About
364
Publications
31,141
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
5,978
Citations
Introduction
Skills and Expertise
Additional affiliations
November 1994 - present
Publications
Publications (364)
Background/Objectives: To translate the OSD-6 questionnaire (6-item quality of life questionnaire for children with obstructive sleep disorders) to Spanish and analyze the reliability and validity of the Spanish version. Methods: We included children with obstructive sleep apnea (OSA). All underwent polysomnography before and after adenotonsillecto...
Sleep disorders that involve circadian rhythm disruption and sleep-disordered breathing (SDB) such as obstructive sleep apnea (OSA) are closely linked to respiratory infections. SDB leads to a proinflammatory state due to intermittent hypoxia, sleep fragmentation, increased oxidative stress, and elevation of inflammatory mediators such as tumor nec...
Pulmonary surfactant, the primary substance lining the epithelium of the human Lower Respiratory Tract (LRT), is rich in lipids, with dipalmitoyl-phosphatidylcholine (DPPC) being the most abundant. Although surfactants are known to have antifungal activity against some yeast species, the significant presence of species like Malassezia restricta in...
Rationale:
Although obstructive sleep apnea (OSA) is a prevalent condition among patients with acute coronary syndrome (ACS), the impact of OSA on cardiovascular event (CVE) recurrence is not homogeneous. We previously defined a specific phenotype of first-ACS patients without previous cardiovascular disease who are at increased risk of OSA-relate...
Interventional pulmonology can be helpful in cases of malignant airway stenosis. We present a 73-year-old man diagnosed with lung cancer who presented with symptomatic airway stenosis caused by a large endobronchial tumor. Oncological treatment was started with chemotherapy, radiotherapy, and a multimodality bronchoscopic approach using balloon bro...
Background: The objective of this study was to evaluate, the clinical benefit of benralizumab in patients with uncontrolled severe asthma associated with chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The study included patients with uncontrolled severe asthma associated with CRSwNP who started therapy with benralizumab. Pulmonary f...
Background: The objective of this study was to evaluate, the clinical benefit of benralizumab in patients with uncontrolled severe asthma associated with chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The study included patients with uncontrolled severe asthma associated with CRSwNP who started therapy with benralizumab. Pulmonary f...
Objectives: To analyze the characteristics of adult patients admitted for asthma exacerbation and determine optimization, treatment adherence, and follow-up in clinics.
Methods: Patients ≥ 18 years old admitted from May 2021 to June 2023 with a primary diagnosis of asthma exacerbation were included. Patients with a secondary diagnosis of asthma exa...
Pulmonary surfactant is the main substance that lines the epithelium of the human Lower Respiratory Tract (LRT). It has a high lipidic content, being dipalmitoyl-phosphatidylcholine (DPPC) the most abundant one. Although surfactants have a well-known antifungal activity for some yeast species, the important presence of species like Malassezia restr...
Study Objectives: Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS. Methods: In a post hoc analysis of the Pickwick trial, we...
Objective:
Patients with severe eosinophilic asthma experience high risk of exacerbations and reduced quality of life. Benralizumab, a monoclonal antibody binding to IL-5 receptor α subunit, is an approved drug for its treatment. The objective was to describe clinical remission after benralizumab prescription in routine clinical practice.
Methods...
Biliothorax is a rare but serious condition, as the presence of bile is damaging and can lead to empyema. Here, we report a case of a 51‐year‐old man recently diagnosed with unresectable cholangiocarcinoma, admitted to the hospital for malignant obstructive jaundice. After interventional management of biliary obstruction, the patient developed a si...
Background. Obstructive sleep apnea (OSA) has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.
Research Question. Are OSA and CPAP treatment independently associated with a poor prognosis for cutaneous melanoma?
Study Des...
Background:
Obstructive sleep apnea (OSA) has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.
Research question:
Are OSA and CPAP treatment independently associated with a poor prognosis for cutaneous melanoma?
Study...
Background:
To compare the clinical and polysomnographic features of obstructive sleep apnea (OSA) in children with adenotonsillar hypertrophy (Group A) and comorbidities (Group B).
Methods:
A five-year prospective study using nocturnal polysomnography before and after treatment.
Results:
We included 168 patients: 121 in Group A and 47 in Grou...
