Ethem Tankurt

Ethem Tankurt
Kent Hospital Izmir Turkey · Gastroenterology

MD, Professor

About

54
Publications
4,728
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812
Citations
Citations since 2016
0 Research Items
149 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530

Publications

Publications (54)
Article
Full-text available
Introduction: Helicobacter pylori (H. pylori) occurs throughout the world and causes gastroduodenal diseases. There is data indicating a change in the prevalence of H. pylori infection worldwide. The prevalence of H. pylori is 80% in Turkey, while it is higher in many developing countries, and the rate of infection varies throughout the world. In...
Article
Full-text available
To the Editor, Drug-induced esophageal injury is a common cause of esophageal diseases. Many drugs have beenreported to cause esophagitis and esophageal ulcers; among these are antibiotics such as doxycycline and tetracycline, nonsteroid anti-inflammatory drugs, aspirin, and potassium chloride (1). Isotretioin is a synthetic analogue of vitamin A a...
Article
Cinacalcet is a type II calcimimetic agent which is an allosteric modulator of the calcium-sensing receptor (CaR) located on the surface of the parathyroid cells. Cinacalcet increases the sensitivity of CaR via binding to the transmembrane region of CaR. Increasing sensitivity of CaR causes reduced secretion of parathyroid hormone (PTH) and suppres...
Article
Full-text available
This study was conducted to demonstrate the plasminogen activator inhibitor- 1 (PAI-1) and thrombin activatable fibrinolysis inhibitor antigen (TAFI-Ag) levels in non-alcoholic steatohepatitis (NASH). Twenty-seven patients with biopsy-proven NASH and 18 healthy controls (HC) were recruited for the study. Anthropometric data, liver histology (no.=20...
Article
Full-text available
Forty-eight hepatitis B virus (HBV) E antigen-negative chronic hepatitis B patients received pegylated interferon alfa-2b either alone or with lamivudine for 48 weeks and were followed for an additional 24 weeks. At the end of follow-up, virological response rates (HBV DNA levels of <400 copies/ml) were similar in the monotherapy (24%) and combinat...
Article
Objective: High serum levels of carboxy-terminal propeptide of Type 1 procollagen (PICP) were reported in patients with chronic viral hepatitis, alcoholic liver disease and cirrhosis as a marker of liver fibrosis. However, its status in nonalcoholic steatohepatitis (NASH) is uncertain. The aim of this study was to determine serum PICP levels in NAS...
Article
Mutations of hepatitis B virus (HBV) polymerase, especially occurring at the highly conserved YMDD region, are related to resistance to lamivudine. Although these mutations are frequently secondary to lamivudine use, they can also occur naturally. The aim of the present study was to determine the prevalence of YMDD variants that exist naturally in...
Article
The combination of hepatitis B immunoglobulin (HBIG) and antivirals (nucleos[t]ide analogs) has extended the applicability of orthotopic liver transplantation (OLT) for patients with hepatitis B virus (HBV)-related liver disease. However, HBIG administrations have an extremely high cost. Herein, we evaluated our results with low-dose, on-demand, in...
Article
Hepatotoxicity is a rare complication of paroxetine, a selective serotonin reuptake inhibitor. Regarded as safe in therapeutic use, there have been reports of cases of severe hepatic dysfunction with gross elevations of transaminase levels that may be related to this drug. We report here severe adverse cholestatic and hepatocellular injury in a pat...
Article
Full-text available
Carbohydrate antigen-125 (CA-125) is a tumor marker that has been used for differential diagnosis of peritoneal malignancies. The aim of the present study was to evaluate the diagnostic usefulness of simultaneous quantification of CA-125 in peritoneal fluid and serum for abdominal cancer cases and noncancer diseases. Noncancer disease group include...
Article
Full-text available
About a quarter of familial Mediterranean fever (FMF) patients are partially or totally resistant to colchicine. A previous observation reported that acute attacks may be shortened by administration of interferon alpha (IFN). We designed a double-blind, placebo-controlled trial to test our initial observations of a beneficial response with IFN in F...
