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Publications (14)
Nanocomposite solid polymer electrolytes (NSPEs) comprising lithium salt based on two representative sulfonylimide anions (i.e., bis(fluorosulfonyl)imide ([N(SO2F)2]⁻, FSI⁻) and bis(trifluoromethanesulfonyl)imide ([N(SO2CF3)2]⁻, TFSI⁻)) have been prepared by simply dissolving the corresponding lithium salt in poly(ethylene oxide) matrix in the pres...
Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation of six- and seven membered rings, providing an efficient route to fused...
Electrochemical energy storage is one of the main societal challenges to humankind in this century. The performances of classical Li-ion batteries (LIBs) with non-aqueous liquid electrolytes have made great advances in the past two decades, but the intrinsic instability of liquid electrolytes results in safety issues, and the energy density of the...
Asymmetric Mizoroki-Heck reaction is one of most important palladium(0)-catalyzed C-C bond-forming reactions, which has allowed the preparation of optically active molecules with tertiary and quaternary stereocenters. In particular, Heck-Heck cascade reactions are a powerful synthetic strategy for rapidly increasing structural and stereochemical co...
Different 2-alkenyl-substituted pyrroles and pyrrolidines are investigated as cyclization precursors: Pd sources, ligands (chiral and achiral), bases and solvents are tested to produce an optimal result concerning the required stereocenters.
Enantioselective intramolecular Heck–Heck cascade reactions have emerged as an excellent tool for the construction of polycyclic frameworks, such as lycorane alkaloids, xestoquinone and analogues. However, it is particularly difficult to rationalize the effect of simultaneous changes in both the structure of many molecular entities and experimental...
The generation of quaternary and tertiary stereocentres at C-10 of the pyrroloisoquinoline skeleton through intramolecular Mizoroki-Heck reactions of 2-alkenyl-substituted pyrroles and pyrrolidines has been studied. The cyclizations proceeded in moderate to good yields (up to 81 %), but with low enantioselectivity when chiral phosphanes such as (R)...
(Pyrrolo[1,2-a]benzazepinyl)acetamides, obtained through carbolithiation reactions, have been used as intermediates in the access to Apoerysopine skeleton. Derivatization implies reduction to the correponding aldehyde using the Snieckus procedure for in situ generation of the Schwartz reagent, followed by Wittig reaction and intramolecular Pd(II)-c...
Mizoroki-Heck reaction constitutes an effective method for the formation of quaternary stereocenters. This reaction has been applied to functionalized 2-alkenylpyrroles as substrates in which the b-elimination is blocked by a methyl substituent. 10,10-Disubstituted pyrrolo[1,2-b]isoquinolines can be obtained using different palladium catalysts and...
A rapid and efficient access to a wide variety of enantiomerically enriched C‐11b substituted lycorane analogues can be achieved via a catalytic asymmetric Heck–Heck 6‐ exo /6‐ endo cascade reaction in the presence of ( R )‐BINAP.
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A simple, flexible, and straightforward method for the functionalization of all the positions of the imidazole heterocycle through regioselective arylations, allylations, acylations, and additions to aldehydes is disclosed. Starting from the readily available key imidazole 1, highly functionalized imidazole derivatives have been synthesized in a re...
The intramolecular palladium‐catalyzed reaction of N ‐(iodoarylalkyl)pyrroles can be applied for the selective synthesis of medium‐sized rings by choosing the appropriate catalytic systems to direct the reaction to the alkene or to the pyrrole nucleus. These reactions can also be extended to the corresponding heteroaryl halides. Thus, reaction cond...
Eine einfache und flexible Methode für die selektive Funktionalisierung aller Positionen des Imidazolrings durch regioselektive Arylierungen, Allylierungen, Acylierungen und Additionen an Aldehyde ist entwickelt worden. Ausgehend von dem leicht herzustellenden Imidazol 1 konnten durch dirigierte Metallierungen und einen Sulfoxid-Magnesium-Austausch...
Mesityllithium (MesLi) was found to be superior to butyllithium for the formation of aryllithium intermediates by iodine–lithium exchange. Subsequent intramolecular carbolithiation of the 2-alkenyl-substituted ortho-lithiated N-benzylpyrroles proceeded efficiently when the alkene was substituted with an electron-withdrawing group. The procedure is...
