Eric Thouvenot

Eric Thouvenot
Centre Hospitalier Régional Universitaire de Nîmes · Department of Neurology

MD PhD

About

190
Publications
40,925
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3,337
Citations
Introduction
Eric Thouvenot is mainly involved in research of biomarkers of and using proteomics. He has implemented and adapted to CSF samples a powerful immunodepletion method to remove the 20 most abundant plasma proteins from CSF, allowing in-depth characterization of CSF proteome, including low-abundant proteins secreted by CNS cells, especially using SILAC to investigate the neuronal secretome. As a Neurologist, Eric Thouvenot is involved in MS and leads the MS clinic in Nîmes University Hospital. He got several grants from pharmaceutical companies and charities (ARSEP) dedicated to clinical and physiopathological studies in MS. He coordinates a national PHRC aimed at evaluating the clinical efficacy of Vitamin D to reduce conversion to MS after a clinically isolated syndrome in 316 patients.
Additional affiliations
September 2015 - present
Centre Hospitalier Régional Universitaire de Nîmes
Position
  • Professor (Full)
Description
  • Head of Neurology Department Multiple Sclerosis Clinics
May 2011 - present
French National Centre for Scientific Research
Position
  • Professor (Full)
November 2007 - May 2011
Centre Hospitalier Universitaire de Montpellier
Position
  • Professor (Assistant)
Education
November 2005 - October 2009
Institut de Génomique Fonctionnelle,
Field of study
  • Neuroscience
November 2000 - October 2005
Université de Montpellier
Field of study
  • Medecine
September 1996 - August 2000
Sorbonne Université
Field of study
  • Medecine

Publications

Publications (190)
Article
Vitamin D deficiency has been associated with the risk of multiple sclerosis, disease activity and progression. Results from in vitro experiments, animal models and analysis of human samples from randomized controlled trials provide comprehensive data illustrating the pleiotropic actions of Vitamin D on the immune system. They globally result in im...
Article
Full-text available
Background Natalizumab and fingolimod are used as high-efficacy treatments in relapsing–remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different methods to control treatment indication bias and manage censoring. The objective of this empirical study was to elucidate the impac...
Article
Background: Therapeutic management of relapsing-remitting multiple sclerosis (RRMS) has evolved towards early treatment. The objective was to assess the impact of early treatment initiation on disability progression among RRMS first-line treated patients. Methods: This study included all incident RRMS cases starting interferon or glatiramer acet...
Article
Features of resting brain metabolism in motor functional neurological disorder are poorly characterized. This study aimed to investigate the alterations of resting brain metabolism in a cohort of patients experiencing a first episode of motor functional neurological disorder with recent symptom onset, and their association with persistent disabilit...
Article
MRI signal changes in the brainstem are observed in a multitude of disorders including vascular diseases, neoplastic lesions, degenerative diseases, inflammatory disorders, metabolic diseases, infections, and trauma. In some diseases, brainstem involvement is typical and sometimes isolated, while in other diseases, brainstem lesions are only observ...
Article
Full-text available
Radiologically Isolated Syndrome (RIS) is characterized by MRI-typical brain lesions fulfilling the 2009 Okuda criteria, detected in patients without clinical conditions suggestive of MS. Half of all RIS patients convert to MS within 10 years. The individual course of the disease, however, is highly variable with 12% of RIS converting directly to p...
Article
Context: Posterior spinal cord lesions are found in patients with ganglionopathy. These are normally found in later stages of the neuronopathy as a consequence of dorsal root ganglia degeneration. Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS) is an emerging neurological disorder. Myelitis lesions have been described in conf...
Article
In France, two therapeutic strategies can be offered after fingolimod (FNG) withdrawal to highly active relapsing–remitting multiple sclerosis (RRMS) patients: natalizumab (NTZ) or anti-CD20. We compared the effectiveness of these two strategies as a switch for FNG within the OFSEP database. The primary endpoint was the time to first relapse. Other...
Article
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Multiple paraneoplastic syndromes are a rare clinical manifestation. We describe the case of an 82-year-old woman who presented with neurological (rapidly progressive cerebellar syndrome and combined sensory-motor neuronopathy) and rheumatological (palmar fasciitis and polyarthritis syndrome) paraneoplastic syndromes associated with two onconeural...
