Eva Alegre Cortés

Eva Alegre Cortés
Universidad de Extremadura | UNEX · Department of Biochemistry, Molecular Biology and Genetics

Biochemist
pHD. Investigating about the relation between endosomal-lysosomal-autophagy pathway and myotonic dystrophy type 1.

About

8
Publications
506
Reads
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14
Citations
Introduction
-Working in myotonic dystrophy and autophagy, lisosomal and endosomal pathway. -Cells cultures, PCR, Western Blot, Cytometry, inmunofluorescence.
Additional affiliations
October 2019 - present
Universidad de Extremadura
Position
  • Researcher
Description
  • I am doing my thesis in myotonic dystrophy type 1 and autophagy, lisosomal and endosomal pathway.
Education
September 2014 - July 2018
Universidad de Extremadura
Field of study
  • Science

Publications

Publications (8)
Article
Full-text available
Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative capacity, mitochondrial respiration, and energetic demands. This review focuses on the versatile role...
Article
Full-text available
KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1. Loss of KEAP1 leads to an accumulation of protein ubiquitin aggregates and defective autophagy. To better understand the role of KEAP1 in the degradati...
Article
Full-text available
Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effect...
Article
Full-text available
Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised in several diseases, including neurodegenerative disorders. Parkinson’s disease (PD) can be considered a multifactorial disease because environmental factors, genetic factors, and agin...
Article
Full-text available
Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. This neuronal loss, inherent to age, is related to exposure to environmental toxins and/or a genetic predisposition. PD-induced cell death has been studied thoroughly, but its characterization rem...
Poster
Increased reactive oxygen species (ROS) production during cryopreservation impairs sperm post-thaw quality. Our objective was to alleviate this oxidative burst supplementing a commercial canine sperm freezing extender with N-acetylcysteine (NAC). Ejaculates were collected from 6 healthy dogs and evaluated for concentration and total motility (> 70%...
Poster
The cauda epididymis is a good sperm source in case of an unexpected decease or castration. We aimed to elucidate if canine epididymal sperm is better preserved at 4°C within the epididymis or in an extender. Testicles were retrieved after neutering and one epididymis was dissected and cooled for 24 hours and the other was flushed, sperm were exten...

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