Esvieta Tenorio-Borroto

Universidad Autónoma del Estado de México (UAEM) ·  Centro de Investigación y Estudios Avanzados en Salud Animal

p> Background. Caseous lymphadenitis is a worldwide distribute disease that affects the sheep and goat industry. Corynebacterium pseudotuberculosis ovis is a facultative intracellular Gram-positive bacterium, considered the etiologic agent of the disease. Complete genome sequences of Mexican isolates have been obtained and different strain has been...

Objective. Determine risk factors for stroke in Young people under 45 years of age in the Toluca Valley. Methodology. Cross-sectional and correlational study. A questionnaire was applied to determine the risk factors for the cerebrovascular event in young adults. Two age groups of 18 to 32 and 33 to 45 years were compared, using a Mann Whitney U. S...

Aims: The present study aims to determine the phototoxic and haemolytic activity of organophosphorus. The use of alternative in vitro assays with human erythrocytes is suggested to predict the polluting effect of these products on health. Methodology: Human erythrocytes from Toluca Blood Bank were used. Sodium dodecyl sulfate was employed as a p...

Background: Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in ticks. Resistance to protein...

El objetivo de este estudio fue determinar la distribución sanguínea de linfocitos T CD4, CD8, LT γδ (WC1) en carneros infectados experimentalmente con Brucella ovis. Se utilizaron 18 carneros de 1 a 4 años y libres de B. ovis distribuidos en tres grupos: Control (n=6); Inoculado en las mucosas ocular y prepucial (n=6); Inoculados vía endovenosa (n...

ChEMBL biological activities prediction for 1-5-bromofur-2-il-2-bromo-2-nitroethene (G1) is a difficult task for cytokine immunotoxicity. The current study presents experimental results for G1 interaction with mouse Th1/Th2 and pro-inflammatory cytokines using a cytometry bead array (CBA). In the in vitro test of CBA, the results show no significan...

A total of 269 cows in small family herds in the central region of México from different municipalities of México State were studied. Composed milk samples were obtained to detect subclinical mastitis and S. aureus infection and for characterization of phenotypes as follows: biotypes, capsular exopolysaccharide 5 and 8, ORSA/MRSA and MRSA strains;...

The dairy products industry is going toward safe milk and its products in the food market. Milk quality and food safety concern in the consumers' health and nutrition in public health surveillance prevent food-borne diseases, food poisoning , and zoonosis risk by raw milk and fresh dairy products. The aim of this work is focused on milk microbial c...

Background and Introduction In the last decade, the harmful use of dioxin has been demonstrated in human health and in the whole environment. It is well known among scientists as 2, 3, 7, 8-tetrachloro dibenzo-p-dioxin (TCDD), is an environmental pollutant that causes endocrine disruption, which causes male reproductive toxicity. Objective The obj...

The efforts for the development and testing of vaccines against Trypanosoma cruzi infection have increased during the past years. We have designed a TcVac series of vaccines composed of T. cruzi derived, GPI-anchored membrane antigens. The TcVac vaccines have been shown to elicit humoral and cellular mediated immune responses and provide significant...

Drug-resistant Salmonella is frequently detected in most parts of the world, and its rate of resistance has increased significantly in recent years. However, this study aimed to evaluate the minimum inhibitory concentration (MIC, determined with the Kirby-Bauer method) of quinolones in 86 Salmonella spp. strains isolated from pigs. Both the inside...

In this work, we developed a general Perturbation Theory and Machine Learning (PTML) method for data mining of proteomes, in order to discover new B-cell epitopes useful for vaccine design. The method predicts the epitope activity εq(cqj) of one query peptide (q-peptide) in a set of experimental query conditions (cqj). The method uses as input the...

During Trypanosoma cruzi infection, oxidative stress is considered a contributing factor for dilated cardiomyopathy development. In this study, the effects of astaxanthin (ASTX) were evaluated as an alternative drug treatment for Chagas disease in a mouse model during the acute infection phase, given its anti-inflammatory, immunomodulating, and ant...

The development of vaccines against Chagas disease during the past years have provided a partial control of Trypanosoma cruzi infection. GPI-anchored T. cruzi genes are conserved in all T. cruzi life cycle stages and were tested as vaccine candidates in previous studies, they elicited humoral and cellular mediated immune responses and controlled pa...

Chagas disease, or American trypanosomiasis, is caused by Trypanosoma cruzi, a hemoflagellate Trypanosomatidae family parasite, widely distributed in the American tropics and subtropics. Cruzipain (Cz) is a crucial parasitic proteases belong to the papain-like CA C1 family and have close structural mammalian homologues and considered to be a good v...

Chagas disease is one of the most important in America transmitted by Trypanosoma cruzi diseases with approximately 7 million people at risk,most of them from latin american. Due the non availability of an ideal drug or treatment , development of an effective, and affordable vaccine could be a solution for control and prevention o f this disease. I...

