Eric T. Klopack

Eric T. Klopack
University of Southern California | USC · School of Gerontology

Doctor of Philosophy

About

40
Publications
4,170
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296
Citations
Citations since 2017
39 Research Items
289 Citations
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2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Introduction
Eric T. Klopack is a postdoctoral scholar in the Leonard Davis School of Gerontology at the University of Southern California. His research interests include the social determinants of health and the use of biomarkers of health for social research. His research also explores higher-order statistical modeling for longitudinal research.

Publications

Publications (40)
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Background: Shortened lifespans are associated with having Attention Deficit Hyperactivity Disorder (ADHD), which is likely mediated by its characteristic behavioral and sociodemographic factors that are also associated with accelerated physiological aging. Such factors include exhibiting more depressive symptoms, more cigarette smoking, higher bod...
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Socioeconomic and demographic factors including educational attainment, race and ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities in aging, morbidity, and mortality. Immune aging, including accumulation of late-differentiated, senescent-like lymphocytes and lower levels of naïve lymphocytes, may play a rol...
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Background Cigarette smoke is a major public health concern. Epigenetic aging may be an important pathway by which exposure to cigarette smoke affects health. However, little is known about how exposure to smoke at different life stages affects epigenetic aging, especially in older adults. This study examines how three epigenetic aging measures (Gr...
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In a sample of 685 late middle-aged Black adults (M age at 2019 = 57.17 years), we examined the effects of loneliness and per capita income on accelerated aging using a newly developed DNA-methylation based index: the DunedinPACE. First, using linear, mixed effects regression in a growth curve framework, we found that change in DunedinPACE was depe...
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Early experiences of school disengagement may serve as a warning sign for later young adult adjustment difficulties and eventually contribute to accelerated aging among Black American youth. At the same time, supportive parenting may play a protective role. Using longitudinal data from the Family and Community Health Study (FACHS), we examined psyc...
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Exposure to stress is a risk factor for poor health and accelerated aging. Immune aging, including declines in naïve and increases in terminally differentiated T cells, plays a role in immune health and tissue specific aging, and may contribute to elevated risk for poor health among those who experience high psychosocial stress. Past data have been...
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Growing evidence suggests that social relationship quality can influence age-related health outcomes, although how the quality of one’s relationships directly relates to the underlying aging process is less clear. We hypothesized that lower social support and higher relationship strain would be associated with an accelerated epigenetic aging profil...
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Past research suggests that social, psychological and biological processes underlying common health problems are highly interrelated and may be comonents of a larger biopsychosocial process. This process may be influenced by marital status. The current study investigated a biopsychosocial process involving social, psychological and physcial health...
Preprint
Background: Life course socioeconomic and demographic factors including educational attainment, race and ethnicity, and childhood (SES) are very powerful predictors of large inequalities in aging, morbidity, and mortality. Immune aging, including accumulation of late-differentiated, senescent-like lymphocytes and lower level of naive lymphocytes, m...
Preprint
Exposure to stress is a well-established risk factor of poor health and accelerated aging. Immune aging, including declines in naive and increases in late memory and terminally differentiated T cells, plays an important role in immune health and tissue specific aging, and may contribute to the observed elevated risk for poor health among those who...
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Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages and have been linked to accelerated biological aging. We hypothesize that accelerated epigenetic aging, a marker of biological aging, may partially mediate the link between ACEs and depression. This study examines three second-generation epigenetic aging measures (...
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Conflictual marital and parental relationships mutually reinforce each other generating family-level stress. The cumulative experiences of stressful family conflictual circumstances (a family-level construct of family conflictual circumstances (FCC), based on marital and parental conflictual behaviors) affect a couple’s well-being. The present stud...
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This study investigates (a) heterogeneous trajectories of couple intimacy over the mid-later years (average ages of 40-65) and (b) how these intimacy classes are differentially associated with spouses' midlife financial strain as well as their later-life health and wellbeing outcomes. The sample was comprised of white couples in long-term marriages...
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Little is known about how biological and psychological consequences of adolescent stressful life events (SLEs) are jointly associated with socioeconomic and relational outcomes in adulthood. To address this gap, the present study involved testing a model based on the life course perspective that posits adolescent SLE trajectories produce parallel t...
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Adverse childhood experiences (ACEs) increase risk for depression in adolescents and older adults and have been linked to accelerated biological aging. We hypothesized that accelerated epigenetic aging may partially explain the link between ACEs and depression. This study examines second-generation epigenetic clocks (viz., GrimAge, PhenoAge, and Du...
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Using prospective data over 25 years from a sample of 416 women, the first objective of the current study was to investigate the biopsychosocial process over the second-half of the life course comparing mothers with diferent marital histories. The second objective was to investigate this biopsychosocial process for 296 maried mothers focusing on th...
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Objectives: Consistent with biopsychosocial models, shared pathophysiological conditions underlying both physical pain and depressive symptoms can result in the clustering of pain and depressive symptoms. However, previous studies have not investigated a higher-order construct capturing both pain and depressive symptoms over time. Furthermore, rese...
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Objectives: The recent biological clocks GrimAge and PoAm are robust predictors of morbidity and mortality. Little research, however, has investigated the factors that influence their ticking speed. No study has used multivariate analyses to examine whether childhood adversity, adult hardship, lifestyle practices, or some combination of these facto...
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The steeling hypothesis suggests experiencing moderate strain may improve an individual's ability to cope with future strain, whereas crisis theory suggests that experiencing temporary strain will reduce the effect of future strain. The current study improves on past research by utilizing data from two independent prospective panel studies (one of...
