Ernest Kiswaya Sumaili

University of Kinshasa | UNIKIN · Department of Nephrology and Dialysis

Introduction : Worldwide, 72 countries criminalize homosexuality. Only one country in Africa recognizes homosexuality. While 10 countries criminalize it, against only one that protects it. Exceptionally, the DRC does not have legislation against or for homosexuality. The aim of this study was to describe the attitudes and perceptions of Congolese a...

Introduction Glomerular hyperfiltration is highly frequent, theoretically dependent on cardiac output, low systemic vascular resistance and hemolysis markers. In sickle cell disease (SCD), hyperfiltration is an extremely common phenomenon and occurred in young and early adult patients. Despite the fact that the glomerular hyperfiltration is known a...

Introduction: It has been established that homosexuality plays a considerable role in the persistence of the Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) infections, but data related to their extent remains paradoxically fragmentary. Objectives: This study aimed to determine the prevalence and determinant...

The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children is unclear. In a cross-sectional study, 513 apparently healthy African children aged 6 to 16 years were randomly recruited in school area of...

The rapid introduction and evolution of artificial intelligence (AI), machine learning (ML), natural language processing (NLP), and large language models (LLMs) combined with the emergence of text-generating chatbots have ushered in a transformative era in scholarly publishing.

Background Data on 25 [OH] vitamin D and intact parathyroid hormone [iPTH] in hemodialysis patients are very limited in sub-Saharan African countries. The present study aimed to assess the magnitude of hypovitaminosis D, and to evaluate the achievement of iPTH KDIGO 2017 targets among chronic hemodialysis patients followed in Kinshasa. Methods We...

Chronic kidney disease (CKD), a global public health problem, is increasing at an alarming rate across Africa. The increasing CKD burden in this region is mainly driven by a rapid surge in the prevalence of risk factors including diabetes, hypertension, obesity, and infectious diseases. To further aggravate the situation, CKD is known to progress r...

Context Worldwide, 72 countries criminalize homosexuality. Only one country in Africa recognizes homosexuality. While 10 countries criminalize it, against only one that protects it. Exceptionally, the DRC does not have legislation against or for homosexuality. The aim of this study was to describe the attitudes and perceptions of Congolese and sexu...

Introduction Acute kidney injury (AKI) is a complication of severe coronavirus disease 2019 (COVID-19). Kidney damage associated with COVID-19 could take specific features due to environmental and socio-cultural factors. This study evaluates the incidence of AKI, the associated factors, and mortality in COVID-19 patients in a Sub-Saharan African in...

Introduction: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). Methods: A single-centre cohort survey evaluated the clinical profil...

Introduction L’agression rénale aiguë (ARA) requérant un traitement de suppléance rénale est accompagnée d’une mortalité considérable. Description L’étude a évalué les prédicteurs de la mortalité à l’initiation de l’hémodialyse (HD) chez des patients atteints d’ARA à Goma (République démocratique du Congo [RDC]). Méthodes Une enquête de cohorte m...

Introduction Dans la maladie rénale chronique (MRC), la carence martiale (CM) représente l’une des causes de l’anémie et contribue à la résistance à l’action de l’érythropoïétine (EPO). Description L’objectif était d’en déterminer la fréquence et les facteurs associés chez les patients avec MRC non dialysés en consultations ambulatoires de néphrol...

Introduction L’hypovitaminose D contribue à la surmortalité en hémodialyse (HD). Description L’objectif de l’étude était d’en déterminer la fréquence et les déterminants chez les patients suivis à Kinshasa. Méthodes Étude menée entre 2018 et 2019 dans 6 centres d’HD. Hormis la 25-OH (D), les autres paramètres étaient : calcémie ionisée, phosphaté...

Introduction Malgré le développement des centres d’hémodialyse (HD) en Afrique subsaharienne, les anomalies du métabolisme phosphocalcique (MPC) sont peu étudiées avec comme corollaire un traitement sous-optimal et inadapté. Description Notre objectif était de déterminer leurs fréquences et les phénotypes du remodelage osseux correspondants chez l...

