Euclides Nenga Manuel Sacomboio

• PHD
• Professor (Associate) at Agostinho Neto University

Background: the sickle cell anemia is a chronic disease, incurable, although treatable, the number of cases of sickle cell anemia in Angola is considered worrying, in Luanda and it is estimated that around 16,000 babies are born with anemia in Angola each year sickle cell disease. Objective: estimate the sickle cell trait and its relationship with...

Sexually transmitted infections (STIs) are a global health concern. Blood donation centres employ comprehensive screening measures to identify donors with STIs, such as HIV, HBV, HCV, and syphilis, which can also transmitted through blood transfusions. Herein, we investigated the seroprevalence of STIs and demographic determinants related to multip...

Introdução: A gravidez na adolescência é um problema global de saúde pública, com taxas mais elevadas na África Subsariana. Este fenómeno contribui para mortalidade materna e neonatal e pode ter diversas consequências económicas e psicológicas. O conhecimento dos seus determinantes pode ajudar os decisores políticos no desenho de políticas locais d...

Background Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola. Meth...

Background: Malaria continues a concern in Angola. Liver dysfunction is a relevant feature of malaria. There is no published study exploring liver function dynamics during P.falciparum infection in Angola.Objectives: We investigated the dynamics of liver function among patients with malaria in Luanda, Angola.Methods: This was a cross-sectional stud...

In the first six months of 2022, 4.2 million cases and 6,000 deaths were related to malaria in Angola. We investigated biosocial characteristics related to the parasitic levels among malaria patients from Luanda, Angola. Was a cross-sectional study with 206 malaria patients. Low(41.3%) and high(58.7%) were observed. High parasitemia were observed i...

The surveillance of drug resistance in the HIV-1 naïve population remains critical to optimizing the effectiveness of antiretroviral therapy (ART), mainly in the era of integrase strand transfer inhibitor (INSTI) regimens. Currently, there is no data regarding resistance to INSTI in Angola since Dolutegravir-DTG was included in the first-line ART r...

Background and Aim: This study aimed to describe the community pharmacies in the city of Malanje, focusing on staff, facilities and equipment, to propose actions that can be implemented to improve the quality of services, and consequently the safety of the population. A community pharmacy, sometimes referred to as a retail pharmacy, is the most pre...

Introduction Introduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In 2023, in the first quarter, 2,744,682 cases were registered, and of these 2,673 patients died due to malaria disease. Previous studies have shown that the ABO blood group can affect the progression of mal...

Besides the relationship with each other, forms of abuse are risk factors for the use of alcoholic beverages, early initiation of sexual activity, and early pregnancy. There are still gaps in the literature regarding maltreatment events in specific groups. This study aims to identify the relationship between physical violence and other forms of mis...

Background Diabetes is a chronic disease characterized by alterations in glucose, lipid, and protein metabolism, which can be identified by detecting high blood glucose levels. In this study we evaluated the frequency of ABO/Rh blood groups in patients with diabetes treated in Luanda, during the second half of 2020. Methods This was an observationa...

Background: Resistance to antimalarial drugs often used in emerging countries, including combination therapies, has forced scientists to search for and develop drugs with novel mechanisms of action, especially resistance to Plasmodium falciparum and Plasmodium vivax, which are highly prevalent in Southeast Asia, Africa, and South America. Objective...

Background: Resistance to antimalarial drugs often used in emerging countries, including combination therapies, has forced scientists to search for and develop drugs with novel mechanisms of action, especially resistance to Plasmodium falciparum and Plasmodium vivax, which are highly prevalent in Southeast Asia, Africa, and South America. Objective...

Tumor biomarkers have great potential in screening and their role could extend further from general population risk assessment to treatment response estimation and recurrence monitoring. Different molecular and cellular elements in blood, which give information about the status of an individual, make it a perfect compartment to develop noninvasive...

Background Sexually transmitted infections (STIs) are a global health concern. Blood donation centres employ comprehensive screening measures to identify donors with STIs, including HIV, HBV, HCV, and syphilis ensuring the safety of the donated blood and protecting the recipients. Herein, we investigated the seroprevalence of STIs and risk factors...

Background & objectives: Dengue caused by dengue virus (DENV) is the most widespread arbovirosis in the world. Around 100 million people are infected annually, causing a high economic burden for public health, especially in low- and middle-income countries. Herein, we investigate the sociodemographic characteristics and risk factors related to DENV...

Introduction: Malaria continues to be the main cause of hospitalization and death in Angola, a sub-Saharan African country. In 2023, in the first quarter, 2,744,682 cases were registered, and of these 2,673 patients died due to the malaria disease. Previous studies showed that the ABO blood group can affect the progression of malaria to serious sit...

Background and Aims SARS‐CoV‐2 infection is a public health concern. Several aspects related to the pattern of infection remain unclear. This study aimed to investigate the blood pressure pattern among blood donors exposed to SARS‐CoV‐2 in Luanda, Angola, a sub‐Saharan African country. Methods We performed a retrospective analysis containing 343 b...