Article
Background and Purpose Intraplaque hemorrhage (IPH) is a key feature of vulnerable carotid atherosclerotic plaque (CAP), associated with low densities (<25 Hounsfield unit, HU) on CTA. This study aimed to analyze CAP on routine CTA performed in patients with symptomatic and asymptomatic carotid stenosis undergoing carotid endarterectomy (CEA) by as...
Article
Dissociative disorders (DD) and conversion disorders (CD) are frequent in general and psychiatric populations. Some evidence suggest that the hypothalamic-pituitary axis (HPA) and autonomic nervous system (ANS) are dysregulated in both disorders. We carried out a systematic review of the literature to summarize the existing knowledge on the stress...
Poster
Full-text available
Introduction: Younger age, oligoclonal bands, infratentorial, and presence of spinal cord lesions are factors associated with an increased 10-year risk of clinical conversion from radiologically isolated syndrome (RIS). Whether disease-modifying therapy is beneficial in RIS remains currently unknown. Objectives: To evaluate the 2-year risk of a cli...
Article
Full-text available
Importance: Younger age, oligoclonal bands, and infratentorial and spinal cord lesions are factors associated with an increased 10-year risk of clinical conversion from radiologically isolated syndrome (RIS) to multiple sclerosis (MS). Whether disease-modifying therapy is beneficial for individuals with RIS is currently unknown. Objectives: To e...
Article
IntroductionNatalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.Objective The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS s...
Article
Full-text available
We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and...
Article
Diagnosis of inherited ataxia and related diseases represents a real challenge given the tremendous heterogeneity and clinical overlap of the various causes. We evaluated the efficacy of molecular diagnosis of these diseases by sequencing a large cohort of undiagnosed families. We analyzed 366 unrelated consecutive patients with undiagnosed ataxia...
Article
Background: Acute infarction patterns have been described in cardioembolic stroke, mainly with atrial fibrillation (AF) or patent foramen ovale. We aimed to analyse acute infarction magnetic resonance imaging (MRI) characteristics in stroke patients with intracardiac thrombus (ICT) compared with stroke patients with AF. Methods: We performed a r...
Article
Full-text available
Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their central role in the pathogenesis but also as drug targets, even if nowadays, they have no impact in clinical practice. Recently, high-resolution approaches, such as ma...
Article
Full-text available
Objective To determine whether adult cases of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) may be related to familial hemophagocytic lymphohistiocytosis (HLH) causes, we have screened patients with adult-onset CLIPPERS for mutations in primary HLH-associated genes. Methods In our cohort o...
Article
Background Natalizumab and fingolimod were the first preparations recommended for disease breakthrough in priorly treated relapsing-remitting multiple sclerosis. Of three published head-to-head studies two showed that natalizumab is the more effective to prevent relapses and EDSS worsening. Methods By re-analyzing original published results from M...
Article
Full-text available
Introduction 3,4-Dihydroxy-6-[¹⁸F]-fluoro-l-phenylalanine (FDOPA) positron emission tomography (PET) is sensitive for identifying primary brain tumors. However, increased FDOPA uptake has been reported in pseudotumoral brain lesions. Our aim was to analyse FDOPA-PET in patients with pseudotumoral brain lesions and to compare them with patients with...
Article
Full-text available
We compared SimoaTM and EllaTM immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The EllaTM instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a c...
Article
Introduction Le syndrome d’ataxie cérébelleuse avec neuropathie et aréflexie vestibulaire (CANVAS) est une pathologie héréditaire autosomique récessive dont la mutation a été publiée en 2019. Observation Un homme de 55 ans d’origine portugaise a consulté pour troubles de l’équilibre évoluant depuis trois ans, associant des paresthésies des quatre...
Article
Introduction La diplégie faciale révélant un syndrome de Guillain–Barré (SGB) est une manifestation neurologique qui émerge comme associée à l’infection virale émergente SARS-CoV-2. Observation Nous rapportons deux cas consécutifs de diplégie faciale en lien avec un SGB. Les patients remplissaient les critères cliniques (diplégie faciale, parésie,...
Article
Introduction L’usage de protoxyde d’azote (PA) à but récréatif est fréquent parmi les jeunes. Une consommation intense et prolongée peut entraîner des effets neurotoxiques. Plusieurs tableaux neuropsychiatriques différents ont été décrits. Observation Nous rapportons trois tableaux neurologiques consécutifs après consommation de PA. Le premier pat...