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Research focussing on individual biopsychosocial processes leading to physical pain as a health condition is rare. The present study investigated sense of control as a mechanism linking early midlife stress to later‐life physical pain for husbands and wives in long‐term marriages. Using data from 508 rural husbands and wives over 27 years (1991–201...
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Objectives: To investigate how midlife chronic stress (40–50 years) and subsequent acute stressful events (50–65 years) influence husbands’ and wives’ later life mental and physical health (65+ years). Methods: Dyadic structural equation modeling was used with prospective data over 25 years from 256 husbands and wives in enduring marriages. Results...
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Some prior studies have found that, for boys, earlier puberty is linked to higher crime and delinquency, while other studies have found that earlier puberty is associated with greater social competence and beneficial psychosocial development. The current study suggests that these seemingly contradictory results actually represent two divergent path...
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Background The weathering hypothesis views the elevated rates of illness, disability, and mortality seen among Black Americans as a physiological response to the structural barriers, material hardships, and identity threats that comprise the Black experience. While granting that lifestyle may have some significance, the fundamental explanation for...
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It is widely accepted that socioeconomic status (SES) is a fundamental cause of health inequality. There is evidence, however, that race is also a fundamental cause of disparities in health. Based on this idea, the weathering hypothesis developed by Geronimus and her colleagues views the elevated rates of illness and disability seen among Black Ame...
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This article discusses the value of studying past social and psychological responses to pandemics and natural disasters in understanding reactions to COVID-19. By examining severe acute respiratory syndrome (SARS) experiences in both Taiwan and Hong Kong, we indicate that psychological trauma might be a pathway whereby the COVID-19 outbreak affects...
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Previous research has not adequately investigated the persistent influence of stressful work experiences, particularly person‐work mismatch (PWM), on the later‐life physical health outcomes of working husbands and wives. Using prospective data collected from 235 working husbands and wives over a period of 27 years (1991–2017), this study examined P...
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Reports an error in "Sibling relationships in older adulthood: Links with loneliness and well-being" by Clare M. Stocker, Megan Gilligan, Eric T. Klopack, Katherine J. Conger, Richard P. Lanthier, Tricia K. Neppl, Catherine Walker O'Neal and K. A. S. Wickrama (Journal of Family Psychology, 2020[Mar], Vol 34[2], 175-185). In the original article, th...
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The current study, using prospective data over 25 years (1991–2015; N = 245 couples), investigates life course dyadic patterns of positive and negative marital trajectories (i.e., marital strength and strain, respectively) in middle-aged husbands and wives and an array of physical and mental health outcomes associated with these patterns. Spousal w...
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Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction, with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year perio...
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Objective The present study investigated the factorial structure of the dyadic stress proliferation process in couples in enduring marriages leading to their psychological distress in later years. Background Stress proliferation during short and long periods of time has been shown to drive complex stress–distress processes during the life course....
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Researchers have documented associations between family relationships and a variety of well-being outcomes. Yet, sibling relationships, the longest lasting relationships in most people's lives, have received very little research attention beyond young adulthood. The goals of the current study were to: provide descriptive information about sibling r...
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Many developmental and life course researchers are interested in modeling dynamic developmental processes. Latent change score (LCS) modeling is a potentially powerful modeling technique that can be used to assess complex life course processes, as well as the direction of longitudinal bivariate associations. Advances in modeling software, like Mplu...
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This study investigated actor and partner effects involving middle‐aged husbands' and wives' stressful work conditions (SWCs), positive affect (PA) and health outcomes in a dyadic trajectory context in three steps. First, examination of husbands' and wives' individual trajectories showed significant inter‐individual variations in SWC and PA over ti...
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Although researchers have explored negative individual consequences of racial discrimination, very little work has examined the connection between discrimination and intimate partner violence (IPV) among African American men. Existing work tends to be cross-sectional and does not specify mediators or moderators that might explain this link. Thus, i...
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The purpose of this study is to evaluate the quality of observer ratings of neighborhood disorder using a many-facet Rasch model (MFRM). Our goal is to investigate observer severity and observer consistency. Observers trained in the use of a systematic social observation visited and rated residential neighborhoods. Data for this study are drawn fro...
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Loneliness is relatively common among older adults in the United States, and there can be significant physical, psychological, and cognitive impairments associated with feelings of loneliness. Consequently, this study seeks to uncover determinants of loneliness, particularly the impact of couples’ negative and positive marital experiences (i.e., ma...
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A substantial amount of research indicates precocious pubertal development is associated with delinquent behavior in girls. However, no clear consensus on theoretical mechanisms underlying this association has been established. Using a prospective panel study of 480 African-American girls, the current study uses latent growth curve analysis to comp...
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Using data from 416 middle‐aged mothers gathered over the course of a decade, this study examined the influence of mastery trajectories (the initial level and change), on change in physical health. Mastery is defined as one's ability to control and influence his/her life and environment to reach a desired outcome or goal. Both the initial level and...
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For good reason, social scientists have a long history of being suspicious of biological explanations of human behavior. Importantly, however, recent paradigmatic shifts in the life sciences have largely obviated these longstanding concerns. We highlight the changes that have occurred in genetics with its movement away from genetic determinism to a...

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