Eugenio Santoro

Eugenio Santoro
Mario Negri Institute for Pharmacological Research | Mario Negri · Department of Epidemiology

About

130
Publications
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Publications

Publications (130)
Article
Full-text available
Investigating pediatric overweight and physical activity correlates is essential to design effective preventive programs. We used regional data (Lombardy, northern Italy) from the 2019 survey “OKKio alla Salute” (3093 children aged 8–9 years with measured anthropometric data), and from the 2018 wave of the “Health Behaviour in School-aged Children”...
Preprint
BACKGROUND The use of technology and social media among adolescents are an increasingly prevalent phenomenon. However, there is a paucity of evidence on the relationship between frequency of the use of electronic devices and social media and sleep-onset difficulties among the Italian population. OBJECTIVE The aim of this study is to investigate th...
Article
Background The use of technology and social media among adolescents is an increasingly prevalent phenomenon. However, there is a paucity of evidence on the relationship between frequency of use of electronic devices and social media and sleep-onset difficulties among the Italian population. Objective The aim of this study is to investigate the ass...
Article
The need to characterize and assess health apps has inspired a significant amount of research in the past years, in search for methods able to provide potential app users with relevant, meaningful knowledge. This article presents an overview of the recent literature in this field and categorizes - by discussing some specific examples - the various...
Article
Full-text available
Background: Technological tools such as Web-based social networks, telemedicine, apps, or wearable devices are becoming more widespread in health care like elsewhere. Although patients are the main users, for example, to monitor symptoms and clinical parameters or to communicate with the doctor, their perspective is seldom analyzed, and to the bes...
Preprint
BACKGROUND Technological tools such as Web-based social networks, telemedicine, apps, or wearable devices are becoming more widespread in health care like elsewhere. Although patients are the main users, for example, to monitor symptoms and clinical parameters or to communicate with the doctor, their perspective is seldom analyzed, and to the best...
Article
Data scientists and physicians are starting to use artificial intelligence (AI) even in the medical field in order to better understand the relationships among the huge amount of data coming from the great number of sources today available. Through the data interpretation methods made available by the recent AI tools, researchers and AI companies h...
Article
Full-text available
Pancreaticoduodenectomy (PD) is associated with high postoperative morbidity. The management of postoperative complications is paramount for reducing the mortality rate. The aim of this study was to evaluate the importance of surgical and hospital experience on outcomes by comparing postoperative results in three different hospitals with increasing...
Conference Paper
Obesity is now one of the most critical and demanding public health condition due to the correlation with many medical and psychological comorbidities, such as cardiovascular, orthopedic, pneumological, endocrinological, psychopathological complications, above all the type 2 diabetes. Obesity traditionally needs long and expensive treatments in a c...
Article
Full-text available
Background: Hepatocellular carcinoma (HCC) with or without underlying liver disease can be treated by surgical resection. The aim of this study was to evaluate the feasibility, morbidity and mortality of a laparoscopic approach in cirrhotic patients with HCC. Methods: From 2004 to September 2014, 90 patients underwent a laparoscopic liver resect...
Article
Full-text available
Limited, outdated, and poor quality data are available on the prevalence of tinnitus, particularly in Italy. A face-to-face survey was conducted in 2014 on 2,952 individuals, who represented the Italian population aged 18 or more (50.6 million). Any tinnitus was defined as the presence of ringing or buzzing in the ears lasting for at least 5 min in...
Article
Full-text available
Social media, online social networks and apps for smartphones and tablets are changing the way we communicate. According to a recent Pew Research Center survey, 73% of Internet users among US adults engage in social networking to access, create, and share contents (Duggan and Smith, 2013). The number of smartphone users is growing worldwide [56% of...
Article
Full-text available
Chronic diseases and conditions typically require long-term monitoring and treatment protocols both in traditional settings and in out-patient frameworks. The economic burden of chronic conditions is a key challenge and new and mobile technologies could offer good solutions. mHealth could be considered an evolution of eHealth and could be defined a...