Article
Background: Disease modifying therapies (DMTs), have an impact on relapses and disease progression. Nonetheless, many patients with multiple sclerosis (pwMS) remain untreated. The objective of the present study was to determine the proportion of untreated patients with multiple sclerosis (pwMS) followed in expert centers in France and determine th...
Article
Background: The prognosis in Myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease (MOGAD) is a matter of debate. Our aim was to assess long-term outcomes of patients with MOGAD. Methods: We retrospectively analysed clinical and paraclinical data of patients who tested positive for MOG-IgG and had clinical follow-up of at lea...
Article
Background A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. Objectives The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. Methods Data from MSBase, a...
Article
Full-text available
Background Amyloid pathology, which is one of the characteristics of Alzheimer’s disease (AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis, clearance, or aggregation. A decrease in cerebrospinal fluid (CSF) level Aβ1–42 is evident in AD, and the CSF ratio Aβ42/Aβ40 has recently been identified as one of th...
Article
Objectives: The main objective was to compare clinical features, disease course, myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab) dynamics, between children and adults with MOG-Ab-associated disease (MOGAD). Methods: Retrospective multicentric, national study including 98 children and 268 adults with MOGAD between January 2014, and Septem...
Article
Objectives: Establish recommendations for the management of UTIs in MS patients. Background: Urinary tract infections (UTIs) are common during multiple sclerosis (MS) and are one of the most common comorbidities potentially responsible for deaths from urinary sepsis. Methods: The recommendations attempt to answer three main questions about UTI...
Article
Introduction Les atteintes cognitives sévères dans la sclérose en plaques (SEP) sont rarement inaugurales et les amnésies sont exceptionnelles. Observation Une patiente de 26 ans, droitière, sans antécédent, a été hospitalisée pour des troubles mnésiques s’aggravant en une semaine. L’examen clinique retrouvait une amnésie antérograde et rétrograde...
Article
L’incidence de la maladie de Basedow (MB) est plus élevée en cas de Sclérose en plaque (SEP) que dans la population générale (3,1 % vs 0,4 %). Le traitement par Anticorps Monoclonaux anti CD52 (Alentuzumab) prescrit dans la SEP a pour principal effet indésirable l’apparition d’une maladie de Basedow lors de la restauration de l’immunité, nécessitan...
Article
Purpose The purpose of this study was to create an algorithm that combines multiple machine-learning techniques to predict the expanded disability status scale (EDSS) score of patients with multiple sclerosis at two years solely based on age, sex and fluid attenuated inversion recovery (FLAIR) MRI data. Materials and methods Our algorithm combined...
Preprint
Full-text available
Background: Amyloid pathology, which is one of the characteristics of Alzheimer's disease (AD), results from altered metabolism of the beta-amyloid peptide (Aβ) in terms of synthesis, clearance or aggregation. A decrease in cerebrospinal fluid (CSF) level Aβ1-42 is evident in AD, and the CSF ratio Aβ40 /Aβ40 has recently been identified as one of t...
Article
Objective To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD). Methods Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (...
Article
Simultaneous multiple intracerebral hemorrhage (SMICH) is defined as ICH in two or more discrete noncontiguous acute intraparenchymal locations on initial CT. About 5% of ICH patients present with SMICH. ICH/SMICH etiology is classically divided into disorders of primary or secondary origin. About half of primary SMICH cases are caused by cerebral...
Article
Background: In acute infarction patients, small cortical cerebellar infarctions (SCCI) on MRI (assessed on diffusion-weighted imaging, with SCCI often chronic and asymptomatic) are associated with acute cardioembolic infarction. In young cryptogenic stroke patients, patent foramen ovale (PFO) is thought to be a potential source of cardioembolic in...
Article
Purpose: New multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients' quality of life, have recently emerged. Nonetheless, these DMTs are not without associated complications (severe adverse events like. progressive mu...
Article
En dépit des nombreuses réticences à légaliser le cannabis à travers le monde du fait de son effet psychotrope, l’usage médical de cette plante devient aujourd’hui autorisé dans de nombreux pays. Ceci est largement dû à l’évolution des connaissances scientifiques qui ont permis d’objectiver des propriétés thérapeutiques du cannabis, connues depuis...
