demand for post-acute care in patients after a severe disease course. Various longterm sequelae are expected and rehabilitation medicine is challenged to support physical and cognitive recovery. Aim: We aimed to explore the dysfunctions and outcome of COVID-19 survivors...
Article
Full-text available
Background Pancreatic cancer (PC) ranks among the deadliest malignancies worldwide. In the MPACT study, first-line nab-paclitaxel plus gemcitabine (nab-P/G) demonstrated activity (median overall survival [OS], 8.7 months) and tolerability in patients with metastatic PC (mPC). However, the clinical evidence of nab-P/G in the elderly (>70 years), who...
Article
Full-text available
Background: After the 2002/2003 SARS outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. Methods: In this prospective, multicentre, observational study, we systematically...
Article
Introduction Carfilzomib-based induction therapy is highly effective in newly diagnosed pts with multiple myeloma (NDMM), but information on quality of life (QoL) during first line and maintenance therapy is not available. Here, we analyze patient-reported QoL in transplant-non eligible (TNE) NDMM pts randomized to either KTd or KRd induction thera...
Article
Full-text available
Hyperdiploidy (HRD) and specific IGH translocations are primary chromosomal abnormalities (CA) in multiple myeloma (MM). In this retrospective study of 794 MM patients we aimed to investigate clinical features and common CA including gain(1q) in separate subgroups defined by primary CA. In the entire group, we confirmed that gain(1q) was associated...
Article
Background: 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side effects and the treatment-related mortality rate is 0.2-1.0%. Summary: Among other risk factors associated with increased toxicity, a genetic deficiency in dihydropyrim...
Article
Full-text available
Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology. Methods We herein present data from the ongoing prospective, multicen...
Article
Full-text available
Background The pretreatment De Ritis ratio [aspartate transaminase (AST)/alanine transaminase (ALT)] has been shown to be an adverse prognostic marker in various cancer entities. However, its relevance to advanced pancreatic ductal adenocarcinoma (PDAC) has not yet been studied. In the present study we investigated the AST/ALT ratio as a possible p...
Article
Full-text available
Trastuzumab in combination with a platinum and fluorouracil is the treatment of choice for patients with advanced human epidermal growth factor receptor 2 (HER2) positive gastric cancer and gastroesophageal junction (GEJ) cancer. Pathological assessment of the HER2 status in gastric/GEJ cancer, however, still remains difficult. However, it is a cru...
Article
Introduction: Recent data from the ARROW and CHAMPION-1 study show significant activity of once weekly carfilzomib administration. Furthermore, the recent MUK5 and CARF studies show significantly increased PFS with carfilzomib maintenance therapy. Here, we compare 9 cycles of weekly KRd with weekly KTd (after 2 cycles of biweekly therapy) followed...
Article
Full-text available
Background The management of patients with metastatic pancreatic cancer (mPC) is challenging, and the optimal treatment strategy is debated among experts. In an attempt to identify treatment decision criteria and to investigate variations in the first-line management of this disease, we performed an analysis of treatment algorithms among experts in...
Article
Full-text available
Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones of patient management. Targeted treatments that include anti-angiogenic agents and the advent of immunotherapies can contribute to improved patient prognosis. Herein, we present an A...
Article
Results from studies in upper gastrointestinal cancer presented at the 2018 American Society of Clinical Oncology (ASCO) meeting are promising. Prophylactic treatment of Barrett’s esophagus with high proton pump inhibitor therapy plus aspirin showed positive results on death, esophageal adenocarcinoma and dysplasia. Current studies on the treatment...
Article
Background/aim: Although high response rates using the doublet-chemotherapy of oxaliplatin and irinotecan as well as its combination with cetuximab in advanced gastric cancer were shown in previous trials, time to progression was short, suggesting acquired chemotherapy resistance. Patients and methods: Sequential chemotherapy (oxaliplatin and ir...
Article
Chemotherapy is still the most important component of systemic therapy in gastric cancer. It is not replaced by targeted agents so far. Novel chemotherapies like 5‑fluorouracil (5FU) prodrugs are applied. Agents such as nanoliposomal irinotecan or nanoparticle albumin-bound paclitaxel are still under investigation. In patients overexpressing the ep...
Article
Background: The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use. Patients and methods:...
Article
Gastric cancer incidence is decreasing in western countries in the last decades. During the last years diagnostic and therapeutic options in gastric cancer have improved substantially. The aim of this short review is to highlight the progress and setbacks in therapy of gastric cancer over the last 10 years and to set them into perspective. Back in...
Article
Treatment of gastric cancer has improved substantially during the past decade. The aim of this short review is to highlight abstracts from this year’s ASCO Annual Meeting and the ASCO GI Meeting. The CRITICS trial showed no significant difference in overall survival by the addition of postoperative radiochemotherapy in the curative setting. In the...
Article
To our knowledge this is the first systemic review that provides an overview of the cutaneous paraneoplastic syndromes (CPS) (i.e., clinical manifestations, pathomechanisms, and treatment modalities) occurring in stomach cancer. CPS are caused by substances produced by stomach cancer and may precede, coincide with, or follow the diagnosis of this m...
