Erik J. Aarnoutse

Erik J. Aarnoutse
Utrecht University | UU · University Medical Center Utrecht

PhD

About

60
Publications
11,081
Reads
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1,677
Citations
Citations since 2016
35 Research Items
1338 Citations
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2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Additional affiliations
June 2003 - present
University Medical Center Utrecht

Publications

Publications (60)
Article
Implantable brain–computer interfaces (BCIs) promise to be a viable means to restore communication in individuals with locked-in syndrome (LIS). In 2016, we presented the world-first fully implantable BCI system that uses subdural electrocorticography electrodes to record brain signals and a subcutaneous amplifier to transmit the signals to the out...
Article
Full-text available
Objective: Implanted Brain-Computer Interfaces (BCIs) employ neural signals to control a computer and may offer an alternative communication channel for people with locked-in syndrome (LIS). Promising results have been obtained using signals from the sensorimotor (SM) area. However, in earlier work on home-use of an electrocorticography (ECoG)-bas...
Preprint
Development of brain-computer interface (BCI) technology is key for enabling communication in individuals who have lost the faculty of speech due to severe motor paralysis. A BCI control strategy that is gaining attention employs speech decoding from neural data. Recent studies have shown that a combination of direct neural recordings and advanced...
Article
Full-text available
Positive blood oxygenation level-dependent (BOLD) responses (PBR), as measured by functional Magnetic Resonance Imaging (fMRI), are the most utilized measurements to non-invasively map activity in the brain. Recent studies have consistently shown that BOLD responses are not exclusively positive. Negative BOLD responses (NBR) have been reported in r...
Article
Full-text available
Intracranial human recordings are a valuable and rare resource of information about the brain. Making such data publicly available not only helps tackle reproducibility issues in science, it helps make more use of these valuable data. This is especially true for data collected using naturalistic tasks. Here, we describe a dataset collected from a l...
Article
Full-text available
The Eighth International Brain-Computer Interface (BCI) Meeting was held June 7-9, 2021 in a virtual format. The conference continued the BCI Meeting series' interactive nature with 21 workshops covering the breadth of topics in BCI (also called brain-machine interface) research. Some workshops provided detailed examinations of methods, hardware, o...
Article
Full-text available
While brain computer interfaces (BCIs) offer the potential of allowing those suffering from loss of muscle control to once again fully engage with their environment by bypassing the affected motor system and decoding user intentions directly from brain activity, they are prone to errors. One possible avenue for BCI performance improvement is to det...
Article
Full-text available
Objective Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) can be used to restore communication in individuals with locked-in syndrome. In motor-based BCIs, the number of degrees-of-freedom, and thus the speed of the BCI, directly depends on the number of classes that can be discriminated from the neural activity in the sensorimot...
Preprint
Full-text available
Intracranial human recordings are a valuable and rare resource that the whole neuroscience community can benefit from. Making such data available to the neuroscience community not only helps tackle the reproducibility issues in science, it also helps make more use of this valuable data. The latter is especially true for data collected using natural...
Article
Full-text available
Background: Brain-computer interfaces (BCIs) have been proposed as an assistive technology (AT) allowing people with locked-in syndrome (LIS) to use neural signals to communicate. To design a communication BCI (cBCI) that is fully accepted by the users, their opinion should be taken into consideration during the research and development process....
Article
Full-text available
The objective of this study was to test the feasibility of using the dorsolateral prefrontal cortex as a signal source for brain-computer interface control in people with severe motor impairment. We implanted two individuals with locked-in syndrome with a chronic brain-computer interface designed to restore independent communication. The implanted...
Article
The Seventh International Brain-Computer Interface (BCI) Meeting was held May 21-25th, 2018 at the Asilomar Conference Grounds, Pacific Grove, California, United States. The interactive nature of this conference was embodied by 25 workshops covering topics in BCI (also called brain-machine interface) research. Workshops covered foundational topics...
Article
Full-text available
This study uses electrocorticography in humans to assess how alpha-and beta-band rhythms modulate excitability of the sensorimotor cortex during psychophysically-controlled movement imagery. Both rhythms displayed effector-specific modulations, tracked spectral markers of action potentials in the local neuronal population, and showed spatially syst...
Article
Full-text available
