Eric Perakslis

Eric Perakslis
Duke University | DU

About

39
Publications
13,156
Reads
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705
Citations
Citations since 2017
24 Research Items
584 Citations
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2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (39)
Article
A draft policy is generally supportive but should start mandating data sharing
Article
Full-text available
The coronavirus outbreak is sweeping the globe with outbreaks reported on every continent except Antarctica as of March 2020. Data scientists are uniquely and diversely skilled in ways that can be highly effective in minimizing, combatting, and recovering from the impacts of the COVID-19 outbreak. In this Opinion, the basics of biodefense as well a...
Article
Full-text available
Wearable digital devices offer potential advantages over traditional methods for the collection of health‐related information, including continuous collection of dense data while study subjects are ambulatory or in remote settings. We assessed the utility of collecting continuous actigraphy and cardiac monitoring by deploying two FDA 510(k)‐cleared...
Article
Although the sharing of misleading information is likely as old as humanity, an unfortunate concomitant of the current digital environment is the amplification and accelerated spread of medical misinformation.¹,2 Growing distrust of medical professionals is causing some people to eschew drugs that have been proven effective, such as statins for hyp...
Article
Full-text available
Technology is changing how we practice medicine. Sensors and wearables are getting smaller and cheaper, and algorithms are becoming powerful enough to predict medical outcomes. Yet despite rapid advances, healthcare lags behind other industries in truly putting these technologies to use. A major barrier to entry is the cross-disciplinary approach r...
Data
Figure S3. The comparison of activity measurements by the HealthPatch (step counts, x‐axis) and Actiwatch (activity counts, y‐axis) devices for study subjects 58001_003 (a), 58001_007 (b) 58001_0011 (c), 58001_0012 (d), 58001_0015 (e), and 58001_0018 (f).
Data
Table S3. Quantification of time intervals with missing data.
Data
Table S2. Correlation of activity measurements by the HealthPatch and Actiwatch devices.
Data
Figure S1. Data flow diagrams for the Actiwatch and the HealthPatch devices in the phase I study.
Data
Table S1. Completeness of data collection for the HealthPatch and Actiwatch devices for each study subjects.
Data
Figure S2. Completeness of data collection for the HealthPatch (a) and Actiwatch (b) devices.
Article
Full-text available
Background: Over the past decade, clinical care has become globally dependent on information technology. The cybersecurity of health care information systems is now an essential component of safe, reliable, and effective health care delivery. Objective: The objective of this study was to provide an overview of the literature at the intersection of...
Article
Full-text available
We assessed the performance of two US Food and Drug Administration (FDA) 510(k)‐cleared wearable digital devices and the operational feasibility of deploying them to augment data collection in a 10‐day residential phase I clinical trial. The Phillips Actiwatch Spectrum Pro (Actiwatch) was used to assess mobility and sleep, and the Vitalconnect Heal...
Preprint
BACKGROUND Over the past decade, clinical care has become globally dependent on information technology. The cybersecurity of healthcare information systems is now an essential component of safe, reliable, and effective healthcare delivery. OBJECTIVE The objective of this study is to provide an overview of the literature at the intersection of cybe...
Article
Full-text available
Background Over the past decade, clinical care has become globally dependent on information technology. The cybersecurity of health care information systems is now an essential component of safe, reliable, and effective health care delivery. Objective The objective of this study was to provide an overview of the literature at the intersection of c...
Article
Clinical trials for Alzheimer disease drugs have an exceptionally high failure rate, discouraging investment in the field despite the unmet medical need. Drug developers need to more effectively harness existing and emerging data and digital technologies to improve the likelihood of success.
Article
Full-text available
Conducting research in a humanitarian setting requires quantifiable quality measures to ensure ethical study conduct. Digital health technologies are proven to improve research study quality and efficacy via automated data collection, improvement of data reliability, fidelity and resilience and by improved data provenance and traceability. Addition...
Article
Full-text available
The development of innovative wearable technologies has raised great interest in new means of data collection in healthcare and biopharmaceutical research and development. Multiple applications for wearables have been identified in a number of therapeutic areas; however, researchers face many challenges in the clinic, including scientific methodolo...
