Eva Bock

• University Hospital Essen

Background: The aim of this publication is to demonstrate similarities and differences in the association of risk factors with the prevalence of different manifestations of Chronic Venous Disease (CVD), like varicose veins (VV), venous oedema (C3) and severe Chronic Venous Insufficiency (CVI) in the population-based cross-sectional Bonn Vein Study...

Objective To assess the natural history of saphenous and non-saphenous varicose veins using the results of the Bonn Vein Studies and data published in literature. Methods We used the data of the Bonn Vein Studies (BVS) 1 and 2 to assess if preexisting non-saphenous varicose veins (NSVV) in persons who had no saphenous varicose veins (SVV) at baseli...

Background Trigeminal neuralgia is characterized by paroxysmal facial pain attacks. Adequate prophylactic drug therapy is often limited by the lack of efficacy and intolerance due to central nervous system side effects. Subcutaneous injections of botulinum toxin type A are a promising treatment option for patients with unsatisfactory response to dr...

The aim was to study the association between venous disorders and leg symptoms in the population based cross sectional Bonn Vein Study 1 (BVS1). A total of 1,350 men and 1,722 women aged 18-79 years were enrolled into BVS1. Chronic venous insufficiency (CVI), varicose veins (VVs), and clinical classes (C-classes/CEAP [Clinical, Etiological, Anatomi...

To investigate the long-term outcome of interdisciplinary treatment in a tertiary care neuro-otology institution after 2 years as part of the Dizziness and Vertigo Registry study. Risk factors associated with unfavourable outcome were assessed. 3113 consecutive patients with disorders of vertigo and dizziness were recruited prospectively between Ma...

We studied the association between stress intensity and headache frequency for tension-type headache (TTH), migraine and migraine with coexisting TTH (MigTTH). We studied a population-based sample of 5159 participants (21-71 years) who were asked quarterly between March 2010 and April 2012 about headache and stress. Log-linear regression in the fra...

Background: Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with refractory GIST. Methods: Foll...

Background: According to the WHO headache disorders are a public-health concern given the large amount of associated disability and financial costs to society. Headache disorders result in personal and societal burdens of pain, disability, damaged quality of life and high financial costs. However, evidence based knowledge about headache triggering...

Background: Despite the frequent use of medical compression stockings (MCS), reliable data are lacking on the frequency of MCS use and experience of patients with the treatment. Patients and methods: The Bonn Vein Study included 3,072 participants from the general population aged 18 to 79 years (1,350 men/1,722 women). Between 2007 and 2008 (Bon...

Different modes of ankle-brachial -index (ABI) calculation lead to different information. We looked for the peripheral arterial disease (PAD) prevalence estimated from ABI-high and ABI-low and analysed the effect of age and classical risk factors. Based on the Arteriomobil Project data, ABI was calculated considering the lowest of the four ankle ar...

The Benchmarking Project "National Register for Quality Control in Intensive Care Medicine" has so far been attended by 59 Intensive care units from the majority of those specialties practicing intensive care, with 127,872 patients and a total of 589.635 treatment days. The underlying idea was the revision of the "1999 core data set". The high dail...

Peripheral Arterial Disease in Germany is underestimated with regard to incidence and the consequences. In 1997 the Federal Association of the Peripheral Arterial Disease Self Help Groups started the Arteriomobil Project to increase the awareness for venous and arterial diseases in the general population. We report peripheral arterial disease (PAD)...

In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position. Multiple trauma patients of the intensive care units of two university hospitals were considered eligible if they met the criteria for acu...

Diseases of the venous system are among the most frequently occurring diseases in the German population. However, the last comprehensive population-based German data were obtained in 1979. Since then, diagnostic methods have improved substantially. Here, we examine the prevalence of venous diseases in women and their association with pregnancies an...

In a randomized trial the effect of a predefined strategy of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients with acute lung injury or acute respiratory distress syndrome. Patients in the prone group (n = 21) were continuously kept prone for at least 8 hours and a maximum of 24 hours per day. Pr...

Objective: The Bonn Vein Study to investigate the prevalence and severity of chronic venous disorders in the German urban and rural residential population was conducted with individuals aged between 18 and 79 years between 13. 11. 2000 and 15. 3. 2002. A total of 3072 persons took part. The overall response proportion was 59%. Results: A history of...

Zusammenfassung Ziel: Die Bonner Venenstudie zur Frage der Häufigkeit und Ausprägung von chronischen Venenkrankheiten in der städtischen und ländlichen deutschen Wohnbevölkerung im Alter von 18-79 Jahren fand zwischen dem 13. 11. 2000 und 15. 3. 2002 statt. Es nahmen insgesamt 3072 Probanden teil, die Response-Proportion lag insgesamt bei 59%. Erge...