Esra Köngül Şafak

• Master of Science
• Research Assistant at Erciyes University

Objective: In the current research, 6-gingerol (GA)-loaded nanofiber drug delivery system were developed, and their potential usage in wound healing was evaluated. Significance: This study investigates the effectiveness of nanofibrous membranes composed of sodium alginate (SA), poly(vinyl alcohol) (PVA), and 6-gingerol (GA) as delivery systems f...

In this study, the antioxidant (DPPH and ABTS radical-scavenging, ferric-reducing, iron (II)-chelating), anti-inflammatory (LPS-induced Raw 264.7 cell line), and cytotoxic activities (Du145 and A549 cell lines) of raw fruit, ripe fruit and leaves of the Lycium ferocissimum species were examined. By using high-pressure liquid chromatography, p-OH be...

BACKGROUND Allergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L. (Rutaceae) fruit peels, with known anti‐inflammatory activity but low solubility. It was complexed with cyclodextrin and encapsulated in situ gel to extend its dur...

Olea europaea L. (Oleaceae), is rich in phenolic content and has powerful antioxidant and antidiabetic activity. However, there are no medicinal products prepared due to this feature. Therefore, this study aims to characterize an O. europaea extract with strong antioxidant and antidiabetic properties and to prepare nanoformulations containing this...

Background: The current research centers on exploring the antioxidant, antimicrobial, and antidiabetic features of Schinus molle L. grown in Turkey. Methods: Quantitative analysis of chlorogenic acid, caffeic acid, and hyperoside levels in leaf, ripe fruit, and raw fruit extracts was conducted using High-Performance Liquid Chromatography (HPLC)...

Objective: The present study aimed to evaluate the biological activities of Myrtus communis L., which has traditional medicinal use for different purposes, from a broad perspective. Material and Method: The antioxidant (DPPH, ABTS, total phenol, and flavonoid amounts) anti-inflammatory (LOX enzyme inhibition), antidiabetic (α-glucosidase enzyme inh...

In this study, cyclodextrin (HP-β-CD) inclusion complexes were prepared with Curcumin (CUR) by cosolvency/lyophilization method. Characterization studies were performed with phase-solubility diagrams, scanning electron microscopy (SEM), FT-IR, FT-Raman, XRD, Differential scanning calorimetry (DSC). The prepared CUR:HP-β-CD complexes were evaluated...

Arctium minus (Hill) Bernh. (Asteraceae), which has a wide distribution area in Turkey, is a medicinally important plant. Eighty percent methanol extracts of the leaf, flower head, and root parts of A. minus were prepared and their sub-fractions were obtained. Spectrophotometric and chromatographic (high-performance liquid chromatography) technique...

Amaç: Allium sativum L. (Sarımsak) bitkisinin belli bir derecede nem ve sıcaklık ile işlem görmesi sonucu, elde edilen fermente ürün tek diş siyah sarımsağın biyoaktivitesinin tespit edilmesi amaçlandı.Yöntem: Çalışmada, siyah sarımsak dişlerinin etanol ve su ekstresi hazırlandı, yine ayrılan kabuk kısımları da etanol ile ekstre edilerek, DPPH● ve...

Nepeta is one of the largest genera of the Lamiaceae family. Nepeta species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical content of methanolic extracts and infusio...

Green tea is one of the extensively used drinks in the world. Green tea extract contains several polyphenolic compounds and catechins. Epigallocatechin-3-gallate (EGCG) and epicatechin 3-gallate (ECG) are the most effective antioxidants. In this study, the relation between EGCG content and the antioxidant effect of samples purchased from four diffe...

The Lime Basra (Citrus aurantifolia Linn., Rutaceae) plant also known as dried lime, and Limoo Omani, is used both as a spice in meals and as an herbal tea in the treatment of some diseases in the Middle East. It was aimed to determine the biological activity screening of the 70% methanol, ethanol extracts and infusion which were prepared from drie...

Origanum haussknechtii Boiss. (Lamiaceae), an endemic herb growing in Turkey, is consumed as a tea in folk medicine. This study aimed to investigate antimicrobial, antibiofilm, and cytotoxic activities of the methanol, and water extracts from the aerial parts of O. haussknechtii, as well as to determine their phenolic profiles by using HPLC analysi...

Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), is one of the most widely consumed spices worldwide due to its pungent smell and taste. It has also traditionally been used since antiquity for the treatment of ailments like common colds, fever, arthritis, rheumatism, gastrointestinal complications, motion sickness, diabetes, infe...

The liver is one of the most important organs in the human body with crucial functions such as metabolism, secretion, storage, and detoxification. Due to the liver’s vital duties, hepatic diseases are among the most important health problems because they can cause various complications and also may result in death. Plants have traditionally been us...

The present study was conducted to investigate the effects of phosphorus fertilizer treatments (0, 30, 60, 90 and 120 kg ha⁻¹ P2O5) on crude oil, diosgenin, and trigonelline contents and on fatty acid composition of fenugreek plants. Experiments were conducted in a randomized block design with four replications. Results revealed under different pho...

Context: Eryngium kotschyi is one of the species of Eryngium genus and was endemic to Turkey. It was known, that traditionally uses of this plant in the South-Western part of Turkey for the treatment of various diseases. Aims: To evaluate the antioxidant capacities of methanol extract and ethyl acetate, n-butanol and water sub-extracts as well as t...

Context: Eryngium kotschyi is one of the species of Eryngium genus and was endemic to Turkey. It was known, that traditionally uses of this plant in the SouthWestern part of Turkey for the treatment of various diseases. Aims: To evaluate the antioxidant capacities of methanol extract and ethyl acetate, n-butanol and water sub-extracts as well as to...

We have studied Hypericum scabrum L. plant which belongs to the Hypericaceae family, naturally growing in Anatolia. The aim of this research is to investigate the chemical composition (total phenol, total flavonoid) of 70% methanol and water extracts prepared from the underground and flowering aerial parts to investigate the antioxidant and cytotox...

Vitex agnus-castus L. (agnus castus) is a deciduous shrub that belongs to the Verbenaceae family. It is also commonly known as the chaste tree, chaste berry, or monk’s pepper. The fruits of the plant have traditionally been used for treating gynecological complaints, mainly premenstrual disorders, for a long time. V. agnus-castus contains iridoids,...

The Apiaceae (previously known as the Umbelliferae) is one of the largest plant families in the world. This family comprises approximately 450 genera and 3700 species worldwide. The members of this family are well known as vegetables, culinary and medicinal plants. Members of Apiaceae possess various compounds with many biological activities. Some...

Achillea millefolium L. an herbaceous perennial plant from Asteraceae family which has antitumor, anti-inflammatory and antioxidant activity. Breast cancer is the most common cancer in woman. Therefore, in this study we aimed to investigate the effects of the different extracts of A. millefolium on breast cancer with in vitro cytotoxicity assay. Wi...

Bu çalışma kapsamında Apiaceae familyasına dahil Eryngium billardieri Delar. 'ın toprak üstü kısımlarından hazırlanan %70 metanol ekstresinin ve bu ekstreden elde edilen fraksiyonların İnce Tabaka Kromatografisi (İTK) ile analizleri, saponin teşhis reaksiyonları ile saponin içerikleri, DPPH● ve ABTS●+radikallerini süpürücü aktiviteleri, Folin- Cioc...

İlk çağlardan itibaren insanlar beslenmek ve sağlık sorunlarını gidermek amacıyla bitkilere başvurmuşlardır. Mitolojide de bitkiler tanrıların insana verdiği en değerli armağan olarak ele alınmıştır. Mitolojiden günümüze uzun bir hikayesi olan Melissa officinalis (Oğulotu, Melisa) bir Akdeniz bitkisi olup, yurdumuzda da yetişen çok yıllık otsu bir...

Capsicum annuum L. (Solanaceae) originates from Central America (native of Mexico). It is cultivated throughout Turkey as a condiment and vegetable, in fields or greenhouses, for its unripe green or ripe red fruits (in Turkish, “biber”). In this study, microscopical, physico-chemical analysis of 10 red pepper samples bought from Kayseri market were...