Ewa Oledzka- Medical University of Warsaw
Ewa Oledzka
- Medical University of Warsaw
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Publications (81)
Background/Objectives: Camptothecin (CPT) is a well-known chemical compound recognized for its significant anticancer properties. However, its clinical application remains limited due to challenges related to CPT’s high hydrophobicity and the instability of its active form. To address these difficulties, our research focused on the development of f...
Background/Objectives: Camptothecin (CPT) is a well-known chemical compound recognized for its significant anticancer properties. However, its clinical application remains limited due to challenges related to CPT’s high hydrophobicity and the instability of its active form. To address these difficulties, our research focused on the development of f...
Dermatology and cosmetology currently prioritize healthy, youthful-looking skin. As a result, research is being conducted worldwide to uncover natural substances and carriers that allow for controlled release, which could aid in the battle against a variety of skin illnesses and slow the aging process. This study examined the biological and physico...
Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms and inflammatory reactions of the organism, thus inevitably affecting maintenance of homeostasis. Medical Cannabis popularity has surged since its legal regulation growing ar...
Worldwide cancer statistics have indicated about 20 million new cancer cases and over 10 million deaths in 2022 (according to data from the International Agency for Research on Cancer). One of the leading cancer treatment strategies is chemotherapy, using innovative drug delivery systems (DDSs). Self-immolative domino dendrimers (SIDendr) for trigg...
Xanthohumol (Xn), a prenylated chalcone found in Hop (Humulus lupulus L.), has been shown to have potent anti-aging, diabetes, inflammation, microbial infection, and cancer properties. Unfortunately, this molecule has undesirable characteristics such as inadequate intake, low aqueous solubility, and a short half-life. To address these drawbacks, re...
The aim of this study was to develop an innovative, dual-stimuli-responsive smart hydrogel local drug delivery system (LDDS), potentially useful as an injectable simultaneous chemotherapy and magnetic hyperthermia (MHT) antitumor treatment device. The hydrogels were based on a biocompatible and biodegradable poly(ε-caprolactone-co-rac-lactide)-b-po...
Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor active-form stability. To address these shortcomings, our research focuses on the encapsulation of this drug in the poly(amidoamine) (PAMAM) dendrimer macromolecule. The PAMAM dendrimer/CPT compl...
Camptothecin (CPT) has demonstrated antitumor activity in lung, ovarian, breast, pancreas, and stomach cancers. However, this drug, like many other potent anticancer agents, is extremely water-insoluble. Furthermore, pharmacology studies have revealed that prolonged schedules must be administered continuously. For these reasons, several of its wate...
Thermosensitive liquid suppositories (LSs) carrying the model antihypertensive drug metoprolol tartrate (MT) were developed and evaluated. The fundamental purpose of this work was to produce, for the first time, liquid MT suppositories based on biodegradable nanoparticles and optimize their rheological and mechanical properties for prospective rect...
Aliphatic polyesters are the most common type of biodegradable synthetic polymer used in many pharmaceutical applications nowadays. This report describes the ring-opening polymerization (ROP) of l-lactide (L-LA), ε-caprolactone (CL) and glycolide (Gly) in the presence of a simple, inexpensive and convenient PEG200-BiOct3 catalytic system. The chemi...
In this paper, injectable, thermosensitive smart hydrogel local drug delivery systems (LDDSs) releasing the model antitumour drug 5-fluorouracil (5-FU) were developed. The systems were based on biodegradable triblock copolymers synthesized via ring opening polymerization (ROP) of ε-caprolactone (CL) in the presence of poly(ethylene glycol) (PEG) an...
Paklitaksel (PTX) jest naturalnym lekiem przeciwnowotworowym - alkaloidem terpenowym z grupy taksanów stosowanym w terapii raka niedrobnokomórkowego płuc, nowotworów jajnika i piersi oraz mięsaka Kaposiego. PTX daje bardzo dobry efekt terapeutyczny zarówno w monoterapii, jak i w połączeniu z innymi lekami przeciwnowotworowymi. Po raz pierwszy zosta...
Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and...
Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to stud...
A novel and promising hydrogel drug delivery system (DDS) capable of releasing 5‑fluorouracil (5-FU) in a prolonged and controlled manner was obtained using ε‑caprolactone‑poly(ethylene glycol) (CL-PEG) or rac‑lactide-poly(ethylene glycol) (rac‑LA-PEG) copolymers. Copolymers were synthesized via the ring-opening polymerization (ROP) process of cycl...
Recently, growing interest in biodegradable polyesters as drug carriers in the development of innovative anticancer drug delivery systems (DDSs) has been observed. These compounds are thermally unstable, and are therefore, particularly demanding due to the limited number of available sterilization techniques. Furthermore, the DDSs sterilization pro...