Article
Leptin has recently been suggested to play a role in the pathogenesis of hepatic steatosis and steatohepatitis in the absence of viral infection. The aim of this study was to evaluate whether leptin levels are associated with hepatic steatosis in chronic hepatitis C. Thirty-one patients (22 female, 9 male, mean age: 51 +/- 9) with histologically pr...
Article
The aim of the present study was to investigate serum leptin levels in relation to anthropometric features in patients with liver cirrhosis (LC) and chronic viral hepatitis (CVH), and to determine the effect of the severity and aetiology of the LC on serum leptin levels. Forty-nine patients with LC, 32 patients with CVH and 69 control subjects were...
Article
Non-steroidal anti-inflammatory drug (NSAID) use has been closely associated with an increased risk of bleeding peptic ulcers, while the prevalence of Helicobacter pylori infection has been reported to be lower in bleeding ulcers than in non-bleeding ones. However, whether an interaction exists between NSAID use and H. pylori infection has not clea...
Article
Full-text available
Giriş ve Amaç: Kolorektal poliplerde gelişen erken invaziv kolorektal kanserlerin tedavisi tart›şmal›d›r. Bu çal›şman›n amac›, kliniğimizde saptanan ve tedavi edilen erken kolorektal kanserli olgular›n tedavi stratejilerini ve uzun süreli sonuçlar›n› değerlendirmektir. Gereç ve Yöntem: Bir y›l içinde Mart 1996-1997 tarihleri aras›nda hastanemizde r...
Article
Ursodeoxycholic acid (UDCA) has been shown to have hepatoprotective effects in various liver diseases. This drug has also been found to be effective in patients with nonalcoholic steatohepatitis, improving hepatic steatosis (HS) significantly. The aim of this study was to evaluate whether UDCA has an effect on both preventing and regressing HS in r...
Article
Full-text available
This report presents a hepatitis B surface antigen positive case presenting with acute hepatitis and with findings of low serum alanine aminotransferase in contrast to very high levels of aspartate aminotransferase. A 64 year-old female patient was admitted to our hospital with fatigue and jaundice. Hepatitis B surface antigen was positive. During...
Article
The contribution of hepatitis B, hepatitis C, and excess alcohol intake to the development of hepatocellular carcinoma in Turkey was assessed. The study was conducted through a questionnaire sent to seven major medical referral centers in different regions of Turkey and is based on 207 patients seen in the period 1994-1997. Of the seven centers, tw...
Article
Ursodeoxycholic acid (UDCA) has been shown to have hepatoprotective effects in various liver diseases. This drug has also been found to be effective in patients with nonalcoholic steatohepatitis, improving hepatic steatosis (HS) significantly. The aim of this study was to evaluate whether UDCA has an effect on both preventing and regressing HS in r...
Article
Insulin-like growth factor-I is a liver-derived humoral factor, which has important anabolic and metabolic actions and is predominantly bound by insulin-like growth factor binding protein-3. Low serum concentrations of both insulin-like growth factor-I and insulin-like growth factor binding protein-3 have been reported in patients with chronic live...
Article
Full-text available
Mirizzi's syndrome is a rare complication of long-standing cholelithiasis. Many surgical approaches of varying complexity have been advocated for treatment. However, the distorted extrahepatic biliary anatomy continues to be threatening, with a high risk of biliary complications. Presented here is a series of 25 patients with Mirizzi's syndrome who...
Article
Mirizzi's syndrome is a rare complication of long-standing cholelithiasis. Many surgical approaches of varying complexity have been advocated for treatment. However, the distorted extrahepatic biliary anatomy continues to be threatening, with a high risk of biliary complications. Presented here is a series of 25 patients with Mirizzi's syndrome who...
Article
We present the case of a 22 year-old man with biliary leakage caused by partial hepatectomy. He was successfully treated with endoscopic sphincterotomy alone.
Article