This study uses electrocorticography in humans to assess how alpha- and beta-band rhythms modulate excitability of the sensorimotor cortex during psychophysically-controlled movement imagery. Both rhythms displayed effector-specific modulations, tracked spectral markers of action potentials in the local neuronal population, and showed spatially sys...
Article
Full-text available
For people suffering from severe paralysis, communication can be difficult or nearly impossible. Technology systems called brain-computer interfaces (BCIs) are being developed to assist these people with communication by using their brain activity to control a computer without any muscle activity. To benefit the development of BCIs that employ neur...
Article
Full-text available
The sensorimotor cortex is a frequently targeted brain area for the development of Brain-Computer Interfaces (BCIs) for communication in people with severe paralysis and communication problems (locked-in syndrome; LIS). It is widely acknowledged that this area displays an increase in high-frequency band (HFB) power and a decrease in the power of th...
Article
Full-text available
Objective: Brain-computer interfaces (BCIs) are being developed to restore reach and grasping movements of paralyzed individuals. Recent studies have shown that the kinetics of grasping movement, such as grasp force, can be successfully decoded from electrocorticography (ECoG) signals, and that the high-frequency band (HFB) power changes provide d...
Article
Full-text available
Objective: We investigated the long-term functional stability and home use of a fully implanted electrocorticography (ECoG)-based brain-computer interface (BCI) for communication by an individual with late-stage Amyotrophic Lateral Sclerosis (ALS). Methods: Data recorded from the cortical surface of the motor and prefrontal cortex with an implan...
Poster
Full-text available
Direct cortical recordings in humans link the spectral structure of local field potentials to inhibition/disinhibition mechanisms coordinating sensorimotor neuronal populations during movement selection.
Preprint
Full-text available
Alpha-and beta-band rhythms over the sensorimotor cortex are prominent and functionally relevant for movement selection. However, it remains unclear whether these rhythms modulate excitability of the same neuronal ensembles in the same direction when a movement is selected across the sensorimotor cortex. Using electrocorticography in humans (N=11),...
Preprint
Full-text available
Alpha- and beta-band rhythms over the sensorimotor cortex are prominent and functionally relevant for movement selection. However, it remains unclear whether these rhythms modulate excitability of the same neuronal ensembles in the same direction when a movement is selected across the sensorimotor cortex. Using electrocorticography in humans (N=11)...
Article
Locked-in syndroom (LIS) is een situatie waarin iemand bij bewustzijn is, maar niet kan bewegen en spreken. De oorzaak ervan kan een hersenstaminfarct zijn of een neurodegeneratieve aandoening, zoals amyotrofe laterale sclerose (ALS). De cognitieve vermogens bij LIS zijn veelal intact. Brain-Computer Interfaces (BCI’s) zijn apparaten die gebruikmak...
Article
Objective: High-frequency band (HFB) activity, measured using implanted sensors over the cortex, is increasingly considered as a feature for the study of brain function and the design of neural-implants, such as Brain-Computer Interfaces (BCIs). One common way of extracting these power signals is using a wavelet dictionary, which involves the sele...
Article
For people who cannot communicate due to severe paralysis or involuntary movements, technology that decodes intended speech from the brain may offer an alternative means of communication. If decoding proves to be feasible, intracranial Brain-Computer Interface systems can be developed which are designed to translate decoded speech into computer gen...
Article
Full-text available
Over the last decades, the brain-computer interface (BCI) research field has seen steep progress and now recognizes several types of applications, each with its own target population. Despite this evolution, BCIs seem to remain a research application, and are hardly used in daily life at home, work or in the clinic. Therefore, as a field, we need t...
Article
Full-text available
Background: People who suffer from paralysis have difficulties participating in society. Particularly burdensome is the locked-in syndrome (LIS). LIS patients are not able to move and speak but are cognitively healthy. They rely on assistive technology to interact with the world and may benefit from neurotechnological advances. Optimal research an...
Article
Full-text available
The Sixth International Brain–Computer Interface (BCI) Meeting was held 30 May–3 June 2016 at the Asilomar Conference Grounds, Pacific Grove, California, USA. The conference included 28 workshops covering topics in BCI and brain–machine interface research. Topics included BCI for specific populations or applications, advancing BCI research through...
Article
Full-text available
Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Stil...
Article
Full-text available
Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with latestage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain–computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed...
Article
Full-text available
Preparation for an action, such as grasping an object, is accompanied by an enhanced perception of the object's action-relevant features, such as orientation and size. Cortical feedback from motor planning areas to early visual areas may drive this enhanced perception. To examine whether action preparation modulates activity in early human visual c...
