Esteban Durán-Lara

Esteban Durán-Lara
Universidad de Talca · Faculty of Health Sciences

PhD in Science

About

56
Publications
24,188
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979
Citations
Citations since 2017
45 Research Items
908 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Introduction
Esteban Durán is an Associate Professor from Departament of Microbiology, Universidad de Talca. His research area is focused on the design and development of advanced bio and nanomaterials that include hydrogels and metallic nanoparticles with different biomedical applications such as drug delivery systems for the treatment of infectious and cancer diseases. Duran group has a full laboratory for the synthesis of advanced biomaterials and biological applications.

Publications

Publications (56)
Article
Nano-based drug delivery research is increasing due to the therapeutic applications for human health care. However, traditional chemical capping-based synthesis methods lead to unwanted toxicity effects. Hence, there is an urgent need for green synthesis-based and biocompatible synthesis methods. The current work describes for the first time the gr...
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In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. However, there are few studies that focus on the devel...
Article
In currently, biosynthesis of copper oxide nanoparticles (CuO NPs) are most widely used numerous in biological applications such as biosensor, energy, medicine, agriculture, environmental and industrial wastewater treatment. The hierarchical CuO NPs was synthesized via green chemistry method by using of Abutilon indicum (A. indicum) leaf extract, i...
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The present study shows porous activated carbon obtained from Chenopodium quinoa Willd and Quillaja saponaria and their use as potential adsorbents to remove three types of dyes from aqueous solutions. The adsorption results were compared with commercial charcoal to check their efficiency. All porous carbon materials were activated using carbon dio...
Article
Local cancer treatment by in situ injections of thermo-responsive hydrogels (HG) offers several advantages over conventional systemic anti-cancer treatments. In this work, a biodegradable and multicompartmental HG composed of N-isopropylacrylamide, cellulose, citric acid, and ceric ammonium nitrate was developed for the controlled release of hydrop...
Article
Bacteria and their enzymatic machinery, also called bacterial cell factories, produce a diverse variety of biopolymers such as polynucleotides, polypeptides and polysaccharides, with different and fundamental cellular functions. Polysaccharides are the most widely used biopolymers, especially in biotechnology. This type of biopolymer, thanks to the...
Article
In the current scenario where more and more products containing nanomaterials are on the technological or pharmaceutical market, it is crucial to have a thorough knowledge of their toxicity before proposing possible applications. A proper analysis of the toxicity of the nanoproducts should include both in vitro and in vivo biological approaches and...
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In recent decades, aquaculture and environment plays a noteworthy role in rewarding the massive stipulate in all industries. Environmental damage and disease domination are seen as essential issues in the region. In addition to these, nanotechnology as a fresh and imaginative instruments were extremely feasible in aquaculture and environmental appl...
Article
A rational design accurate based on the use of Statistical Design of the Experiments (DoE) and Molecular Dynamics Simulations Studies allows the prediction and the understanding of thermo-responsive hydrogels prepared regarding their gelation temperature and anti-cancer drug release rate. N-isopropylacrilamide (NIPAM) modified with specific co-mono...
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Two of the main challenges in medicine are the fight against antibiotic resistance and cancer, and nowadays, nanomaterials are being postulated as potential alternatives to traditional treatments. Particularly, metal oxide nanoparticles could be an attractive option to replace conventional drugs, which generally present undesirable side effects. Be...
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Citation: Valdés, C.; Valdés, O.; Bustos, D.; Abril, D.; Cabrera-Barjas, G.; Pereira, A.; Villaseñor, J.; Polo-Cuadrado, E.; Carreño, G.; Durán-Lara, E.F.; et al. Use of Poly(vinyl alcohol)-Malic Acid (CLHPMA) Hydrogels and Chitosan Coated Calcium Alginate (CCCA) Microparticles as Potential Sorbent Phases for the Extraction and Quantitative Determi...
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Metal oxide nanoparticles (NPs) have gained attention in biomedicine due to their broad spectrum of applications, such as targeted drug delivery, their use as antibacterial agents or in cancer treatments. In particular, zinc oxide nanoparticles (ZnO NPs) have become one of the most popular metal oxide NPs in biomedical applications. The present stu...
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In the present study, phytochemical analysis, synthesis and characterization of zinc oxide nanoparticles (NG-ZnO NPs) from neem gum as a capping agent. GC–MS analysis confirms the phytochemical oxadiazol-2yl-benzothiazole-(21.5%) on the synthesized ZnO nanoparticles. Various sophisticated analytical instrumentations characterized the morphological...
Article