Background and Aims Hypertension is a public health concern, mainly in resource‐limited countries. We investigated the characteristics and risk factors related to high blood pressure in healthy blood donors from, Luanda, the capital city of Angola. Methods This was a retrospective study that included 343 healthy donors from December 2019 to Septem...

HBV remains a public health concern. Blood donors screened for HBsAg along with AST/ALT could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola. This was a cross-sectional study conducted with 164 rejected donors. Donors were screened for HBsAg from March...

Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmodium falciparum malaria, the onset of life-threatening anemia is associated with acute kidney injury (AKI), i...

Background and Aims Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is a public health concern. Until 2021, more than 2 million cumulative deaths were reported worldwide. Herein, we investigated the immune profile of healthcare professionals 6 months after vaccination or exposure to SARS‐CoV‐2 in Angola. Methods This was a p...

Introduction: Data from UNAIDS in 2021 pointed out that in Angola the number of individuals living with HIV is about 320,000. The system is the most exclusive group polymorphism is associated worldwide and has infected P.falciparum, P.vivax, Candida, H.pylori, HIV, V.B19, and Influenza Virus.

Background and objectives: SARS-CoV-2 is a public health concern worldwide. Identification of biological factors that could influence transmission and worsen the disease has been the subject of extensive investigation. Herein, we investigate the impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, An...

Background and objectives: SARS-CoV-2 is a public health concern worldwide. Identification of biological factors that could influence transmission and worsen the disease has been the subject of extensive investigation. Herein, we investigate the impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angol...

Background Diabetes is a chronic disease characterized by alterations in glucose, lipid, and protein metabolism, which can be identified by detecting high blood glucose levels. In this study we evaluated the frequency of ABO/Rh blood groups in patients with diabetes treated in Luanda, during the second half of 2020. Methods This was an observationa...

Background Diabetes is a chronic disease characterized by alterations in glucose, lipid, and protein metabolism, which can be identified by detecting high blood glucose levels. In this study we evaluated the frequency of ABO/Rh blood groups in patients with diabetes treated in Luanda, during the second half of 2020. Methods This was an observationa...

Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 pa...

SARS-CoV-2 is a public health concern worldwide. Identification of biological factors that could influence transmission and worsen the disease has been the subject of extensive investigation. Herein, we investigate the impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola. This was a multicentric...

Background SARS-CoV-2 infection is a global public health concern. Several aspects related to the pattern of infection remain unclear. Herein, we investigated the blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, the capital city of Angola, a sub-Saharan African country. Methods We performed a retrospective analysis contai...

Hypertension is a public health concern, mainly in resource-limited countries. We investigated the characteristics and risk factors related to high blood pressure in healthy blood donors from Angola. This was a multicentre retrospective study that includes 343 donors from December 2019 to September 2020. Men represented 93% of the population. The m...

Introduction: Leprosy, caused by Mycobacterium leprae is one of the oldest infectious diseases in human history and its eradication is linked to poverty control, lack of basic sanitation, the fragility of health, and education services. Objective: To evaluate the frequency of blood groups (ABO/Rh) and the sociodemographic and clinical profile of An...

Background Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. Objective Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. Methodology A cross-sectional study with a quantitative approach. Results Of the 21...

Background Malaria is a public health problem, particularly in low- and middle-income countries. In Angola, it is the leading cause of death, morbidity, and absenteeism from work and school. Objective To evaluate the social and clinical factors associated with resistance to in-hospital treatment. Methodology A prospective analytical cross-section...

A community pharmacy, also known as a retail pharmacy, is the most common type of pharmacy that allows the public access to their medications and advice about their health. The conditions existing in the community pharmacy, as well as the qualification of the staff who work there, are fundamental for the compliance of good pharmacy practices. Objec...

Background: The global emergence of coronavirus disease 2019 (COVID-19) has challenged healthcare and rapidly spread over the globe. Early detection of new infections is crucial in the control of emerging diseases. Evidence of early recorded COVID-19 cases outside China has been documented in various countries. In this study, we aimed to identify...

Anemia is a clinical hallmark and independent risk factor of malaria caused by Plasmodium spp. infection. While it is known that anemia arises from parasite-induced hemolysis, whether and how host metabolic adaptation to malaria regulate anemia severity is less understood. Here we demonstrate that reprogramming of renal iron (Fe) metabolism is a ce...

Tuberculosis (TB) is a major cause of illness and public health concern, especially in resource-limited countries. This study analyzed the characteristics related to anti-TB drug resistance. Moreover, we examined the evidence-based indications for the treatment of active TB in Angola. This study evaluated the medical records of 176 patients screene...

RESUMO Objetivo: avaliar os fatores associados ao baixo Apgar em recém-nascidos de Angola.Método: estudo analítico e transversal, quali-quantitativo, em um Hospital Geral deLuanda, Angola, entre março e maio de 2021. Realizou-se entrevistas em sala deobservação e consulta aos prontuários das parturientes. Os dados foram analisados peloteste qui-qua...

