Evgeny Nasonov

Evgeny Nasonov
Russian Academy of Medical Sciences | RAMS · Nasonova Institute of rheumatology

MD

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968
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5,401
Citations
Citations since 2016
118 Research Items
2735 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400

Publications

Publications (968)
Article
The article presents a case of periodic fever (PF) in a 35-year-old patient, who did not have hereditary and proven genetic factors of the disease, which was characterized by an atypical course with variable in duration and frequency severe abdominal pain and febrile fever attacks, increased acute phase reactants and ineffectiveness of colchicine i...
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The clinical presentation and outcomes of infection with the novel coronavirus (COVID-19) are characterized by exceptional variability in manifestations, which depend on many factors, one of which is the patient’s age. One of the severe life-threatening manifestations in adults is severe acute respiratory syndrome (SARS-CoV-2), in some cases accomp...
Article
The coronavirus disease 2019 (COVID-19) pandemic has drawn attention to new clinical and fundamental issues in the immunopathology of human diseases. Since in COVID-19 it is the ‘‘hyperimmune’’ response, called cytokine storm syndrome, which forms the basis of the pathogenesis of acute respiratory distress syndrome (ARDS) and multiorgan dysfunction...
Article
Treatment adherence in patients with osteoporosis (OP) is rather low throughout the world, and 50 to 75% of patients stop taking anti-osteoporotic drugs within a year after therapy prescription. Objective : to establish determinants that affect patient adherence to OP therapy. Subjects and methods . The investigation enrolled 150 women older than 5...
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Deciphering immunopathogenesis, expanding the scope of diagnostics and developing new methods for treating human autoimmune diseases are among the priority areas of XXI century medicine. Particularly widely autoimmune pathology is presented in immunoinflammatory rheumatic diseases (IIRD), such as rheumatoid arthritis, systemic lupus erythematosus,...
Article
Rheumatoid arthritis (RA) and glucocorticoid use are the most common causes of secondary osteoporosis (OP). Early detection of individuals at high risk for osteoporotic fractures among RA patients allows timely prevention of OP and its complications. Objective: to evaluate the diagnostic possibilities of using a FRAX® calculator without introducing...
Conference Paper
Background In previous studies tofacitinib (TF) had demonstrated efficacy of two dosages (10 and 20 mg/day) in patients with rheumatoid arthritis (RA). However, the expected results of switching of TF’ dosages are unknown. Objectives The aim of the study was to evaluate the results of switching of TF’s dosages in RA patients. Methods Were analyz...
Conference Paper
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Background The latest data show that axial involvement in psoriatic arthritis (PsA) patients (pts) is associated with significantly worse disease status and widespread impairment of patient-reported outcomes (PRO’s) (1). Objectives To analyze clinical characteristics and PRO’s in PsA pts with and without radiographic sacroiliitis (rSI) in the Russ...
Conference Paper
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Background MDA is a treatment target of PsA. There is limited data about the frequency and the time of MDA achievement by the use of bDMARD therapy in early and long-term PsA in clinical practice. RU-PsART collected data from 25 rheumatology clinics in the Russian Federation. Objectives: to investigate the cumulative frequency and timing of MDA att...
Conference Paper
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Background Persistence with bDMARDs has only been studied recently in the last few years. But this information is very relevant for choice of bDMARDs treatment in real-life practice. RU-PsART collected data from 25 rheumatology clinics in the Russian Federation. Objectives: to investigate drug survival and persistence rates, reasons for discontinua...
Conference Paper
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Background The latest data show that axial involvement in psoriatic arthritis (PsA) patients (pts) is associated with significantly more severe disease status (1). Objectives To analyze, in clinical practice, disease activity and characteristics of PsA pts with and without radiographic sacroiliitis (rSI). Methods 385 pts (M/F–172/213) with PsA ac...
Conference Paper
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Background Tofacitinib (TF) is an oral Janus Kinase inhibitor for the treatment of rheumatoid arthritis (RA). Objectives To evaluate the one-year effectiveness of tofacitinib as first-line therapy in RA conventional synthetic (cs) DMARDs non-responders. Methods Data from 415 patients from Russian national register of patients with RA treated with...