Article
Full-text available
By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affected. The outbreak required rapid innovation and adaptation. M?decins sans Fronti?res (MSF) scaled up its usual 20-30 bed Ebola management centres (EMCs) to 100-300 beds with over 300 workers in some settings. This brought c...
Article
Full-text available
By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affected. The outbreak required rapid innovation and adaptation. Médecins sans Frontières (MSF) scaled up its usual 20-30 bed Ebola management centres (EMCs) to 100-300 beds with over 300 workers in some settings. This brought c...
Article
Full-text available
By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affected. The outbreak required rapid innovation and adaptation. Médecins sans Frontières (MSF) scaled up its usual 20-30 bed Ebola management centres (EMCs) to 100-300 beds with over 300 workers in some settings. This brought c...
Article
“Exceptional responders” teach researchers how to improve therapies and can be assessed in the same way as patients with undiagnosed diseases.
Article
Virtually all health care organizations have had at least one data breach since 2012. Most of the largest data breaches and Health Care Information Privacy and Accountability Act fines could have been prevented by the simplest of strategies. Each researcher must clearly understand his or her responsibilities and liability.
Article
To date, cybercrime against health care has manifested as data loss, monetary theft, and attacks on medical devices and infrastructure. To find feasible solutions, organizations need to understand the interplay among threats, vulnerabilities, risks, and resilience.
Article
Many things have changed but much has remained the same as we have seen a dramatic increase in the generation of genetics, genomics and a variety of clinical data leading to increased data density and continued challenges in organizing and managing that data in pursuit of personalized medicine. Simultaneously, we have seen an increase in commercial...
Article
Full-text available
Non-communicable diseases, such as cancer, diabetes, and chronic cardiovascular and respiratory diseases, remain a major cause of mortality and morbidity worldwide resulting in more than 36 million deaths annually. Of primary importance in the reduction of this pain and suffering is the local use of education to eliminate misconception, enable prev...
Article
Personalized medicine is often associated and discussed in the context of advances from the human genome project. It is true that significant breakthroughs and advancement of deep sequencing and other analytical technologies have greatly expanded the pool of available biological data, but integrating this data into medically meaningful knowledge vi...
Article
Full-text available
The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as academic and government supported initiatives such as Clinical and Translational Science Awards (CTSA) in t...
Article
Full-text available
Much enthusiasm and energy are being directed toward open-source software approaches, precompetitive data sharing, and external innovation in the biopharmaceutical industry. At Johnson & Johnson (J&J), we have undertaken aggressive approaches to optimizing productivity and progress to address unmet medical needs. In this article, tranSMART, a fully...
Article
The insulin-transport enhancing effects of a pH-sensitive poly((methacrylic acid)-grafted-poly(ethylene glycol)) hydrogel system were studied using Caco-2 monolayers as an in vitro model of intestinal transport. Further, the ability of the hydrogel system to protect entrapped proteins through the upper gastrointestinal tract via digestion in simula...
Article
Type II, PAN-based carbon fibers (unsized and commercially treated) have been exposed to nitric acid and oxygen plasma individually and also to combined nitric acid/oxygen plasma treatments and the surface compositions have been determined using angle-resolved X-ray photoelectron spectroscopy (ARXPS) and ion scattering spectroscopy (ISS). Most of t...
Article
The promise of oral delivery formulations of therapeutic protein and peptides is one of high hopes but also of disappointment as, to date, parenteral administration remains the standard of care. A good example of this is in the case of human insulin delivery for diabetes where disease control, reduction of degenerative side effects and increased pa...

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Projects

Projects (2)
Project
Develop programs for cancer education for professionals in both high and low resource settings. Current work is on the Alicanto Cloud platform http://www.alicantocloud.com
Project
Development of systems and technologies to improve global health. Reducing health disparities with innovative uses of online and mobile health systems. Platforms Developed: Cure4Kids, POND4Kids, Alicanto