Eva Onjukka

Eva Onjukka
Karolinska University Hospital | Karolinska · Department of Medical Radiation Physics

PhD

About

41
Publications
4,305
Reads
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295
Citations
Introduction
Additional affiliations
October 2010 - December 2013
The Clatterbridge Cancer Centre NHS Foundation Trust
Position
  • Trainee Clinical Scientist
October 2007 - September 2010
University of Liverpool
Position
  • PhD Student

Publications

Publications (41)
Article
Full-text available
Aim: To evaluate Stereotactic body radiotherapy (SBRT) in metastatic colorectal cancer (mCRC) and identify the benefit of the treatment by using a predictive algorithm. Methods: 85 patients treated with SBRT for mCRC were retrospectively analyzed. The CLInical Categorical Algorithm (CLICAL©) was used to predict probability of relapse after SBRT....
Article
Full-text available
The bronchial tolerance to high doses of radiation is not fully understood. However, in the event of a radiological accident with unintended exposure of the central airways to high doses of radiation it would be important to be able to anticipate the clinical consequences given the magnitude of the absorbed dose to different parts of the bronchial...
Article
Full-text available
Re-irradiation in head and neck cancer is challenging, and cumulative dose constraints and dose/volume data are scarce. In this study, we present dose/volume data for patients re-irradiated for head and neck cancer and explore the correlations of cumulative dose to organs at risk and severe side effects. We analyzed 54 patients re-irradiated for he...
Article
Full-text available
Background and purpose Stereotactic body radiotherapy (SBRT) for tumours ≥5 cm is poorly studied and its utility and feasibility is uncertain. We here report the Karolinska experience of SBRT in this setting. Material and methods All patients had a gross tumour volume (GTV) ≥70 cc, a prescribed physical dose of at least 40 Gy and received treatmen...
Article
Full-text available
Aim: Data from a local quality registry are used to model the risk of late xerostomia after radiotherapy for head and neck cancer (HNC), based on dosimetric- and clinical variables. Strengths and weaknesses of using quality registry data are explored. Methods: HNC patients treated with radiotherapy at the Karolinska University hospital are enter...
Article
Full-text available
Purpose: For prostate cancer treatment, comparable or superior biochemical control was reported when using External-Beam-Radiotherapy (EBRT) with High-Dose-Rate-Brachytherapy (HDRB)-boost, compared to dose-escalation with EBRT alone. The conformal doses produced by HDRB could allow further beneficial prostate dose-escalation, but increase in dose i...
Article
Full-text available
Background: There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the re-irradiated volume that might better predict the risk of serious side-effects from treatment. Methods: Fifty-four consecutive...
Preprint
Full-text available
Background: There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the re-irradiated volume that might better predict the risk of serious side-effects from treatment. Methods: Fifty-four consecutive pa...
Preprint
Full-text available
Background: There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the re-irradiated volume that might better predict the risk of serious side-effects from treatment. Methods: Fifty-four consecutive pa...
Article
Full-text available
Purpose: The aim of this work was to determine how the spatial pattern of dose in the ano-rectal wall is related to late gastro-intestinal toxicity for prostate cancer patients treated with mainly IMRT.Patients and methods: Patients from the DUE-01 multicentre study with patient-reported (prospective) follow-up and available dosimetric data were in...
Article
Full-text available
A fundamental problem in radiotherapy is the variation of organ at risk (OAR) volumes. Here we present our initial experience in engaging a large Radiation Oncology (RO) community to agree on national guidelines for OAR delineations. Our project builds on associated standardization initiatives and invites professionals from all radiotherapy departm...
Article
Full-text available
Purpose: To evaluate the rate and dose response of brachial plexus toxicity post stereotactic body radiation therapy (SBRT) of apically situated lung lesions. Material/methods: We retrospectively identified all patients with apically located tumors, defined by the epicenter of the tumor being located superiorly to the aortic arch, and treated with...
Article
Background and purpose: Patients with breast cancer receiving mastectomy in our institution are offered immediate breast reconstruction (IBR). IBR may have an impact on the optimisation of radiation therapy (RT). Therefore, we aimed to evaluate the clinical target volume (CTV) dose coverage when disregarding the dose received by the breast implant...
Article