Among modern drug formulations, stimuli-responsive hydrogels also called “smart hydrogels” deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnet...
Polymer-drug conjugates are currently being more widely investigated for the treatment of hypertension. In view of the above, in the first stage of our work, we used nontoxic β-cyclodextrin (β-CD) as effective, simple, inexpensive, and safe for the human body initiator for the synthesis of biocompatible and biodegradable functionalized polymers sui...
Biodegradable polyesters gain significant attention because of their wide potential biomedical applications. The ring-opening polymerization method is widely used to obtain such polymers, due to high yields and advantageous properties of the obtained material. The preparation of new, effective, and bio-safe catalytic systems for the synthesis of bi...
Angioplasty with stent implantation is considered to be the basic treatment method of stenosis of the blood vessels. The process of stent implantation was changed through the years. From stents...
Introduction: Arterial hypertension is a disease of civilization that requires long-term treatment. Recently, growing interest in natural and synthetic polymers as drug delivery vehicles in controlled release dosage forms for improving the efficacy of treatment has been observed.
Areas covered: This review introduces biodegradable synthetic polyest...
Infections associated with biometrics represent a significant challenge to the most widespread medical applications. In this study, new macromolecular conjugates containing ciprofloxacin (CIP) and the bisphosphonate (BP) molecules were synthesized. Polymeric matrices (disyndiotactic and atactic polylactides, and poly(ε-caprolactone)) used in macrom...
This literature review presents the recent developments on dendrimeric drug carriers, which can undergo degradation under various chemical, physical or biological factors. Based on selected examples, the structure, preparation methods and possible applications of first-, second-, and third-generation domino dendrimers are discussed, with particular...
Recently, growing interest in polymers (natural and synthetic) as drug carriers in controlled release formulations and drug targeting systems that may improve the efficacy of treatment and reduce the side effects of a drug therapy, has been observed. Special attention has been paid to improving the effectiveness of antibiotics, which constitute a v...
Cationic antimicrobial peptides represent a promising therapeutic option against
multidrug-resistant bacteria for the treatment of local infections. However, due to their low stability and potential toxicity, there are limited possibilities for their application in clinical practice. In this study, different poly("-caprolactone) (PCL) microparticle...
Antimicrobial peptides (AMPs) are prospective therapeutic options for treating multiple-strain infections. However, clinical and commercial development of AMPs has some limitations due to their limited stability, low bioavailability, and potential hemotoxicity. The purpose of this study was to develop new polymeric carriers as highly controlled rel...
The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of D-PLA units and poly(ethylene glycol) methyl ether methacrylate (PEGMA). Six PLA, n...
The paper is a review of the literature concerning the application of non-toxic and natural compounds, as initiators and/or catalysts of ring-opening polymerization (ROP) of cyclic esters in the synthesis of biodegradable and bioresorbable polymers for medical and pharmaceutical purposes. The classifi cation of natural ROP initiators as those conta...
Three-arm polylactides (PLA) containing 0.2, 7.6, and 13% of d-lactic acid monomeric units were obtained and refunctionalized into ATRP macroinitiators via esterification of hydroxyl groups with 2-bromoisobutyryl bromide. These polymeric matrices underwent enzymatic degradation with various rates and revealed negative results on cytotoxicity and ge...
Nanocrystalline hydroxyapatite containing selenite ions (SeHA; 9.6 wt.% of selenium) was synthesized using wet method and subject to careful physicochemical analysis by powder X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, solid-state nuclear magnetic resonance, wavelength dispersive X-ray fluorescence...
PXRD patterns of the SeHA and HA samples.
Abbreviations: HA, hydroxyapatite; PXRD, powder X-ray diffractometry; SeHA, selenium-containing hydroxyapatite.
31P CP MAS NMR spectra of the SeHA and HA samples (νMAS =7.0 kHz).
Abbreviations: CP, cross polarization; HA, hydroxyapatite; MAS, magic angle spinning; NMR, nuclear magnetic resonance; SeHA, selenium-containing hydroxyapatite.
FT-IR spectra of the SeHA and HA samples.
Abbreviations: FT-IR, Fourier transform infrared spectroscopy; HA, hydroxyapatite; SeHA, selenium-containing hydroxyapatite.
The need for development of comprehensive therapeutic systems, (e.g., polymer-apatite composites) as a bone substitute material has previously been highlighted in many scientific reports. The aim of this study was to develop a new multifunctional composite based on hydroxyapatite porous granules doped with selenite ions (SeO3²⁻) and a biodegradable...
