Erik Nilsen

Erik Nilsen
Bio-Signal Technologies, LLC · Neurotechnology

PhD

About

18
Publications
4,550
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518
Citations
Introduction
Noninvasive high-resolution neuroelectric interfaces Objective biomarkers for emotion types and intensities Engineered molecules for potent non-narcotic analgesia (safe & non-addictive opioid alternatives) Modeling & analysis of complex systems Single-trial detection of extremely weak signals buried in noise 3D deterministic model for large-scale (GR) & small-scale (QM) physics

Publications

Publications (18)
Article
Full-text available
Gain: and loss-of-function mutations in Nav1.7 cause chronic pain and pain insensitivity, respectively. The preferential expression of Nav1.7 in peripheral nervous system and its role in human pain signaling make Nav1.7 a promising target for next-generation pain therapeutics. However, pharmacological agents have not fully recapitulated these pain...
Patent
Full-text available
In an embodiment, an electrical-line-noise canceller includes a phase detector, a phase lock loop, a zero-crossing detector, and an adaptive filter. The phase detector is configured to receive a composite input signal including an input neural signal combined with electrical line noise and to detect a phase of the electrical line noise. The phase l...
Conference Paper
Full-text available
Full Waveform Inversion of seismic data requires the solution of a strongly non-linear optimization problem. Usually iterative gradient based methods are employed for the solution. These methods is based on the Born approximation and assumes that the derivative of the error function with respect to the velocity can be adequately represented by a li...
Article
Full-text available
NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine, or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory. In spite of the widespread use of NMDAR antagonists in preclinical and clinical studies, our understan...
Article
Full-text available
Interest in local field potentials (LFPs) and action potential shape has increased markedly. The present work describes distortions of these signals that occur for two reasons. First, the microelectrode recording circuit operates as a voltage divider producing frequency-dependent attenuation and phase shifts when electrode impedance is not negligib...
Article
Full-text available
This paper presents design, fabrication, and characterization of easy-to-handle electroplated nickel microgrippers with SU-8 adaptors for heterogeneous micro/nano assembly applications. Two distinctive designs of microgrippers as end-effectors of micro/nano assembly applications have been developed in this work. The first design is 200 m thick elec...
Article
Full-text available
To measure the response rate of normal human subjects to a low-strength, low-frequency magnetic field (MF), using nonlinear quantitative analysis of the electroencephalogram (EEG). Eight subjects were exposed to a series of trials, each consisting of the application of the MF (1 G, 60 Hz) for 2 s followed by a field-free period of 5 s, and the EEG...
Article
Full-text available
The detection process by which animals react to the presence of electromagnetic fields (EMFs) may be a form of sensory transduction. However, the anatomic location of signal transduction in most species is unknown. Attempts to solve this problem by applying local EMFs and registering the resulting changes in the electroencephalogram (EEG) have not...
Article
Full-text available
We studied the effect of an electromagnetic field from a cellular telephone on brain electrical activity, using a novel analytical method based on a nonlinear model. The electroencephalogram (EEG) from rabbits was embedded in phase space and local recurrence plots were calculated and quantified using recurrence quantitation analysis to permit stati...
Article
Full-text available
The reports dealing with the effects of electromagnetic fields (EMFs) on brain electrical activity have been inconsistent. We suspected that the use of linear methods and models accounted for some of the variability, and we explored the issue by using a novel approach to study the effects of EMFs on the electroencephalogram (EEG) from rabbits. The...
Conference Paper
Full-text available
It is of great interest to develop an efficient and reliable manufacturing approach that allows for the integration of microdevices each of which is optimally fabricated using a different process. We present a new method to achieve electrical and mechanical interconnects for use in heterogeneous integration. This method combines metal reflow and a...
Article
Full-text available
Animal studies of the effects of low-frequency electromagnetic fields (EMFs) on the immune system appear inconsistent, and recent evidence indicates that inconspicuous experimental problems are not responsible. We hypothesized that the inconsistencies resulted from use of linear methods and models to study inherently nonlinear input-output relation...
Article
Full-text available
The results of many different types of animal and human studies dealing with the biological effects of exposure to low frequency electromagnetic fields (EMFs) have consistently been both positive and negative. We addressed the question of why this pattern had occurred so commonly in biological studies involving exposure to EMFs and hypothesized tha...
Article
Full-text available
The characteristic biological effects of low-frequency electromagnetic fields (EMFs) appear to be functional changes in the central nervous, endocrine and immune systems. For unapparent reasons, however, the results of similar studies have often differed markedly from one another. We recognized that it had generally been assumed, in the studies, th...
Article
Full-text available
Studies of the effects of power-frequency electromagnetic fields (EMFs) on the immune and other body systems produced positive and negative results, and this pattern was usually interpreted to indicate the absence of real effects. However, if the biological effects of EMFs were governed by nonlinear laws, deterministic responses to fields could occ...
Article
Thesis (Ph.D. in Computational Analysis and Modeling) -- Louisiana Tech University, August 2007. Includes bibliographical references (leaves 104-110) and abstract.
Article
Thesis (M.S. in Electrical Engineering)--Louisiana Tech University, April 2000. Bibliography: leaves 120-122.

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