Conference Paper
Background Prevalence of hyperuricemia worldwide has been steadily increasing over the past decades and becomes higher with age. The number of studies on the prevalence of hyperuricemia and its role in development of diseases in some social groups is low, yet there is data on its high frequency in professional athletes. Objectives: to assess impact...
Conference Paper
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Background Anxiety and depressive disorders (ADD) affect rheumatoid arthritis (RA) disease activity and remission rate. Psychopharmacotherapy (PPT) of ADD attempts to improve the remission rate. Objectives To determine factors associated with RA remission rate. Methods 128 RA-patients (pts) were enrolled, 86% were women with a mean age of 47,4±11...
Conference Paper
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Background The aim of psoriatic arthritis (PsA) therapy is to achieve minimal disease activity (MDA) or clinical remission. Methotrexate (MTX) is the first-line treatment; however, the extent of the disease-modifying effect of MTX on PsA is a matter of debate. It has been shown that the MTX treatment achieves MDA in 6 months in <20% of patients (pt...
Conference Paper
Background BCD-020 (BIOCAD) is the first Russian rituximab (RTX) biosimilar which was approved for medical use in rheumatoid arthritis (RA) patients in Russia and some CIS countries Objectives To evaluate the changes in acute phase reactants, autoantibodies, immunoglobulins, cytokine profile and CD19+B lymphocytes in patients (pts) with RA during...
Conference Paper
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Background The PsAID-12 is an instrument for assessment the impact of PsA on patients’ lives by examine both physical and psychological components of health. DAPSA is a valid and discriminative tool for evaluation of the PsA activity. There is limited data about the PsAID-12 correlations with PsA activity by DAPSA in clinical care [1]. The Russian...
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Objective: to assess bone mineral density (BMD) changes in rheumatoid arthritis (RA) patients with osteoporosis (OP) and in women with postmenopausal OP during therapy with denosumab (DSB) for 1 year Subjects and methods. 121 women were included: the main group – 69 patients with RA (mean age – 60±7 years), 34 (49.3%) from them received glucocortic...
Article
A significant part of patients with gout has contraindications to taking nonsteroidal anti-inflammatory drugs, colchicine and glucocorticoids. Such therapy is often ineffective, particularly in patients with the severe tophaceous gout what hampers treatment of acute arthritis attack assuming the need for other methods of therapy. During the last ye...
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Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune diseases characterized by cross-striated muscle inflammation accompanied by muscle weakness. The rarity of these diseases and a large number of other diseases with similar clinical presentation, along with the absence of simple laboratory tests for confirming the diagnosis of IIMs...
Article
Objective: to estimate the prevalence of individual risk factors (RFs) for osteoporosis (OP) and fractures, the frequency of high-risk osteoporotic fractures by the Fracture Risk Assessment Tool (FRAXR) and OP according to distal forearm X-ray densitometric findings in men aged 50 years or older in different regions of Russia. Patients and methods....
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Strontium ranelate (SR) that has a proven efficacy in reducing the risk of fractures and in increasing bone mineral density is currently recommended as a second choice drug for the treatment of severe osteoporosis (OP) in postmenopausal women and elderly men. Subjects and methods. In 2014–2015, a survey within the framework of the MARC program (The...
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Objective: to analyze the levels of CD3+, CD3+CD4+, CD3+CD8+, and CD3-CD56+ T lymphocytes, FoxP3+ regulatory T cells (Treg), and CD19+ B lymphocytes in patients with early and advanced rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 45 patients previously untreated with methotrexate (MTX-naive) who had early RA and 15 pa...
Article
Rheumatoid arthritis (RA) and the use of glucocorticoids (GCs) are proven risk factors for osteoporosis (OP) and osteoporotic fractures (OPF). There are also other reasons for increased fracture risk in RA. Objective : to determine the rate of RA in an epidemiological sample of persons aged 50 years and older and to identify those in need of antios...