Article
Social media, online social networks and apps for smartphones and tablets are changing the way to communicate health and health issues to consumers and health professionals. Google, Facebook, Apple, and other companies have launched tools to make easier the doctor-patient communication, to group patients with similar diseases allowing them to share...
Article
The role of Billroth I (BI) subtotal gastrectomy (SG) for gastric cancer (GC) remains controversial in Western countries. The aim of the study is to critically analyze the long term outcomes of this procedure in a large single-institution experience. Between 1990 and 2004, 158 patients underwent BI SG for GC at the Regina Elena Cancer Institute of...
Article
The cost effectiveness of early treatment with lisinopril in acute myocardial infarction (MI) was estimated using survival and cost data gathered prospectively during the hospitalisation of the overall population of patients enrolled in the third study of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto (GISSI-3), which assessed t...
Article
Full-text available
New media tools such as web 2.0 are increasingly being used in the medical field. RSS feeds, podcasts, blogs, wikis, online social networks and social media have all been proposed as innovative tools for the education and updating of clinicians, nurses, other health workers and medical students because of their ease of access and widespread use. Ne...
Article
Social media and medical apps for smartphones and tablets are changing health communication, education and care. This change involves physicians and other health care professionals which for their education, training and updating have started to follow public pages and profiles opened by medical journals and professional societies on the online soc...
Article
The aim of this study was to critically analyze the early and long-term results of a newborn liver transplantation (LTx) centre using piggyback technique (PT) without venovenous bypass and portocaval shunt in the era of extended criteria donors (ECDs). Between 2002 and 2010, a total of 229 LTx were performed in 225 patients, with the shortest as po...
Article
The features and tools of Web 2.0 are increasingly introduced and used in the medical field. RSS feeds, podcasts, blogs, online social networks, and social media are proposed as innovative tools for the education and update of clinicians, physicians, nurses, and medical students because of their easy and widespread use. Cardiology area is one of th...
Article
This study aimed to evaluate the early results of colorectal laparoscopic surgery with special attention to surgical and medical complications. The risk factors of such surgery are also investigated on the basis of a large series of operated cases: the preoperative knowledge of such factors could guide the operative program and the postoperative tr...
Article
Full-text available
BACKGROUND. If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. METHODS: Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countri...
Article
The Internet and the World Wide Web have been proposed as tools to improve medical and cardiovascular research. These new technologies have been mainly applied to large-scale clinical trials, with the development of clinical-trial websites. They include tools for the management of some aspects of clinical trials, such as the dissemination of inform...
Article
The surgical strategy for adenocarcinoma of the esophagogastric junction is still controversial. The aim of this study was to evaluate surgical results of the abdominal-transhiatal approach for 100 consecutively operated type II and III cardia adenocarcinoma, to clarify clinicopathological differences between these tumors, and to define prognostic...
Article
Full-text available
Solitary true cysts of the pancreas in adults are extremely rare and only few cases have been reported in the literature. The etiology and natural history of these lesions remain unknown and treatment is not standardized. We describe two additional resected cases. The first patient was a young woman with an incidental 3 cm cyst located in the pancr...
Book
Full-text available
Il corso per rappresentanti di associazioni di cittadini e pazienti organizzato ogni anno da Partecipasalute può contare ora su una dispensa che ne presenta i principali contenuti: dalla sperimentazione clinica all’informazione in medicina e sanità; dall’incertezza ai conflitti di interesse, ai comitati etici; da come funzio- nano le agenzie regola...
Article
Podcasting is a new technology tool for the automatic dissemination of audiovisual material to anyone with an Internet connection. For this and other reasons it is now proposed as a new service to educate and continuously update doctors, health professionals and medical students. International medical journals such as the New England Journal of Med...
