Evaezi Okpokoro

Evaezi Okpokoro
International Research Center of Excellence Institute of Human Virology Nigeria

MD

About

32
Publications
12,575
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217
Citations
Introduction
Dr. Evaezi Okpokoro currently works at the International Research Center of Excellence, Institute of Human Virology, Nigeria. Evaezi does research in Clinical Trials, Epidemiology and Infectious Diseases. Their most recent publication is 'Delay in the Provision of Antiretroviral Therapy to HIV-infected TB Patients in Nigeria'.

Publications

Publications (32)
Article
Full-text available
Objective To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection. Design Emulation of a target trial. Setting Linked databases in Ontario, Canada. Participants 9803 men aged ≥18 years with a history of being tested for syphilis and a laboratory confirmed bacterial sexually tra...
Article
Full-text available
This paper presents a formative assessment for the implementation of mobile portable chest X-ray (PDX) machines for tuberculosis (TB) contact tracing in the Oyo and Osun states, Nigeria. This descriptive qualitative study was carried out in eight local government areas, and 24 focus group discussions and 30 key informant interviews were conducted u...
Article
Full-text available
The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria. This has greatly improved test turnover rates and significantly decrease...
Article
Full-text available
Tuberculosis (TB) remains a significant public health challenge in Nigeria, with high rates of transmission and low case detection rates. This paper presents the challenges of screening and investigation of contacts of patients with TB in Oyo and Osun State, Nigeria. This descriptive-qualitative study was conducted in eight Local Government Areas w...
Preprint
Full-text available
This paper presents the formative assessment to implement mobile portable chest X-ray (PDX) machines for Tuberculosis (TB) contact tracing in Oyo and Osun States, Nigeria. This descriptive qualitative study was carried out in 8 Local Government Areas, and 24 FGDs and 33 KIIs were conducted using a 4-stage sampling technique to select participants....
Preprint
Full-text available
Tuberculosis (TB) remains a significant public health challenge in Nigeria, with high rates of transmission and low case detection rates. This paper presents the challenges of TB screening and the existing gaps in Contact Investigation (CI). This descriptive qualitative study was conducted in 8 local government areas with high TB burdens in Oyo and...
Preprint
Full-text available
Immune imprinting or original antigenic sin (OAS) originally referred to a phenomenon of suboptimal immune response to a repeat exposure to a virus that was antigenically distinct from the original virus infection. OAS has been implicated in higher mortality in young people during the 2009-10 H1N1 pandemic where the elderly (H1N1 exposure in childh...
Preprint
Full-text available
Background: Limited evidence is available on the real-world effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN) against mpox infection. Methods: We emulated a target trial using linked databases in Ontario, Canada to estimate the effectiveness of one dose of MVA-BN. Our study included males aged ≤18 years who: (1) had a histo...
Article
Full-text available
Mycobacterium tuberculosis and HIV constitute a public health challenge. Health workers (HWs) in HIV clinics maybe at greater risk of M. tuberculosis infection, considering the high rates of HIV/tuberculosis (TB) coinfection among patients. Hence, we measured the prevalence of M. tuberculosis infection and the effect of working in an HIV clinic. We...
Article
Full-text available
Background: COVID-19 is a global health crisis. By 2021, Nigeria had 230,000 cases. As the national public health institute, NCDC leads the COVID-19 response. Due to constant contact with infected patients, agency employees are a t high-risk. Here, we describe the transmission and psychosocial effects of COVID- 19 among infected NCDC workers as a...
Article
Full-text available
Monkeypox (MPX) is a viral zoonosis with lesions like smallpox. Though rare in Nigeria, sporadic outbreaks have been reported in 17 states since September 2017. Unfortunately, the COVID-19 pandemic has further reduced surveillance and reporting of MPX disease. This study seeks to assess the effect of an enhanced surveillance approach to detect MPX...
Article
Full-text available
Background Globally, drug resistant tuberculosis (DR-TB) continues to be a public health threat. Nigeria, which accounts for a significant proportion of the global burden of rifampicin/multi-drug resistant-TB (RR/MDR-TB) had a funding gap of $168 million dollars for TB treatment in 2018. Since 2010, Nigeria has utilized five different models of car...
Preprint
Full-text available