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Objective: to assess the long-term safety and efficiency of tocilizumab (TCZ) therapy in patients with early rheumatoid arthritis (RA) of moderate and high activity, who have completed the basic WA19926 study, as well as the rate of sustained drug-free remission. Subjects and methods . A long-term open-label multicenter Phase III extension study (M...
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Objective. To assess the efficacy and safety of amtolmetin guacil (AMG) in patients with knee joint osteoarthritis (KJOA) and associated dyspepsia in real clinical practice.Methods. 220 patients with KJOA with severe pain syndrome in KJ ≥ 40 mm in VAS and dyspepsia were included in the observation study. AMG was administered at a dose of 600 mg twi...
Article
According to modern ideas, chronic low-grade inflammation, which development is associated with uncontrolled activation of both innate and adaptive immunity, plays a fundamental role in all stages of the atherosclerotic process. The contribution of inflammation to the development of atherosclerotic vascular lesions attracts attention to the similar...
Article
Full-text available
Giant cell arteritis (GCA), formerly known as Horton's disease, is among the most common diseases from a group of systemic vasculitides; its clinical significance is complemented with the potential involvement of the coronary arteries, aorta, and cranial arteries with development of ischemic optic neuropathy if there is no timely treatment that res...
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Objective: to compare the efficacy of methotrexate (MTX) and colchicine in patients with chronic arthritis in calcium pyrophosphate crystal deposition disease (CPPDD). Subjects and methods. Data from a controlled prospective cross-sectional study of 10 patients (8 women and 2 men) with chronic arthritis in CPPDD are presented. In the initial period...
Article
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Objective: To assess 5-year safety, tolerability, and efficacy of subcutaneous (SC) abatacept (ABA) in methotrexate (MTX)-refractory patients with rheumatoid arthritis (RA). Methods: The Abatacept Comparison of sub[QU]cutaneous versus intravenous in Inadequate Responders to methotrexatE (ACQUIRE) phase IIIb, randomized, double-dummy, multination...
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The paper deals with the mechanisms of a T-cell immune response, which depends on the balance between costimulatory and coinhibitory signals that have been called as immune checkpoints (ICP). The imbalance of T-cell activation within ICTs (CTLA4/CD28 and PD1/PD1L) is considered to be a fundamental mechanism not only of autoimmune disease, but also...
Article
According to modern ideas, chronic low-grade inflammation, which development is associated with uncontrolled activation of both innate and adaptive immunity, plays a fundamental role in all stages of the atherosclerotic process. The contribution of inflammation to the development of atherosclerotic vascular lesions attracts attention to the similar...
Article
Full-text available
In this transglobal, randomized, double-blind, placebo-controlled, treat-to-target study, the maintenance of efficacy was compared between biologic–and biologic-free–disease-modifying antirheumatic drug (DMARD) combination regimens after low disease activity (LDA) was achieved with biologic DMARD induction therapy. Patients with moderate-to-severe...
Article
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Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the potentially curable forms of pulmonary hypertension, in which pulmonary thromboendarterectomy is the gold standard treatment. However, over the last decade, great attention has been given to a combined therapeutic approach including both drug therapy and surgical treatment and the...
Conference Paper
Background Monotherapy with MTX is the first step of RA therapy as recommended by EULAR. According to “Treat to Target” (T2T) strategy principles insufficient response to MTX requires prompt switch to a combination therapy with biological agents. Objectives To find out whether polymorphisms of immune response genes are associated with early prescr...
Conference Paper
Background Only postmenopausal women were in the researcher's focus in the majority of publications on osteoporosis (OP) risk factors (RF) in RA female patients (pts). Meanwhile the data on OP RF in menstruating women presented in the rare available papers are not consistent. Objectives To identify the major OP RF in RA female pts with normal mens...
Conference Paper
Background Low back pain (LBP) is associated with 2.3, 2.2, and 1.6 times greater odds for mood disorders, anxiety disorders and alcohol abuse respectively (1). Continued anxiety may lead to a state of “learned helplessness”, and both can propagate in a vicious cycle. Glucosamine-chondroitin sulfate (GCS) combination is widely used in the treatment...
