Evelyn E Newby

Evelyn E Newby
IQVIA · Project Leadership, Asia

Master of Science

About

25
Publications
1,623
Reads
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100
Citations
Additional affiliations
December 2016 - February 2019
IQVIA
Position
  • Managing Director
January 2013 - December 2016
GlaxoSmithKline
Position
  • Medical Director, Oral Health & Skin Health China
June 2006 - December 2012
GlaxoSmithKline
Position
  • Principal Clinical Scientist

Publications

Publications (25)
Article
Objectives: Data generated from three similar in situ caries crossover studies presented the opportunity to conduct a pooled analysis to investigate how dentifrice formulations with different fluoride salts and combinations at concentrations of 1400-1450 ppm F, different abrasive systems and in some cases, carbomer (Carb), affect enamel caries les...
Conference Paper
Objective: Sodium fluoride dentifrices with the same level of ionic fluoride do not necessarily have the same intra-oral remineralisation potential. This study aimed to compare the remineralisation potential of three dentifrices, each with 1100-1150 ppm fluoride as sodium fluoride, with a fluoride-free placebo using an in situ model. Methods: Sub...
Conference Paper
Objective: Enhanced in situ remineralization performance has been observed for sodium fluoride (NaF) dentifrices versus sodium monofluorophosphate (NaMFP) dentifrices of equivalent fluoride concentration. This study investigated whether the difference is still observed when the enamel specimens are exposed only to the fluoride retained intra-orally...
Conference Paper
Objective: To evaluate the efficacy of 67%w/w and 62%w/w sodium bicarbonate toothpastes on gingivitis and dental plaque control compared to a control toothpaste (0% sodium bicarbonate). Method: This was a single-centre, randomized, examiner blind, three treatment, parallel group, stratified design. Following informed consent and screening there w...
Conference Paper
In situ caries models have been widely adopted to evaluate the clinical efficacy of fluoride toothpastes mainly in adult subject panels. In situ studies in children have been limited due to technical and compliance difficulties. Objectives: To compare a children’s sodium fluoride toothpaste to a placebo with respect to enamel remineralisation, en...
Article
To compare the effect of 40 seconds versus 2 minutes brushing on saliva and dental biofilm fluid fluoride in children ages 4–5 years over 1 hour. This was a single-blind, cross-over, randomised, two-period clinical study in healthy children. Three days before the start of each treatment subjects received a thorough brushing and then refrained from...
Article
Objectives To compare three children's sodium fluoride toothpastes to placebo with respect to enamel remineralisation potential, enamel fluoride uptake and net acid resistance using an in situ palatal caries model in children aged 11–14 years following a single brushing. DesignThis was a randomised, single blind (laboratory analyst), single-centre,...
Conference Paper
Objective: To compare the effect of 40 seconds vs. 2 minutes brushing on saliva and dental biofilm fluid fluoride in children ages 4 to 5 years old over one hour. Method: This was a single-blind, cross-over, randomized, two-period clinical study in healthy children. Three days before the start of each treatment subjects received a thorough brushi...
Article
To evaluate the novel assessment of gingival contour volume measurement from digital impressions compared with traditional clinical indices (Modified Gingival Index and Bleeding Index) and oral microflora following a dental prophylaxis. Following baseline examinations and full mouth digital impression using the LAVA™ Oral Chairside Scanner (COS), s...
Article
To assess the ability of 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice. Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This included a professional prophylaxis supported by oral hygiene instructi...
Article
To assess the ability of 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride gel to foam dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice. Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This involved a professional dental prophylaxis supported by ora...
Conference Paper
Objectives: To compare the treatment effect of a dental prophylaxis measured by traditional indices and gingival contour volume over a 12 week period. Methods: This was a single center, single (examiner) blind, exploratory, split-mouth, randomized, clinical study in healthy volunteers. 38 eligible subjects underwent a mouth dental prophylaxis (on...
Conference Paper
Full-text available
Objectives: To investigate the effect of toothpastes on oral bacteria in tongue and salivary rinse samples immediately post brushing with Colgate Total and Aquafresh Fresh & Minty. Methods: This was a two treatment, laboratory blinded, randomized crossover study in ten subjects. Subjects were permanent GSK employees, aged over 18 years, in good g...
Conference Paper
Objective: To demonstrate the use of meta analysis for the comparison of products across a variety of in vitro laboratory models. Methods: Two silica sodium fluoride dentifrices were studied using variations of published models: Enamel Fluoride Uptake (EFU), Enamel Solubility Reduction (ESR), Cycling Protection (CP) and Cycling Remineralisation/...
Conference Paper
Objective: To determine the efficacy of an experimental dentifrice to promote enamel fluoride uptake (EFU), lesion remineralisation (REM) and diminish subsequent demineralisation (DEM) using an established in-vitro caries cycling model, and to compare the results with marketed dentifrices. Methods: Artificial caries-like lesions were formed in hu...
Conference Paper
Objective: To determine the average amount of time children spend brushing their teeth when not provided with specific instruction. Methods: This was a single-visit study to evaluate the average amount of time children spend brushing their teeth when not provided with instructions. One hundred and sixty six subjects between the ages of 7 to 11 ye...
Conference Paper
Objectives: To evaluate the extrinsic stain removal efficacy of two experimental gel to foam dentifrices containing 10% and 5% sodium tripolyphosphate (STP) to a STP-free gel to foam dentifrice after 6 weeks measured by the MacPherson's Modification of the Lobene stain index (MLSI) in a forced stain model. Methods: This was a single centre, doubl...
Conference Paper
Objective: Compare the effects of experimental sodium fluoride/silica toothpaste [ED: 1100 ppm fluoride (F)]and commercially-available dentifrice Aquafresh Cavity Protection (CD: 1100 ppm F; sodium monofluorophosphate) on in situ enamel remineralization, F uptake, plaque fluid and salivary F during the retention phase of F delivery. Methods: The...
Article
Full-text available
The aim of the present study was to investigate the anticaries potential of a new sodium fluoride dentifrice in comparison to two commercial dentifrices containing different fluoride compounds by determining enamel fluoride uptake (EFU) and early caries lesion remineralization (REM) in an established in vitro caries remineralization/demineralizatio...
Article
To evaluate the effect of toothpaste treatments on levels of oral volatile sulphur compounds (VSCs) measured by gas chromatography in two clinical studies. These were blinded, randomised, controlled, crossover studies with 16 (study A) or 20 (study B) healthy volunteers between the ages of 19-54. Study A: breath samples were collected at baseline,...
Conference Paper
Primary Objective: To investigate the bacteria removal efficacy of a gel to foam whitening product compared to a commercially-available dentifrice after brushing. Methods: Thirty-nine healthy subjects aged 18-75 years with good oral health participated in this single centre, randomized, examiner blind crossover clinical study. After review and...

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