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18
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Introduction
I am a Researcher with transdisciplinary expertise in physiology, biomechanics, mathematics, data analytics, and advanced 3D imaging. Building upon this expertise, my research aims to gain a comprehensive mechanistic understanding of human physiology, with a specific focus on skeletal muscles and their complex multiscale interactions with other systems. I prioritise clinical translation, aiming to improve health across the lifespan through targeted interventions.
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Publications
Publications (18)
Dysferlinopathies are a form of muscular dystrophy caused by gene mutations resulting in deficiency of the protein dysferlin. Symptoms manifest later in life in a muscle specific manner, although the pathomechanism is not well understood. This study compared the impact of dysferlin-deficiency on in vivo and ex vivo muscle function, and myofibre typ...
Muscular dystrophies (MDs) encompass a wide variety of inherited disorders that are characterized by loss of muscle tissue associated with a progressive reduction in muscle function. With a cure lacking for MDs, preclinical developments of therapeutic approaches depend on well-characterized animal models that recapitulate the specific pathology in...
Many neuromuscular disorders can have a differential impact on a specific myofibre-type, forming the central premise of this review. The many different skeletal muscles in mammals contain a spectrum of slow- to fast-twitch myofibres with varying levels of protein isoforms that determine their distinctive contractile, metabolic, and other properties...
Exercise‐induced muscle damage (EIMD) can affect athlete performance and is a risk factor for major muscle injury. The temporal profile of thiol‐oxidized albumin, a marker of oxidative stress, has shown potential in assessing recovery from EIMD in non‐athletically trained participants but not yet in trained participants. Our primary aim was to asse...
Background
Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in deficiency of the membrane-associated protein dysferlin. They manifest post-growth and are characterised by muscle wasting (primarily in the limb and limb-gridle muscles), inflammation, and replacement of myofibres with ad...
This commentary provides an independent consideration of data related to the drug vamorolone (VBP15) as an alternative steroid proposed for treatment of Duchenne muscular dystrophy (DMD). Glucocorticoids such as prednisone and deflazacort have powerful anti-inflammatory benefits and are the standard of care for DMD, but their long-term use can resu...
[This corrects the article DOI: 10.1371/journal.pone.0214908.].
Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by a genetic deficiency of the membrane-associated protein dysferlin, which usually manifest post-growth in young adults. The disease is characterized by progressive skeletal muscle wasting in the limb-girdle and limbs, inflammation, accumulation of lipid droplets...
Skeletal muscle function is governed by both the mechanical and structural properties of its constituent tissues, which are both modified by disease. Characterizing the mechanical properties of skeletal muscle tissue at an intermediate scale, i.e., between that of cells and organs, can provide insight into diseases such as muscular dystrophies. In...
Dysferlinopathies are a form of limb girdle muscular dystrophy (LGMDR2 dysferlin-related) caused by gene mutations resulting in deficiency of the membrane-associated protein dysferlin. Symptoms manifest post growth in a muscle specific manner, although the pathomechanism is not well understood. One feature is many lipid droplets present in slow-twi...
Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a resultant myopathy called dysferlinopathy. Dysferlinopathy manifests postgrowth with a progressive loss of skeletal muscle function, early intramyocellular lipid accumulation, and a striking later replacement of selective...
Completed ARRIVE Guidelines Checklist.
(PDF)
Whole dataset for this study.
Each tab contains a particular dataset as follows: Body + muscle weights etc; In vivo muscle function; Ex vivo muscle function; Myofibre typing.
(XLSX)
The Lloyd & Preece Psychometric Auto-Scorer is a programmed Excel sheet designed by Erin M Lloyd and David A Preece, which auto-scores a variety of common psychological questionnaires. Subscale and composite scores will be automatically calculated for these questionnaires, compared to a reference sample, and used to generate profile graphs showing...