Conference Paper
Objectives To analyze the effect of methotrexate (MT) therapy on the percentage and absolute number of FoxP3+ regulatory T (Treg) cells in the peripheral blood of MT-naïve patients (pts) with early RA we used Treg immunostainingwith antibodies to surface markers and Foxp3 with subsequent flow cytometric analysis Methods 45 MT-naïve pts with early...
Conference Paper
Objectives To study B-cell subpopulation dynamics in SLE patients following Rituximab (RTX) therapy. Methods The study included 31 SLE pts (3m/28f) with high (SLEDAI2K≥10–28 pts.) and moderate (SLEDAI2K<10–3 pts.) disease activity; out of them 12 pts with SLE nephritis, 5 pts with neurolupus and 8 with vasculitis. RTX was administered to pts who f...
Article
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Aim: To determine risk factors for severe cardiovascular (CV) events (CVEs) in male patients with crystal-verified gout. Subjects and methods: 251 male patients with crystal-verified gout were prospectively followed up in 2003 to 2013. The mean follow-up period was 6.9±2.0 years. New severe CVE cases and deaths were recorded. Logistic regression...
Conference Paper
Objectives To assess the impact of ABA on disease activity and functional status in patients with different duration of RA. Materials and methods 85 patients (pts) with early (less than three years, 51%) and LS (more than three years, 49%) RA were enrolled in the study. Most of them were females (48,8±13,5 years) with high disease activity (DAS28=...
Article
Objective: to investigate the efficacy and tolerability of amtolmetin guacil (AMG; Niselat®, Dr. Reddy's Laboratories Ltd, India) versus previous therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with knee osteoarthritis (OA) and signs of dyspepsia. Subjects and methods. The open-label observational study included 220 patients...
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The paper discusses the use of the recommended methotrexate doses for the treatment of rheumatoid arthritis in the randomized clinical comparative trials with biological agents.
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The paper analyzes the key biological effects of cytokines that play a central role in the pathogenesis of immunoinflammatory rheumatic diseases. Special attention is drawn to major proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-17. There are data from a preclinical study of the innovative original...
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The results of the PRECISION trial were published in late 2016. During this trial, a total of 24,081 patients at high cardiovascular risk took celecoxib 200-400 mg/day, naproxen 750-1000 mg/day or ibuprofen 1800-2400 mg/day for more than 1.5 years (20.3±16.0 months). The findings show that the frequency of vascular catastrophes (death, nonfatal myo...
Article
Full-text available
Objective: To analyze the relationship of the count of FoxP3+ T regulatory cells (Tregs) to the clinical and laboratory parameters of disease activity and the levels of antibodies in a group of patients with early rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 45 patients with early RA (2010 ACR/EULAR criteria) who had...
Article
Thew antinuclear antibodies (ANA) consist heterogeneous group of auto antibodies reacting with various components of nucleus and cytoplasm. The ANA is a main serological marker of systemic lupus erythematosus (SLE). The implementation in clinical practice of new highly productive techniques of immune analysis using automated systems sets up prerequ...
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The need for further improvement of treatments for Takayasu’s arteritis (TA), the progress in understanding the mechanisms of the disease, and the introduction of biological agents (BA) in rheumatology practice have created preconditions for developing a new TA pharmacotherapy using BA associated with interleukin 6 (IL-6) inhibition. The authors de...
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Objective: to assess the psychometric properties (reliability, sensitivity, and validity) of a Russian-language version of the VEINES-QOL/Sym questionnaire in patients with rheumatic diseases and lower extremity chronic venous diseases. Subjects and methods. The investigation enrolled 89 patients (66 (74%) women and 23 (26%) men) (their mean age wa...
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У больных ревматоидным артритом (РА) остеопороз (ОП) в 2-3 раза чаще диагностируется, чем в популяции, а риск переломов увеличен в 1,5-2,5 раза. Наиболее опасными в отношении дальнейшего качества и прогноза жизни больных являются переломы шейки бедренной кости. Цель. Выделить основные факторы риска развития ОП в шейке бедренной кости у женщин с РА....