Canine parvovirus type 2 (CPV-2) is the main etiological agent of viral enteritis in dogs. Actually in literature, CPV-2 has been reported with clinical signs that vary from the classical disease. In this study, we evaluated the clinical signs presented in 50 dogs infected naturally with CPV-2. All the infected dogs were analyzed by PCR and sequenc...

Background: The emergence of reduced susceptibility to fluoroquinolones among Salmonella enterica serotype Typhimurium isolates leading to clinical failure of treatment poses a great therapeutic challenge. Methods: The current study is focused on the evaluation of the minimum inhibitory concentration (MIC) of quinolones in 29 Salmonella Typhimur...

The present communication introduces a new classification model for fatty acids (FA) distribution networks in ruminal microbe membrane based on experimental and computational studies. In the experimental part, long chain fatty acids and volatile fatty acids in ruminal microbe membrane or liquid phase were investigated by supplementation of differen...

Unbalanced uptake of Omega 6 / Omega 3 (ω-6/ω-3) ratios could increase chronic disease occurrence, such as inflammation, atherosclerosis, or tumor proliferation etc., and the methylation methods for measuring the ruminal microbiome fatty acids (FA) composition/distribution play a vital role in discovering the contribution of food components to rumi...

The immune system has the essential function of protecting the body against the damaging effects of pathogenic microbial agents. The incidence of parasitic diseases, including respiratory helminthosis varies greatly from place to place depending on the relative importance of the factors. Several report the periods of high risk of infection by small...

The immune system helps to halt the infections caused by pathogenic microbial and parasitic agents. The ChEMBL database lists very large datasets of cytotoxicity of organic compounds but notably, a large number of compounds have unknown effects over molecular and cellular targets in the immune system. Flow Cytometry Analysis (FCA) is a very importa...

Quantitative StructureeActivity (mt-QSAR) techniques may become an important tool for prediction of cytotoxicity and High-throughput Screening (HTS) of drugs to rationalize drug discovery process. In this work, we train and validate by the first time mt-QSAR model using TOPS-MODE approach to calculate drug molecular descriptors and Linear Discrimin...

Quantitative Structure-Activity (mt-QSAR) techniques may become an important tool for prediction of cytotoxicity and High-throughput Screening (HTS) of drugs to rationalize drug discovery process. In this work, we train and validate by the first time mt-QSAR model using TOPS-MODE approach to calculate drug molecular descriptors and Linear Discrimin...

Entropy measures are universal parameters useful to codify biologically-relevant information in many systems. In our previous work, (González-Díaz, H., et al. Chem. Res. Toxicol. 2003, 16, 1318-1327), we introduced the molecular structure information indices called 3D-Markovian electronic delocalization entropies (3D-MEDNEs) to study the quantitati...

Bibliometric methods for analyzing and describing research output have been supported internationally by the establishment and operation of organizations such as the Institute for Scientific Information (ISI) or Scimago Ranking Institutions (SRI). This study provides an overview of the research performance of major World countries in the field cyto...

This study provides an overview of the research performance of the most developed countries in the area of computational and experimental immunotoxicity related to cytokines, flow cytometry bead assays and QSAR models. Some relevant journals and the most important academic institutions that publish them are also reviewed herein. The scientometric a...

Multiplexed biological assays provide multiple measurements of cellular parameters in the same test. In this work, we have trained and tested an Artificial Neural Network (ANN) model for the first time, in order to perform a multiplexing prediction of drugs effect on macrophage populations. In so doing, we have used the TOPS-MODE approach to calcul...

The application of 3D-MEDNEs as a novel alternative technique to reduce the use of animal experimentation in toxicology in the early stages of medicinal chemistry research has been extended from agranulocytosis to chemically induced eosinophilia. Firstly, a heterogeneous series of organic compounds, which are classified either as eosinophilia induc...

Most of present molecular descriptors just consider the molecular structure. In the present article we pretend extending the use of Markov chain models to define novel molecular descriptors, which consider in addition to molecular structure other parameters like target site or toxic effect. Specifically, this molecular descriptor takes into conside...

A novel approach to molecular negentropy from the point of view of Markov models is introduced. Stochastic negentropies (MEDNEs) are used to develop a linear discriminant analysis. The discriminant analysis produced a set of two discriminant functions, which gave rise to a very good separation of 93.38% of 151 chemicals (training series) into two g...

Se realizó la evaluación del posible efecto irritante de un formulado que se empleará como desodorante y que contiene como principio activo la hexamina, la cual es empleada como antiséptico urinario. Este formulado se aplicó por vía oftálmica en 6 conejos de la raza Nueva Zelandia durante 7 d. Las valoraciones se basan en las observaciones macroscó...

An evaluation of the possible irritant effect of a formulation (RLV) that will be used as a deodorant and whose active principle is hexamine, which is utilized as a urinary antiseptic, was made. This formulation was applied by ophthalmic route to 6 New Zealand breed rabbits during 7 days. The assessments take into consideration the macroscopic obse...