Ernest Obese

Ernest Obese
University of Cape Coast | UCC · Department of Pharmacology

Doctor of Philosophy (Pharmacology)

About

29
Publications
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75
Citations
Education
August 2014 - November 2019
August 2010 - November 2012
August 2005 - June 2009

Publications

Publications (29)
Article
Full-text available
Aidia genipiflora (DC.) Dandy (Rubiaceae) is used to treat various microbial and inflammatory conditions by traditional healers in West African countries. However, there is no information on anti-inflammatory potential of A. genipiflora. This work therefore provides information on the anti-inflammatory and the antioxidant activities of the stem bar...
Article
Full-text available
Malaria remains a global health threat due to its overwhelming statistics on morbidity and mortality, especially in pregnant women and children under five years. This study evaluated the effectiveness of a hydroeth-anolic leaf extract of Calotropis procera (CPE) in managing malaria utilizing in vivo and in vitro models. Methods: The curative antipl...
Article
Full-text available
Introduction: Xylopic acid (XA), the major constituent of the fruit of Xylopia aethiopica, has shown several pharmacological properties. Traditionally, the plant is used to treat several diseases and is being used in the preparation of several local foods despite the lack of information about its safety, food-drug interaction, and other pharmacoki...
Article
Full-text available
Background: Patients with gynaecological disorders often suffer from psychological disorders including anxiety and depression. Although depression and anxiety have been studied in Ghana, data regarding the prevalence of these disorders in patients with gynaecological disorders is non-existent. The aim of the study was to investigate the prevalence...
Article
Full-text available
Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolaemia associated with CCl 4 -induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed...
Article
Full-text available
Modern advances in dosage forms require innovative excipients that make them more efficient than conventional dosage forms. Natural excipients like gums are known to be cheap, biodegradable, and readily available. However several natural gums are yet to be fully characterized and utilized. This study sought to determine the physicochemical properti...
Article
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Background: Calotropis procera has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Methods:...
Article
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The diversity offered by natural products has timelessly positioned them as a good source for novel therapeutics for the management of diverse medical conditions, including pain. This study evaluated hydro-ethanolic root bark extract of Ziziphus abyssinica (ZAE) as well as β-amyrin and polpunonic acid isolated from the plant for analgesic property....
Article
Full-text available
A number of currently used drugs have been obtained from medicinal plants which are a major source of drugs. These drugs are either used in their pure form or modified to a semisynthetic drug. Drug discovery through natural product research has been fruitful over the years. Traditionally, Calotropis procera is used extensively in the management of...
Article
Full-text available
Persicaria lanigera is used traditionally to treat pain. The antinociceptive properties of the hydroethanolic leaf extract of Persicaria lanigera (PLE) were evaluated in rats and mice. Mice were pretreated orally with PLE (30, 100, and 300 mg kg−1) and evaluated for antinociceptive effects in the acetic acid-, glutamate-, and formalin-induced nocic...
Article
Ethnopharmacological relevance Pain remains real and still a major problem in clinical medicine which requires new agents with improved efficacy for more therapeutic benefits. Plant sources can serve as a basis for the search for some novel drugs hence the analgesic effects of the hydroethanolic extract of Calotropis procera (CPE) which is widespre...
Article
Full-text available
Background: Neuropathic pain is a very disturbing condition commonly found in diabetic patients. This study investigated xylopic acid (XA), the major constituent of Xylopia aethiopica in diabetic neuropathy as well as established possible toxicity of the compound on some selected tissues.Methods: Diabetes was induced in six groups of male rats with...
Article
Full-text available
Background: Evidence of Plasmodium resistance to some of the current anti-malarial agents makes it imperative to search for newer and effective drugs to combat malaria. Therefore, this study evaluated whether the co-administrations of xylopic acid-amodiaquine and xylopic acid-artesunate combinations will produce a synergistic anti-malarial effect....
Preprint
Full-text available
Hyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed wi...
Article
Full-text available
