Ester Cerdeira Sabino

Ester Cerdeira Sabino
University of São Paulo | USP · Departamento de Moléstias Infecciosas e Parasitárias (FM) (São Paulo)

MD, PhD

About

827
Publications
80,227
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
14,082
Citations
Citations since 2016
415 Research Items
10376 Citations
201620172018201920202021202201,0002,0003,000
201620172018201920202021202201,0002,0003,000
201620172018201920202021202201,0002,0003,000
201620172018201920202021202201,0002,0003,000
Introduction
Ester Cerdeira Sabino currently works at the Departamento de Moléstias Infecciosas e Parasitárias (FM) (São Paulo), University of São Paulo. Ester does research in Infectious Diseases. Their current project is REDS III (blood safety) and SaMiTrop (Chagas Disease) and arbovirus (FAPESP ARBOBIOS PROJECT)
Additional affiliations
January 2010 - December 2010
January 1999 - present
Universidade de São Paulo
January 1998 - December 2011
Education
August 1991 - July 1993
University of California, Berkeley
Field of study
  • Molecular Biology
August 1989 - December 1994
Independent Researcher
Independent Researcher
Field of study
  • Immunology
February 1978 - December 1984
Independent Researcher
Independent Researcher
Field of study
  • Medicine

Publications

Publications (827)
Article
Full-text available
The ongoing COVID-19 pandemic caused a significant loss of human lives and a worldwide decline in quality of life. Treatment of COVID-19 patients is challenging, and specific treatments to reduce COVID-19 aggravation and mortality are still necessary. Here, we describe the discovery of a novel class of epiandrosterone steroidal compounds with catio...
Article
Full-text available
Background COVID-19 caused more than 622 thousand deaths in Brazil. The infection can be asymptomatic and cause mild symptoms, but it also can evolve into a severe disease and lead to death. It is difficult to predict which patients will develop severe disease. There are, in the literature, machine learning models capable of assisting diagnose and...
Article
Reducing the transmission of SARS-CoV-2 from asymptomatic and pre-symptomatic patients is critical in controlling the circulation of the virus. This study evaluated the prevalence of RT-PCR positivity in serial tests (every 20 days) in 429 asymptomatic health care workers (HCW) and its impact on absenteeism from May to August 2020. Asymptomatic HCW...
Article
Full-text available
Insect-specific viruses (ISVs) are viruses that replicate exclusively in arthropod cells. Many ISVs have been studied in mosquitoes as many of them act as vectors for human etiological agents, such as arboviruses. Aedes (Stegomyia) albopictus is an important potential vector of several arboviruses in Brazil, such as dengue (DENV), Zika (ZIKV) and c...
Article
Full-text available
Background: Chronic Chagas Cardiomyopathy (CCC) usually develops between 10 and 20 years after the first parasitic infection and is one of the leading causes of end-stage heart failure in Latin America. Despite the great inter-individual variability in CCC susceptibility (only 30% of infected individuals ever present CCC), there are no known predi...
Article
Objetivos O objetivo do estudo foi determinar a incidência de possíveis reinfecções por SARS-CoV-2 em doadores de sangue de um hemocentro público referência da Organização Pan-Americana de Saúde, localizado no estado de São Paulo. Material e Métodos O presente trabalho utilizou os dados de um estudo de coorte prospectivo, com a coleta de amostras...
Article
Objetivos A COVID-19 foi a doença que causou o quadro de pandemia, ocasionando diversos casos e óbitos ao longo do mundo. Uma estratégia para o tratamento de quadros graves da COVID-19 foi o uso de plasma convalescente, obtido de doadores convalescentes da doença, com alta produção de anticorpos, de forma a permitir a neutralização do vírus e melho...
Article
Introduction Vaso-occlusive painful episodes (VOE) are the most common clinical manifestation of sickle cell disease (SCD) and the primary reason for hospitalizations and emergency visits. Objectives This project aims to identify the clinical predictors of VOE hospitalization in adult participants of the Recipient Epidemiology and Donor Evaluation...
Article
Background and aims High consumption of ultra-processed food (UPF) has been associated with increased risk of obesity and other metabolic diseases, and this dietary pattern seems to be responsible for chronic changes in the gut microbiota. The aim of this study was to assess the associations of UPF with the gut microbiota and obesity-associated bio...
