
Evelyn CampbellUniversity of Chicago | UC · Department of Microbiology
Evelyn Campbell
Doctor of Philosophy
About
15
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Introduction
My dissertation research investigated host-microbe interactions contributing to food allergy pathology. I utilized big datasets, such as 16S sequencing, metagenomic sequencing, RNAseq, and scRNAseq data to understand microbial contributors to atopic immunological phenotypes at transcriptomic and cellular levels.
Currently, I am interested in pursuing research in STEM education, particularly in data science.
Publications
Publications (15)
We have previously reported that the gut microbiota of healthy infants harbors allergy-protective bacteria taxa that are depleted in infants with cow’s milk allergy (CMA). Few reports have investigated the role of the gut microbiota in promoting allergic responses. In this study we selected a CMA-associated microbiota with increased abundance of Gr...
The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). L...
There has been a striking generational increase in life-threatening food allergies in Westernized societies1,2. One hypothesis to explain this rising prevalence is that twenty-first century lifestyle practices, including misuse of antibiotics, dietary changes, and higher rates of Caesarean birth and formula feeding have altered intestinal bacterial...
Food allergies are a major public health concern due to their widespread and rising prevalence. The increase in food allergy is partially due to Western lifestyle habits which deplete protective commensal microbiota. These microbial perturbations can result in adverse host–microbe interactions, altering the phenotype of various immune cells and ins...
Data science is a growing and evolving field, and as such, lacks standard references and resources on methods of teaching. To meet this need, more discussion around best practices for training data science students of diverse backgrounds is a necessary step to ensuring quality learning experiences. As Data Science Preceptors (PostDoctoral Teaching...
The impact of endemic parasitic infection on vaccine efficacy is an important consideration for vaccine development and deployment. We have examined whether intestinal infection with the natural murine helminth Heligmosomoides polygyrus bakeri alters Ag-specific Ab and cellular immune responses to oral and parenteral vaccination in mice. Oral vacci...
The microbiome modulates host immunity and aids the maintenance of tolerance in the gut, where microbial and food-derived antigens are abundant. Yet modern dietary factors and the excessive use of antibiotics have contributed to the rising incidence of food allergies, inflammatory bowel disease and other non-communicable chronic diseases associated...
The impact of endemic parasitic infection on vaccine efficacy is an important consideration for vaccine development and deployment. We have examined whether intestinal infection with the natural murine helminth Heligmosomoides polygyrus bakeri alters antigen-specific antibody and cellular immune responses to oral and parenteral vaccination in mice....
The increasing prevalence of food allergies has been causally associated with the depletion of allergy protective intestinal bacteria. However, few studies have investigated the role of the gut microbiota in promoting allergic responses. In a cohort of infants affected by cow’s milk allergy (CMA), we have identified a patient with a proinflammatory...
The gut microbiome modulates the body’s response to food antigens ¹ . Beneficial taxa, specifically butyrate-producing Clostridia, are depleted in food-allergic individuals 2,3 . Although butyrate is known to play important roles in regulating gut immunity and maintaining epithelial barrier function 4–6 , its clinical translation is challenging due...
Lifestyle-induced changes to the diversity of the commensal microbiota have been causally linked to the increasing prevalence of food allergies and other non-communicable chronic diseases. We have shown that bacteria from the Clostridia class prevent an allergic response to food by eliciting an IL-22 dependent barrier protective response that limit...
Diet-induced changes in the microbiome can alter immune function and promote inflammation. In a new paper in Cell, Wastyk et al. report that intervention with diets high in fermented foods or plant-based fiber have the potential to increase microbial diversity and reduce markers of immune-mediated inflammation.
We previously reported that a consortium of bacteria from the Clostridia class modulates intestinal barrier function through induction of IL-22 and prevents allergic sensitization to food in mice. We further investigated the properties of these bacteria and the mechanisms that underly their protective impact. Shotgun metagenomic sequencing of the a...
Allergies have become increasingly more prevalent over recent years, and this increase has been found to correlate with dysbiosis of the gut microbiota. Bacterial signaling through TLR4 is known to be play a role in allergic sensitization, but the specific host-bacterial interactions and cellular immunological networks have not been elucidated. Pre...
A marked increase in disease prevalence has made food allergies a major public health concern. One hypothesis for this rise is that recent lifestyle factors have altered the composition of the intestinal microbiota, increasing susceptibility to allergic disease. Host-microbiota interactions are essential for immune homeostasis, and perturbations of...