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Представлены опубликованные в 2015 г. международные рекомендации по диагностике и лечению эозинофильного гранулематоза с полиангиитом, ранее известного как синдром Черджа—Строс, и предпринята попытка расширения доказательной базы привлечением более поздних доступных публикаций. Новые рекомендации не следует рассматривать как окончательные стандарты...
Article
Background Bone loss in patients (pts) with early axial spondyloarthritis is insufficiently studied. Objectives To assess 1-year bone mineral density (BMD) changes at the femoral neck (FN) and lumbar spine (LS) in pts with early axial spondyloarthritis (axSpA). Methods 47 pts (20 men and 27 women) with axSpA and <5 years duration of inflammatory...
Article
Background Methotrexate is commonly used in patients with calcium pyrophosphate deposition (CPPD) condition, although data on methotrexate use for chronic arthritis in CPPD pts are controversial [1], and it's not clear yet, whether methotrexate can be used as an alternative to colchicine in this group of pts. Objectives The comparison of efficacy...
Article
Objectives to study B-cell subsets dynamics in SLE patients receiving rituximab (RTX) therapy with following 6 months observation. Methods The study included 16 SLE pts (1m/15f) with high (SLEDAI2K>10 - 13 pts.) and moderate (SLEDAI2K<10- 3 pts.) disease activity. Out of them 7 pts with lupus nephritis and 3 pts with neurolupus. RTX was administer...
Article
Background Tofacitinib (TOFA) was approved in Russia for treatment of patients with rheumatoid arthritis (RA) in 2013, but published information about its post-approval use limited to some individual clinical observations. Objectives To study the efficacy and safety of TOFA in patients with severe active RA in clinical practice. Methods We presen...
Article
Background Systemic lupus erythematosus (SLE) is a devastating disease affecting different organs, ultimately leading to organ failure and death. To date, there are no data regarding the real-life picture of SLE in Kyrgyzstan. Objectives To study the outcomes of SLE according prospective study among residents of Kyrgyzstan. Methods An 2-year pros...
Article
Background Interstitial lung disease (ILD) is the most common internal organ manifestation of idiopathic inflammatory myopathies (IIM) that can severely affect the course of the disease. IIM patients with ILD often show resistance to conventional treatment with glucocorticoids (GC) and cytotoxic drugs so addition of biologic agents is an interestin...
Article
Background Systemic lupus erythematosus (SLE) is a devastating disease affecting different organs, ultimately leading to organ failure and death. To date, there are no data regarding the real-life picture of SLE in Kyrgyzstan. Objectives To study of clinical symptoms, course and outcome of SLE according to the prospective study among residents of...
Article
Background - Objectives To identify risk factors for progression of knee joint osteoarthrosis (OA) in the first 5 years of disease. Methods Prospective 5-year study included 110 female-patients with primary knee OA (CCR criteria), in 52 of them disease duration did not exceed 5 years, (mean age – 59,11±8,95 years). All relevant patients' data, in...
Article
Background Chronic synovitis and RANKL-dependent osteoclastogenesis in rheumatoid arthritis (RA) lead to bone damage, such as local and systemic bone destruction (osteoporosis (OP), erosions and joint space narrowing). RANK-ligand is essential for osteoclast development, activation, and survival. The addition of an anti-RANKL antibody (denosumab) t...
Article
Background Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by increased cardiovascular morbidity and mortality. Coronary angiography (CAG) is the gold standard to identify and assess the degree of coronary artery (CA) involvement. CA diseases (CAD) development in RA patients (pts) is associated with the accumulation of tr...
Article
Background RA pts commonly present with multiple concurrent chronic disease, compromising pts quality of life, limiting the use of potential therapies, contributing into disability, rate and costs of hospitalization [1–3]. Objectives To identify the prevalence and extent of multi-morbid background in RA pts (ACR 1987 y) and relate pts multimorbidi...