Introduction L’agression rénale aiguë (ARA) est un problème mondial majeur de Santé publique. Cependant, le fardeau et le devenir de l’ARA restent peu documentés dans les pays d’Afrique subsaharienne. Description La présente étude avait pour objectif de déterminer l’incidence, les facteurs de risque et la mortalité à 2 mois des adultes hospitalisé...

Although medicinal plants are beneficial, they also can be important risk factors for the development of acute and chronic kidney injury, as well toxicity of other solid organs. There are a lack of reports of adverse kidney events and drug interactions resulting from medicinal plants owing to a lack of professional surveillance and specific data on...

Context and objective: Like all epidemics, the COVID-19 pandemic occurs in several highly diverse waves. The objective of the present study was to compare the demographic and clinical characteristics and mortality of patients between the first and second waves of COVID-19. Methods: This was a historical follow-up study conducted at the Kinshasa Uni...

Context and objective: Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) plays an important role in lipid homeostasis. The present study aimed to determine whether PCSK9 is a potential cardiovascular risk (CVR) factor among apparently healthy people. Methods: A cross-sectional study was conducted between August 2016 and July 2020 in the City of...

Delivery of kidney care in Africa is significantly constrained by various factors. In this review, we used International Society of Nephrology–Global Kidney Health Atlas (ISN–GKHA) data for Africa to address sub-regional differences in care delivery in the continent with focus on infrastructure, workforce, and the economic aspects of kidney care. F...

BACKGROUND AND AIMS Current Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, A = Age, S = Sex, R = Race). A new equation without race (CKD-EPIAS) has been proposed. However, this equation...

Contexte et Objectifs. Le nombre des patients hémodialisés en Afrique subsaharienne en constante augmentation ; justifiant de ce fait une meilleure prise en charge de ces patients. La présente étude détermine la prévalence de l’infection par le virus de l’hépatite C en en determinant les génotypes ainsi que les facteurs y associés dans ce groupe de...

Background Cardiovascular (CV) disease is the leading cause of mortality in patients with end-stage kidney disease (ESKD). The aim of the present study was to determine whether Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) could be an independent predictor of CV events and all-cause mortality in black African haemodialysis patients. Method...

Background In symptomatic patients, the diagnostic approach of COVID-19 should be holistic. We aimed to evaluate the concordance between RT-PCR and serological tests (IgM/IgG), and identify the factors that best predict mortality (clinical stages or viral load). Methods The study included 242 patients referred to the University hospital of Kinshas...

Background Urolithiasis is increasingly diagnosed worldwide. Stone analysis is an important part in the assessment of patients with urolithiasis. However, in sub-Saharan Africa, data on the composition of urinary stones are limited. This study aimed to describe the composition and sites of urinary stones and to investigate relationship between soci...

Introduction: metabolic abnormalities are key factors in urolithiasis patients because they can be modified to prevent the risk of urinary stones. The objectives of this study were to estimate the frequency of metabolic abnormalities in the urine of patients with urolithiasis and to determine their possible link with the chemical composition of st...

Introduction Apolipoprotein-L1 (APOL1), Glutathione S-transferase mu1 (GSTM1) risk variants and sickle cell trait (SCT) are associated with chronic kidney disease (CKD) among African Americans. However, such evidence remain scarce in sub-Saharan Africa (SSA) populations. Methods In a cross-sectional study, we assessed the prevalence of these risk...

Background The objective of our retrospective study was to establish a comparison between the first and the second waves of demographic and clinical characteristics as well as mortality and its determinants. Methods A total of 411 COVID-19 patients were enrolled in Kinshasa University Hospital and categorized into two groups according to the pandem...

Introduction Les maladies cardiovasculaires sont la principale cause de mortalité chez les insuffisants rénaux. Cette étude cherche à déterminer si la Proproteine Convertase Subtilisine/Kexine 9 (PCSK9) est un facteur de risque de mortalité chez les patients hémodialysés (HD) chroniques. Description Étude de cohorte prospective (2016–2020). Métho...