Article
Full-text available
COVID-19 disease is spread worldwide and diagnostic techniques have been studied in order to contain the pandemic. Immunochromatographic (IC) assays are feasible and a low-cost alternative especially in low and middle-income countries, which lack structure to perform certain diagnostic techniques. Here we evaluate the sensitivity and specificity of...
Article
Full-text available
Background Despite their worldwide occurrence, the distribution and role of insect-specific flaviviruses (ISFs) remain unclear. Methods We evaluated the presence of ISFs in mosquitoes collected in São Paulo, Brazil, using reverse transcription and semi-nested polymerase chain reaction (PCR). Some of the positive samples were subjected to nanopore...
Article
Full-text available
In this prospective cohort of 30 vaccinated healthcare-workers with mild Omicron variant infection, we evaluated viral culture, rapid antigen test(RAT), and RT-PCR of respiratory samples at days 5,7,10, and 14. Viral culture was positive in 46%(11/24) and 20%(6/30) of samples at days 5 and 7, respectively. RAT and RT-PCR(Ct≤35) showed 100% negative...
Article
Full-text available
Background: The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Understanding these patterns is crucial to understand future outbreaks of SARS-CoV-2 or other respiratory pathogens in the country. Methods: We tested 97,950 blood donation samples for IgG antibodies from March 2020 to Marc...
Article
Full-text available
Objectives Analyze the hospitalizations of patients admitted for Chagas disease with gastro-intestinal involvement (CD-GI) in the Brazilian Unified Health System, describe the epidemiological profile, mortality and costs. Methods This is an observational study that uses secondary data from the National Hospital Information System (SIH-SUS) for the...
Article
Full-text available
This study aimed to assess the prevalence of non-use of health services in the last year by people with Chagas disease (CD) in an endemic area in Brazil and the contextual and individual factors associated with this non-use. This is a multilevel study that considered contextual and individual data. Contextual data were collected from official publi...
Article
We describe monkeypox virus (MPXV) transmission from a patient to a healthcare worker through needlestick injury. A lesion appeared at the inoculation site 5 days after injury. Blood tested MPXV-positive by PCR before symptoms worsened; blood remained MPXV-positive at discharge 19 days after symptom onset. Postexposure prophylaxis could prevent pot...
Article
Full-text available
Background: Obesity is one of the main health problems in the world today, and dysbiosis seems to be one of the factors involved. The aim of this study was to examine the impact of synbiotic supplementation on obesity and the microbiota in ob/ob mice. Twenty animals were divided into four groups: obese treated (OT), obese control (OC), lean treate...
Article
Full-text available
In 2022, an outbreak of monkeypox is being reported in non-endemic areas, with unusual clinical manifestations. The detailed clinical description of the first patient that received the diagnosis of monkeypox in Brazil is reported here, whose clinical manifestations can easily lead to misdiagnosis of sexually transmitted infections. A 41 years old m...
Article
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, is the causative agent of the coronavirus disease 2019 (COVID-19). Since its first notification in São Paulo state (SP) on 26th February 2020, more than 22,300,000 cases and 619,000 deaths were reported in Brazil. In early pandemic, SARS-CoV-2 spread...
Article
Introdução Bactérias gram-negativas são importantes agentes de Infecções Relacionadas a Assistência à Saúde (IRAS), sendo a Klebsiella pneumoniae responsável por 16,9% das infecções de corrente sanguínea no Brasil. É um agente oportunista que ao longo dos anos vem adquirindo inúmeros mecanismos de resistência, sendo a resistência a carbapenêmicos o...
Article
Introdução A infecção pelo vírus da hepatite C (HCV) é um importante problema de saúde associado a uma elevada morbimortalidade. No entanto, entre indivíduos coinfectados pelo HCV e pelo vírus da imunodeficiência humana (HIV), estudos sobre mortalidade por causas não hepáticas demonstraram resultados inconsistentes. Objetivo Investigar a contribui...
Article
Introdução A resistência aos antibióticos é considerada uma ameaça global à saúde humana e, sua disseminação ambiental é bem reconhecida. Os aglomerados subnormais, comumente conhecidos como “favelas”, podem ser reservatórios de bactérias resistentes a antibióticos (ARB) e genes de resistência (ARGs). Objetivo Este estudo visa i) explorar a ocorrê...