Despite the enormous efforts done by the scientific community in the last decades, advanced cancer is still considered an incurable disease. New formulations are continuously under investigation to improve drugs therapeutic index, i.e., increase chemotherapeutic efficacy and reduce adverse effects. In this context, hydrogels-based systems for drug...
Article
The appearance of silver nanoparticles (Ag NPs), their exponential production and the consumer products that contain them have raised concerns about their potential risks. Hence, the monitoring of Ag NPs in environmental and biological systems is of vital importance. Furthermore, until now, the information about the toxicity of Ag NPs synthesized f...
Article
In recent years the use of gold nanoparticles (AuNPs) has risen in fields as different as biomedicine or electronics. The most widely used method for their synthesis is citrate reduction, but alternative green methods are being sought. In this sense, the substitution of citrate with natural compounds such as marine polysaccharides is a noteworthy o...
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Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemotherapy and the development of drug resistance impairs a safe and efficiency anticancer therapy. Ther...
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It is a well explored facts that need of biosynthesized nanomaterials has emerged for its several advantages in biomedical applications and the search for potential biosynthesized-nanomaterials is still ongoing. In this study an attempt was made to meet the requirement of potential biosynthesized-silver nanoparticles using the aqueous seed extract...
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Background: Drug delivery systems such as hydrogels have become relevant in cardiovascular and metabolic therapies due to their sustained and controlled release properties of drugs, versatile polymer structures, safety and biodegradability. Results: The literature presented demonstrates that a hydrogel-based controlled release system increases the...
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A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and cha...
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The data article refers to the paper “supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties”[1]. The dataset includes the synthesis and characterization of (E)-1,3-bis(4-(allyloxy)phenyl)prop‑2-en-1-one (3) (crosslinking agent). Moreover, the multiwall carbon nanot...
Article
SARS-CoV2 is a source of coronavirus infectious disease (COVID-19), this is considered as a fatal disease to universal communal health apprehension. This rapid pathogenic virus plays an important role in finding the pathogenic virus, treatment and prevention of pandemics. Virus can present everywhere in Global village. As it is virus it can extend...
Book
Full-text available
Printed Edition of the Special Issue Published in Pharmaceutics 2020.
Article
In this study, we investigated the potential of polyurethane foams (LPUF) prepared from Lesquerella fendleri (A. Grey) oil-derived polyol to use as an ecological and cheap substitute for the petroleum-based polyurethane foams. The polyol was synthesized by a one-single step reaction using a mixture of hydrogen peroxide and acetic acid. The L. fendl...
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Chemical fertilizers, pesticides, and fungicides are widely used in agriculture to improve crop yields. Most of the compounds used are synthetic, and their overuse causes environmental pollution and human health problems. Currently, several countries are working to reduce the use of agrochemicals. Organic agriculture is now emerging as a sustainabl...
Article
Kappa-Carrageenan wrapped ZnO nanoparticles (KC-ZnO NPs) was synthesized, physico-chemically characterized and evaluated their biocompatibility and antimicrobial therapy against MRSA. XRD showed the highly crystalline and hexagonal phase structure of ZnO NPs. FETEM confirmed the spherical and hexagonal shape particle with mean size of 97.03 ± 9.05...
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We investigated the potential of two oil extracts from seeds of Colliguaya integerrima (CIO) and Cynara cardunculus (CO) to use as nutritionally edible oils. For this purpose, oil quality was accessed by determining the fatty acid composition, peroxide value, acid value, iodine value, saponification number, phenolic contents, and oxidative stabilit...
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This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-ta...
Article
Facile and low cost garlic clove extract based silver nanoparticles was synthesized and its broad spectrum of therapeutic activity including antibiofilm, antiparasitic and anti-breast cancer activity was evaluated. The synthesized garlic‑silver nanoparticles (G-AgNPs) were characterized by various physico-chemical techniques. G-AgNPs showed good op...
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Background Injectable hydrogels are a thermo-responsive system based on biomaterials. Injectable hydrogels have been broadly investigated mainly as vehicles or scaffolds of therapeutic agents that include drugs, proteins, cells, and bioactive molecules among others, utilized in the treatment of diseases such as cancers and the repair and regenerati...
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In this study, a versatile synthesis of silver nanoparticles of well-defined size by using hydrogels as a template and stabilizer of nanoparticle size is reported. The prepared hydrogels are based on polyvinyl alcohol and maleic acid as crosslinker agents. Three hydrogels with the same nature were synthesized, however, the crosslinking degree was v...
