Ettore Lanzarone

Ettore Lanzarone
University of Bergamo | UNIBG · DIGIP

PhD

About

106
Publications
52,895
Reads
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1,073
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Introduction
Ettore Lanzarone is a tenure-track assistant professor (ricercatore di tipo B) at the Department of Management, Information and Production Engineering of the University of Bergamo, Dalmine (BG), Italy. He is also a research collaborator at the Institute for Applied Mathematics and Information Technology “E. Magenes” (IMATI) of the National Research Council of Italy (CNR), Milan, Italy, where he worked as a researcher from 2011 to 2020.
Additional affiliations
September 2012 - present
Politecnico di Milano
Position
  • Adjunt Professor of Mathematical Analysis
November 2011 - present
Italian National Research Council
Position
  • Researcher (Assistant Professor)
March 2008 - November 2011
Politecnico di Milano
Position
  • PostDoc Position
Education
March 2005 - February 2008
Politecnico di Milano
Field of study
  • Bioengineering
September 1998 - April 2004
Politecnico di Milano
Field of study
  • Bioengineering

Publications

Publications (106)
Article
Peripheral vasomotion, interstitial liquid exchange, and cardiovascular system behaviour are investigated by means of a lumped parameter model of the systemic and peripheral circulation, from the aortic valve to the venules. This modelling work aims at combining arterial tree hemodynamics description, active peripheral flow regulation, and fluid ex...
Article
Home Care includes medical, paramedical and social services which are delivered to patients at their domicile rather than in hospital. Managing human and material resources in Home Care services is a difficult task, as the provider has to deal with peculiar constraints (e.g., the continuity of care, which imposes that a patient is always cared for...
Article
In recent years, home care (HC) service systems have been developed as alternatives to conventional hospitalization. Many resources are involved in delivering HC service, including different categories of human resources, support staff, and material resources. One of the main issues encountered while planning human HC resources is the patient assig...
Chapter
Background: Effective communication is a key factor in healthcare, essential for improving process efficiency and quality of care. This is particularly true in new services, e.g., the 3D printing service inside the hospital. Objectives: A web platform, called 3DSCT, has been developed to act as an interface between the three categories of operat...
Article
Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes uncontrolled growth of fluid-filled cysts in the kidney. Kidney enlargement resulting from the expansion of cysts is continuous and often associated with decreased renal function and kidney failure. Mouse and rat models are necessary to discover new drugs able to halt the...
Article
Background Spinal cord ischemia (SCI) is still a feared complication for patients suffering from thoracoabdominal aortic aneurysm (TAAA) who undergo endovascular treatment. The aims of this work are to review the available literature on different reperfusion methods of the aneurysm sac, and to analyze whether the different reperfusion methods, also...
Article
Full-text available
Nowadays, manufacturing industries are increasing their interest in the energy-efficiency topic, mostly due to the major environmental impact of machining activities. Manufacturing processes sustainability can be improved by controlling machine state with energy-efficient control (EEC) policies that switch off/on the device. Recently, research demo...
Article
Full-text available
The Intra-Voxel Incoherent Motion (IVIM) model allows to estimate water diffusion and perfusion-related coefficients in biological tissues using diffusion weighted MR images. Among the available approaches to fit the IVIM bi-exponential decay, a segmented Bayesian algorithm with a Conditional Auto-Regressive (CAR) prior spatial regularization has b...
Article
Home health care (HHC) is a very popular service that plays an important role in reducing hospitalization costs and improving the quality of life for patients. Human resource planning is one of the most important processes in HHC facilities, and service providers must deal with several operational problems, e.g., the assignment of nurses to patient...
Article
Full-text available
Structural topology optimization (STO) is usually treated as a constrained minimization problem, which is iteratively addressed by solving the equilibrium equations for the problem under consideration. To reduce the computational effort, several reduced basis approaches that solve the equilibrium equations in a reduced space have been proposed. In...
Article
A fair prediction of energy consumption in machine tools is an essential requirement to optimize work cycles, processes and equipments also in the light of energy efficiency, as promoted by Industry 4.0. In this work, we focus on the energy behavior of machinery controlled rotary axes commanded by brushless electric motors, and propose a framework...