Article
Immunologic tumor therapy was the leading theme of this year’s ASCO. In this context first results for check point inhibitors active in esophageal and gastric cancer were presented. Phase III trials involving c-met inhibitors however were not successful. First phase II results with regorafenib emphasize a potential role for TKI’s in gastric cancer.
Article
Full-text available
Different strategies for neoadjuvant chemotherapy in patients with early stage NSCLC have already been evaluated. The aim of this study was to evaluate the tolerability and efficacy of a chemoimmunotherapy when limited to two cycles. Between 01/2007 and 03/2010 41 patients with primarily resectable NSCLC stage IB to IIIA were included. Treatment co...
Article
Intravenous thrombolysis for ischaemic stroke remains underused worldwide. We aimed to assess whether our statewide comprehensive stroke management programme would improve thrombolysis use and clinical outcome in patients. In 2008-09, we designed the Tyrol Stroke Pathway, which provided information campaigns for the public and standardised the enti...
Article
Background: Postoperative relapse rate after gastrectomy and perioperative chemotherapy remain high in patients with advanced gastric cancer due to the spread of disseminated tumour cells in the peritoneal cavity. Perioperative administration of catumaxomab could potentially eliminate residual tumour cells after intended curative resection of the p...
Article
Soft tissue sarcoma is a rare and very heterogeneous disease. The prognosis of these cancers is mainly influenced by histological grading size location and type of histology. Many aspects argue in favor of neoadjuvant chemotherapy but no singular trial could unambiguously prove an advantage of neoadjuvant therapy. This short review has a focus on n...
Article
Background Regulatory T cells (Treg) are critical for cancer immune evasion; whereas natural killer (NK) cells are central for effective anti-tumor immunity including antibody-induced cellular cytotoxicity (ADCC). The predictive role of Treg levels for clinical response to chemo-immunotherapy in non-small cell lung cancer (NSCLC) as well as therapy...
Article
Das Magenkarzinom ist nach wie vor eine Erkrankung mit ungünstiger Prognose. Aufgrund der unspezifischen Symptomatik und fehlender Vorsorgeprogramme wird die Diagnose häufig erst in fortgeschrittenen Stadien gestellt, sodass über 70 % der Patienten zum Zeitpunkt der Diagnose nicht mehr kurativ behandelbar sind. In der palliativen Therapie gewinnen...
Article
Therapeutic options for patients with advanced pretreated soft tissue sarcomas are limited. However, in this setting, sorafenib has shown promising results. We reviewed the data of 33 patients with soft tissue sarcoma treated with sorafenib within a named patient program in Austria. Twelve physicians from eight different hospitals provided records...
Article
Overall survival of patients suffering from upper gastrointestinal (GI) cancer is still poor. Most of the patients are diagnosed in advanced stages. But even in patients with operable disease, the recurrence rates, especially of gastric and pancreatic neoplasias, are still very high. Much effort has therefore been put in the development of palliati...
Article
e15041 Background: We could show efficacy of oxaliplatin and irinotecan as well as oxaliplatin, irinotecan and cetuximab in previous trials.Time to progression however was short suggesting acquired chemotherapy resistance.To address this problem sequential chemotherapy combined with bevacizumab is investigated in the presented Gastric-3 trial. Meth...
Article
Cancers of the upper gastrointestinal tract and pancreas are still among the most devastating neoplastic diseases. Cure is achieved only if the diagnosis is made at an early stage. Given the low incidence of these neoplasias in the Western world, surveillance programs are not available and practicable; therefore, most of the patients suffering from...
Article
Gastric cancer is still a devastating disease. Two thirds of the patients are diagnosed in a locally advanced or metastatic stage. Even if surgery is possible, long-term survival is low. Optimal therapy in a curative and a palliative setting is still not clear yet. ASCO 2010 could shed some light on optimal chemotherapy and the introduction of mole...
Article
In recent times, the treatment of advanced disease stages of thyroid cancer (TC) followed the strategy of targeted therapy with encouraging results. Thus, eight patients with metastasized thyroid carcinomas, who had multiple lines of prior interventions, were treated with sorafenib and have now been retrospectively evaluated. This retrospective eva...
Article
Full-text available
Background In previous phase II trials (AGMT-Gastric-1 and AGMT Gastric-2) we could show efficacy of oxaliplatin and irinotecan as well as oxaliplatin, irinotecan and cetuximab in advanced gastric cancer. Time to progression however was short suggesting acquired chemotherapy resistance. To address this problem sequential chemotherapy combined with...
Article
Das colorektale Karzinom ist eine Erkran­kung älterer Patienten. Das mittlere Er­krankungsalter bei Frauen liegt bei 72 Jahren, bei Männern bei 67 Jahren. Ein Viertel aller Männer und 44 Prozent der Frauen sind zum Zeitpunkt der Diagnose älter als 75 Jahre. Die Behandlung von äl­teren Patienten stellt somit eine große He­rausforderung dar, wobei di...
