Estelle Cuttaz

Imperial College London | Imperial · Department of Bioengineering

Fluorescence in situ hybridization (FISH) is a well-recognized technique for evaluating the human epidermal growth factor receptor 2 (HER2) gene status in breast cancer, despite its traditionally long and costly experimental procedure. While microfluidics was found to help reducing the experimental duration by improving the mass transport of the re...

Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectrum of possibilities to tackle this issue. Nevertheless, despite the advancements in this field...

Flexible polymeric bioelectronics have the potential to address the limitations of metallic electrode arrays by minimizing the mechanical mismatch at the device-tissue interface for neuroprosthetic applications. This work demonstrates the straightforward fabrication of fully organic electrode arrays based on conductive elastomers (CEs) as a soft, f...

Localized and actively controlled delivery of drugs presents an opportunity for improving bioavailability, therapeutic efficacy, and long-term treatment of injury or disease. Conductive polymer (CP) based systems present a unique opportunity for using inherent electrochemical and actuating properties to ensure that drugs are delivered or retained u...

The advent of closed‐loop bionics has created a demand for electrode materials that are ideal for both stimulating and recording applications. The growing complexity and diminishing size of implantable devices for neural interfaces have moved beyond what can be achieved with conventional metallic electrode materials. Polymeric electrode materials a...

Soft bioelectronic neural interfaces have great potential as mechanically favourable alternatives to implantable metal electrodes. In this pursuit, conductive hydrogels (CHs) are particularly viable, combining tissue compliance with the required...

This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene bl...

Conventional wet Ag/AgCl electrodes are widely used in electrocardiography, electromyography (EMG), and electroencephalography (EEG) and are considered the gold standard for biopotential measurements. However, these electrodes require substantial skin preparation, are single use, and cannot be used for continuous monitoring (>24 h). For these reaso...

Patterning of conducting polymers (CPs) into fully functioning devices remains a challenge for the creation of polymeric bioelectronics. Presently, the most successful method for patterning CPs is preprocess blending with structural components and using either subtractive or additive processes to produce the desired design. This work focuses on the...

Soft, flexible polymer-based bioelectronics are a promising approach to minimize the chronic inflammatory reactions associated with metallic devices, impairing long-term device reliability and functionality. This work demonstrates the fabrication of conductive elastomers (CEs) consisting of chemically synthesized poly(3,4-ethylenedioxythiophene) (P...

There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are composites of conductive polymers in elastomeric matrices that provide both flexibility and enhanced electrochemical properties compar...

Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for motor learning related brain network interactions also, may fur...

Conductive polymer (CP)–elastomer composites have been proposed as an alternative to the metals conventionally used for bioelectronic devices. Being softer and more stretchable than metals such as platinum and gold, they can mitigate the adverse effects associated with mechanical mismatch and fatigue failure. Such composites are conventionally made...