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This work depicts the rational development (in-silico design, synthesis, characterization and in-vitro evaluation) of polyvinyl alcohol hydrogels (PVAH) cross-linked with maleic acid (MA) and linked to γ-cyclodextrin molecules (γ-CDPVAHMA) as systems for the controlled and sustained release of nifedipine (NFD). Through computational studies, the st...
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This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to genera...
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This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for sustained release of prednisone (PDN). Through in-silico studies using semiempirical quantum mechanical calculations the effectiveness of 20 dicarboxylic acids to generate a s...
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Immunosuppressants are a class of drugs that can inhibit the immune response, mainly through the inhibition of IL-2 production, among other mechanisms. The most studied representatives of this class of therapeutic agents are Cyclosporin-A, FK506, and Rapamycin. Due to the structural complexity of these molecules, their chemical synthesis has been d...
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This study describes the in-silico design, synthesis, and evaluation of a cross-linked PVA hydrogel (CLPH) for the absorption of organophosphorus pesticide dimethoate from aqueous solutions. The crosslinking effectiveness of 14 dicarboxilic acids was evaluated through in-silico studies using semiempirical quantum mechanical calculations. According...
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The main organic pollutants worldwide are pesticides, persistent chemicals that are of concern owing to their prevalence in various ecosystems. In nature, pesticide remainders are subjected to the chemical, physical, and biochemical degradation process, but because of its elevated stability and some cases water solubility, the pesticide residues pe...
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This study describes the absorption of methamidophos (MMP) from aqueous solution by crosslinked poly(vinyl alcohol) (PVA) hydrogel synthesized using malic acid (MA) as a crosslinker (CLPHMA). The prepared hydrogels were characterized by FTIR spectroscopy, scanning electron microscopy, and the thermal properties were studied by using thermal gravime...
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The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized accor...
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Currently, dendrimers are molecules widely investigated due to its strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which al...
Patent
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The present invention is directed to a polymeric compound with a size in a nanometric scale, useful as a biocompatible carrier for the transport and delivery of active agents into a fish, insect, animal, reptile, bird, human, or plant, wherein said polymeric compound comprises PAMAM (polyamidoamine) dendrimers, a spacer molecule, and cafestol, wher...
Article
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Lysine-containing polymers have seen broad application due to their amines' inherent ability to bind to a range of biologically relevant molecules. The synthesis of multiple generations of polyester dendrimers bearing lysine groups on their periphery is described in this report. Their hydrolytic stabilities with respect to pH and time, their toxici...
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Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to prove their interaction with uranium and their effect on the viability of red blood cells in vi...
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For the first time, the adsorption of pesticides such as azinphos-methyl and methamidophos by polyamidoamine (PAMAM) derivatives was studied. Amine groups of PAMAM (G4 and G5) were functionalized with different biomolecules such as folic acid, coumarine, arginine, lysine, and asparagine. Subsequently, the synthesized compounds were used to trap org...
Patent
The present invention is directed to nanoparticles with antithrombotic activity, more particularly, the nanoparticles are PAMAM dendrimers derivatives, which present low toxicity and high anticoagulant or antithrombotic activity. The invention also considers methods for treating a condition wherein anticoagulation activities are needed.
Article
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Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared...
Article
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An efficient enantioselective approach for preparation of quaternary centers from proline 5 building block has been developed through [2,3]-sigmatropic Stevens rearrangement co-catalyzed by ionic liquid. The sigmatropic rearrangement was stereospecific because the [2,3]-migrations were restricted to the same face, and the stereoselectivity arose fr...

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Projects (4)
Project
Evaluate the efficiency of new insoluble materials based on hydrogels as a potential sorption phase to extract and preconcentrate methamidophos, dimethoate, carbofuran and methomyl from aqueous matrices and their subsequent desorption for its determination by chromatography