Introduction Les données relatives greffe rénale en République démocratique du Congo sont fragmentaires. La présente étude avait pour objectif de décrire la survie des greffons et des patients greffés rénaux à l’étranger, et d’identifier les prédicteurs de la perte totale de la fonction du greffon (PFG) et du décès lors du suivi post-greffe rénale...

Context and Objective: Cardiovascular diseases are the leading cause of mortality in patients. In this context, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to be the new biomarker identified as interfering in lipid homeostasis. This study aimed to investigate the association between PCSK9, dyslipidemia, and future risk of cardiova...

Background Most studies of chronic kidney disease (CKD) in Sub-Saharan Africa (SSA) have been conducted in urban settings. They relied on GFR estimated from serum creatinine alone and on the inexpensive, convenient urinary dipstick to assess proteinuria. The dipstick for proteinuria has not been directly compared with the gold standard albumin-to-c...

Résumé Cette étude a comparé les composants chimiques des calculs du haut et du bas appareil urinaire chez des patients congolais, et identifié les facteurs associés aux différents types de calculs. Les calculs extraits du haut appareil urinaire de 119 patients et les calculs extraits du bas appareil urinaire de 75 autres patients ont été analysés...

Kidney disease in Black Africans appears to be more frequent, severe, and develops earlier in contrast to its occurrence in Caucasians. More than 10% of the Congolese urban population exhibits signs of chronic kidney disease, impacting adults in their productive years. Glomerular disease remains the leading cause followed by hypertension and diabet...

Introduction The steady increase in the number of chronic hemodialysis patients in sub-Saharan Africa (SSA) calls for improved management of those patients. The present study aimed to determine the frequency of hepatitis C virus (HCV) infection, the prevalent genotypes and the risk factors associated with HCV in hemodialysis patients in Kinshasa (D...

Objective: Early identification of atherosclerosis using a non-invasive tool like ankle-brachial index (ABI) could help reduce the risk for cardiovascular disease among long-term hemodialysis patients. The study objective was to assess the frequency and impact of abnormal ABI as a marker of subclinical peripheral artery disease (PAD) in chronic he...

Background: In symptomatic patients, the diagnostic approach of Covid-19 should be holistic. We aimed to evaluate the concordance between RT-PCR and serological tests (IgM/IgG), and identify the factors that best predict mortality (clinical stages or viral load). Methods: The study included 242 patients referred to the University hospital of Kinsha...

p>Obesity is a significant public health crisis affecting millions of children globally. The objective of this study was to identify the prevalence and associated factors of overweight/obesity among school children in Kinshasa, Democratic Republic of Congo (DRC). This was a descriptive cross-sectional study among school children and adolescents (n...

Background Although cardiovascular diseases in particular Pulmonary Arterial Hypertension (PAH) is associated with, high morbid-mortality in chronic hemodialysis, but its magnitude remains paradoxically unknown in sub-Saharan Africa. The aim of this study was to evaluate the prevalence of PAH and associated factors in chronic hemodialysis in Sub-Sa...

Objective This study aimed to analyze different therapeutic modalities used in the treatment of urolithiasis in the Democratic Republic of Congo.ResultsAmong the 194 patients included in this study, 69% (n=133) were males, with a male to female ratio of 2.2: 1, and an age mean (SD) of 48.1 (17.3) years. Urolithiasis was symptomatic in 52.6% (n=141)...

Abstract Background: Kidney disease is now recognized as a public health problem worldwide, particularly in Africa [1] with the increasing prevalence of kidney disease observed in African countries, it is likely that it has the share of medicinal plants. Cultural and economic reasons explain the use of traditional healers. Objectives: This study a...

Valvular calcifications (VCs) are one of the major cardiovascular complications in patients on chronic hemodialysis (HD) due to its prevalence and predictive morbidity and mortality. The current study assessed the prevalence, location, and risk factors of VC among chronic HD Congolese patients in Kinshasa. This observational study involved three HD...