Article
The ideal treatment for multiple sclerosis (MS) would target both the neuroinflammatory component of the disease (peripheral and central) and its neurodegenerative component, via modulation of a ubiquitous and pleiotropic common target. Sphingosine-1-phosphate (S1P), a product of sphingosine metabolism, regulates many biological functions (includin...
Article
Objective: To describe the clinico-radiological features and long-term prognosis in patients with cerebral amyloid angiopathy-related inflammation (CAA-ri). Methods: Twenty-eight CAA-ri patients were recruited retrospectively from 6 neurological centers. We recorded the clinico-radiological and biological data, at baseline and during follow-up....
Conference Paper
Full-text available
Radiologically Isolated Syndrome: A 10-year Follow-up Study to Identify Factors Predicting a Clinical Event. Christine Lebrun-Frénay1, Orhun Kantarci2, Aksel Siva3, Clarisse Carra-Dallière4, Celine Louapre5, Françoise Durand-Dubief6, Eric Thouvenot7, Patrick Vermersch8, Matilde Inglese9, Nicola de Stefano10, Guillaume Mathey11, Emmanuelle Le page1...
Article
Importance Risk of developing progressive multifocal leukoencephalopathy (PML) is the major barrier to using natalizumab for patients with multiple sclerosis (MS). To date, the association of risk stratification with PML incidence has not been evaluated. Objective To describe the temporal evolution of PML incidence in France before and after intro...
Article
Full-text available
Objective: To evaluate the safety and efficacy of cholecalciferol in patients with relapsing-remitting MS (RRMS). Methods: In this double-blind, placebo-controlled parallel-group, 2-year study, 181 patients with RRMS were randomized 1:1. Key inclusion criteria were a low serum 25-hydroxy vitamin D (25OHD) concentration (<75 nmol/L), a treatment...
Article
Background: There are limited data on the comparative prevalence of neurocognitive impairment (NCI) in aging people living with human immunodeficiency virus (PLHIV) and people not living with HIV. Methods: This was a cross-sectional study of PLHIV randomly matched by age (±4 years), gender, and education with 5 HIV-uninfected individuals from th...
Article
Full-text available
Background: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed to describe the response to different therapeutic strategies in adult patients with relapsing MOG-Ab-associated disease. Methods: This is a retrospectiv...
Article
Full-text available
Background The diagnosis of atypical inflammatory demyelinating lesions can be difficult. Brain biopsy is often required to exclude neoplasms. Moreover, the relationship between these lesions and multiple sclerosis and NMOSD is not clear. Objectives Our objectives were to describe radiological and pathological characteristics of patients with acut...
Article
Full-text available
Objective: In this study, we compared the effectiveness of teriflunomide (TRF) and dimethyl fumarate (DMF) on both clinical and MRI outcomes in patients followed prospectively in the Observatoire Français de la Sclérose en Plaques. Methods: A total of 1,770 patients with relapsing-remitting multiple sclerosis (RRMS) (713 on TRF and 1,057 on DMF)...
Article
Objectives: We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated myelitis and (2) determine baseline prognostic factors among MOG-Ab-positive patients whose disease s...
Article
Full-text available
Background A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI) representing end zone infarctions on MRI would be associated with cardiac embolism. Methods We retrospectively analyzed consecut...
Article
Full-text available
Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status...
Article
Background: Recently, finger-like projections (FLP) and subarachnoid haemorrhage extension (SAHE) of lobar intracerebral haemorrhage (LH) on acute CT together with ApoE4 genotype have been used in a prediction model for histopathologically proven cerebral amyloid angiopathy (CAA). Our aim was to analyse FLP and SAHE on acute/early subacute magneti...
Article
Full-text available
Objective To analyze whether myelin oligodendrocyte glycoprotein antibody (MOG-Ab) titres at onset of the disease were different according to the clinical phenotype at presentation, and to investigate whether the titres were associated with risk of further relapses or predicted clinical outcome in adult patients. Finally, we assessed an alternative...
Article
Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to...
Article
Received: June 26, 2018 Accepted: October 05, 2018 Published online: November 21, 2018 Issue release date: February 2019
Article
Background Neuroimaging studies suggest that social distress and suicidal vulnerability share common cerebral bases. Moreover, increased peripheral inflammatory activity is involved in both social distress and suicidal behavior. Objective To evaluate, in suicidal and non-suicidal individuals, the association between the activation of specific cere...