Article
To describe the results and conclusions of DEC-net, an international, publicly available register of paediatric drug therapy clinical trials, and to assess which paediatric health areas are covered by research and by which trial types. The contents of the register, which was set up by four groups (Italy, UK, France, Spain) who searched for paediatr...
Article
The causes of death occurring in clinical trials of myocardial infarction (MI) are scarcely reported in the literature. The present analysis is aimed to describe the inhospital causes of death in patients with acute MI stratified to angiotensin converting enzyme (ACE) inhibitor treatment/no treatment, as described in the GISSI-3 trial. Furthermore,...
Article
The indications for a pancreatectomy with a partial resection of the portal or superior mesenteric vein for pancreatic cancer, when the vein is involved by the tumor, remain controversial. It can be assumed that when such involvement is not extensive, resection of the tumor and the involved venous segment, followed by venous reconstruction will ext...
Article
Full-text available
Liver Hanging Maneuver (LHM) provides better exposure of the deeper section plane together with Inferior Vena Cava (IVC) protection during right hepatectomies without primary liver mobilization. This study assessed the feasibility and complication rates of LHM focusing on the anatomical distribution of the accessory hepatic veins in the retrohepati...
Article
In the recent years, we have witnessed a new revolution in the field of communication through Internet. Web 2.0, whose contents are provided by the collaboration, discussion, and sharing between more users, is replacing the traditional web (the web 1.0). The use of podcasts, wikis, and blogs is rapidly increasing, and today they are proposed as edu...
Article
Full-text available
To define NGF (nerve growth factor) and its high-affinity receptor trkA(NGF) presence and distribution in fibrotic liver and in HCC, and to verify if NGF might have a role in fibrosis and HCC. Intracellular distribution of NGF and trkA(NGF) were assessed by immunohistochemistry and immuno-electron microscopy in liver specimens from HCC, cirrhosis o...
Article
Full-text available
Thermal neutron flux monitors were fabricated using chemical vapor deposited single crystal diamond in a p -type/intrinsic/metal/ <sup>6</sup> Li F layered structure. They were placed 80 cm above the core midplane of a 1 MW research fission reactor, where the maximum neutron flux is 2.2×10<sup>9</sup> neutrons / cm <sup>2</sup> s . Good stability a...
Article
The recent advances in liver surgery have made it possible to perform liver resections in an increasing number of patients with consequent improvement in the results. This coincides with an amplification of the indications to liver surgery for metastases. Besides the development of radiological procedures as applied to liver surgery and more effect...
Article
There is widespread recognition that clinical trials need to be registered. The only paediatric clinical trials register is based in Europe (www.dec-net.org). The register has been successful with 270 paediatric clinical trials registered. The register has been freely accessible to both health professionals and the public. Unfortunately this small...
Article
Myxoid liposarcoma (ML) has a high predilection for extrapulmonary sites of metastases, including intra-abdominal metastases, but pancreatic involvement is extremely rare. Here, we report the case of a 66-year-old male patient, who underwent pancreaticoduodenectomy for isolated pancreatic metastasis of ML of the left lower extremity that had been e...
Article
Intralesional massive haemorrhage responsible for inferior vena cava syndrome is a very rare complication of hepatocellular carcinoma. A 36-year-old man with no past medical history was referred to hospital for abdominal pain with clinical and biological signs of internal bleeding. An abdominal CT scan showed a huge right liver mass, with regular m...
Article
Intralesional massive haemorrhage responsible for inferior vena cava syndrome is a very rare complication of hepatocellular carcinoma. A 36-year-old man with no past medical history was referred to hospital for abdominal pain with clinical and biological signs of internal bleeding. An abdominal CT scan showed a huge right liver mass, with regular m...
Article
Full-text available
Clinical data management is a vital vehicle in medical research to ensure the integrity and quality of data used to take medical decisions. When applied to clinical trials or observational studies it must comply with several regulations and guidelines developed in recent years; these include general purpose national and international legislation fo...