Article
Introdução A variante Ômicron do vírus SARS-CoV-2 (B.1.1.529) foi designada uma variante preocupante (VOC) devido à alta transmissibilidade e capacidade de escapar da imunidade natural e induzida por vacina. Objetivo Caracterizar a duração da infectividade da variante Ômicron em indivíduos vacinados com sintomas leves de COVID-19. Método Estudo t...
Article
Introdução O vírus da dengue (DENV) é o arbovírus de maior relevância global. Classificado como flavivírus, família Flaviviridae, é um vírus de RNA fita simples e sentido positivo. O DENV é o agente etiológico da febre da dengue, apresentação sintomática caracterizada por febre, cefaléia, mialgia, artralgia e náusea. O DENV é dividido em 4 sorotipo...
Article
Introdução A hesitação a vacinas é uma tendência crescente que tem sido associada à redução das coberturas vacinais e ao ressurgimento de doenças imunopreveníveis. Além disso, dentre as crianças com vacinação completa, a imunogenicidade da vacina, é inferior a 100%. Diferentes fatores são associados à soroconversão vacinal, variando de acordo com o...
Article
Introdução A elucidação dos preditores de proteção contra infecção pelo SARS-CoV-2 após a vacinação contra o mesmo pode auxiliar no controle da pandemia. Objetivo Identificar fatores de proteção contra infecção por SARS-CoV-2 após recebimento de duas doses de CoronaVac. Método Trata-se de uma coorte prospectiva de profissionais de saúde (PS) do H...
Article
Introdução O sequenciamento de genoma viral, projeções e visualizações por meio de modelos matemáticos, estatísticos e computacionais permitem acompanhar a disseminação de doenças infecciosas como a causada pela infecção pelo vírus SARS-CoV-2, a COVID-19. O monitoramento ativo e contínuo da evolução epidemiológica depende diretamente da vigilância...
Article
Full-text available
Background: Optimal COVID-19 management is still undefined. In this complicated scenario, the construction of a computational model capable of extracting information from electronic medical records, correlating signs, symptoms and medical prescriptions, could improve patient management/prognosis. Methods: The aim of this study is to investigate...
Article
Full-text available
SARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants, which nears 100% in many settings. New approaches are required to fully exploit serosurvey data. Using a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained a semi-quantitative measurement of population...
Preprint
Full-text available
Zoonotic viruses that originate in wildlife harm global human health and economic prosperity. Understanding virus transmission at the human-animal-environment interface is a key component of pandemic risk-reduction. Zoonotic disease emergence is highest in biodiverse, tropical forests undergoing intensive land-use change. Phylodynamic analyses of v...
Preprint
Full-text available
Background: Ischemic stroke is a common complication of sickle cell disease (SCD) and without screening or intervention can affect 11% of children with SCD before the age of 20. This study sought to find genetic biomarkers for risk of stroke occurring at younger ages. Methods: Within the Trans-Omics for Precision Medicine (TOPMed), a genome-wide as...
Preprint
Full-text available
Chikungunya virus (CHIKV) is an Aedes mosquito-borne virus that has caused explosive epidemics linked to acute, chronic, and severe clinical outcomes. Since 2014, Brazil has had the highest number of chikungunya fever (CHIKF) cases in the Americas. Here, we report and contextualize the spatiotemporal dynamic of CHIKF in Brazil and combine genomic,...
Article
Full-text available
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known meta...
Article
Full-text available
Cardiomyopathy is a major cause of death in Chagas disease and early detection of cardiac involvement is essential. Myocardial strain is a reliable technique for assessment of subtle left ventricular (LV) contractility alterations. This study assessed LV global longitudinal strain (GLS) in a large Chagas disease population living in remote areas. B...
Article
Full-text available
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant of concern has spread rapidly across Brazil since late 2020, causing substantial infection and death waves. Here we used individual-level patient records after hospitalization with suspected or confirmed coronavirus disease 2019 (COVID-19) between 20 January 2020 and 26...