The aim of this study was to investigate the frequency of HBsAg/anti- HCV seropositivity and its association with risk factors in patients with extrahepatic malignancies. Ninety-eight patients diagnosed extrahepatic malignancies (56 female, 42 male, mean age: 52.1±13.7) and, as a control group, 76 patients who had no detected malignancy (49 female,...
Article
The clinical features of hepatitis C virus (HCV) infection and the distribution of HCV genotypes in 86 patients with chronic non-A, non-B (NANB) liver disease were examined in this study. The HCV infection was diagnosed using anti-HCV testing, and by the detection of HCV RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). HCV genotypes...
Article
Full-text available
About a quarter of familial Mediterranean fever (FMF) patients have recurrent painful attacks of polyserositis despite regular colchicine treatment. There is no known alternative drug for colchicine-resistant cases. We had previously observed a patient with FMF whose painful attacks disappeared during the 6 month period of interferon alpha (IFN) tr...
Article
Objective: This study aims to investigate surgical intervention as a risk factor for HCV infection. Methods: Eighty eight HCV positive cases and 182 HCV negative controls were compared with regards to history of operation and transfusion. Results: History of surgical intervention was present in 51 (57.9%) in case group and 78 (42.8%) in control gro...
Article
Full-text available
PAPsyst 60-55-50-45-40-35-30-[, 0 0 9 months Fio. 1.—Systolic pulmonary artery pressure (PAPsyst) in eight SSc patients before and after treatment with intermittent iloprost infusion for 6 months. #, patients with stationary PAPsyst (±5 mmHg); O. patients whose PAPsyst decreased > 5 mmHg.
Article
The mechanism of the contractile effect of domperidone on gallbladder smooth muscle has been investigated by using an in-vivo and an in-vitro model. In the in-vivo part of the study 14 healthy males were administered 20 mg domperidone or two placebo tablets orally and gallbladder emptying was measured by ultrasonography. The reduction in the gallbl...
Article
Although the histopathologic findings in chronic hepatitis infections have been extensively studied, there are few studies dealing with the proliferative activity. The aim of the study was to investigate the hepatocyte proliferative activity in chronic hepatitis (CH) B and C cases with reference to the Knodell score, and to compare the two groups w...
Article
Purpose: During the last decade the description of hepatitis C Virus chronic hepatitis and new hepatitis classification have brought new sights into hepatology. In this study biopsies from chronic Hepatitis C Virus hepatitis have been reexamined for disease stage, grade and descriptive histopathologic features. Also a comparison with hepatitis B vi...
Article
The mechanism(s) by which cholinergic innervation modulates gallbladder contraction are not fully understood. To elucidate the role of muscarinic M1 receptors in the mediation of gallbladder contraction, we investigated gallbladder volume reduction, plasma cholecystokinin (CCK), and pancreatic polypeptide (PP) responses in humans during cephalic an...
Article
Pirenzepine, an M1 muscarinic receptor antagonist, was tested for its ability to antagonize sham feeding- and intraduodenal fatty meal-stimulated gallbladder contraction in man. Intravenously administered pirenzepine abolished sham feeding-induced gallbladder contraction. Pirenzepine also inhibited contraction induced by intraduodenal meal, but thi...
Article
Calcium channel blockers have strong vasodilator, natriuretic and diuretic actions in normal and hypertensive subjects. The aim of this study was to evaluate the effect of diltiazem on renal function, renin-angiotensin-aldosterone axis (RAA) and atrial natriuretic factor (ANF) in patients with liver cirrhosis. Seven patients (3 females and 4 males)...
Article
The effect of pirenzepine on cholecystokinin (CCK)-stimulated gallbladder contraction in man was compared with that of atropine. Following pretreatment with atropine, pirenzepine or physiological saline in a random order, 6 healthy male volunteers were infused for 75 min with CCK-octapeptide in doses that are reported to mimic physiological plasma...

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