Article
4074 Background: In our previous phase II trials (AGMT-Gastric-1 and AGMT Gastric-2) efficacy of oxaliplatin and irinotecan as well as oxaliplatin, irinotecan and cetuximab was shown. Time to progression however was short suggesting acquired chemotherapy resistance. Therefore sequential chemotherapy combined with bevacizumab is investigated in the...
Article
4095^ Background: Perioperative chemotherapy (CT) has demonstrated as survival benefit in locally advanced gastric cancer (GC) in randomized trials. However, the overall cure rate is 30-40% and a significant number of patients are not able to receive the postoperative part of their CT regimen. In Europe, the trifunctional antibody catumaxomab is ap...
Data
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The file Supplementary-BMC Cancer in the PDF format contains supplementary results, methods and tables.
Article
Full-text available
The activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab combined with oxaliplatin/leucovorin/5-fluorouracil (FUFOX) was assessed in first-line metastatic gastric and oesophago-gastric junction (OGJ) cancer in a prospective phase II study showing a promising objective tumour response rate of 65% and a low m...
Article
This phase II trial assessed the feasibility and safety of induction chemotherapy with cisplatin (25 mg/m(2) d1-5, d29-34)/docetaxel (75 mg/m(2) d1, d29)/5-fluorouracil (5-FU, 750 mg/m(2) d1-5, d 29-34) followed by external beam radiotherapy concurrent with docetaxel (15 mg/m(2) d1,8,15,22) and 5-FU (300 mg/m(2) continuous infusion on the days of r...
Article
Full-text available
Patients suffering from advanced gastric cancer still have a poor prognosis and treatment options are limited. In our previous phase II trial (AGMT-Gastric-1), we showed that the combination of oxaliplatin and irinotecan was well tolerated and effective. The same chemotherapy regimen was now tested in combination with cetuximab in a multicenter pha...
Article
Neurotensin subtype 1 receptor overexpression is found in a variety of human tumors. The aim of this pilot/phase I study was to assess the safety profile, pharmacokinetics, and imaging characteristics of (99m)Tc-Demotensin VI in tumor patients. Scintigraphy with (99m)Tc-Demotensin VI was performed in 14 patients (2 female and 12 male) with advanced...
Article
Full-text available
Treatment of gastrointestinal neoplasias has changed substantially during the last decade. Nihilism and poor response rates have been replaced by aggressive treatment strategies and even curative approaches in metastatic colorectal cancer for example. A major achievement is the multidisciplinary treatment – lead by tumour boards – enabling optimal...
Article
4074 Background: In our previous phase II trials (AGMT-Gastric-1 and AGMT Gastric-2) efficacy of oxaliplatin and irinotecan as well as oxaliplatin, irinotecan and cetuximab was shown. Time to progression however was short suggesting acquired chemotherapy resistance. Therefore sequential chemotherapy combined with bevacizumab is investigated in the...
Article
7062 Background: Despite several theoretical advantages, neoadjuvant/perioperative chemotherapy in patients with early stage NSCLC has not proven to be superior to the standard adjuvant approach. The aim of this study has therefore been to increase the efficacy of neoadjuvant treatment by combining a platinum doublet (cisplatin/docetaxel) with a mo...
Article
Full-text available
Cetuximab enhances the efficacy of chemotherapy in several cancer types. This trial assessed the activity of cetuximab and chemotherapy in advanced gastric cancer. Patients with previously untreated, metastatic, gastric cancer received cetuximab 400 mg m(-2) at first infusion followed by weekly infusions of 250 mg m(-2) combined with FUFOX (oxalipl...
Article
Individualized tumour therapy was the leading theme of this year's ASCO. In this context Her2Neu testing could detect a subgroup of patients suffering from advanced gastric cancer who showed substantial benefit from the addition of trastuzumab to standard chemotherapy. This first phase III trial with a biological agent is the beginning of individua...
Article
Overall survival of patients suffering from gastric cancer is still poor. Two-thirds of patients are diagnosed in a locally advanced stage or with metastatic tumour. But even in patients with operable disease recurrence rate is high. To increase the prognosis of this devastating disease much effort has been put in the development of curative and pa...
Article
Full-text available
The aim of the study was to evaluate the feasibility and efficacy of an outpatient oxaliplatin/irinotecan chemotherapy in chemonaive patients suffering from unresectable gastric cancer. Biweekly oxaliplatin (85 mg/m2) and irinotecan (125 mg/m2) was chosen since it has been shown previously in colorectal cancer that oxaliplatin (85 mg/m2) is superio...
Article
Gastric cancer is still one of the predominant causes of death on account of gastrointestinal neoplasias. In recent years, chemotherapy and radiotherapy have substantially improved the outcome in operable gastric cancer patients. A benefit in median overall survival is reported for perioperative chemotherapy as well as for postoperative adjuvant ra...
Article
15587 Background: Survival of patients (pts.) suffering from gastric cancer is still poor and treatment options for advanced gastric cancer are limited. In a previous phase II trial we could show that an outpatient combination of oxaliplatin and irinotecan was well tolerated and showed an objective response rate of 58% and a median overall survival...