Aims: For patients with high-risk, locally bulky prostate cancer, an intra-prostatic boost to tumour volumes (dose-painting) offers a risk-adapted dose escalation. We evaluated the feasibility of hypofractionated dose-painting radiotherapy and the associated toxicity. The possibility to streamline a radiobiologically optimised planning protocol wa...
Article
Purpose: To develop an infrastructure for structured and automated collection of interoperable radiation therapy (RT) data into a national clinical quality registry. Materials and methods: The present study was initiated in 2012 with the participation of seven of the 15 hospital departments delivering RT in Sweden. A national RT nomenclature and...
Article
This work explores different methods for accounting for patient-specific factors in normaltissue complication probability (NTCP) modeling, and compares the performance of models using pseudoclinical datasets for “lung” and “rectum” complications. Datasets consisting of dose distributions and resulting normal-tissue complications were simulated, le...
Article
107 Background: Prostate dose-painting radiotherapy and hypo-fractionation both can improve biochemical contol in localised disease. We report toxicity and outcome for a cohort of high risk patients. Methods: We selected 28 patients with high-risk localised prostate cancer and 2 or 3 risk factors. Functional MRI’s were used to define boost volumes...
Conference Paper
As normal tissues are unavoidably exposed to radiation during external beam radiotherapy, cell-kill is the most important mechanism for toxicity. The complex aggregation of cells into tissues and organs, as well as interactions between tissues, need to be considered when modelling the effect of a 3D dose distribution on organ function mechanistical...
Article
To evaluate the dose-response relationship between radiation-induced atelectasis after stereotactic body radiation therapy (SBRT) and bronchial dose. Seventy-four patients treated with SBRT for tumors close to main, lobar, or segmental bronchi were selected. The association between incidence of atelectasis and bronchial dose parameters (maximum poi...
Article
Full-text available
Objective: This work explores the biological basis of a mechanistic model of radiation-induced lung damage; uniquely, the model makes a connection between the cellular radiobiology involved in lung irradiation and the full three-dimensional distribution of radiation dose. Methods: Local tissue damage and loss of global organ function, in terms o...
Conference Paper
Purpose: In dose-volume analyses of normal tissue outcome data Vx, the volume receiving at least x Gy, is often calculated for different cut-off doses, and the Vx which correlates most strongly with the complication rate has been proposed as an NTCP surrogate [1, 2]. The factors influencing the association between Vx and the complication rate are s...
Article
Full-text available
We retrospectively reviewed the results of stereotactic body radiotherapy (SBRT) in 46 patients with a total of 136 metastases from primary sarcoma. The purpose of this study was to evaluate the overall response rate and side effects of SBRT in metastatic sarcoma. The patients were treated at Karolinska University Hospital between 1994 and 2005, us...
Article
Hypofractionated liver stereotactic radiotherapy has produced long-term survival, but the hepatobiliary system is radiosensitive and may be severely damaged by the treatment. We have evaluated long-term radiation effects on hepatobiliary functions in the first long-term survivors reported after radiotherapy to the hepatobiliary system for liver tum...
Article
In this study we explore whether a reductionist approach to modelling radiation pneumonitis (RP) can accommodate clinical and preclinical data on the pathogenesis of this dose-limiting complication. A previously developed mechanistic 3D model (Rutkowska et al., Phys. Med. Biol. 55 (2010) 2121-2136) is used as a framework for summarising current rad...
Article
Full-text available
A radiobiologically based 3D model of normal tissue has been developed in which complications are generated when 'irradiated'. The aim is to provide insight into the connection between dose-distribution characteristics, different organ architectures and complication rates beyond that obtainable with simple DVH-based analytical NTCP models. In this...
Article
Full-text available
About 2% of patients with a carcinoma in one kidney develop either metastases or a new primary tumor in the contralateral kidney. Often, renal cancers progress rapidly at peripheral sites and a metastasis to the second kidney may not be the patient's main problem. However, when an initial renal cancer is more indolent yet spreads to the formerly un...

Questions

Question (1)
Question
I'm looking for a solution which can be used both for reading data stored in a DICOM archive of treatment plans from different treatment planning systems and/or for managing data from multi-institutional studies. I know there are a couple of options out there but it would be great to hear about your experience.

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