Article
Parameter uncertainty is common to several optimization problems, especially in health care where patients’ conditions and service times are highly uncertain. Moreover, in Home Health Care services, where patients are treated over a long time horizon, their clinical condition may change and result in uncertain but also highly time-correlated servic...
Article
Energy efficiency is becoming a key subject in manufacturing, especially if related to the major environmental impact of machining activities. Nowadays, great research efforts are performed to find new methodologies to improve sustainability of manufacturing processes. Energy consumption can be lowered controlling machine state during idle periods....
Article
Full-text available
Background and objectives: Healthcare systems require effective and efficient blood donation supply chains to provide an adequate amount of whole blood and blood components to hospitals and transfusion centres. However, some crucial steps of the chain, for example blood collection, are not adequately studied in the literature. This work analyses t...
Article
Full-text available
A new scheduling problem arising in the home care context is addressed, whose novelty with respect to the literature lies in the way overtime is paid. In this problem, some clients are willing to pay a higher fee to cover the additional overtime cost, if such overtime is incurred because a caregiver works extra time with the client to preserve cont...
Article
Objectives We analyze the cardiovascular risk factors in patients undergoing screening for Isolated Iliac Aneurysm (IIA) and Abdominal Aortic Aneurysm (AAA), and propose a logistic regression model to indicate patients at risk of IIA and/or AAA. Methods A screening program was carried out to identify the presence of aneurysm based on Duplex scan e...
Article
Home Health Care (HHC) human resource management is a complex process. Moreover, as patients are assisted for a long time, their demand for care evolves in terms of type and frequency of visits. Under continuity of care, this uncertain evolution must be considered even when scheduling the visits in the short-term, as the corresponding operator-to-p...
Article
Careful planning of an ambulance service is critical to reduce response times to emergency calls and make assistance more effective. However, the demand for emergency services is highly variable, and good prediction of the number of future emergency calls, and their spatial and temporal distribution, is challenging. In this work, we propose a Bayes...
Article
Full-text available
Blood is a key resource in all health care systems, usually drawn from voluntary donors. We focus on the operations management in blood collection centers, which is a key step to guarantee an adequate blood supply and a good quality of service to donors, by addressing the so-called Blood Donation Appointment Scheduling problem. Its goal is to emplo...
Article
Home care (HC) services represent an effective solution to face the health issues related to population aging. However, several scheduling problems arise in HC, and the providers must make several scheduling and routing decisions, e.g., the assignment of caregivers to clients, in order to balance operating costs and client satisfaction. Starting fr...
Article
Full-text available
Home health care (HHC) consists of care services provided to patients at their domicile rather than in hospitals or other health facilities. HHC human resources are largely studied in the optimization literature, to improve service quality and efficiency. However, the growth of complex HHC services that include the delivery of devices and disposabl...
Article
Computational and mathematical models are a must for the in silico analysis or design of Gene Regulatory Networks (GRN) as they offer a theoretical context to deeply address biological regulation. We have proposed a framework where models of network dynamics are expressed through a class of nonlinear and temporal multiscale Ordinary Differential Eq...
Chapter
We consider the management of a blood collection center, which includes the features of both a production system and a service provider. In particular, we analyze the scheduling of donors and the related appointment system, addressing the so-called Blood Donation Appointment Scheduling (BDAS) problem. From the production system viewpoint, the requi...
Article
This study addresses the Ambulance Location and Dispatching Problem (ALDP), which jointly determines the location of available ambulances and their dispatching policy. The latter takes the form of a dispatching list that defines, for each zone of the covered territory, an ordered list providing a hierarchy of ambulances to be chosen whenever a call...
Book
This book demonstrates how optimization, system engineering and statistics can help to improve health care provision and health systems. It gathers the proceedings of the Fourth International Conference on Health Care Systems Engineering (HCSE 2019), which was held in Montreal, Canada, from May 30 to June 1, 2019. The conference provided an opportu...
