Espérance Moine

Health Research and Innovation Department Clariane France

Introduction: Hydroxytyrosol (HT) is one of the main phenolic compounds in olive oil with health benefits. HT derivatives esterified with different fatty acids (lipophenols, HT-FAs) have recently been identified in olive oil. Objective: The effect of the food matrix and digestive enzymes on the bioaccessibility and bioavailability of HT-FAs was inv...

Objectives: While dyspnea is the main symptom in chronic obstructive pulmonary disease (COPD), it is often inadequately evaluated in pulmonary rehabilitation (PR), as it is typically measured using only the impact dimension (ID). However, dyspnea is a multidimensional construct including perception (PD) and emotional (ED) domains. Our work aimed to...

Due to the high prevalence and persistence of long COVID, it is important to evaluate the safety and efficacy of pulmonary rehabilitation (PR) for patients who experience long-lasting symptoms more than six months after initial COVID-19 onset. Enrolled patients were admitted for a four-week in-patient-PR due to long COVID symptoms (n = 47). The saf...

Presently, the attention given to natural substances to counteract damage produced by oxidative stress (OS) has risen sharply. In this scenario, hydroxytyrosol (HT) derivatives, formed as a result of HT conjugation with fatty acids (FAs) (lipophenols), have been recently described in foodstuffs such as extra virgin olive oil, as being powerful bioa...

Dry age-related macular degeneration and Stargardt disease undergo a known toxic mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for accumulation in the retinal pigment epithelium (RPE) of A2E, a main toxic pyridinium bis-retinoid lipofuscin component. Previous studies have shown that carbonyl stress in retinal cells...

Environmental light has deleterious effects on the outer retina in human retinopathies, such as ABCA4-related Stargardt’s disease and dry age-related macular degeneration. These effects involve carbonyl and oxidative stress, which contribute to retinal cell death and vision loss. Here, we used an albino Abca4−/− mouse model, the outer retina of whi...

Lipophenols have been stressed as an emerging class of functional compounds. However, little is known about their diversity. Thus, this study is aimed at developing a new method for the extraction, clean-up, and UHPLC-ESI-QqQ-MS/MS-based analysis of the lipophenols derived from hydroxytyrosol (HT): α-linolenic (HT-ALA), linoleic acid (HT-LA), and o...

All‐trans‐retinal (atRAL) is a highly reactive carbonyl specie, known for its reactivity on cellular phosphatidylethanolamine in photoreceptor. It is generated by photoisomerization of 11‐cis‐retinal chromophore linked to opsin by the Schiff's base reaction. In ABCA4‐associated autosomal recessive Stargardt macular dystrophy, atRAL results in carbo...

Age-related macular degeneration (AMD) is a multifactorial pathology and its progression is exacerbated by oxidative stress. Oxidation and photo-oxidation reactions modify lipids in retinal cells, contribute to tissue injury, and lead to the formation of toxic adducts. In particular, autofluorescent pigments such as N-retinylidene-N-retinylethanola...

The current therapeutic arsenal for toxoplasmosis is restricted to drugs non-specific to the parasite which cause important side effects. Development of more efficient and specific anti-Toxoplasma compounds is urgently needed. Imidazo[1,2-b]pyridazines (IPs) designed to inhibit the calcium-dependent protein kinase 1 of Toxoplasma gondii (TgCDPK1) a...

Des imidazo[1,2-b]pyridazines ciblant la CDPK1 de Toxoplasma gondii diminuent drastiquement la charge parasitaire dans un modèle de toxoplasmose murine aiguë.

Des imidazo[1,2-b]pyridazines ciblant la CDPK1 comme nouvelle chimiothérapie anti-toxoplasmose.

Imidazo[1,2-b]pyridazines targeting TgCDPK1 as new anti-Toxoplasma gondii chemotherapeutic treatments.

Développement de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique.

Conception, synthèse et évaluation de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique.

Using a structure-based design approach, we have developed a new series of imidazo[1,2-b]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii. Twenty derivatives were thus synthesized. Structure-activity relationships and docking studies confirmed the binding mode of these inhibitors within the ATP binding po...

Conception, synthèse et évaluation de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique.

Conception, synthèse et évaluation de nouveaux inhibiteurs de CDPK1 à visée anti-apicomplexes.

Conception, synthesis and evaluation of new anti-Toxoplasma gondii agents designed to target CDPK1.

Conception, synthesis and evaluation of new anti-Toxoplasma gondii agents designed to target CDPK1 Toxoplasmosis is a disease of public health concern caused by the protozoan parasite Toxoplasma gondii, a food pathogen that can infect mammals and birds. Infection with T. gondii during pregnancy can be responsible for serious disorders in newborns (...