Article
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Background The ACQUIRE study demonstrated non-inferiority of the SC to the IV formulation.¹ Objectives To assess the 5-yr safety and efficacy of SC ABA 125 mg/wk plus background MTX in the LT extension (LTE). Methods The 6-month, double-blind (DB) period was followed by an open-label LTE in which patients (pts) received SC ABA 125 mg/wk. Dose adj...
Article
Background Abatacept (ABA) is a selective co-stimulation modulator, which is widely used in treatment of RA. There isn't enough data about its effectiveness and impact on functional status in patients with early (ERA) and long-standing (LS) rheumatoid arthritis (RA). Objectives To assess the impact of ABA on disease activity and functional status...
Article
Objectives to study the effect of antirheumatic therapy administered in accordance with “treat-to-target” principles on NT-proBNP level in early rheumatoid arthritis (RA) patients (pts) during 18-month follow-up Methods A total of 66 early RA pts (ACR/EULAR criteria, 2010) were included in the study: 71% of women, age 56 [46;61] years, disease dur...
Article
Background ANA are a large family of autoantibodies directed at various cellular constituents. The measurement of ANA is a useful tool to confirm the diagnosis of SLE. New automated bead-based arrays can simultaneously and rapidly determine a profile of multiple ANA. Clinical performance of multiplexed technologies for detection of ANA specificitie...
Article
Background Systemic lupus erythematosus (SLE) is a devastating disease affecting different organs, ultimately leading to organ failure and death. To date, there are no data regarding the real-life picture of SLE in Kyrgyzstan. Objectives The goal of the study is evaluation of the quality of life among Kyrgyz cohort of patients with SLE according t...
Article
Background The main therapeutic goals that can determine success of biologic treatment in systemic juvenile idiopathic arthritis (SJIA) include achieving and maintaining clinical remission, controlling disease activity and tapering corticosteroids (CS). Canakinumab (CAN) has been shown to improve several of these parameters in previous studies¹. Ho...
Article
Background Due to the smaller size of the molecule and low affinity for platelet factor (f) 4, fondaparinux (F) does not cross react with heparin-induced-thrombocytopenia- antibodies [1]. Also F has some more beneficial mechanisms: reduction of aPl-production (BAFF/Blys) and tissue f expression, C3/C5-inactivation, fXa-C3 cleavage blocking, increas...
Article
Background The aim of therapy rheumatoid arthritis (RA) is the achievement of remission of the disease and slowing destruction of the joints. Tocilizumab (TCZ), anti-interleukin-6 receptor monoclonal antibody was used in treatment of active RA. TCZ has a rapid positive effect on the clinical manifestations and laboratory disoders, slowing destructi...
Article
Background Patient's age at RA onset predefines the course of the disease, rate of progression and severity of erosive-destructive changes in hand and feet joints, mineral bone density (BMD) and deformities of the spine vertebrae. Objectives To compare the changes in axial and peripheral skeleton in pts in relation to the age of RA onset. Methods...
Article
Background Systemic lupus erythematosus (SLE) is a devastating disease affecting different organs, ultimately leading to organ failure and death. To date, there are no data regarding the real-life picture of SLE in Kyrgyzstan. Objectives To define retrospectively the pattern of clinical features, disease course and outcome of patients with SLE in...
Article
Background Venous thromboembolic events (VTE) such as deep vein thrombosis, thrombophlebitis and thromboembolism of pulmonary artery are an important clinical problem that concerns all spheres of medicine. Patients with chronic inflammatory diseases including RA have an increased risk of venous thromboembolism. It is important to determine risk fac...
Article
Background Rheumatoid arthritis (RA) – is a chronic inflammatory disease, which by natural course of the disease results in erosive polyarthritis, i.e. destruction and dysfunction of joints. Objectives To investigate the relationship between ultrasonographic (US) evidence of “active” inflammation and radiographic progression in patients with RA an...
Article
Background Rheumatoid arthritis (RA) is associated with insulin resistance (IR), a precursor to type 2 diabetes mellitus (DM). However, IR indexes are uncomfortable to examine the DM risk in clinical practice. International Diabetes Federation recommends the use of patient questionnaires to quickly identify people who may be at a higher risk of DM...