Microorganism resistance is an important challenge in modern medicine due to the global uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMPs) symbolize a new family of antibiotics, which have stimulated research and clinical interest as new therapeutic options for infections. They represent one of the most promising a...
To evaluate the effects of ionic liquids (ILs) on the microstructural features of aliphatic polyesters for biomedical applications, a series of copolymers were synthesized by lipase ring opening polymerization of rac-lactide (rac-LA) and ε-caprolactone (CL). The chemical structures of resulting polymers were characterized by ¹H- and ¹³C-NMR and the...
Purpose:
The purpose of this study was to develop the perspective biodegradable poly(ester-urethane) (PUR) carriers based on "predominantly isotactic" and atactic polylactides (PLAs), and poly(ε-caprolactone) (PCL), for the controlled release of epirubicin (EPI).
Methods:
The biodegradable PURs containing different soft segments as new and effec...
A preliminary evaluation of cyto- and genotoxicity of the biomedical polyesters obtained in the presence of new zinc catalytic systems was carried out. A series of biomedical poly(ε-caprolactone)s (PCLs) and poly(rac-lactide)s (PLAs) synthesized in the presence of diethylzinc/propyl gallate or diethylzinc/gallic acid catalytic systems were tested u...
In this study, “predominantly isotactic”, disyndiotactic, and atactic polylactides (PLAs) and poly(ε-caprolactone)s (PCLs) were loaded with anticancer agents, epirubicin (EPI) and cyclophosphamide (CYCLOPHO), to investigate their properties as highly controlled delivery devices. It was found that the kinetic release of drugs from the obtained polye...
This paper describes the development of covalent star-shaped poly(L-lactide/ϵ-caprolactone) random copolymer-oxprenolol (OXP) conjugates as a potential approach to controlling drug release from implantable delivery systems. We prepared synthesized materials containing 14–17 mol% OXP, which were conjugated via an ester bond. The conjugates, which we...
The present study evaluated a new concept of combined scaffolds as a promising bone replacement material for patients with a bone tumour or bone metastasis. The scaffolds were composed of hydroxyapatite doped with selenium ions and a biodegradable polymer (linear or branched), and contained an active substance—bisphosphonate. For this purpose, a se...
The sustained release of alprenolol, a β-adrenergic antagonist, could be beneficial for the treatment of various heart diseases while reducing the side effects resulting from its continuous use. The novel and branched copolymers uniquely composed of biodegradable components (lactide and glycolide) have been synthesized using natural and therapeutic...
Novel and promising macromolecular conjugates of the α1-adrenergic blocker prazosin were directly synthesized by covalent incorporation of the drug to matrices composed of biodegradable polymers and α-amino acids for the development of a polymeric implantable drug delivery carrier. The cyto- and genotoxicity of the synthesized matrices were evaluat...
Poly(l-lysine) dendrimer end-functionalized with arginine-6-oligomer conjugated biodegradable poly(3-hydroxybutyrate) (PHB)–poly(ethylene glycol) (PEG)–PHB copolymer may be considered a promising macromolecular drug delivery vehicle. To prepare amphiphilic triblock copolymers, bulk ring-opening polymerization (ROP) of (R,S)-β-butyrolactone initiate...
The substitution of selenium oxyanions in the hydroxyapatite structure was examined using multinuclear solid-state resonance spectroscopy (ssNMR). The study was supported by powder X-ray diffractometry (PXRD) and wavelength dispersion X-ray fluorescence (WD-XRF). Samples of pure hydroxyapatite (HA300) and selenate (HA300-1.2SeO4) or selenite (HA300...
Supplementary Materials to Conjugation of β-Adrenergic Antagonist Alprenolol to
Implantable Polymer-Aescin Matrices for Local Delivery
Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both c...
The paper is a literature review concerning the preparation and biomedical properties of polyurethanes for pharmaceutical applications. The basic uses of polyurethanes in pharmacy comprise modem drug formulations (including therapeutical systems, carriers and conjugates). Clinical studies indicate that the application of polymer - drug conjugates h...
Selenium-substituted hydroxyapatites containing selenate SeO42 − or selenite SeO32 − ions were synthesized using a wet precipitation method. The selenium content was determined by atomic absorbance spectrometry. The raw, unsintered powders were also characterized using powder X-ray diffraction, middle-range FT-IR spectroscopy and transmission elect...
The development and characterization of novel macromolecular conjugates of ampicillin using branched biodegradable polymers has been described in this study. The conjugates have been prepared coupling the β-lactam antibiotic with branched polymer matrices based on the natural oligopeptide core. The cyto- and genotoxicity of the synthesized polymers...