Article
L’hémorragie intra-tumorale responsable d’un syndrome cave est une complication très rare des carcinomes hépatocellulaires. Un homme âgé de 36 ans, a été admis en urgence pour des douleurs abdominales associées à des signes cliniques et biologiques d’hémorragie. Une tomodensitométrie abdominale révélait une volumineuse masse du foie droit aux conto...
Article
The need to register a clinical trial in a public database has been widely discussed in the last few years. Several general clinical trial registers have been developed, but none are dedicated to children. A web-based register of trials on drug therapy in children was therefore developed. The general objective of the project, called DEC-NET (Europe...
Article
To evaluate the role of surgical treatment for isolated loco-regional recurrences of operated gastric adenocarcinoma. Among the 837 patients operated for gastric adenocarcinoma between December 1979 and April 2004, 713 (85%) underwent resection with curative intent. A retrospective review of a prospectively collected gastric cancer database was car...
Article
In locally advanced gastric carcinoma infiltrating adjacent organs, an extended resection including invaded organs is required to improve the prognosis. We retrospectively analyzed our experience with extended multiorgan resection (EMR) in patients with advanced gastric cancer. Between December 1979 and April 2004, 65 patients were resected for ext...
Article
We report a new case of benign solitary fibrous tumor (SFT) of the liver. A 65-year-old man presented to our unit with upper right abdominal discomfort. On examination abdominal distension was present and palpation showed a large firm mass in the right hypochondrium and epigastrium. The patient's past medical history was not significant and laborat...
Article
Full-text available
Laparoscopic surgery for gastric cancer (GC) was introduced in the past decade because it was considered less invasive than open surgery, resulting in less postoperative pain, faster recovery, and improved quality of life. Several studies have demonstrated the safety and feasibility of this procedure. We analyzed our preliminary experience with thi...
Article
Any new knowledge obtained from clinical research cannot easily be transferred to clinical practice for several reasons, including publication bias, lack of medical knowledge databases (or lack of their completeness), and lack of integration among these databases. Several initiatives have been launched to organize and combine scientific information...
Article
We report a case of drug-related toxicity after liver transplantation for hepatocellular carcinoma in a HIV-HCV co-infected patient. Before transplant the patient was on a triple antiretroviral therapy (zidovudine and lamivudine and efavirenz) with a stable CD4+ cell count >500 cells/microL. Liver transplantation was performed with a liver graft sh...
Article
The aim of this work was to study the feasibility and complication rates of liver hanging maneuvers: the Belghiti liver hanging maneuver (BLHM) in liver resection and the modified liver hanging maneuver (MLHM) in orthotopic liver transplantation (OLT) with inferior vena cava (IVC) preservation. From January 2001 to August 2003, BLHM was planned in...
Article
In the past few years, many Internet breast cancer resources have appeared, including medical journals and clinical trial registries. Examples of online breast cancer journals are the The Breast, The Breast Journal, and the Breast Cancer Research and Treatment. These have replicated the experience of general medical and cancer journals such as the...
Article
Liver transplantation for malignancies still remains a controversial issue. There is concern for tumour recurrence, poor results and waste of organs, which in the sitting of organ shortage would penalize patients with non-malignant disease. Many centers worldwide perform liver transplantation (OLT) for hepatocellular (HCC) carcinoma associated with...
Article
Delayed massive arterial hemorrhage from the operating field occurs in 1-4% of cases after pancreaticoduodenectomy, with a mortality rate up to 50%. The purpose of this study was to define diagnostic and treatment methodologies to maximize survival. Between 1990 and 1999, 84 pancreaticoduodenectomies were performed for periampullary and pancreatic...
Article
The aims of the study were to evaluate the performance of the Duke Treadmill Score (DTS) and the Veteran Affairs Medical Center Score (VAMCS) in predicting 6-month death in GISSI-2 study survivors of acute myocardial infarction treated with thrombolytic agents, and to develop a simple predictive scoring system from the same database. Patients of th...