Background: The ongoing Coronavirus disease 2019 (COVID-19) pandemic is unprecedented in scope. High income countries (HIC) seemingly account for the majority of the mortalities considering that these countries have screened more persons. Low middle income countries (LMIC) countries may experience far worse mortalities considering the existence of...
Article
Full-text available
Background Nigeria accounts for a significant proportion of the global drug-resistant tuberculosis (DR-TB) burden, a large proportion of which goes untreated. Different models for managing DR-TB treatment with varying levels of hospitalization are in use across Nigeria, however costing evidence is required to guide the scale up of DR-TB care. We ai...
Article
Full-text available
Background: Nigeria has a high burden of HIV and tuberculosis (TB). To reduce TB-associated morbidity and mortality, the World Health Organization recommends that HIV-positive TB patients receive antiretroviral therapy (ART) within eight weeks of TB treatment initiation, or within two weeks if profoundly immunosuppressed (CD4<50 cell/μL). Methods...
Article
Full-text available
Background: The need to expand malaria diagnosis alongside policy requirements for mandatory testing before treatment motivates exploration of non-invasive rapid diagnostic tests (RDTs). We report the outcome of the first cross-sectional, single-blind clinical performance evaluation of a Urine Malaria Test (UMT) for Plasmodium falciparum ( Pf ) mal...
Article
Full-text available
Background HIV/AIDS continues to be a global health problem. With currently no cure, it is critical to get an effective vaccine to add to the arsenal of prevention and treatment tools. HIV Exposed Sero-Negative (HESN) individuals were enrolled and followed for 2 years. Methods A prospective observational cohort study to enroll HESN volunteers and...
Article
Full-text available
Background: The biomedical prevention of HIV transmission that medical male circumcision confers was confirmed by three clinical trial setting and then rolled out in VMMC programs in sub-Saharan Africa. Data assessing the effectiveness of this under programmatic conditions is not available. Concerns about possible risk compensation in circumcised m...
Article
Full-text available
The burden and viral diversity of HIV in Nigeria makes it suitable to evaluate biomedical prevention strategies including HIV vaccines. We document baseline clinical characteristics of a cohort of HIV Exposed Sero-Negative (HESN) partners to highlight background morbidities that might impact the interpretation of research findings especially in low...
Article
Full-text available
Isoniazid preventive therapy (IPT) is the administration of isoniazid (INH) to people with latent tuberculosis (TB) infection (LTBI) to prevent progression to active TB disease. Despite being life-saving for human immunodeficiency virus (HIV)-infected persons who do not have active TB, IPT is poorly implemented globally due to misconceptions shared...
Conference Paper
Full-text available
The HIV sero positive partner has a significant role in the retention of the HIV sero negative partner in clinical trials. In addition to support of the HIV+ partner to HIV-participant in the trial, our study also demonstrated the importance of the wellness of the HIV+ partner as indicated by their viral load and CD4 count. Separation/divorce is al...
Article
Full-text available
Resource limited countries continue to be plagued with rising prevalence of malaria, tuberculosis, HIV/AIDS as well as other emerg-ing diseases despite the huge financial sup-port provided by bilateral and multilateral agencies to combat these diseases. While progress may have been made in reducing the global burden caused by these diseases on one...
Article
Full-text available
Copyright: © 2013 Okpokoro E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: There is paucity of high-level clinical trials in Nigeria for se...
Conference Paper
Full-text available
Result Conclusion Background Methods Discordant couples have been known to be medium risk group for HIV transmission. This group is suitable for HIV vaccine trials due to the natural exposure and high retention rates recorded in the past. A cohort of discordant couples is being developed in Nigeria to record HIV incidence, STI infections, retention...
Chapter
Full-text available
The human Immunodeficiency virus (HIV) infects and replicated mainly in the CD4+ T lymphocytes making the CD4+ T cells an important marker for disease progression and for improved response to antiretroviral therapy. In HIV infected pregnant women the deleterious effect of HIV on CD4+ T cells is even more dramatic since pregnant women have been docu...

Questions

Question (1)
Question
Hello, Please what statistical test is appropriate for
1) Matched polytomous (i.e. 3 or more levels) outcome variable vs dichotomous exposure variable
2) Matched polytomous (i.e. 3 or more levels) outcome variable vs polytomous exposure variable. Thanks

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