Article
The Intra‐Voxel Incoherent Motion (IVIM) model is largely adopted to estimate slow and fast diffusion coefficients of water molecules in biological tissues, which are used in cancer applications. The most reported fitting approach is a voxel‐wise segmented non‐linear least square, whereas Bayesian approaches with a direct fit, also considering spat...
Chapter
The Intra-Voxel Incoherent Motion (IVIM) model is largely adopted to estimate slow and fast diffusion parameters of water molecules in biological tissues, which are used as biomarkers for different diseases. However, the standard approach to obtain the maps of these parameters is based on a voxel-by-voxel estimation and neglects the spatial correla...
Article
Several deterministic models have been proposed in the literature to solve the machine loading problem (MLP), which considers a set of product types to be produced on a set of machines using a set of tool types, and determines the quantity of each product type to be produced at each time period and the corresponding machine tool loading configurati...
Chapter
Electrospinning is a versatile and promising technology for the production of polymer-based nanofibres. Composite nanofibres suitable for filtration of air and water have been developed by merging biopolymer processing and sol-gel techniques using electrospinning technology. A fine control of large-scale nanofibre formation is required to achieve r...
Chapter
Full-text available
The fabrication of personalised prostheses tailored on each patient is one of the major needs and key issues for the future of several surgical specialties. Moreover, the production of patient-specific anatomo-functional models for preoperative planning is an important requirement in the presence of tailored prostheses, as also the surgical treatme...
Article
Sustainable circular economy is introducing new industrial challenges, including recycling, to move from the cradle-to-grave paradigm to the innovative cradle-to-cradle concept. The core of several recycling systems consists of mechanical comminution, which aims at producing homogeneous mixtures of highly liberated particles. However, the complexit...
Article
We design and manufacture a silicone model of the human aorta, able to mimic both the geometrical and the mechanical properties of physiological individuals, with a specific focus on reproducing the compliance. In fact, while the models available in the literature exhibit an unrealistic compliant behavior, though they are detailed from the geometri...
Article
Computational and mathematical models have significantly contributed to the rapid progress in the study of gene regulatory networks (GRN), but researchers still lack a reliable model-based framework for computer-aided analysis and design. Such tool should both reveal the relation between network structure and dynamics and find parameter values and/...
Article
Hemodialysis is the most common therapy to treat renal insufficiency. However, notwithstanding the recent improvements, hemodialysis is still associated with a non-negligible rate of comorbidities, which could be reduced by customizing the treatment. Many differential compartment models have been developed to describe the mass balance of blood elec...
Article
Structural Topology Optimization optimizes the mechanical performance of a structure while satisfying some functional constraints. Nearly all approaches proposed in the literature are iterative, and the optimal solution is found by repeatedly solving a Finite Elements Analysis (FEA). It is thus clear that the bottleneck is the high computational ef...
Article
Three stakeholders are involved in health care services: patients, operators and service provider managers. They usually have conflicting needs: patients aim at obtaining good quality of service, operators require fair workloads, and managers try to reduce costs. Moreover, a fourth stakeholder, i.e., the contracting authority, pays for the service...
Article
Many optimisation problems arise in managing the Blood Donation (BD) supply chain. Most of them have been addressed in the literature, while other problems, e.g. donation scheduling, have not been sufficiently addressed so far. However, blood collection from donors may have a disruptive impact on the entire BD supply chain if not properly managed....
Article
Blood is fundamental in several care treatments and surgeries, and plays a crucial role in the health care system. It is a limited resource, as it can be produced only by donors and its shelf life is short; thus, the blood donation (BD) system aims at providing adequate supply of blood units to transfusion centers and hospitals. An effective collec...
Article
Biomedical tests play a crucial role in helping physicians to make accurate diagnoses. To perform these tests, thousands of samples are daily transported from several healthcare facilities, where they are collected from patients, to laboratories, where they are analyzed. We consider the challenging Biomedical Sample Transportation Problem (BSTP), w...