Introduction: CKD is an important public health concern in SSA, the risk is generally strongly associated with traditional risk factors such as age and chronic diseases, such as diabetes and hypertension. Objective: investigate the relationship between ABO/Rh blood groups and clinical characteristics among patients with CKD in Luanda, Angola.

Introduction: The ABO system has been the subject of hundreds of publications, some reports suggest associations with gastric cancer, hepatitis B infection, selective cholera pressure, gastrointestinal infections, malaria, and other diseases, but few studies have shown a relationship between blood groups and genetic disorders. Objective: Determine...

SARS-CoV-2 emerged in China in December 2019, creating a massive public health concern. Although previous studies have identified SARS-CoV-2 in pregnant women, the possibility of transmission to newborns remains uncertain. Herein, we investigated SARS-CoV-2 infection and risk factors among parturients and newborns. This was a cross-sectional study...

The pathogenesis of acute kidney injury (AKI) in malaria is not yet fully understood, however, it is a well-known complication that occurs in 40% of patients with severe P. falciparum disease and can contribute to high mortality rates (around 75% of cases). The present study aimed to analyze whether vital signs can indicate AKI in patients with mal...

Co-epidemics happening simultaneously can generate a burden on healthcare systems. The co-occurrence of SARS-CoV-2 with vector-borne diseases (VBD), such as malaria and dengue in resource-limited settings represents an additional challenge to the healthcare systems. Herein, we assessed the coinfection rate between SARS-CoV-2 and VBD to highlight th...

Type O blood appears to be susceptible to the incidence and severity of cholera and diarrhoea, type B is common in Iceland and India, however, in Africa more than half of the population is type O. Preliminary data from studies developed by our team in Angola in 2020, to assess the frequency of blood groups and social conditions of hypertensive pa...

The global community is racing to slow down and eventually stop the spread of COVID-19, which is a pandemic that has killed thousands of lives and made tens of thousands sick. The new coronavirus has already reached Angola, with 25 confirmed cases, among them 2 died and 6 were cured. The government has decreed a state of emergency on 24 March 2020...

Introduction: Hypertension is a well-known clinical challenge worldwide, especially in low and middle-income countries. Previous studies have shown a relationship between sociodemographic characteristics and ABO/RH blood groups distribution with the increase in cases of hypertension. Objective: Herein, we evaluated the frequency of ABO/Rh blood gr...

Introduction: Malaria is the leading cause of death in Angola, followed by road accidents, and represents about 20% of hospitalizations in health facilities and about 35% of the demand for curative care. The objective of this study was to assess the effect of social and clinical conditions on the variation of blood pressure in hospitalized Angola...

Kidney disease is a global public health problem, affecting more than 750 million people worldwide, the magnitude and impact of kidney disease are better defined in developed countries, clinical evidence suggests that in developing countries like Angola, the impact may be greater. Objective: To verify the sociodemographic conditions of Angolan pati...

According to the National Malaria Control Program, from January to March of this year 2020, 2,065,673 cases and 2,548 deaths were recorded in Angola in 2019. To verify the uremic changes of patients with malaria according to their social and clinical conditions during a period of 5 days of hospitalization. The study was conducted as cross-sectional...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Background The incidence of Acute Kidney Injury (AKI) due malaria has increased and in low and middle-income countries with negative impact in the death and hospitalization. The aim of this study was to evaluate AKI incidence and effects of parasitemia levels in the kidney function of patients hospitalized with malaria in Josina Machel hospital fro...

Background Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. The aim of this study was to assess the diagnostic performance of salivary urea nitrogen (SUN) dipstick to detect and monitor kidn...

The NTR system is the major regulator of nitrogen metabolism in Bacteria. Despite its broad and well-known role in the assimilation, biosynthesis and recycling of nitrogenous molecules, little is known about its role in carbon metabolism. In this work, we present a new facet of the NTR system in the control of NADPH concentration and the biosynthes...

Título RELAÇAO ENTRE RESULTADOS DA FITA REAGENTE DE NITROGENIO UREICO SALIVAR E PH SALIVAR NA MONITORIZAÇAO DA FUNÇAO RENAL EM PACIENTES COM DRC EM HEMODIALISE EM ANGOLA Introdução A doença renal crônica (DRC) é considerada um problema de saúde pública em Angola. Devido à crise econômica que se instalou em Angola em 2009 as unidades de hemodiálise...

A disfunção renal aguda (DR-a) é uma complicação comum em pacientes acometidos por malária. Em locais de baixos recursos a presença DR-a nestes pacientes aumenta a morbimortalidade, devido a falta de métodos diagnósticos e de tratamento precoce. O objetivo deste estudo foi avaliar o desempenho diagnóstico da fita reagente de nitrogênio urêico saliv...