Article
Many trials have proved the benefits of early systematic treatment with angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction (AMI). Pathophysiological studies, however, suggest potential harm in excessive reduction of blood pressure (BP) in hypertensive patients with ischemic heart disease. We analyzed data from the...
Article
Purpose of this study is to define the effectiveness of surgical resection of liver metastases from operated breast cancer. Nineteen patients underwent surgical exploration to resect liver metastases from previously operated breast carcinoma. Seventeen patients were resected: 15 patients had unique metastases and were submitted to a wedge liver res...
Article
We evaluated the prognostic relevance of the extent of myocardial injury, as measured by a standard electrocardiographic (ECG) method, on the patients' long-term prognosis, its time dependence and its relation to fibrinolytic therapy efficacy. Many clinical and instrumental variables influence the short- and long-term prognoses of patients with acu...
Article
Following the researches performed on lymphatic spread of gastric carcinoma, our study aimed to add useful informations to establish the extension of exeresis with radical intent on the basis of recent studies on sentinel node mapping. The study includes 120 consecutive cases of gastric cancer operated between 1996 and 2000. Sixty-nine (57.5%) male...
Article
The rapid advances in communication and information technology, and the deep impact on the daily life of everybody, both at the South and North of the world, have important implications for health care and medical education. However, the increase in sophisticated communication techniques has not always coincided with improved quality or a better ap...
Article
Despite the widely demonstrated association of reduced heart rate variability (HRV) to bad prognosis after myocardial infarction (MI), reference values for HRV parameters are still not available. The GISSI-3 Arrhythmias Substudy studied short-term HRV in a relatively unselected population of patients (324) with recent MI (13 +/- 7 days) providing t...
Article
There is little epidemiologic information from large multicenter databases on sustained monomorphic ventricular tachycardia occurring after the initial 48 hours of myocardial infarction. We reassessed its incidence and short-term prognosis in 16,842 patients with a definite myocardial infarction enrolled in the Gruppo Italiano per lo Studio della S...
Article
This study aims at assessing the specific effects of bidirectional filters (BF) and spectral filters (SF) on signal-averaged ECG (SAECG) analysis. The GISSI-3 Arrhythmias Substudy collected SAECGs of 598 patients 10 +/- 4 days after myocardial infarction (MI) from 20 Italian coronary care units. BF and SF were applied on 340 and 258 patients, respe...
Article
We sought to determine whether the clinical effects of early angiotensin-converting enzyme (ACE) inhibitor (ACEi) treatment for acute myocardial infarction (MI) are influenced by the concomitant use of aspirin (ASA). Aspirin and ACEi both reduce mortality when given early after MI. Aspirin inhibits the synthesis of vasodilating prostaglandins, and,...
Article
Aspirin (ASA) and angiotensin-converting enzyme inhibitor (ACEi) therapy reduce mortality when administered early after the onset of myocardial infarction. ASA can antagonize some effects of ACEi therapy by inhibiting the synthesis of vasodilating prostaglandins; however, the evidence for this effect from large controlled trials is contradictory. T...
Article
The efficacy of reperfusion therapy after acute myocardial infarction is time dependent. The risk profile of every patient should be available as soon as possible. Our aim was to determine whether collection of simple clinical markers at hospital admission might allow reliable risk stratification for in-hospital mortality. The subjects were 11,483...
Article
NegriWeb was born in 1995 and has quickly grown ever since. NegriWeb is a site open to physicians and researchers interested in the results of pharmacological research and to the public of those who want to keep informed on health related issues. NegriWeb counts more than 2,000 pages, consulted monthly by thousands of people all over the world. It...
Article
The Coordinating Centre (CC) of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI) used telecommunication technology to develop a computerized network system for the data management of the GISSI studies. Through a personal computer (PC), a communication program, a modem and a telephone line, the investigator in ea...