Article
Emergency Medical Services (EMS) are responsible of providing medical assistance to any person who requires it in case of emergency, with the main goal of reducing the response time. To do so, several management strategies have been proposed, e.g., districting and preassigned dispatching lists. However, districts are often a priori defined at the s...
Article
The use of advanced optimization-based techniques will be a fundamental step towards performance enhancement of flexible manufacturing plants. However, the mixed integer nature of the resulting optimization problems and the associated computational issues can represent a bottleneck and a severe limitation to their diffusion. This paper describes th...
Conference Paper
Full-text available
The Machine Loading Problem (MLP) refers to the allocation of operative tasks and tools to machines for the production of parts. Since the uncertainty of processing times might affect the quality of the solution, this paper proposes a robust formulation of an MLP, based on the cardinality-constrained approach, to evaluate the optimal solution in th...
Article
Goal: Ascending aorta aneurysms represent a severe life-threatening condition associated with asymptomatic risk of rupture. Prediction of aneurysm evolution and rupture is one of the hottest investigation topics in cardiovascular science, and the decision on when and whether to surgically operate is still an open question. We propose an approach f...
Article
Full-text available
Objectives Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. Methods Twenty porcine thoracic aortas were connected to a pulsatile mock loop system....
Data
Table with raw data on pulse wave velocity measurements per aortic specimen. Attached to: H.W.L. de Beaufort, M. Coda, M. Conti, T.M.J. van Bakel, F.J.H. Nauta, E. Lanzarone, F.L. Moll, J.A. van Herwaarden, F. Auricchio, S. Trimarchi. Changes in aortic pulse wave velocity of four thoracic aortic stent grafts in an ex vivo porcine model. PLoS ONE 20...
Article
Introduction: Predicting aortic growth in acute type B dissection is fundamental in planning interventions. Several factors are considered to be growth predictors in the literature and, among them, size and location of entry tears have been recognized to particularly influence the false lumen pressure. In this study, we develop an in vitro setting...
Article
Full-text available
Control interventions in sustainable pest management schemes are set according to the phenology and the population abundance of the pests. This information can be obtained using suitable mathematical models that describe the population dynamics based on individual life history responses to environmental conditions and resource availability. These r...
Conference Paper
Emergency Medical Services (EMS) systems aim to provide immediate care in case of emergency. A careful planning is a major prerequisite for the success of an EMS system, in particular to reduce the response time. Unfortunately, the demand for emergency services is highly variable and uncertainty should not be neglected while planning the activities...
Conference Paper
The nurse-to-patient assignment is one of the main decisions in planning Home Care (HC) services under continuity of care. In the literature, this problem has been tackled with several approaches to take demand variability into account. However, patient’s demands at different time periods have been always assumed as independent, while they are high...
Conference Paper
Home Health Care (HHC) is a relatively new service that plays an important role to reduce hospitalization costs and improve the life quality for patients. Human resource planning is one of the most important processes in HHC systems, for which service providers have to deal with several operational problems, e.g., the assignment of operators to pat...
Article
Electrospinning is affected by high variability, and an accurate setting of process parameters is fundamental for producing high quality nanofibers. This work aims at determining the optimal values of the main process parameters (polymer concentration, polymer feed rate, and voltage) as a function of the environmental factors (temperature and humid...
Conference Paper
Emergency Medical Service (EMS) systems aim at providing immediate medical care in case of emergency. A careful planning is a major prerequisite for the success of an EMS system, in particular to reduce the response time to emergency calls. Unfortunately, the demand for emergency services is highly variable and uncertainty should not be neglected w...
Conference Paper
Hemodialysis (HD) is nowadays the most common therapy to treat renal insufficiency. However, despite the improvements made in the last years, HD is still associated with a non-negligible rate of co-morbidities, which could be reduced by means of an appropriate treatment customization. Many differential multi-compartment models have been developed t...
Article
Nanoproducts represent a potential growing sector and nanofibrous materials are widely requested in industrial, medical and environmental applications. Unfortunately, the production processes at the nanoscale are difficult to control, and nanoproducts often exhibit localized defects that impair their functional properties. Therefore, defect detecti...