Background
Obstructive sleep apnea (OSA) is associated with a recurrent cardiovascular event (CVE) risk in patients with a first acute coronary syndrome (ACS). However, the pathological pathways by which OSA promotes this deleterious role are unknown. We aim to explore the proteomic profile associated with OSA that promote the recurrent CVE risk in...
Introduction
Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acu...
Rationale:
Obstructive sleep apnea (OSA) is prevalent in acute coronary syndrome (ACS) patients and is a cause of secondary hypertension.
Objective:
To explore the long-term effects of OSA and CPAP treatment on blood pressure (BP) in ACS patients.
Methods:
Post-hoc analysis of the ISAACC study included 1803 patients admitted for ACS (NCT013350...
In addition to recommendations for pharmacological treatment stratified for risk and phenotype, the new 2021 edition of the Spanish COPD Guidelines (GesEPOC 2021) proposes a personalized approach to treatable traits, defined as a characteristic (clinical, physiological, or biological) that can be identified by diagnostic tests or biomarkers, for wh...
The main aim of this international consensus document on obstructive sleep apnea is to provide guidelines based on a critical analysis of the latest literature to help health professionals make the best decisions in the care of adult patients with this disease. The expert working group was formed primarily of 17 scientific societies and 56 speciali...
Background:
Cutaneous metastasis (CM), while uncommon, is usually an indicator of poor prognosis. With cancer patients living longer, the incidence of CM has increased, which justifies its analysis.
Objectives:
The objective of this study was to carry out a descriptive study of CM diagnosed for 18 years in a dermatology department of a tertiary...
Study Objective. There is very limited information about the effect of continuous positive airway pressure (CPAP) in the very elderly. Here we aimed to analysed the effect of CPAP on a clinical cohort of patients with obstructive sleep apnea (OSA) ≥80 years old.
Methods. Post-hoc pooled analysis of 2 open-label, multicenter clinical trials aimed to...
Introduction
Little is known about adult asthma patients' perspective of their disease burden. This study aimed to obtain a comprehensive picture of patient needs, evaluate their knowledge, source of information, and perception of the severity of their asthma, and compare these variables between severe (SA) and non‐severe (NSA) asthma patients.
Me...
Study objectives:
Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.
Methods:
In a post-hoc analysis of the Pickwick trial,...
The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/j.arbres.2021.05.029. The duplicate article has therefore been withdrawn.
The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal
The main aim of this international consensus document on obstructive sleep apnea is to provide guidelines based on a critical analysis of the latest literature to help health professionals make the best decisions in the care of adult patients with this disease. The expert working group was formed primarily of 17 scientific societies and 56 speciali...
We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and...
Resumen
Los modelos de atención sanitaria actuales descritos en GesEPOC indican la mejor manera de hacer un diagnóstico correcto, la categorización de los pacientes, la adecuada selección de la estrategia terapéutica y el manejo y la prevención de las agudizaciones. Además, en la EPOC concurren diversos aspectos que resultan cruciales en una aproxi...
Resumen
La nueva edición de 2021 de la Guía Española de la EPOC (GesEPOC 2021) propone, junto al tratamiento farmacológico ajustado por estratificación de riesgo y fenotipo, el abordaje personalizado de los rasgos tratables, definidos como una característica (clínica, fisiológica o biológica) que se puede identificar mediante pruebas diagnósticas o...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with thrombotic phenomena in the early stages of the disease, but also, less frequently, with major bleeding between the second and third week after onset, particularly in patients treated with therapeutic anticoagulation. This article describes four cases of...
Some solid cancers (such as lung, breast, and esophageal cancer, and melanoma) can lead to pericardial effusion by metastatic spread, potentially provoking hemodynamic instability. Detection by echocardiography is therefore essential.
Pericardiocentesis can help restore cardiac function and provide fluid for establishing an etiology through cytolog...
RESUMEN Se trata de una forma infrecuente de infección por Ochrobactrum anthropi, de la que existen muy pocos casos comunicados en pacientes con bronquiectasias no debidas a fibrosis quística. En nuestro conocimiento, este sería el primer caso de bronquiectasias no debidas a fibrosis quística, asociadas a hipogammaglobulinemia, en el que se comunic...
Archivos de Bronconeumología 58 (2022) 228-236 w w w. a r c h b r o n c o n e u m o l. o r g
Rationale: Obesity hypoventilation syndrome (OHS) with concomitant severe obstructive sleep apnea (OSA) is treated with CPAP or noninvasive ventilation (NIV) during sleep. NIV is costlier, but may be advantageous because it provides ventilatory support. However, there are no long-term trials comparing these treatment modalities based on OHS severit...