Article
Full-text available
Chagas disease (CD) is recognized by the World Health Organization as one of the thirteen most neglected tropical diseases in the world. Self-perceived health is considered a better predictor of mortality than objective measures of health status, and the context in which one lives influences this predictor. This study aimed to evaluate the prevalen...
Article
Full-text available
Dengue infection is the most prevalent arthropod-borne viral disease in subtropical and tropical regions, whose primary vector is Aedes aegypti mosquitoes. The mechanisms of dengue virus (DENV) pathogenesis are little understood because we have no good disease models. Only humans develop symptoms (dengue fever, DF, or dengue hemorrhagic fever, DHF)...
Article
Manifestations of sickle cell disease (SCD) begin early in childhood and cause morbidity and decreased life expectancy. Hematopoietic stem cell transplantation (HSCT) is curative but associated with risk of mortality attributable to the transplant. This risk should be counterbalanced with SCD morbidity and mortality. A severity score using a Bayesi...
Article
Full-text available
Chagas disease is a tropical zoonosis caused by Trypanosoma cruzi. After infection, the host present an acute phase, usually asymptomatic, in which an extensive parasite proliferation and intense innate immune activity occurs, followed by a chronic phase, characterized by low parasitemia and development of specific immunity. Most individuals in the...
Article
O SaMi-Trop é um estudo de coorte que acompanha pacientes com doença de Chagas, desenvolvido em 21 municípios endêmicos. Objetivo: Realizar o consolidado das publicações produzidas pela coorte. Metodologia: Trata-se de uma revisão narrativa dos artigos publicados com dados da coorte. Resultados: Foram identificados 18 estudos, sendo 17 publicados e...
Article
Full-text available
Monkeypox virus (MPXV), a zoonotic virus endemic to the African continent, has been reported in 33 non-endemic countries since May 2022. We report an almost complete genome of the first confirmed case of MPXV in Brazil. Shotgun metagenomic sequencing was completed in 18 hours, from DNA extraction to consensus sequence generation. Viral metagenomics...
Article
Full-text available
SARS-Cov2 has already infected over 482 million people and caused more than 6.1 million deaths. The beginning of the pandemic has led the health authorities of several countries to adopt non-pharmacological preventive measures such as daycare closures. The reopening took place when the country had the highest rates of infection and mortality (mainl...
Article
Full-text available
Introduction Mosquitoes (Diptera: Culicidae) are vectors that transmit numerous pathogens to humans and other vertebrates. Haemagogus leucocelaenus is a mosquito associated with transmission of yellow fever virus. The insect gut harbors a variety of microorganisms that can live and multiply within it, thus contributing to digestion, nutrition, and...
Preprint
Background SARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants which nears 100% in many settings. New analytic approaches are required to exploit the full information in serosurvey data. Method Using a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained...
Article
Full-text available
Objectives: The aim of the present study was to evaluate if neutralizing antibody responses induced by infection with the SARS-CoV-2 strain that was dominant at the beginning of the pandemic or by the Gamma variant was effective against the Omicron variant. Methods: Convalescent sera from 109 individuals, never exposed to a SARS-CoV-2 vaccine, w...
Article
Background: Except for public health case reports, the incidence of Zika virus (ZIKV), chikungunya virus (CHIKV) and dengue virus (DENV) infection are not available to assess the potential blood transfusion safety threat in Brazil. Methods: Pools of 6 donation samples (MP6) left over from HIV, HBV, and HCV nucleic acid testing were combined to c...
Article
Full-text available
Objectives To determine the incidence and risk of adverse obstetric and neonatal outcomes according to SARS-CoV-2 infection severity in pregnant women. Method Open prospective study of pregnant women tested for SARS-CoV-2 by serological and molecular assays during pregnancy or delivery in two hospitals in Sao Paulo, Brazil from April 12, 2020, to...
Article
Full-text available
Infections caused by multidrug-resistant A. baumannii are a worldwide health concern with high mortality rates. Rapid identification of this infectious agent is critical as it can easily spread with difficult or no options for treatment. In this context, the development of reliable and economically viable detection and therapeutic methodologies are...
Article
Full-text available
Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study...
Preprint
Full-text available
Antimicrobial resistance has grown exponentially in the last decade and become a global health threat. The antibiotic resistance crisis has guided the scientific community to explore non-conventional interventions to target resistant bacteria. Development of new technologies, such as aptamers-based treatment and diagnosis, has shown to be promising...
