Estibaliz González de San Román Martín

Polymat · Polymerization processes group

We report the synthesis of a macrocyclic poly(ethylene oxide) (PEO) connected by one [Ru(bpy)3]2+ unit (where bpy = 2,2'-bipyridine), a photoactive metal complex that provides photosensitivity and potential biomedical applications to this polymer structure. The PEO chain provides biocompatibility, water solubility, and topological play. The macrocy...

Recent technical advances in mass spectrometry, as applied to the analytical chemistry of lipid molecules, enable the simultaneous detection of the multiplicity of lipid complex species present in the human brain. This, in combination with quantitative studies carried out in plasma samples, helps to identify disease biomarkers including for Alzheim...

B(C6F5)3 is a strong electrophilic catalyst that promote the ring-opening polymerization of a number of epoxides via the formation of zwitterionic growing chains. Cyclic chains frequently are the major component of the reaction, which makes this synthetic route a viable strategy for the generation of cyclic polyethers in large quantities. We presen...

When applied to the cationic polymerization of styrene, thiocarbonylthio compounds can lead to a dual control mechanism, where degenerative chain transfer occurs concurrent with a reversible addition mechanism.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations. Recently, the regulation of neurolipid-mediated signaling and cerebral lipid species was shown in AD patients. The triple transgenic mouse model (3xTg-AD), harboring βAPPSwe, PS1M146V, and tauP301L transgenes, mimics many...

A mathematical model of a thermally initiated thiol‐ene polymerization was developed and assessed with experimental data gathered in the polymerization of 2,2’‐(ethylenedioxy)diethanol (EDDT) as dithiol and diallyl adipate (DAA) as diene. The model considers the main mechanisms of addition (propagation) and chain transfer reactions by which the thi...

Composite Fenton nanocatalyst was prepared by water-based in situ creation of Fe3O4 nanoparticles integrated within the self-assembly 3D reduced graphene oxide (rGO) aerogel. The hybrid applied for the degradation of Acid Green 25 (AG-25) organic dye in an aqueous solution, in the presence of H2O2. By investigating the conditions that maximize the...

Taking advantage of the reversible Diels–Alder (DA) reaction, a simple strategy to obtain recyclable epoxy resins is presented. For this purpose, blends of furan‐functionalized and nonfunctionalized epoxy resin are prepared. After the addition of diamine and bismaleimide, blends are heated at 150 °C for 5 min, where the permanent amine/epoxy reacti...

β-pinene is a well-known bio-based monomer that can be polymerized via cationic polymerization to give low molecular weight resins that find use commercially as tackifiers. However, the controlled synthesis of these polymers by cationic polymerization is challenging due to the reactivity of commonly used Lewis acid catalysts and the propagating car...

Dipolar microstructure is a property related to the orientation of dipole moments along a polymer chain, which is dependent on how asymmetric monomers are oriented (i.e., regioorder). The control over the dipolar microstructure offers the possibility to monitor single-chain behavior in an electric field thus providing important structural and dynam...

The increasing amount of organic dye-polluted wastewater from the textile industry makes the development of techniques for the efficient purification and reuse of wastewater an urgent issue. Accordingly, solid adsorbents based on three-dimensional (3D) reduced graphene oxide (rGO) aerogels combined with magnetic nanoparticles (rGO@Fe3O4) appear to...

Lipidoak funtzio energetikoa eta egitura-funtzioez gain, deskribatu diren beste funtzioei esker garrantzitsuak bilakatzen ari dira. Funtzio neurotransmisorea edota neuromoduladorea aurkeztu duten lipidoen artean, lisofosfolipidoak aurki ditzakegu. Lisofosfolipidoak lipido molekula txiki bioaktiboak, karbonodun katea bakarra eta buru polar bat eduki...

3D monolithic integrated photocatlysts were prepared by self‐assembly of graphene platelets decorated with manganese doped TiO 2 nanoparticles. The self‐assembly was induced by chemical reduction at mild reaction conditions. The physico‐chemical properties of the photocatalysts were improved by addition of polymer nanoparticles within the 3D struct...

We introduce an approach to synthesize macrocyclic poly(ethylene oxide)s containing a pendant protected thiol group (pSH-CPEO), which is demonstrated to be able to attach to gold surfaces without prior deprotection. Our strategy is based on a bimolecular approach by which a di-alkyne molecule derived from thiol-protected 3-mercapto-1,2-propanediol...

Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lysophosphatidic acid (LPA) are ex...

Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver injury and the third most common reason for liver transplantations in Western countries. It is unclear so far how different fat sources in Western diets (WD) influence the development of NASH. Our study investigates the impact of non-trans fat (NTF) and corn oil (Corn) as fa...

Alzheimer’s disease (AD) is a neurodegenerative disorder leading to dementia. Aggregation of the amyloid-β peptide (Aβ) plays an important role in the disease, with Aβ oligomers representing the most toxic species. Previously, we have developed the Aβ oligomer eliminating therapeutic compound RD2 consisting solely of D-enantiomeric amino acid resid...

The primary visual cortex (area V1) is an extensively studied part of the cerebral cortex with well-characterized connectivity, cellular and molecular architecture and functions (for recent reviews see Amunts and Zilles, Neuron 88:1086–1107, 2015; Casagrande and Xu, Parallel visual pathways: a comparative perspective. The visual neurosciences, MIT...

Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting millions of patients worldwide. Previous studies have demonstrated alterations in the lipid composition of lipid extracts from plasma and brain samples of AD patients. However, there is no consensus regarding the qualitative and quantitative changes of lipids in brains fr...

Lipids not only constitute the primary component of cellular membranes and contribute to metabolism but also serve as intracellular signaling molecules and bind to specific membrane receptors to control cell proliferation, growth and convey neuroprotection. Over the last several decades, the development of new analytical techniques, such as imaging...

Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein-coupled receptors (GPCRs): LPA1 -LPA6 . LPA evokes several responses in the CNS including cortical development and folding, growth of the axonal cone and its retraction process. Those cell processes involve survival, migration, adhesion proliferation, differentiat...

Autoradiography is used to determine the anatomical distribution of biological molecules in human tissue and experimental animal models. This method is based on the analysis of the specific binding of radiolabeled compounds to locate neurotransmitter receptors or transporters in fresh frozen tissue slices. The anatomical resolution obtained by the...

The activity of CB1 cannabinoid receptors was studied in postmortem brain samples of Alzheimer's disease (AD) patients during clinical deterioration. CB1 activity was higher at earlier AD stages in limited hippocampal areas and internal layers of frontal cortex, but a decrease was observed at the advanced stages. The pattern of modification appears...