Article
Full-text available
The increasing understanding of human brain functions makes it possible to directly interact with the brain for therapeutic purposes. Implantable brain computer interfaces promise to replace or restore motor functions in patients with partial or complete paralysis. We postulate that neuronal states associated with gestures, as they are used in the...
Article
Mental calculation is a complex mental procedure involving a frontoparietal network of brain regions. Functional MRI (fMRI) studies have revealed interesting characteristics of these regions, but the precise function of some areas remains elusive. In the present study, we used electrocorticographic (ECoG) recordings to chronometrically assess the n...
Article
Full-text available
Recent scientific achievements bring the concept of neural prosthetics for reinstating lost motor function closer to medical application. Current research involves severely paralyzed people under the age of 65, but implications for seniors with stroke or trauma-induced impairments are clearly on the horizon. Demographic changes will lead to a short...
Article
Full-text available
Neocortical neuronal activity is characterized by complex spatiotemporal dynamics. Although slow oscillations have been shown to travel over space in terms of consistent phase advances, it is unknown how this phenomenon relates to neuronal activity in other frequency bands. We here present electrocorticographic data from three male and one female h...
Article
Objective: Electrocortical stimulation mapping (ESM) is the current gold standard for functional mapping of the eloquent cortex prior to epilepsy surgery. The procedure is, however, time-consuming and quite demanding for patients. Electrocorticography frequency mapping (ECoG mapping) has been suggested as an adjunct method. Here, we investigated w...
Article
Electrical brain signals are often decomposed into frequency ranges that are implicated in different functions. Using subdural electrocorticography (ECoG, intracranial EEG) and functional magnetic resonance imaging (fMRI), we measured frequency spectra and BOLD responses in primary visual cortex (V1) and intraparietal sulcus (IPS). In V1 and IPS, 3...
Article
Full-text available
It is often assumed that similar behavior is generated by the same brain activity. However, this does not take into account the brain state or recent behavioral history and movement initiation or continuation may not be similarly generated in the brain. To study whether similar movements are generated by the same brain activity, we measured neurona...
Article
Full-text available
The neurophysiological underpinnings of functional magnetic resonance imaging (fMRI) are not well understood. To understand the relationship between the fMRI blood oxygen level dependent (BOLD) signal and neurophysiology across large areas of cortex, we compared task related BOLD change during simple finger movement to brain surface electric potent...
Article
Objective: Intracranial brain computer interfaces (BCIs) can be connected to the user's cortex permanently. The interfaces response when fed with non-task elicited brain activity becomes important as design criterion: ideally intracranial BCIs should remain silent. We study their error probability in the form of false alarms. Methods: Using elec...
Article
Electrocorticography, primarily used in a clinical context, is becoming increasingly important for fundamental neuroscientific research, as well as for brain-computer interfaces. Recordings from these implanted electrodes have a number of advantages over non-invasive recordings in terms of band width, spatial resolution, smaller vulnerability to ar...
Article
Full-text available
For the development of minimally invasive brain-computer interfaces (BCIs), it is important to accurately localize the area of implantation. Using fMRI, we investigated which brain areas are involved in motor imagery. Twelve healthy subjects performed a motor execution and imagery task during separate fMRI and EEG measurements. fMRI results showed...
Article
Objective Brain–computer interfaces (BCIs) translate deliberate intentions and associated changes in brain activity into action, thereby offering patients with severe paralysis an alternative means of communication with and control over their environment. Such systems are not available yet, partly due to the high performance standard that is requir...
Article
Functional mapping of eloquent cortex is often necessary prior to invasive brain surgery, but current techniques that derive this mapping have important limitations. In this article, we demonstrate the first comprehensive evaluation of a rapid, robust, and practical mapping system that uses passive recordings of electrocorticographic signals. This...
Article
The pretectal nucleus of the optic tract is involved in optokinetic nystagmus. Albino animals suffer from inverse optokinetic nystagmus, possibly due to a smaller number of ipsilateral projections. Animals with laterally placed eyes have an asymmetric nystagmus, attributed to a presumed lack of binocular cortical input to the nucleus of the optic t...

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Projects

Projects (2)
Archived project
The iCONNECT project aimed at designing a new generation of implantable BCIs based on high-density ECoG grids.