New macromolecular conjugates of camptothecin were prepared. The polymeric matrixes were obtained by the ring-opening polymerization of -caprolactone, glycolide, rac-lactide or trimethylene carbonate. The synthesized polymers and camptothecin were coupled via 1,6-diisocyanatohexane. The received macromolecular conjugates of camptothecin were charac...
A novel initiator, naturally occurring in soy, has been developed for a direct synthesis of aliphatic star-shaped homo- and copolyesters. The synthesis is based on one of several known isoflavones, genistein, which has been employed as an initiator of homopolymerization of poly(l-Lactide) or co-initiator of copolymerization of ε-caprolactone and l-...
Natural creatine and arginine-6-oligomer have been effectively engaged as ring-opening polymerization initiators of poly(L-lactide) (PLLA) and poly(ɛ-caprolactone) (PCL) in bulk. The nonlinear structure and thermal properties of the resulted polymers were further elucidated by 1H, 13C nuclear magnetic resonance, and a modulated differencial scannin...
A series of novel star-shaped poly(ɛ-caprolactone) (PCL) biodegradable polyesters were synthesized through ring-opening polymerization of ɛ-caprolactone in the presence of a poly(amidoamine) (PAMAM) dendrimer initiator. The polymers (PAMAM/PCLs) were obtained with a high yield (92%) and a number-average molecular weight of up to 14 000 g/mol. The n...
Biodegradable polymers/oligomers were successfully synthesized through a ring-opening polymerization of ε-caprolactone and L,L-lactide, initiated by L-arginine and L-citrulline. The α-amino acid initiators are natural, operationally simple, inexpensive, environmentally friendly and safe for human health. The polymerizations were performed with no s...
Contents of Al, Zn, Sn and Cr have been investigated in several aliphatic polyesters and polycarbonates obtained in ring opening polymerization and copolymerization of heterocyclic monomers in the presence of coordination catalytic systems with these metals. The metals were reliably determined using spectroscopic atomic techniques: flame atomic abs...
The low-molecular weight poly(ϵ -caprolactone) and polylactide were obtained by the polymerization of cyclic esters in the presence of amino acid initiators. The polymer structures were elucidated by means of MALDI TOF, NMR and IR studies. Effects of temperature, reaction time and initiator dosage on the polymerization process were examined.
Two-, three- and four-arm, star-shaped poly(ε-caprolactone) and poly(D,L‑lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained ol...
The article presents the recent state of knowledge of medical applications of natural polymers and their derivatives as well as of synthetic polymers. The review covers the following directions of macromolecular compounds' applications in medical area: technology of implants and prostheses, surgical sutures, dental materials, tissue and genetic eng...
The pharmacy is one of the most important areas in which the macromolecular compounds are applied. They are used as pharmacological substances, blood substitutes, various auxiliary materials or excipients as well as in the production of macromolecular prodrugs, polymeric drug delivery systems, therapeutic systems, etc. (Table 1 and 2). The prodrugs...
On the basis of literature review (72 references) the necessity to solve the world problem of growing amounts of rubber wastes, especially end-of-life tyres (Table 1), has been justified. The methods of their recovery and recycling as well as legislative and economical conditions in this area (Table 2) were presented. Past methods of used tyres' py...
Novel nickelocene based catalysts were used for polymerization of 2-butyne, 1-phenyl-1-propyne, bis(trimethylsilyl)acetylene and trimethylsilylacetylene. The catalyst prepared in the reaction of nickelocene with organolithium compounds in the presence of alkyne was previously isolated and fully characterized. It enabled us to explain the mechanism...
Novel nickelocene-based catalysts were used for polymerization of diphenylacetylene and phenylacetylene. The catalyst obtained in the reaction of nickelocene with organolithium compounds in the presence of alkyne was previously isolated and fully characterized. This enabled us to explain the mechanism of the polymerization. Polymerization of alkyne...
Results of the reactions of nickelocene with phenyl- and methyllithium in the presence of bis(trimethylsilyl)acetylene have been reported. It was found that in the reaction of nickelocene with phenyllithium and bis(trimethylsilyl)acetylene three products were formed: di(cyclopentadienylnickel) complex with bis(trimethylsilyl)acetylene (NiCp)2(μ–η2–...
Reactions of nickelocene, NiCp 2, with organolithium compounds RLi (R = -C≡CPh; -CPh=CPh 2; -CPh 3, -CPh 2SiMe 3), where R does not contain α- and β-hydrogen atoms, have been studied. It was found that {CpNiR}, formed in the first step of the reaction, underwent coupling with the formation of {(NiCp) 2} and R-R. As organolithium substrates are read...