El objetivo principal de este Documento Internacional de Consenso (DIC) sobre Apnea Obstructiva del Sueño es proporcionar unas directrices que permitan a los profesionales sanitarios tomar las mejores decisiones en la asistencia de los pacientes adultos con esta enfermedad según un resumen crítico de la literatura más actualizada. El grupo de traba...
Background. Some studies suggest a relationship between type 2 diabetes mellitus (T2DM) and increased incidence of melanoma. However, no studies have examined the relationship between T2DM and aggressiveness of cutaneous melanoma at diagnosis.
Objetives. To explore potential associations between T2DM, glycemic control and metformin treatment, with...
In conclusion, we found for the first time a positive relationship between a long duration of sleep and some markers of melanoma aggressiveness. Future studies are needed to investigate the main pathophysiological mechanisms that could explain this association and the prognostic relevance of this finding.
Consignas útiles para pacientes, convivientes, cuidadores, profesionales y empresas de Terapias Respiratorias Domiciliarias Recomendaciones del uso de la CPAP para tratar la apnea del sueño en tiempos de COVID-19
Unos 1.000 millones de personas tienen apnea obstructiva del sueño o AOS y unos 425 millones necesitarían tratarse con CPAP para poder c...
nLa aerosolterapia domiciliaria constituye el 10-14% de las terapias respiratorias domiciliarias. Permiteadministrar sustancias por vía inhalada mediante nebulizadores, alcanzando concentraciones superioresen el árbol bronquial, aunque con una gran variabilidad inter- e intraindividual, dependientes del tama˜node las partículas, la edad, el patrón...
Rationale Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent cardiovascular events in acute coronary syndrome (ACS) patients. This lack of homogeneity could suggest that the deleterious effect of OSA and its contribution to CVD could depend on specif...
The utility of home respiratory polygraphy (HRP) was assessed as an alternative to polysomnography (PSG) in the diagnosis of childhood obstructive sleep apnea syndrome (OSAS). PSG was indicated only in patients with concomitant disease or where HRP results were questionable. The follow-up period was 1 year. We recorded clinical and anthropometric d...
Foreign body aspiration is relatively infrequent in adults. Airway foreign bodies (AFBs) can be removed by flexible bronchoscopy (FB) or rigid bronchoscopy (RB). We performed a retrospective analysis of FBs performed in our centre over a 25 year period, focusing on the procedures that revealed an AFB during the examination stage. We recorded demogr...
Resumen
La aerosolterapia domiciliaria constituye 10-14% de las Terapias Respiratorias Domiciliarias. Permite administrar sustancias por vía inhalada mediante nebulizadores, alcanzando concentraciones superiores en el árbol bronquial, aunque con una gran variabilidad inter e intraindividual, dependientes del tamaño de las partículas, la edad, el pa...
Resumen
La problemática de la Apnea Obstructiva del Sueño (AOS), tiene un innegable impacto en la calidad de vida de las personas que lo sufren y es un potencial factor de riesgo que puede empeorar problemas de salud, pero en España apenas un 25% de los pacientes reciben tratamiento.
Se ha demostrado que los costes de salud de los pacientes que no...
RESUMEN
La ventilación mecánica a domicilio (VMD), presenta un objetivo claro; el tratamiento de la insuficiencia respiratoria crónica de pacientes en Fracaso ventilatorio crónico, impactando este tratamiento tanto en la calidad de vida como en la supervivencia de los pacientes. La idea motriz que en su día impulsó la habilitación de la VM en el do...
Background
Noninvasive ventilation (NIV) is an effective form of treatment in obesity hypoventilation syndrome (OHS) with severe obstructive sleep apnea (OSA). However, there is paucity of evidence in OHS patients without severe OSA phenotype.
Research questions
Is NIV effective in OHS without severe OSA phenotype?
Study design and methods
In thi...
We describe the case of a 93-year-old patient who was diagnosed with lymphoepithelial-type pleural mesothelioma, attributed to indirect exposure to asbestos fibers from washing her husband’s clothes, with a long latency period, reviewing occupational exposure to asbestos and its low incidence in women, more frequent in these cases due to indirect o...