Article
Full-text available
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essent...
Article
Despite substantial morbidity and mortality, no therapeutic agents exist for treatment of dengue or Zika, and the currently available dengue vaccine is only recommended for dengue virus (DENV)-immune individuals. Thus, development of therapeutic and/or preventive drugs is urgently needed. DENV and Zika virus (ZIKV) nonstructural protein 1 (NS1) can...
Article
Background Only two naturally occurring human Sabiá virus (SABV) infections have been reported, and those occurred over 20 years ago. Methods We diagnosed two new cases of SABV infection using metagenomics in patients thought to have severe yellow fever and described new features of histopathological findings. Results We characterized clinical ma...
Article
Full-text available
Chagas disease (CD) is recognized by the World Health Organization as one of the thirteen most neglected tropical diseases. More than 80% of people affected by CD will not have access to diagnosis and continued treatment, which partly supports the high morbidity and mortality rate. Machine Learning (ML) can identify patterns in data that can be use...
Article
Full-text available
In the present work, we developed and evaluated the performance of a new flow cytometry-based single platform, referred to as “FC-Duplex IgG1 (HTLV-1/2)”, for universal and differential serodiagnosis of HTLV-1/2 infection. The proposed technology employs a system for detection of IgG1 antibodies in a single competitive immunofluorescence platform b...
Article
Background: The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) is a new iteration of prior National Heart, Lung, and Blood Institute (NHLBI) REDS programs that focus on improving transfusion recipient outcomes across the lifespan as well as the safety and availability of the blood supply. Study design and methods: The...
Article
Full-text available
Tocantins is a state in the cross-section between the Central-West, North and Northeast regions of Brazilian territory; it is a gathering point for travelers and transportation from the whole country. In this study, 9493 genome sequences, including 241 local SARS-CoV-2 samples (collected from 21 December 2020, to 16 December 2021, and sequenced in...
Article
Full-text available
It is unknown whether HTLV-1/2 prevalence has been stable or changing with time in Brazil. We present a 10-year (2007–2016) analysis of HTLV-1/2 infection in first-time blood donors from four blood banks in Brazil. The Brazilian blood centers participating in this multicenter Recipient Epidemiology and Donor Evaluation Study (REDS) are located in R...
Preprint
Full-text available
The SARS-CoV-2 Omicron variant has demonstrated increased transmissibility and ability to escape natural and vaccine-induced immunity. We aimed to characterize the duration of Omicron’s shedding by comparing viral isolation to rapid antigen test (RAT) and real-time polymerase chain reaction (RT-PCR) positivity. Thus, we performed a cross-sectional...
Article
Full-text available
Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. However, it is not known whether the remaining heritability is due to the imperfect tagging of causal variants by common SNPs, in particular...
Article
Full-text available
Background: The SARS-CoV-2 infections are still imposing a great public health challenge despite the recent developments in vaccines and therapy. Searching for diagnostic and prognostic methods that are fast, low-cost and accurate are essential for disease control and patient recovery. The MALDI-TOF mass spectrometry technique is rapid, low cost an...
Article
Full-text available
Introduction: Hepatitis C virus (HCV) can be vertically transmitted from mother to fetus. We evaluated knowledge about HCV vertical transmission in female blood donors who became pregnant following detection of HCV in their donated blood. Methods: This was a retrospective descriptive study of females seen at a single blood bank in Sao Paulo, Bra...
Preprint
Full-text available
There are large differences in the shape and size of regional SARS-CoV-2 epidemics in Brazil. Here we tested monthly blood donation samples for IgG antibodies from March 2020 to March 2021 in eight of Brazil’s most populous cities. There was large variation in the inferred attack rate adjusted for seroreversion across cities, and seroprevalence was...
Preprint
Full-text available
Reducing the transmission of SARS-CoV-2 from asymptomatic and pre-symptomatic patients is critical in controlling the circulation of the virus. This study evaluated the prevalence of RT-PCR positivity in serial tests (every 20 days) in 429 asymptomatic health care workers (HCW) and its impact on absenteeism from May to August 2020. Asymptomatic HCW...