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I am a Biomedical Design Engineer with interests in medical devices and diagnostics, cell culture systems, surface science, and biogerontology. I have extensive experience in device design and CAD - 20+ year SolidWorks user - and advanced prototyping/3D printing. I also provide Expert Witness services on a selective basis. I am the founder of Acme Biosystems - a startup focused on the development of gas-permeable cell cultureware and associated products.
THIS PHASE I SBIR FINAL REPORT DESCRIBES THE PRODUCTION AND TESTING OF FIBROUS POLYMERIC SUBSTRATES PRODUCED BY A NOVEL TECHNIQUE [ELECTROSTATIC SPINNING]. DESIGN AND DEVELOPMENT OF AN ELECTROSTATIC SPINNING DEVICE (ESD) IS DESCRIBED. THE ESD IS CAPABLE OF PRODUCING GEOMETRICALLY DEFINED, NONWOVEN MATS COMPOSED OF 0.01 TO 1.0 MICRON DIAMETER FIBRIL...
Type 1 rat tail collagen. Culture of primary rat and primary human hepatocytes for induction studies. Single-layer (not sandwich) coating. The easier the better but really focused on getting good performance from the hepatocytes so a more elaborate method will also be considered.
I am trying to find a simple method for treating a medical-grade silicone rubber surface to render it permanently or quasi-permanently hydrophilic such that the adsorption of proteins is greatly increased. I have used low pressure gas plasma with some success but would like to make the protein-surface interaction stronger and longer lived.