Book
Full-text available
Although animal locations gained via GPS, etc. are typically observed on a discrete time scale, movement models formulated in continuous time are preferable in order to avoid the struggles experienced in discrete time when faced with irregular observations or the prospect of comparing analyses on different time scales. A class of models able to emu...
Article
The uncertainty associated with patients’ demands and operators’ availabilities is the main complexity factor in planning health care activities. Thus, activity replanning is required to react to the variations and to guarantee a good service quality. A particularly complex replanning activity is required in Home Care (HC) services,where any variat...
Article
The estimation of uncertain future patient demands is a key factor for the appropriate planning of human and material resources in health care facilities, where unplanned demand variations may impact the quality of schedules and, consequently, of the provided services. This issue is even more important for health services that are provided outside...
Conference Paper
The admission of new patients to Home Care (HC) services is a relevant problem, which requires managing waiting lists while respecting a maximum admissible period between patient’s request and service beginning. In the literature, this problem is only marginally addressed when compared to other HC management issues, e.g., visit scheduling and patie...
Article
The great influence of uncertainties on the behavior of physical systems has always drawn attention to the importance of a stochastic approach to engineering problems. Accordingly, in this paper, we address the problem of solving a Finite Element analysis in the presence of uncertain parameters. We consider an approach in which several solutions of...
Article
Knowledge of the thermal conductivity is a key factor for several applications, which benefits from easy and cheap estimation procedures. We consider an existing experimental layout, and we propose a Rao-Blackwellized particle filter that jointly approximates the posterior distribution of the temperatures and analytically estimates the unknown ther...
Article
Home care providers are complex structures which include medical, paramedical and social services delivered to patients at their domicile. High randomness affects the service delivery, mainly in terms of unplanned changes in patients’ conditions, which make the amount of required visits highly uncertain. Hence, each reliable and robust resource pla...
Conference Paper
Home Care (HC) refers to nurse visits and other services provided at patients' homes rather than in hospitals or other health facilities. Planning human resources in HC is a complex activity, which includes several tasks and requires considering uncertain future patients' demands. We focus on the daily rescheduling of nurse visits in HC, for which...
Conference Paper
International standards often require complex experimental layouts to estimate the thermal conductivity of materials, and they marginally take into account the uncertainty in the estimation procedure. In this paper, we propose a particle filtering approach coupled with a simple experimental layout for the real-time estimation of the thermal conduct...
Conference Paper
Aortic diseases are one relevant cause of death inWestern countries. They involve significant alterations of the aortic wall tissue, with consequent changes in the stiffness, i.e., the capability of the vessel to vary its section secondary to blood pressure variations. In this paper, we propose a Bayesian approach to estimate the aortic stiffness a...
Conference Paper
Home care (HC) providers are complex structures which include medical, paramedical, and social services delivered to patients at their domicile. High randomness affects the service delivery, mainly in terms of unplanned changes in patients' conditions, which make the amount of required visits highly uncertain. In this paper, we propose a Bayesian m...
Conference Paper
A Rao-Blackwellized particle filter for estimating the behavioral parameter of the functional response and tracking the biomass of each population in a stochastic predator-prey system is presented in this paper. We consider a predator-prey model with a Lotka-Volterra functional response and small sets of field data. A first validation of the approa...
Conference Paper
Many approaches are applied to deal with uncertainty in health care optimization problems. However, a recently proposed technique, namely, the cardinality-constrained approach, is only marginally applied in health care. This approach accounts for a given degree of uncertainty with a reasonable computational effort, providing a trade-off between com...
Article
The degeneration of the vascular wall tissue induces a change of the arterial stiffness, i.e., the capability of the vessel to distend under the pulsatile haemodynamic load. In the literature the aortic stiffness is usually computed following a simple deterministic approach, in which only the maximum and the minimum values of arterial diameter and...
Article
International standards propose several methods for measuring thermal conductivity; however, they often require expensive experimental layouts and marginally consider the uncertainty in the estimation procedure. In this article, we propose a temperature transient method and a Bayesian procedure to estimate the thermal conductivity of a homogeneous...