In addition to the best knowledge of pharmacokinetics and pharmacodynamics of available drugs used to combat infectious diseases, the best knowledge by healthcare providers of the microbial agent's structure and its interaction with host defense mechanisms is crucial for a rationale use of these drugs and an effective therapeutic education of patie...

Clinical characteristic of COVID 19 epidemic

Background The prevalence of chronic kidney disease (CKD) in African-Americans is high but whether this applies to native populations in sub-Saharan Africa is unclear. Methods In a cross-sectional study, we assessed the prevalence and risk factors of CKD in rural and urban adults in South-Kivu, Democratic Republic of Congo. Glomerular filtration r...

Background: Cardiovascular diseases in particular Pulmonary arterial hypertension (PAH) is associed a high morbi-mortality in chronic hemodialysis, but it’s magnitude remains paradoxically unknown in sub-Saharan Africa. The aim of this study was to evaluate the prevalence of PAH and associated factors in chronic hemodialysis patients. Patients and...

Introduction: Because of the cost, in the hemodialysis centers of Kinshasa, the double dose of hepatitis B (HBV) vaccine is administered only to HIV infected patients while other patients receive a single dose. This study aimed to evaluate the single-dose vaccination Protocol and identify determinants of seroconversion's lack of anti-HBs after vac...

Introduction Les déterminants de l’infection par le virus de l’hépatite C (VHC) en hémodialyse (HD) ont été largement rapportés dans le monde, mais très peu en République démocratique du Congo. Nos objectifs étaient de déterminer la prévalence de l’infection par le VHC, d’identifier les génotypes et les déterminants. Méthodes Étude transversale et...

Introduction Bien que la dénutrition soit connue associée à une forte morbi-mortalité chez les hémodialysés chroniques, les données y relatives sur l’ampleur sont paradoxalement rares, en République démocratique du Congo. Les objectifs de la présente étude étaient d’évaluer la fréquence et les déterminants de la dénutrition chez les hémodialysés ch...

Introduction L’indice de pression cheville/bras anormal (IPCBA) est un puissant prédicateur de la mortalité cardiovasculaire chez les hémodialysés chroniques. Cependant, les données y relatives sont paradoxalement inexistantes dans les pays africains. Les objectifs de la présente étude étaient d’évaluer l’ampleur et de rechercher les facteurs assoc...

Introduction L’hypertension artérielle pulmonaire (HTAP) contribue à la surmortalité cardiovasculaire chez les hémodialysés chroniques, mais son ampleur est paradoxalement inconnue en Afrique sub-saharienne. L’objectif de la présente étude était d’évaluer la prévalence et les déterminants de l’HTAP chez les patients congolais en hémodialyse chroniq...

Introduction La clairance plasmatique de l’iohexol est une technique reconnue avec différentes procédures pour la mesure du débit de filtration glomérulaire (DFG). La clairance à prélèvement unique présente des avantages évidents dans le contexte africain. Dans cette étude, nous comparons les résultats de DFG obtenus à partir de prélèvements multip...

Introduction En dépit de multiples bénéfices de préservation de la diurèse résiduelle (DR) chez les hémodialysés chroniques, les données y relatives sont fragmentaires en Afrique Sub-saharienne. L’objectif de la présente étude était de rechercher l’impact de la DR réduite sur la dysfonction diastolique (DDVG) et systolique du ventricule gauche (DSV...

Introduction Contexte : bien que le débit de filtration glomérulaire (DFG) soit essentiel dans le diagnostic, l’adaptation posologique et le suivi de la maladie rénale chronique (MRC), l’applicabilité des équations d’estimation reste discutable. Cette étude vise à évaluer la performance des différentes équations d’estimation du DFG chez l’adulte en...

Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia. The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according to albuminuria status. This was a post hoc analysis of data from 181 T2DM patients seen at a te...