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder, characterized by persistent elevation of blood glucose either due to insulin resistance or insulin insufficiency. Metformin is the recommended first choice of drug for the management of T2DM and is known to improve insulin sensitivity and prevents hyperglycemia by reducing chronic inflammatio...
Conference Paper
Full-text available
The diversity offered by natural products has timelessly positioned it as a good source for novel therapeutics for the management of diverse medical conditions, including pain. The study aimed at evaluating the hydro-ethanolic root bark extract of Ziziphus abyssinica (ZAE) for analgesic property and the mechanism(s) responsible for this action. Als...
Article
Objectives Ziziphus abyssinica (ZA) is employed in managing several ailments in Traditional African Medicine. Scientific evaluations are necessary to ascertain the medicinal potential of ZA as a source of new drug molecules. This study investigated the possible therapeutic benefit of ZA leaf (ZAL) and root bark (ZARB) extracts in an experimental mo...
Article
Full-text available
Bergapten (5-methoxysporalen) is a furanocoumarin extracted from several species of citrus and bergamot oil. Bergamot essential oil is used traditionally in the management of inflammatory conditions. Previous studies on bergapten have explored mainly its in vitro anti-inflammatory activities which include suppression of the expression and release o...
Preprint
Full-text available
Background: Evidence of plasmodium resistance to some of the current antimalarial agents makes it imperative to search for newer and effective drugs to combat malaria. Therefore, this study evaluated whether the co-administrations of xylopic acid-amodiaquine and xylopic acid-artesunate combinations will produce synergistic antimalarial effect. Meth...
Article
Full-text available
Prior studies on the anti-inflammatory compound bergapten have shown promise in averting allergic airway hyperresponsiveness. This study sought to establish its possible role in modulating an immunologically-induced airway inflammation and hyperresponsiveness in an ovalbumin model of asthma. Asthma is characterised by inflammation and constriction...
Article
Full-text available
Xylopic acid (15β-acetyloxy-kaur-16-en-19-oic acid) is a kaurene diterpene that can be obtained from various Xylopia spp. Xylopic acid has demonstrated several pharmacological activities in vitro and in vivo. The compound has shown promising effect as a potent analgesic, anti-inflammatory and anti-allergic agent. Xylopic acid is a CNS depressant an...
Article
Full-text available
Background: Advertisements of most alcoholic beverages in Ghana persuasively entice consumers with herbal constituents believed to enhance sexual performance, although, alcohol has negative effect onfertility. The impact of herbal constituents in these alcoholic beverages on the known negative effects of alcohol on fertility remains to be evaluated...
Article
Full-text available
Aims: Inflammation has been implicated in many disorders and currently available therapies elicit adverse effects. The coarse shrub of Calotropis procera has been used in folk medicine to treat several ailments such as asthma, rheumatism and also fever. The anti-inflammatory potential of Calotropis procera was assessed in this study to evaluate its...
Article
Full-text available
This work evaluated the analgesic property of ethanolic extract of Jatropha curcas in arthritic/skeletal pain models. Acute skeletal hyperalgesia was induced in knee joints of rats with 3% carrageenan-kaolin mixture. Twelve hours later, the rats were grouped and treated orally with 30, 100 and 300 mg/kg Jatropha curcas or morphine (1, 3 and 10 mg/...
Article
Full-text available
Sustained release diclofenac sodium matrix tablets (~100 mg) were prepared by wet granulation using blends of cashew gum, xanthan gum and HPMC as drug release modifiers. The flow properties of diclofenac sodium granules and the physical properties of the compressed matrix tablets namely, weight variation, tablet thickness, crushing strength, friabi...
Article
Full-text available
Xylopic acid, a diterpenoid isolated from the fruits of Xylopia aethiopica has demonstrated analgesic properties in acute pain models. It was therefore evaluated for its analgesic properties in paclitaxel-induced neuropathic pain, a type of pain difficult to treat clinically. Neuropathic pain was induced in rats by injecting 2 mg kg -1 of paclita...

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Projects (4)
Project
This research aims at investigating the efficacy of xylopic acid-amodiaquine, and xylopic acid artesunate in Plasmodium berghei malaria mice model   Specific objectives 1. To determine ED50S of artesunate, amodiaquine, and xylopic acid monotherapies in P. berghei ANKA-infected mice. 2. To test for synergism, potentiation and inhibition by performing an isobolographic analysis in P. berghei ANKA-infected mice after co-administration of i. Artesunate and xylopic acid ii. Amodiaquine and xylopic acid